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Cancer Cell, ISSN 1535-6108, 05/2012, Volume 21, Issue 5, pp. 614 - 625
Rescuing the function of mutant p53 protein is an attractive cancer therapeutic strategy. Using the National Cancer Institute's anticancer drug screen data, we... 
WILD-TYPE CONFORMATION | DNA-BINDING DOMAIN | RESCUE | ONCOLOGY | IRON CHELATORS | MUTATION | REDOX ACTIVITY | TUMOR-SUPPRESSOR | CANCER MUTANTS | RESTORATION | ANTITUMOR-ACTIVITY | CELL BIOLOGY | Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Zinc - metabolism | Humans | Transcriptional Activation - drug effects | Structure-Activity Relationship | Mutation, Missense | Tumor Suppressor Protein p53 - genetics | Dose-Response Relationship, Drug | Transfection | Neoplasms - genetics | RNA Interference | Time Factors | Antineoplastic Agents - pharmacology | Thiosemicarbazones - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Binding Sites | Cell Line | Cell Survival - drug effects | Oxidation-Reduction | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | Mice, Transgenic | Chelating Agents - pharmacology | DNA - metabolism | Tumor Suppressor Protein p53 - drug effects | Gene Knock-In Techniques | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Mice, Nude | Alleles | Protein Conformation | Mice | Mice, Inbred BALB C | Tumor Suppressor Protein p53 - chemistry | Oxidative Stress - drug effects | Neoplasms - pathology | Care and treatment | Nuclear radiation | Oncology, Experimental | Research | Tumor proteins | Health aspects | Cancer | Antitumor agents | Lymphocytes B | Xenografts | Data processing | Drug development | Zinc | p53 protein | Apoptosis | Structure-function relationships | Tumors
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2013, Volume 31, Issue 17, pp. 2173 - 2181
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 05/2019, Volume 18, Issue 5, pp. 920 - 928
TAS-121 is a novel orally active selective covalent inhibitor of the mutant EGFR. We performed preclinical characterization of TAS-121 and compared its... 
CELL LUNG-CANCER | GEFITINIB | MULTICENTER | AMPLIFICATION | OSIMERTINIB | ONCOLOGY | EML4-ALK FUSION | ACQUIRED-RESISTANCE | CLINICAL ACTIVITY | ACTIVATING MUTATIONS | AZD9291
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 11 - 15
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 2018, Volume 25, Issue 1, pp. 161 - 168
Mutant p53 proteins impart changes in cellular behavior and function through interactions with proteins that alter gene expression. The milieu of intracellular... 
WILD-TYPE P53 | COMPLEX | LI-FRAUMENI-SYNDROME | DRIVE CANCER | METASTASIS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | P63 | BINDING | MOUSE MODELS | GAIN | CELL BIOLOGY | Proteins | Therapy | Missense mutation | Mathematical analysis | p53 Protein | Transcription activation | Crime | Mutation | Gene expression | Protein interaction | Environmental conditions | Review
Journal Article
Journal Article
Journal of Cancer Research and Clinical Oncology, ISSN 0171-5216, 1/2016, Volume 142, Issue 1, pp. 89 - 100
Journal Article