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The Journal of Cell Biology, ISSN 0021-9525, 2/2003, Volume 160, Issue 3, pp. 321 - 328
The protective antigen (PA) of the anthrax toxin binds to a cell surface receptor and thereby allows lethal factor (LF) to be taken up and exert its toxic... 
Receptors | Anthrax | B lymphocytes | Rafts | Antibodies | HeLa cells | Lipids | Reports | Toxins | Cell membranes | CHO cells | Anthrax toxin | Protective antigen | Clustering | Microdomains | rafts | PROTEOLYTIC ACTIVATION | CELL-SURFACE | EUKARYOTIC CELLS | ANCHORED PROTEINS | CELL BIOLOGY | anthrax toxin | KINASE-KINASE | microdomains | MEMBRANE MICRODOMAINS | EPITHELIAL-CELLS | LETHAL FACTOR | protective antigen | SERINE PALMITOYLTRANSFERASE | clustering | Dynamins - metabolism | Membrane Microdomains - metabolism | Eukaryotic Cells - metabolism | Caveolins - metabolism | Phosphoproteins - metabolism | Receptors, Peptide - drug effects | Membrane Microdomains - ultrastructure | MAP Kinase Kinase 1 | Mitogen-Activated Protein Kinase Kinases - metabolism | Caveolin 1 | Transport Vesicles - drug effects | Eukaryotic Cells - microbiology | Protein-Serine-Threonine Kinases - metabolism | CHO Cells | Calcium-Binding Proteins - metabolism | Cricetinae | Endocytosis - drug effects | Anthrax - metabolism | Antigens, Bacterial | Microscopy, Electron | Clathrin - metabolism | Anthrax - physiopathology | Endocytosis - physiology | Macromolecular Substances | Bacterial Toxins - metabolism | Animals | Carrier Proteins - metabolism | Eukaryotic Cells - drug effects | Membrane Microdomains - drug effects | Transport Vesicles - metabolism | Mitogen-Activated Protein Kinase Kinases - drug effects | Protein-Serine-Threonine Kinases - drug effects | Transport Vesicles - ultrastructure | Receptors, Peptide - metabolism | Antigens | Endocytosis | Cell research | Analysis | Physiological aspects | Genetic aspects | Cytoplasm | anthrax toxin; rafts; microdomains; clustering; protective antigen | Report
Journal Article
Immunity, ISSN 1074-7613, 2011, Volume 35, Issue 1, pp. 34 - 44
Detection of microbial constituents by membrane associated and cytoplasmic pattern recognition receptors is the essence of innate immunity, leading to... 
CELLS | CONNEXIN-43 | PHOSPHORYLATION | LETHAL FACTOR | IN-VIVO | BACILLUS-ANTHRACIS | STAPHYLOCOCCUS-AUREUS | RELEASE | IMMUNOLOGY | CASPASE-1 ACTIVATION | NEUTROPHIL RECRUITMENT | Inflammasomes - metabolism | Bacillus anthracis - pathogenicity | Apoptosis - drug effects | Oncogene Protein v-akt - antagonists & inhibitors | Adenosine Triphosphate - secretion | Antigens, Bacterial - immunology | Immunity, Innate - genetics | Macrophages, Peritoneal - pathology | Antigens, Bacterial - genetics | Virulence - genetics | Interleukin-1beta - metabolism | Bacterial Toxins - genetics | Bacillus anthracis - genetics | Anthrax - immunology | Connexin 43 - metabolism | Bacterial Toxins - immunology | Mice, Inbred C57BL | Cells, Cultured | Interleukin-1beta - immunology | Macrophages, Peritoneal - immunology | Mutation - genetics | Anthrax - microbiology | Apoptosis Regulatory Proteins - metabolism | Bacterial Toxins - metabolism | Animals | Macrophages, Peritoneal - microbiology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Bacillus anthracis - immunology | Receptors, Purinergic P2X7 - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | Antigens, Bacterial - metabolism | Oligomers | Disease susceptibility | Macrophages | Protein kinases | Proteins | Kinases | Infections
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e62576
Vascular leakage pathologies such as pleural effusion and hemorrhage are hallmarks of anthrax pathogenesis. We previously reported that anthrax lethal toxin... 
CELLS | PERMEABILITY | MULTIDISCIPLINARY SCIENCES | INHALATIONAL ANTHRAX | IN-VIVO | BARRIER FUNCTION | GENE-EXPRESSION | BACILLUS-ANTHRACIS | VE-CADHERIN | EDEMA TOXIN | PROTECTIVE ANTIGEN | Tight Junctions - metabolism | Cadherins - metabolism | Endothelial Cells - metabolism | Liver - metabolism | RNA, Messenger - genetics | Antigens, Bacterial - pharmacology | Antigens, CD - genetics | Antigens, CD - metabolism | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Proteolysis - drug effects | Animals | Liver - drug effects | Signal Transduction - drug effects | Bacterial Toxins - pharmacology | Endothelium, Vascular - metabolism | Female | Mice | Cell Death - drug effects | Cadherins - genetics | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinases - metabolism | Muscle proteins | Cell death | Anthrax | Endothelium | Transcription factors | Laboratories | Pathogenesis | Virulence | Pleural effusion | mRNA | Infections | Biochemistry | Kinases | Hemorrhage | Cell adhesion & migration | Proteins | Reduction | Blood-brain barrier | Actin | Rodents | Leakage | Edema | Immunoglobulins | Hematology | Effusion | Tight junctions | Pharmacology | Permeability | Gene expression | Cadherin | Anthrax lethal toxin | Zonula occludens-1 protein | Endothelial cells | Brain research | Infectious diseases | Cytoskeleton | Microvasculature | Electrical junctions | Apoptosis
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2008, Volume 283, Issue 1, pp. 529 - 540
Anthrax lethal toxin (LT), a virulence factor secreted by Bacillus anthracis , is selectively toxic to human melanomas with the BRAF V600E activating mutation... 
INACTIVATION | ANGIOGENESIS | ADP-RIBOSYLATING TOXINS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUSCEPTIBILITY | MICE | MELANOMA-CELLS | PROTEIN-KINASE KINASE | CANCER | PROTECTIVE ANTIGEN | Immunohistochemistry | Humans | Antigens, Bacterial - genetics | Neovascularization, Pathologic - pathology | Neoplasms, Experimental - pathology | Mitogen-Activated Protein Kinase Kinases - metabolism | Bacterial Toxins - genetics | Female | Interleukin-8 - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Recombinant Proteins - metabolism | Cell Line | Cell Survival - drug effects | Endothelial Cells - metabolism | Mice, Inbred C57BL | Antigens, Bacterial - administration & dosage | Enzyme Activation - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Recombinant Proteins - administration & dosage | HT29 Cells | Xenograft Model Antitumor Assays | Bacterial Toxins - metabolism | Animals | Mice, Nude | Neovascularization, Pathologic - drug therapy | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Bacterial Toxins - administration & dosage | Mice | Mice, Inbred BALB C | Neovascularization, Pathologic - metabolism | Matrix Metalloproteinases - metabolism | Mutation | Antigens, Bacterial - metabolism | Neoplasms, Experimental - drug therapy | Endothelial Cells - drug effects | Neoplasms, Experimental - blood supply
Journal Article
The EMBO Journal, ISSN 0261-4189, 05/2007, Volume 26, Issue 9, pp. 2240 - 2250
Inhalation of anthrax causes fatal bacteremia, indicating a meager host immune response. We previously showed that anthrax lethal toxin (LT) paralyzes... 
actin‐regulatory proteins | p38 MAP kinase | heat‐shock proteins | anthrax | lethal toxin | Heat-shock proteins | Lethal toxin | Anthrax | Actin-regulatory proteins | LISTERIA-MONOCYTOGENES | CELLS | ACTIVATION | CHEMOTAXIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACROPHAGE CAPPING PROTEIN | NEUTROPHILS | POLYMERIZATION | heat-shock proteins | CELL BIOLOGY | SHIGELLA MOTILITY | ADAPTIVE IMMUNITY | actin-regulatory proteins | Cell Polarity | Phosphorylation | Brain - microbiology | Humans | Actins - metabolism | Bacterial Toxins - toxicity | Neoplasm Proteins - metabolism | Heat-Shock Proteins - genetics | Biological Transport, Active | p38 Mitogen-Activated Protein Kinases - metabolism | Listeria monocytogenes - physiology | Neutrophils - microbiology | Antigens, Bacterial - toxicity | Neoplasm Proteins - genetics | Heat-Shock Proteins - metabolism | Neutrophils - drug effects | Neutrophils - physiology | Rats | Imidazoles - pharmacology | Immunity, Innate | Actin Cytoskeleton - physiology | Animals | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Antigens, Bacterial - physiology | Pyridines - pharmacology | HeLa Cells | Mutation | HSP27 Heat-Shock Proteins | In Vitro Techniques | Listeria monocytogenes - drug effects | Toxicology | Immunology | Cellular biology | Ribonucleic acid | Molecular biology | Ribonucleic acid--RNA
Journal Article