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JOURNAL OF NEUROCHEMISTRY, ISSN 0022-3042, 01/2012, Volume 120, pp. 89 - 98
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2014, Volume 111, Issue 29, pp. 10544 - 10549
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2019, Volume 116, Issue 13, pp. 6385 - 6390
The mechanism by which gamma-secretase activating protein (GSAP) regulates gamma-secretase activity has not yet been elucidated. Here, we show that knockout of... 
γ-secretase modulation | GSAP | Active-site labeling | Alzheimer’s disease | Conformational change | COMPLEX | APH-1 | ACTIVATING PROTEIN | MULTIDISCIPLINARY SCIENCES | NOTCH | conformational change | gamma-secretase modulation | PEN-2 | INHIBITORS | Alzheimer's disease | active-site labeling | PRESENILIN-1 | Proteins | Crosslinking | Presenilin 1 | Secretase | Biological Sciences
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 12/2013, Volume 1828, Issue 12, pp. 2886 - 2897
Presenilin is the catalytic component of the γ-secretase complex, a membrane-embedded aspartyl protease that plays a central role in biology and in the... 
Signal peptide peptidase | Membrane | Protease | Alzheimer's disease | BETA-SECRETASE | ASPARTYL PROTEASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSMEMBRANE DOMAIN | AMYLOID PRECURSOR PROTEIN | ACTIVE GAMMA-SECRETASE | C-TERMINAL FRAGMENT | REGULATED INTRAMEMBRANE PROTEOLYSIS | BIOPHYSICS | FAMILIAL ALZHEIMERS-DISEASE
Journal Article
Biochemistry, ISSN 0006-2960, 06/2019, Volume 58, Issue 27, pp. 2953 - 2966
γ-Secretase is a membrane-embedded protease complex, with presenilin as the catalytic component containing two transmembrane aspartates in the active site.... 
C-TERMINAL FRAGMENT | ACTIVE-SITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATALYTIC PORE | FAMILIAL ALZHEIMERS-DISEASE | TRANSMEMBRANE DOMAIN | MEMBRANE-PROTEIN | NOTCH SIGNALING PATHWAY | PRESENILIN ENDOPROTEOLYSIS | AMYLOID PRECURSOR PROTEIN | BETA-PEPTIDE PRODUCTION
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2004, Volume 279, Issue 42, pp. 43419 - 43426
gamma-Secretase is a multi-component enzyme complex that performs an intramembranous cleavage, releasing amyloid-beta (Abeta) peptides from processing... 
THYMOCYTE DEVELOPMENT | INTRAMEMBRANE CLEAVAGE | ACTIVE-SITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-APP | FAMILIAL ALZHEIMERS-DISEASE | TRANSMEMBRANE DOMAIN |