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Apoptosis, ISSN 1360-8185, 7/2016, Volume 21, Issue 7, pp. 809 - 824
Recently, we demonstrated that melatonin reduced protein kinase RNA (PKR)-like ER kinase (PERK)-eukaryotic initiation factor 2 alpha (eIF2α)-activating... 
Biochemistry, general | Melatonin | Biomedicine | Myocardial ischemia–reperfusion injury | Survivor activating factor enhancement pathway | Cancer Research | Oncology | Reperfusion injury salvage kinase pathway | Cell Biology | Virology | Endoplasmic reticulum stress | H9C2 CARDIOMYOBLAST CELLS | ISCHEMIA/REPERFUSION INJURY | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | Myocardial ischemia-reperfusion injury | CARDIAC DYSFUNCTION | DIABETIC-RATS | CELLULAR STRESS | CELL BIOLOGY | IN-VITRO | SIGNALING PATHWAY | CARDIOVASCULAR-DISEASES | ACTIVATES STAT3 | Myocardial Ischemia - genetics | Myocardial Ischemia - metabolism | Phosphorylation | Oxidative Stress | eIF-2 Kinase - metabolism | Humans | Male | Phosphatidylinositol 3-Kinases - metabolism | Melatonin - administration & dosage | Myocardial Reperfusion Injury - enzymology | Myocardium - metabolism | Eukaryotic Initiation Factor-2 - metabolism | Myocardial Reperfusion Injury - drug therapy | Myocardial Reperfusion Injury - genetics | eIF-2 Kinase - genetics | Signal Transduction | Mice, Inbred C57BL | Activating Transcription Factor 4 - genetics | Glycogen Synthase Kinase 3 - metabolism | Phosphatidylinositol 3-Kinases - genetics | Myocardial Reperfusion Injury - metabolism | Animals | Activating Transcription Factor 4 - metabolism | Glycogen Synthase Kinase 3 - genetics | Endoplasmic Reticulum Stress | Eukaryotic Initiation Factor-2 - genetics | Myocardial Ischemia - surgery | Index Medicus
Journal Article
The American Journal of Pathology, ISSN 0002-9440, 10/2018, Volume 188, Issue 10, pp. 2339 - 2355
Liver cirrhosis is an independent risk factor for hepatocellular carcinoma (HCC). The mechanisms that contribute to HCC development in the cirrhotic... 
OXIDATIVE STRESS | IN-VITRO | UNFOLDED PROTEIN RESPONSE | CARCINOGENESIS | PATHWAY | ER STRESS | ACTIVATES STAT-3 | PERK | PATHOLOGY | HUMAN HEPATOCELLULAR-CARCINOMA | CANCER
Journal Article
PLoS Pathogens, ISSN 1553-7366, 08/2013, Volume 9, Issue 8, pp. e1003544 - e1003544
During viral infection, a massive demand for viral glycoproteins can overwhelm the capacity of the protein folding and quality control machinery, leading to an... 
BAX-DEPENDENT APOPTOSIS | ER STRESS | MICROBIOLOGY | ENDOPLASMIC-RETICULUM STRESS | MUTATIONAL ANALYSIS | ACTIVATES PERK | JNK PHOSPHORYLATION | VIROLOGY | HEPATITIS-C VIRUS | MESSENGER-RNA | GENE-EXPRESSION | PARASITOLOGY | SENSOR IRE1-ALPHA | NIH 3T3 Cells | Endoribonucleases - genetics | Humans | Cytomegalovirus Infections - metabolism | Cytomegalovirus Infections - genetics | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Viral Structural Proteins - genetics | Cytomegalovirus - genetics | Membrane Proteins - genetics | Cytomegalovirus - metabolism | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Endoribonucleases - biosynthesis | Unfolded Protein Response | Regulatory Factor X Transcription Factors | Down-Regulation - genetics | Muromegalovirus - metabolism | Protein-Serine-Threonine Kinases - biosynthesis | Transcription Factors - metabolism | Membrane Proteins - biosynthesis | Animals | Mice | Muromegalovirus - genetics | Viral Structural Proteins - metabolism | Cell Line, Transformed | Physiological aspects | Host-parasite relationships | Research | Cytomegaloviruses | Protein folding | Health aspects | Index Medicus | Enzymes | Cytomegalovirus | Protein synthesis | Plasmids | Homeostasis | Sensors | Kinases | Endoplasmic reticulum | Viral infections
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 12/2018, Volume 129, pp. 454 - 462
Glutathione peroxidase 4 (GPX4) is a regulator of ferroptosis (iron-dependent, non-apoptotic cell death); its inhibition can render therapy-resistant cancer... 
Head and neck cancer | Ferroptosis | GPX4 | Nrf2 | p62 | ACTIVATE NRF2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | P62/SQSTM1 | FOLLOW-UP | AUTOPHAGY | CELL-DEATH | PROTECTS | TRANSCRIPTION FACTOR NRF2 | PATHWAY | ENDOCRINOLOGY & METABOLISM | DEGRADATION | Antioxidants | Development and progression | Cell death | Analysis
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, pp. e98586 - e98586
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0130599 - e0130599
Luteolin and apigenin are dietary flavones and exhibit a broad spectrum of biological activities including antioxidant, anti-inflammatory, anti-cancer and... 
GLUTAMATE CYSTEINE LIGASE | OXIDATIVE STRESS | HEME OXYGENASE-1 EXPRESSION | LIPID-PEROXIDATION PRODUCT | CYSTINE/GLUTAMATE ANTIPORTER | PROTEIN-KINASE | ER STRESS | MULTIDISCIPLINARY SCIENCES | ACTIVATE AUTOPHAGY | FACTOR-KAPPA-B | ENDOPLASMIC-RETICULUM STRESS | Unfolded Protein Response - drug effects | PC12 Cells - cytology | Reactive Oxygen Species - metabolism | Caspase 3 - metabolism | Rats | Antioxidants - pharmacology | Aldehydes - metabolism | Luteolin - pharmacology | Gene Expression Regulation - drug effects | PC12 Cells - drug effects | Animals | MAP Kinase Signaling System - drug effects | Neuroprotective Agents - pharmacology | Signal Transduction - drug effects | PC12 Cells - metabolism | NF-E2-Related Factor 2 - metabolism | Cell Death - drug effects | Lipid Peroxidation | Apigenin - pharmacology | Antioxidants | Nervous system diseases | Flavonoids | Flavones | Cell death | Bioflavonoids | Lipid peroxidation | Development and progression | Biochemistry | Oxidative stress | Biotechnology | Neuroprotection | Cell culture | Reactive oxygen species | Transcription factors | Phosphorylation | Traumatic brain injury | Toxicity | Homeostasis | Cytotoxicity | Activation | Kinases | Caspase-3 | Anticancer properties | Proteins | Biological effects | Pathways | Protein folding | Rodents | Peroxidation | Enzymes | Neurodegenerative diseases | Poly(ADP-ribose) polymerase | Caspase | MAP kinase | Inflammation | Gene expression | Poly(ADP-ribose) Polymerase 1 | Brain research | Diet | Pharmacy | Pheochromocytoma cells | Endoplasmic reticulum | Viability | Apoptosis | Cancer | Index Medicus
Journal Article
Journal Article