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1. Full Text Mutant p53 partners in crime
by Kim, Michael P and Lozano, Guillermina
Cell death and differentiation, ISSN 1350-9047, 2018, Volume 25, Issue 1, pp. 161 - 168
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Proteins | Therapy | Missense mutation | Mathematical analysis | p53 Protein | Transcription activation | Crime | Mutation | Gene expression | Protein interaction | Environmental conditions | Index Medicus | Review
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2. Full Text Allele-Specific p53 Mutant Reactivation
by Yu, Xin and Vazquez, Alexei and Levine, Arnold J and Carpizo, Darren R
Cancer cell, ISSN 1535-6108, 05/2012, Volume 21, Issue 5, pp. 614 - 625
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Zinc - metabolism | Humans | Transcriptional Activation - drug effects | Structure-Activity Relationship | Mutation, Missense | Tumor Suppressor Protein p53 - genetics | Dose-Response Relationship, Drug | Transfection | Neoplasms - genetics | RNA Interference | Time Factors | Antineoplastic Agents - pharmacology | Thiosemicarbazones - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Binding Sites | Cell Line | Cell Survival - drug effects | Oxidation-Reduction | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | Mice, Transgenic | Chelating Agents - pharmacology | DNA - metabolism | Tumor Suppressor Protein p53 - drug effects | Gene Knock-In Techniques | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Mice, Nude | Alleles | Protein Conformation | Mice | Mice, Inbred BALB C | Tumor Suppressor Protein p53 - chemistry | Oxidative Stress - drug effects | Neoplasms - pathology | Care and treatment | Nuclear radiation | Oncology, Experimental | Research | Tumor proteins | Health aspects | Cancer | Index Medicus | Antitumor agents | Lymphocytes B | Xenografts | Data processing | Drug development | Zinc | p53 protein | Apoptosis | Structure-function relationships | Tumors
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3. Full Text Targeting mutant p53 for efficient cancer therapy
by Bykov, Vladimir J. N and Eriksson, Sofi E and Bianchi, Julie and Wiman, Klas G
Nature reviews. Cancer, ISSN 1474-175X, 01/2018, Volume 18, Issue 2, pp. 89 - 102
Life Sciences & Biomedicine | Oncology | Science & Technology | Molecular targeted therapy | Care and treatment | Gene mutations | Innovations | Tumor suppressor genes | Health aspects | Cancer | Medical research | Deactivation | p53 Protein | Clinical trials | Recovery of function | Activation | Pharmacology | Inactivation | Cell death | Mutation | Tumors | Apoptosis | Index Medicus | Medicin och hälsovetenskap
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4. Full Text Cell-type, Dose, and Mutation-type Specificity Dictate Mutant p53 Functions In Vivo
by Lee, Ming Kei and Teoh, Wei Wei and Phang, Beng Hooi and Tong, Wei Min and Wang, Zhao Qi and Sabapathy, Kanaga
Cancer cell, ISSN 1535-6108, 12/2012, Volume 22, Issue 6, pp. 751 - 764
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cellular Senescence - genetics | Proto-Oncogene Proteins c-mdm2 - genetics | Animals | Cell Death - genetics | Cell Transformation, Neoplastic | Transcriptional Activation | Cells, Cultured | Cell Survival - genetics | Mice | Mutation | Gene Knock-In Techniques - methods | Tumor Suppressor Protein p53 - genetics | Analysis | Oncology, Experimental | Stem cells | Research | Tumor proteins | Tumors | Cancer | Index Medicus
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5. Full Text A combinatorial strategy for treating KRAS-mutant lung cancer
by Manchado, Eusebio and Manchado, Eusebio and Weissmueller, Susann and Weissmueller, Susann and Morris, John P and Morris, John P and Chen, Chi-Chao and Chen, Chi-Chao and Wullenkord, Ramona and Wullenkord, Ramona and Lujambio, Amaia and Lujambio, Amaia and de Stanchina, Elisa and De Stanchina, Elisa and Poirier, John T and Poirier, John T and Gainor, Justin F and Gainor, Justin F and Corcoran, Ryan B and Corcoran, Ryan B and Engelman, Jeffrey A and Engelman, Jeffrey A and Rudin, Charles M and Rudin, Charles M and Rosen, Neal and Rosen, Neal and Lowe, Scott W and Lowe, Scott W
Nature (London), ISSN 0028-0836, 2016, Volume 534, Issue 7609, pp. 647 - 651
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Lung Neoplasms - drug therapy | Colonic Neoplasms - genetics | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Pyridazines - pharmacology | Female | Pyrimidinones - pharmacology | Adenocarcinoma - genetics | Cell Death - drug effects | Imidazoles - therapeutic use | Phosphorylation - drug effects | Pyridazines - therapeutic use | Disease Models, Animal | Lung Neoplasms - genetics | Pancreatic Neoplasms - pathology | Pyrimidinones - therapeutic use | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Mutant Proteins - genetics | Antineoplastic Combined Chemotherapy Protocols | Pancreatic Neoplasms - genetics | Imidazoles - pharmacology | Enzyme Activation - drug effects | Adenocarcinoma - drug therapy | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Xenograft Model Antitumor Assays | Feedback, Physiological | Animals | MAP Kinase Signaling System - drug effects | Colonic Neoplasms - pathology | Cell Proliferation - drug effects | Mice | Pyridones - therapeutic use | Mutation | Pyridones - pharmacology | Drug Screening Assays, Antitumor | Molecular targeted therapy | Care and treatment | Cell death | Lung cancer | Methods | Cancer cells | Phosphorylation | Chemotherapy | Inhibitor drugs | Drug resistance | Tumors | Index Medicus
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6. Full Text An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
by Canna, Scott W and De Jesus, Adriana A and Gouni, Sushanth and Brooks, Stephen R and Marrero, Bernadette and Liu, Yin and Dimattia, Michael A and Zaal, Kristien J. M and Sanchez, Gina A. Montealegre and Kim, Hanna and Chapelle, Dawn and Plass, Nicole and Huang, Yan and Villarino, Alejandro V and Biancotto, Angelique and Fleisher, Thomas A and Duncan, Joseph A and O'Shea, John J and Benseler, Susanne and Grom, Alexei and Deng, Zuoming and Laxer, Ronald M and Goldbach-Mansky, Raphaela
Nature genetics, ISSN 1061-4036, 09/2014, Volume 46, Issue 10, pp. 1140 - 1146
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Amino Acid Sequence | Macrophage Activation Syndrome - blood | Interleukin-18 - blood | Oligonucleotide Array Sequence Analysis | Humans | Molecular Sequence Data | Gene Expression Profiling | Mutation, Missense | Sequence Analysis, DNA | Inflammasomes - genetics | Inflammation - blood | CARD Signaling Adaptor Proteins - genetics | Sequence Homology, Amino Acid | Exome - genetics | Macrophages - metabolism | Inflammation - genetics | Female | Macrophage Activation Syndrome - genetics | Child | Interleukin-18 - metabolism | Calcium-Binding Proteins - genetics | Causes of | Inflammation | Genetic aspects | Gene mutations | Macrophages | Health aspects | Disease | Cytokines | Pathogenesis | Rheumatic diseases | Cytotoxicity | Arthritis | Mutation | Hearing impairment | Gene expression | Fever | Crystal structure | Index Medicus
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7. Full Text Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
by Mayers, Jared R and Torrence, Margaret E and Danai, Laura V and Papagiannakopoulos, Thales and Davidson, Shawn M and Bauer, Matthew R and Lau, Allison N and Ji, Brian W and Dixit, Purushottam D and Hosios, Aaron M and Muir, Alexander and Chin, Christopher R and Freinkman, Elizaveta and Jacks, Tyler and Wolpin, Brian M and Vitkup, Dennis and Vander Heiden, Matthew G
Science (American Association for the Advancement of Science), ISSN 0036-8075, 09/2016, Volume 353, Issue 6304, pp. 1161 - 1165
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Lung Neoplasms - genetics | Nitrogen - metabolism | Pancreatic Neoplasms - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Transaminases - genetics | Amino Acids, Branched-Chain - metabolism | Humans | Lung Neoplasms - metabolism | Mice, Inbred C57BL | Pregnancy Proteins - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Carcinoma, Pancreatic Ductal - metabolism | Gene Expression Regulation, Neoplastic | Male | Pancreatic Neoplasms - genetics | Organ Specificity | Carcinoma, Pancreatic Ductal - genetics | Animals | Metabolic Networks and Pathways | Minor Histocompatibility Antigens - genetics | Mice | Mutation | Gene mutations | Branched chain amino acids | Pancreatic cancer | Genetic aspects | Lung cancer, Non-small cell | Health aspects | Amino acid metabolism | Genetics | Amino acids | Tissues | Cancer | Index Medicus | Origins | Enzymes | Lungs | Activation | Formations | Tumors
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8. Full Text HOXB1 Founder Mutation in Humans Recapitulates the Phenotype of Hoxb1−/− Mice
by Webb, Bryn D and Shaaban, Sherin and Gaspar, Harald and Cunha, Luis F and Schubert, Christian R and Hao, Ke and Robson, Caroline D and Chan, Wai-Man and Andrews, Caroline and MacKinnon, Sarah and Oystreck, Darren T and Hunter, David G and Iacovelli, Anthony J and Ye, Xiaoqian and Camminady, Anne and Engle, Elizabeth C and Jabs, Ethylin Wang
American journal of human genetics, ISSN 0002-9297, 07/2012, Volume 91, Issue 1, pp. 171 - 179
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Molecular and cellular biology | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Medical genetics | Humans | Transcriptional Activation | Child, Preschool | Models, Molecular | Male | Hearing Loss, Sensorineural - genetics | Mutation, Missense | Strabismus - genetics | Mobius Syndrome - genetics | Homeodomain Proteins - genetics | Facial Paralysis - genetics | Founder Effect | Phenotype | Animals | Pedigree | Base Sequence | Female | Transcription, Genetic | Mice | Child | Proteins | Genotype & phenotype | Mutation | Minority & ethnic groups | Genes | Deoxyribonucleic acid--DNA | Index Medicus | Report
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