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Cell Metabolism, ISSN 1550-4131, 07/2014, Volume 20, Issue 1, pp. 172 - 182
Oxysterols are cholesterol metabolites that serve multiple functions in lipid metabolism, including as liver X receptor (LXR) ligands. 27-hydroxycholesterol... 
ADHESION | SIGNALING PATHWAYS | HEART-DISEASE | DNA-BINDING | LIVER X RECEPTORS | INFLAMMATION | TRANSCRIPTION | ENDOCRINOLOGY & METABOLISM | NF-KAPPA-B | INTERLEUKIN-6 GENE-EXPRESSION | STEROL 27-HYDROXYLASE | CELL BIOLOGY | Steroid Hydroxylases - metabolism | Apolipoproteins E - deficiency | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | Apolipoproteins E - metabolism | Cytochrome P450 Family 7 | RNA Interference | Estrogen Receptor alpha - metabolism | Female | Cytokines - genetics | Steroid Hydroxylases - genetics | Macrophages - immunology | Cell Line | Atherosclerosis - pathology | NF-KappaB Inhibitor alpha | Cytokines - metabolism | Endothelial Cells - metabolism | Inflammation | Cell Adhesion - drug effects | Cholesterol - metabolism | Hydroxycholesterols - pharmacology | Atherosclerosis - metabolism | Mice, Knockout | Macrophages - metabolism | Animals | Estrogen Receptor alpha - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Endothelial Cells - cytology | Apolipoproteins E - genetics | Steroid Hydroxylases - deficiency | Hydroxycholesterols - metabolism | Macrophages - drug effects | Mice | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Metabolites | Atherosclerosis | Estrogen | Cytochrome P-450 | Physiological aspects | Phenols | Cholesterol | Prevention | Blood circulation disorders | Liver | Endothelium | Index Medicus
Journal Article
Journal Article
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 10/2018, Volume 66, Issue 42, pp. 10964 - 10976
Liver X receptor alpha (LXR alpha) controls important biological and pathophysiological processes such as lipid homeostasis. Inhibiting LXR alpha... 
reverse cholesterol transport | lipogenesis | pregnane X receptor | liver X receptor α | oleanolic acid | ACTIVATED PROTEIN-KINASE | CHOLESTEROL | FOOD SCIENCE & TECHNOLOGY | PXR | liver X receptor alpha | SREBP-1C | LXR-ALPHA | METABOLISM | DISEASE | AGRICULTURE, MULTIDISCIPLINARY | CHEMISTRY, APPLIED | BINDING | EXPRESSION | HEPATIC LIPOGENESIS | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2011, Volume 286, Issue 50, pp. 43112 - 43122
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2015, Volume 290, Issue 16, pp. 10309 - 10324
Lysosomes are ubiquitous membrane-enclosed organelles filled with an acidic interior and are central to the autophagic, endocytic, or phagocytic pathway. In... 
GEMFIBROZIL | GAMMA | Retinoic Acid | BIOCHEMISTRY & MOLECULAR BIOLOGY | Astrocyte | AUTOPHAGY | LIPID-LOWERING DRUG | Peroxisome proliferator-activated Receptor (PPAR) | MESSENGER-RNAS | ADOPTIVE TRANSFER | Neurodegeneration | GENE-EXPRESSION | Lysosomal Storage Disease | RETINOID-X-RECEPTOR | CELLULAR CLEARANCE | UP-REGULATION | Retinoid X Receptor alpha - metabolism | Humans | Neurons - cytology | PPAR gamma - metabolism | Autophagy - drug effects | Brain - metabolism | Lysosomes - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Neurons - metabolism | Neurons - drug effects | PPAR gamma - genetics | Tretinoin - pharmacology | Astrocytes - cytology | Lysosomes - drug effects | Astrocytes - drug effects | Promoter Regions, Genetic | Brain - cytology | PPAR-beta - metabolism | Signal Transduction | Gene Expression Regulation | PPAR alpha - genetics | Gemfibrozil - pharmacology | Transcription Factors - genetics | PPAR-beta - genetics | Brain - drug effects | Transcription Factors - metabolism | Animals | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Lipid Metabolism - drug effects | Retinoid X Receptor alpha - genetics | Protein Binding | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | PPAR alpha - agonists | Mice | PPAR alpha - metabolism | Primary Cell Culture | Astrocytes - metabolism | Index Medicus
Journal Article
Toxicological Sciences, ISSN 1096-6080, 04/2019, Volume 168, Issue 2, pp. 572 - 596
Abstract The nongenotoxic pyrethroid insecticide permethrin produced hepatocellular tumors in CD-1 mice but not in Wistar rats. Recently, based on findings of... 
nongenotoxic | cell proliferation | mode of action | mouse liver tumors | permethrin | peroxisome proliferator-activated receptor alpha | RAT-LIVER | PPAR-ALPHA | CARCINOGENIC MODES | INFORMATION | RODENT LIVER | HUMAN RELEVANCE ANALYSIS | CONSTITUTIVE ANDROSTANE RECEPTOR | CANCER-RISK | MICE | TOXICOLOGY | IPCS FRAMEWORK
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, pp. e30174 - e30174
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2016, Volume 11, Issue 9, pp. e0162628 - e0162628
Peroxisome proliferator-activated receptor alpha (PPAR alpha) is a nuclear hormone receptor involved in the transcriptional regulation of lipid metabolism,... 
RESPONSES | OXIDATIVE STRESS | MESSENGER-RNA EXPRESSION | HUMAN DERMAL FIBROBLASTS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | EPIDERMIS | ULTRAVIOLET | MECHANISMS | SUPEROXIDE-DISMUTASE | MODULATION | RNA, Small Interfering - genetics | Skin - metabolism | Humans | Young Adult | Aging - genetics | Aged, 80 and over | Adult | Female | Catalase - genetics | Cells, Cultured | Aging - radiation effects | PPAR alpha - genetics | Reverse Transcriptase Polymerase Chain Reaction | Skin - enzymology | Blotting, Western | Ultraviolet Rays - adverse effects | Hydrogen Peroxide - metabolism | Catalase - metabolism | Animals | Skin - radiation effects | Aged | Mice | PPAR alpha - metabolism | In Vitro Techniques | Gene Silencing - physiology | Antioxidants | Enzymes | Care and treatment | RNA | Physiological aspects | Skin | Fatty acids | Oxidative stress | Reactive oxygen species | Biomedical research | Transcription | Gene regulation | Irradiated | Homeostasis | Biology | Activation | Matrix metalloproteinase | Dermatitis | Signal transduction | Catalase | Rodents | Fibroblasts | Aging | Tumor necrosis factor-TNF | Oxidation | Metalloproteinase | Lipid metabolism | Growth factors | Interstitial collagenase | Medical research | Procollagen | Dermatology | U.V. radiation | Scavenging | Inflammation | Hairless | Metabolism | Collagenase 3 | Medicine | Ultraviolet radiation | Collagen | Irradiation | Ligands | Topical application | Index Medicus
Journal Article
Neurochemistry International, ISSN 0197-0186, 10/2019, Volume 129, pp. 104501 - 104501
Brain is a site of diabetic end-organ damage. Diabetes-associated cognitive dysfunction, referred as "diabetic encephalopathy" (DE) has been coined for the... 
Neuroprotection | Peroxisome proliferator-activated receptor alpha | Oleoylethanolamide | Spatial cognitive function | Diabetic encephalopathy | Index Medicus
Journal Article
INFECTION AND IMMUNITY, ISSN 0019-9567, 04/2016, Volume 84, Issue 4, pp. 1032 - 1044
Nematode infection upregulates interleukin-4 (IL-4) and IL-13 and induces STAT6-dependent changes in gut function that promote worm clearance. IL-4 and IL-13... 
MURINE GUT | INFECTIOUS DISEASES | ALTERNATIVELY ACTIVATED MACROPHAGES | PROTECTIVE IMMUNITY | HELIGMOSOMOIDES-POLYGYRUS | TH2 CYTOKINE | NIPPOSTRONGYLUS-BRASILIENSIS INFECTION | ENTERIC NEMATODES | IMMUNOLOGY | EPITHELIAL-CELL FUNCTION | NEMATODE INFECTIONS | T-CELLS
Journal Article