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Brain, ISSN 0006-8950, 2012, Volume 135, Issue 11, pp. 3251 - 3264
The neurovascular unit provides a dynamic interface between the circulation and central nervous system. Disruption of neurovascular integrity occurs in... 
traumatic brain injury | matrix metalloproteinase-3 | plasminogen activator inhibitor-1 | tissue plasminogen activator | neurovascular unit | MULTIPLE-SCLEROSIS LESIONS | RECEPTOR-RELATED PROTEIN | TPA | FOCAL CEREBRAL-ISCHEMIA | BARRIER BREAKDOWN | NEUROSCIENCES | CLINICAL NEUROLOGY | STROKE | MATRIX METALLOPROTEINASES | CENTRAL-NERVOUS-SYSTEM | EXPRESSION | BLOOD | Capillary Permeability - physiology | Tissue Plasminogen Activator - metabolism | Brain Injuries - drug therapy | Humans | Middle Aged | Injections, Intraventricular | Capillary Permeability - drug effects | Male | Brain Injuries - metabolism | Brain Injuries - physiopathology | Plasminogen Activator Inhibitor 1 - physiology | Matrix Metalloproteinase Inhibitors - therapeutic use | Brain - metabolism | Dose-Response Relationship, Drug | Brain - blood supply | Tissue Plasminogen Activator - antagonists & inhibitors | Plasminogen Activator Inhibitor 1 - metabolism | Aged, 80 and over | Recovery of Function - physiology | Adult | Disease Models, Animal | Albumins - metabolism | Mice, Inbred C57BL | Plasminogen Activator Inhibitor 1 - administration & dosage | Tissue Plasminogen Activator - administration & dosage | Tissue Plasminogen Activator - physiology | Animals | Brain Injuries - cerebrospinal fluid | Aged | Mice | Matrix Metalloproteinases - metabolism | Index Medicus | Abridged Index Medicus | Stroke | Central nervous system | Membrane permeability | Albumin | Homeostasis | Cerebrospinal fluid | Matrix metalloproteinase | Permeability | Trauma | Plasmin | t-Plasminogen activator | lipoprotein receptors | neuroserpin | plasminogen | Proteolysis | Plasma membranes | Chromium | Serine proteinase | Brain injury | Original
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 2, pp. 203 - 210
PAI-I and PAI-2 (plasminogen-activator inhibitor types I and 2) are inhibitors of cell surface upA (urokinase plasminogen activator). However, tumour... 
Serpin (serine protease inhibitor) | Plasminogen-activator inhibitor type 2 (PAI-2) | Urokinase plasminogen activator (uPA) | Very-low-density lipoprotein receptor (VLDLr) | Plasminogen-activator inhibitor type 1 (PAI-1) | SYSTEM | very-low-density lipoprotein receptor (VLDLr) | PROTEIN | LDL RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | plasminogen-activator inhibitor type 1 (PAI-1) | serpin (serine protease inhibitor) | urokinase plasminogen activator (uPA) | COMPLEX-FORMATION | RAP COMPLEX | plasminogen-activator inhibitor type 2 (PAI-2) | DENSITY-LIPOPROTEIN-RECEPTOR | UROKINASE RECEPTOR | BINDING-SITE | LIGAND | Humans | Receptors, Cell Surface - metabolism | Receptors, LDL - metabolism | Plasminogen Activator Inhibitor 2 - physiology | Plasminogen Activator Inhibitor 1 - physiology | Breast Neoplasms - metabolism | Receptors, Urokinase Plasminogen Activator | Breast Neoplasms - chemistry | Plasminogen Activator Inhibitor 1 - chemistry | Plasminogen Activator Inhibitor 1 - metabolism | Urokinase-Type Plasminogen Activator - metabolism | Breast Neoplasms - pathology | Plasminogen Activator Inhibitor 2 - metabolism | Protein Structure, Secondary - physiology | Signal Transduction - physiology | Urokinase-Type Plasminogen Activator - chemistry | Tumor Cells, Cultured | Plasminogen Activator Inhibitor 2 - chemistry | Protein Binding - physiology | Protein Structure, Tertiary - physiology | Index Medicus | uPA, urokinase plasminogen activator | LDLR, low-density lipoprotein receptor | serpin, serine protease inhibitor | uPAR, urokinase plasminogen activator receptor | VLDLr, very-low-density lipoprotein receptor | PAI, plasminogen-activator inhibitor | RAP, receptor-associated protein | RCL, reactive centre loop | ERK, extracellular-signal-regulated kinase | plasminogen-activator inhibitor type 1 (PAI-1) | LRP, low-density lipoprotein receptor-related protein | SPR, surface plasmon resonance | plasminogen-activator inhibitor type 2 (PAI-2)
Journal Article
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 03/2017, Volume 45, Issue 6, pp. 805 - 815
Glutamate phase shifts the circadian clock in the mammalian suprachiasmatic nucleus ( SCN ) by activating NMDA receptors. Tissue‐type plasminogen activator (... 
urokinase‐type plasminogen activator | circadian rhythms | suprachiasmatic nucleus | tissue‐type plasminogen activator | urokinase-type plasminogen activator | tissue-type plasminogen activator | NEURONAL MIGRATION | CELL-ADHESION MOLECULE | NEUROTROPHIC FACTOR | RECEPTOR | NEUROSCIENCES | IN-VITRO | EXTRACELLULAR-MATRIX | BIOLOGICAL CLOCK | BRAIN | GENE-FUNCTION | Brain-Derived Neurotrophic Factor - genetics | Suprachiasmatic Nucleus - drug effects | Tissue Plasminogen Activator - metabolism | Mice, Inbred C57BL | Plasminogen Inactivators - pharmacology | Male | Tissue Plasminogen Activator - genetics | Suprachiasmatic Nucleus - physiology | Animals | Urokinase-Type Plasminogen Activator - metabolism | Proteolysis | Circadian Clocks | Female | Suprachiasmatic Nucleus - metabolism | Brain-Derived Neurotrophic Factor - metabolism | Mice | Urokinase | Glutamate | Tissue plasminogen activator | Laws, regulations and rules | Suprachiasmatic nucleus | Glutamic acid | Brain | Night | Glutamic acid receptors (ionotropic) | Brain slice preparation | Nuclei | Plasmin | t-Plasminogen activator | Receptors | Casein | Rodents | Entrainment | Inhibition | Biological clocks | Circadian rhythms | Phase transformations | Phase shift | Polyamide-imides | N-Methyl-D-aspartic acid receptors | Circadian rhythm | Mammals | U-Plasminogen activator | Brain-derived neurotrophic factor | Inhibitors | Plasminogen activator inhibitors | TrkB receptors | Glutamatergic transmission | Gates | Index Medicus
Journal Article
Biochemistry, ISSN 0006-2960, 03/2017, Volume 56, Issue 12, pp. 1768 - 1784
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 06/2015, Volume 372, Issue 24, pp. 2285 - 2295
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 03/2012, Volume 366, Issue 12, pp. 1099 - 1107
Journal Article
The Journal of Pathology, ISSN 0022-3417, 01/2011, Volume 223, Issue 1, pp. 54 - 63
The urokinase‐type plasminogen activator (uPA) and the main uPA inhibitor PAI‐1 play important roles in cell migration and invasion in both physiological and... 
invasion | cell signalling | protein microarray | urokinase‐type plasminogen activator (uPA) | migration | paraffin‐embedded tissue (FFPE) | plasminogen activator inhibitor 1 (PAI‐1) | formalin‐fixed | reverse phase protein microarray | plasminogen activator inhibitor 1 (PAI-1) | paraffin-embedded tissue (FFPE) | formalin-fixed | urokinase-type plasminogen activator (uPA) | APOPTOSIS | PHOSPHATIDYLINOSITOL 3-KINASE | EARLY RELAPSE | RECEPTOR | PATHOLOGY | CELL-SURVIVAL | ONCOLOGY | PATHWAY | EPIDERMAL-GROWTH-FACTOR | IN-VIVO | EXPRESSION | CARCINOMA | Urokinase-Type Plasminogen Activator - physiology | Humans | Middle Aged | Neoplasm Proteins - physiology | Lymphatic Metastasis | Neoplasm Proteins - metabolism | Disease Progression | Plasminogen Activator Inhibitor 1 - physiology | Protein Array Analysis - methods | Breast Neoplasms - metabolism | Plasminogen Activator Inhibitor 1 - metabolism | Urokinase-Type Plasminogen Activator - metabolism | Breast Neoplasms - pathology | Adult | Female | Signal Transduction - physiology | Neoplasm Staging | Cluster Analysis | Cell culture | u-Plasminogen activator | Stat3 protein | Extracellular signal-regulated kinase | AKT protein | Adjuvants | Breast cancer | Plasmin | Chemotherapy | Protein arrays | Plasminogen activator inhibitors | Age | Cell migration | Integrins | Index Medicus
Journal Article