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Journal Article
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2007, Volume 12, Issue 4, pp. 367 - 380
Despite their known transforming properties, the effects of leukemogenic FLT3-ITD mutations on hematopoietic stem and multipotent progenitor cells and on... 
STEMCELL | CELLCYCLE | INTERNAL TANDEM DUPLICATION | ACTIVATING MUTATION | PROGNOSTIC-FACTORS | ONCOLOGY | CHRONIC MYELOPROLIFERATIVE DISORDERS | TYROSINE KINASE | CONSTITUTIVE ACTIVATION | BONE-MARROW | LYMPHOMA CELL-LINES | ACUTE MYELOID-LEUKEMIA | MARROW TRANSPLANT MODEL | Cell Proliferation | Exons | Humans | Leukemia, Myelomonocytic, Chronic - genetics | Multipotent Stem Cells - metabolism | Gene Expression Regulation, Neoplastic | Hematopoietic Stem Cells - pathology | Myeloproliferative Disorders - pathology | Leukemia, Myelomonocytic, Chronic - metabolism | Myeloproliferative Disorders - genetics | fms-Like Tyrosine Kinase 3 - genetics | Myeloproliferative Disorders - metabolism | Cell Differentiation | Leukemia, Myelomonocytic, Chronic - pathology | Leukemia, Experimental - pathology | Signal Transduction | Cell Survival | Leukemia, Myelomonocytic, Chronic - mortality | Mice, Inbred C57BL | Cells, Cultured | Kaplan-Meier Estimate | Genotype | Mice, Transgenic | Hematopoietic Stem Cells - metabolism | fms-Like Tyrosine Kinase 3 - metabolism | Multipotent Stem Cells - pathology | Phenotype | Animals | Mice | Mice, Inbred BALB C | Mutation | Leukemia, Experimental - metabolism | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
Journal Article
by Xu, B and Zhao, Y and Wang, X and Gong, P and Ge, W
Leukemia, ISSN 0887-6924, 04/2017, Volume 31, Issue 4, pp. 913 - 921
More than one-third of patients with acute myeloid leukemia (AML) harbor aberrant mutations in Fms-like tyrosine kinase 3 (FLT3). Among them, the internal... 
AML | CELLS | IN-VITRO | ACTIVATION | DOMAIN | F691L MUTATION | MECHANISM | ONCOLOGY | T790M MUTATION | KINASE INHIBITOR | LIGAND | HEMATOLOGY | Gene Duplication | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Phosphorylation | Apoptosis - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | Cell Survival - genetics | Apoptosis - genetics | Male | Antineoplastic Agents - therapeutic use | Tandem Repeat Sequences | Quinolines - pharmacology | Dose-Response Relationship, Drug | fms-Like Tyrosine Kinase 3 - genetics | Bone Marrow Transplantation | Leukemia, Myeloid, Acute - drug therapy | Female | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | Models, Molecular | Phenylurea Compounds - therapeutic use | fms-Like Tyrosine Kinase 3 - chemistry | fms-Like Tyrosine Kinase 3 - metabolism | Leukemia, Myeloid, Acute - mortality | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Protein Conformation | Cell Proliferation - drug effects | Mice | Phenylurea Compounds - pharmacology | Protein Kinase Inhibitors - pharmacology | Quinolines - therapeutic use | Mutation | Leukemia, Myeloid, Acute - genetics | Cell proliferation | Tyrosine | Research | Drug resistance | Mutation (Biology) | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 04/2003, Volume 101, Issue 8, pp. 3164 - 3173
The receptor tyrosine kinase Flt3 is expressed and functionally important in early myeloid progenitor cells and in the majority of acute myeloid leukeimia... 
BINDING-PROTEIN-ALPHA | INTERNAL TANDEM DUPLICATION | C/EBP-ALPHA | CONSTITUTIVE ACTIVATION | RISK GROUP | 32D CELLS | C-MYC | GRANULOCYTIC DIFFERENTIATION | CELL-LINES | HEMATOLOGY | SIGNAL TRANSDUCER | Oligonucleotide Array Sequence Analysis | Humans | Leukemia, Myeloid - genetics | Protein-Serine-Threonine Kinases | Receptor Protein-Tyrosine Kinases - physiology | Recombinant Fusion Proteins - physiology | fms-Like Tyrosine Kinase 3 | Gene Expression Profiling | Tandem Repeat Sequences | Proto-Oncogene Proteins - biosynthesis | Interleukin-3 - pharmacology | Leukemia, Myeloid - pathology | CCAAT-Enhancer-Binding Protein-alpha - biosynthesis | Transfection | Trans-Activators - genetics | Transcription, Genetic | Trans-Activators - biosynthesis | Neoplasm Proteins - genetics | Cell Line - metabolism | Acute Disease | Neoplasm Proteins - biosynthesis | Gene Expression Regulation | Genes, Synthetic | Proto-Oncogene Proteins - genetics | Hematopoietic Stem Cells - metabolism | Gene Expression Regulation, Leukemic | Reverse Transcriptase Polymerase Chain Reaction | Protein Isoforms - physiology | Animals | Receptor Protein-Tyrosine Kinases - genetics | Proto-Oncogene Proteins - physiology | CCAAT-Enhancer-Binding Protein-alpha - genetics | Myeloid Cells - metabolism | Recombinant Fusion Proteins - genetics | Computer Systems | Mice | Cluster Analysis
Journal Article
Journal Article
Blood, ISSN 0006-4971, 12/2000, Volume 96, Issue 12, pp. 3907 - 3914
Somatic mutations of the receptor tyrosine kinase Flt3 consisting of internal tandem duplications (ITD) occur in 20% of patients with acute myeloid leukemia.... 
INTERNAL TANDEM DUPLICATION | STEM-CELLS | HEMATOPOIETIC PROGENITOR CELLS | HUMAN BONE-MARROW | CONSTITUTIVE ACTIVATION | C-KIT | MURINE FLT3 | GROWTH-FACTOR | HEMATOLOGY | RECEPTOR TYROSINE KINASE | HUMAN HOMOLOG | Clone Cells - cytology | Recombinant Fusion Proteins - pharmacology | Apoptosis - drug effects | Apoptosis - radiation effects | DNA Replication - drug effects | Humans | Leukemia, Myeloid - genetics | Myeloid Cells - physiology | Protein-Serine-Threonine Kinases | fms-Like Tyrosine Kinase 3 | ras Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Trans-Activators - physiology | DNA-Binding Proteins - metabolism | Neoplasms, Experimental - pathology | Mitogen-Activated Protein Kinase Kinases - metabolism | Transfection | Milk Proteins | Female | Myeloid Cells - drug effects | Neoplasms, Experimental - mortality | Tumor Cells, Cultured | Tandem Repeat Sequences - genetics | ras Proteins - physiology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - pharmacology | Acute Disease | DNA-Binding Proteins - physiology | Receptor Protein-Tyrosine Kinases - pharmacology | Proto-Oncogene Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Cell Division - drug effects | Mice, Inbred C3H | Proto-Oncogene Proteins c-akt | Animals | STAT5 Transcription Factor | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Leukemia, Myeloid - physiopathology | Recombinant Fusion Proteins - genetics | Trans-Activators - metabolism | Mice | Cell Transformation, Neoplastic - drug effects | Mutation
Journal Article