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Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 05/2009, Volume 10, Issue 5, pp. 319 - 331
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 12/2011, Volume 18, Issue 12, pp. 1323 - 1330
Journal Article
Chemical Communications, ISSN 1359-7345, 2016, Volume 52, Issue 12, pp. 2477 - 2480
We report a facile synthetic strategy to prepare UBL-AMP electrophilic probes that form a covalent bond with the catalytic cysteine of cognate E1s, mimicking... 
DEHYDROALANINE | THERAPY | SUMO E1 | ATG8 | AUTOPHAGY | UBIQUITIN-LIKE PROTEINS | DIUBIQUITIN | CHEMISTRY, MULTIDISCIPLINARY | ACTIVATING ENZYME | INSIGHTS | Enzymes | Covalence | Cysteine | Synthesis | Strategy | Biochemistry | Catalysis | Covalent bonds
Journal Article
Blood, ISSN 0006-4971, 03/2010, Volume 115, Issue 11, pp. 2251 - 2259
Journal Article
Chemical communications (Cambridge, England), ISSN 1359-7345, 02/2016, Volume 52, Issue 12, pp. 2477 - 2480
We report a facile synthetic strategy to prepare UBL-AMP electrophilic probes that form a covalent bond with the catalytic cysteine of cognate E1s, mimicking... 
Enzymes - chemistry | Catalysis | Molecular Probes - chemical synthesis
Journal Article
Analytical Chemistry, ISSN 0003-2700, 08/2017, Volume 89, Issue 15, p. 7852
Protein ubiquitination plays a role in essentially every process in eukaryotic cells. The attachment of ubiquitin (Ub) or Ub-like (UBL) proteins to target... 
Ubiquitin | Enzymes | Phosphorylation | Downstream effects | Mass spectroscopy | Activation | C-Terminus | Hydrophobicity | Machinery | Optimization | Cells | Proteins | E1 protein | Eukaryotes | Ubiquitination | Cascades | Conjugation | Mutation | Mass spectrometry
Journal Article
Journal Article
Atherosclerosis, ISSN 0021-9150, 2016, Volume 247, pp. 142 - 153
Abstract Aims The ubiquitin-activating enzyme E1 (UBA1, E1), the apex of the ubiquitin proteasome pathway, plays a critical role in protein degradation and in... 
Cardiovascular | Ubiquitin-activating enzyme E1 | Restenosis | Inflammation | Vascular injury | MULTIPLE-MYELOMA | KAPPA-B ACTIVATION | INHIBITS NEOINTIMAL HYPERPLASIA | RAT ARTERY | PROLIFERATION | INTIMAL HYPERPLASIA | BALLOON INJURY | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | PROTEASOME SYSTEM | ATHEROSCLEROTIC PLAQUE | Carotid Arteries - drug effects | RNA, Small Interfering - genetics | Recurrence | Carotid Stenosis - prevention & control | Furans - pharmacology | Male | Neointima | Transfection | Time Factors | Carotid Stenosis - genetics | Inflammation Mediators - metabolism | Adenoviridae - genetics | Carotid Arteries - enzymology | Carotid Artery Injuries - genetics | Carotid Artery Injuries - pathology | Disease Models, Animal | Pyrazoles - pharmacology | Ubiquitin-Activating Enzymes - genetics | Cell Cycle Proteins - metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | Carotid Stenosis - pathology | Ubiquitin-Activating Enzymes - metabolism | Rats, Sprague-Dawley | RNAi Therapeutics - methods | Carotid Artery Injuries - therapy | Animals | Carotid Artery Injuries - enzymology | Signal Transduction - drug effects | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Benzoates - pharmacology | Carotid Arteries - pathology | Carotid Stenosis - enzymology | Cell Proliferation - drug effects | Cell Cycle - drug effects | Genetic Vectors | RNA, Small Interfering - metabolism | Ubiquitin | Enzymes | Proteolysis | Health aspects | Proteins | Chemical inhibitors
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. E1
Journal Article
Journal Article