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FRONTIERS IN PHYSIOLOGY, ISSN 1664-042X, 10/2019, Volume 10, p. 1295
Introduction: The upstroke of optical action potentials (APs) recorded from intact hearts are generally recognized to be slower than those recorded with microelectrodes... 
DIRECTIONAL DIFFERENCES | VELOCITY | PHYSIOLOGY | FLECAINIDE | action potential upstroke | VENTRICULAR-TACHYCARDIA | ventricular | VOLTAGE-SENSITIVE DYES | SODIUM CONDUCTANCE | MONTE-CARLO | ORIENTATION | anisotropic conduction | conduction velocity | optical mapping | IMPULSE PROPAGATION | electrophysiology - basic | electrophysiology – basic
Journal Article
Circulation Research, ISSN 0009-7330, 06/1984, Volume 54, Issue 6, pp. 636 - 651
We compared the maximal upstroke velocity of action potentials in short rabbit Purkinje fibers with sodium currents measured with a two-microelecrrode voltage clamp... 
HEMATOLOGY | PERIPHERAL VASCULAR DISEASE | CARDIAC & CARDIOVASCULAR SYSTEMS
Journal Article
Heart Rhythm, ISSN 1547-5271, 2016, Volume 13, Issue 2, pp. 555 - 564
Background Selective inhibitors of Kv 1.5 channels are being developed for the treatment of atrial fibrillation (AF). Objectives The purpose of this study was... 
Cardiovascular | IKur inhibitor XEN-D0103 | QTcF | QTc | Frequency dependence | Atrial fibrillation | Human atrial action potentials | inhibitor XEN-D0103 | Delayed Rectifier Potassium Channels - antagonists & inhibitors | Heart Atria - drug effects | Atrial Fibrillation - drug therapy | Humans | Male | Treatment Outcome | Anti-Arrhythmia Agents - pharmacokinetics | Atrial Fibrillation - physiopathology | Healthy Volunteers | Anti-Arrhythmia Agents - administration & dosage | Anti-Arrhythmia Agents - adverse effects | Adult | Heart Atria - physiopathology | Atrial Fibrillation - diagnosis | Electrophysiologic Techniques, Cardiac - methods | Action Potentials - drug effects | Electrocardiography - methods | Refractory Period, Electrophysiological - drug effects | Index Medicus | APD20, APD50, APD90, action potential duration at 20%, 50%, and 90% of repolarization | dtmax, maximum upstroke velocity | IKur, ultra-rapidly activating delayed-rectifier potassium current | QT, corrected QT | AF, atrial fibrillation | ANOVA, analysis of variance | cAF, chronic atrial fibrillation | TMC, time-matched control | ECG, electrocardiogram | ERP, effective refractory period | QTcF, QT interval corrected by the Fridericia formula | RMP, resting membrane potential | HR, heart rate | AP, action potential | APA, action potential amplitude | PLT20, plateau potential, that is, mean absolute membrane potential (mV) in the time window between 20% and 30% of APD90 | electrocardiographic | SR, sinus rhythm | DMSO, dimethyl sulfoxide | pAF, paroxysmal atrial fibrillation
Journal Article
Heart rhythm, ISSN 1547-5271, 2017, Volume 14, Issue 11, pp. 1704 - 1712
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are in vitro models with the clear advantages of their human origin and suitability for... 
Action potential | Drug test | Long QT syndrome type 3 | Population of models | Human induced pluripotent stem cell-derived cardiomyocyte | In silico modeling | MUTANT SODIUM-CHANNELS | CARDIAC & CARDIOVASCULAR SYSTEMS | MODELS | RANOLAZINE | BLOCK | LONG-QT SYNDROME | Induced Pluripotent Stem Cells - pathology | Cardiac Conduction System Disease - drug therapy | Cell Line | Induced Pluripotent Stem Cells - drug effects | Mexiletine - pharmacology | Anti-Arrhythmia Agents - pharmacology | Humans | Biological Variation, Population | Cardiac Conduction System Disease - pathology | Cardiac Conduction System Disease - physiopathology | Long QT Syndrome - pathology | Long QT Syndrome - physiopathology | Action Potentials | Myocytes, Cardiac - pathology | Patch-Clamp Techniques | Myocytes, Cardiac - drug effects | Computer Simulation | Myocytes, Cardiac - metabolism | Long QT Syndrome - drug therapy | Transplantation | Analysis | Stem cells | Anti-arrhythmia drugs | Heart cells | IKr, rapid delayed rectifying potassium current | INa, fast sodium current | APD, action potential duration | LQT3, long QT syndrome type 3 | AP, action potential | ICaL, L-type calcium current | IpCa, calcium sarcolemmal pump | INaL, late sodium current | MDP, maximum diastolic potential | IK1, inward rectifying potassium current | APA, action potential amplitude | Peak, peak potential | rate, rate of spontaneous action potentials | hiPSC-CM, human induced pluripotent stem cell-derived cardiomyocyte | VMax, maximum upstroke velocity
Journal Article
Journal Article