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Journal of Clinical Oncology, ISSN 0732-183X, 2018, Volume 36, Issue 9, pp. 859 - 866
Journal Article
BLOOD, ISSN 0006-4971, 02/2008, Volume 111, Issue 3, pp. 1654 - 1664
Our recent study demonstrated that a novel proteasome inhibitor NPI-0052 triggers apoptosis in multiple myeloma (MM) cells, and importantly, that is distinct... 
INDUCED APOPTOSIS | ACTIVE-SITES | MOLECULAR-WEIGHT PROTEASES | OVERCOMES DRUG-RESISTANCE | DEGRADATION | PROTEIN BREAKDOWN | UBIQUITIN SYSTEM | CELL-GROWTH | HEMATOLOGY | NF-KAPPA-B | HEMATOLOGIC MALIGNANCIES
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e95846
Celastrol is an active compound extracted from the root bark of the traditional Chinese medicine Tripterygium wilfordii Hook F. To investigate the effect of... 
CARCINOMA CELLS | ANTICANCER | CONSTITUTIVE ACTIVATION | MULTIDISCIPLINARY SCIENCES | PROTEASOME | INFLAMMATORY PATHWAYS | DOWN-REGULATION | PROLIFERATION | THALIDOMIDE | TRANSCRIPTION FACTOR | EXPRESSION | Cell Survival - drug effects | NF-KappaB Inhibitor alpha | Triterpenes - pharmacology | Transcription Factor RelA - antagonists & inhibitors | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Cell Line, Tumor - drug effects | I-kappa B Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Multiple Myeloma - drug therapy | Transcription Factor RelA - metabolism | Active Transport, Cell Nucleus - drug effects | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | G1 Phase Cell Cycle Checkpoints - drug effects | Drug Screening Assays, Antitumor | Cell proliferation | Analysis | Cancer cells | Apoptosis | Flow cytometry | Transcription factors | Bcl-2 protein | Leukemia | Bark | Multiple myeloma | Fluorescence | Propidium iodide | Kinases | Drug resistance | Caspase-3 | Cancer therapies | Proteins | Chinese medicine | Protoporphyrin | Modulation | Penicillin | Heme | Cell cycle | Deoxyribonucleic acid--DNA | Translocation | NF-κB protein | Cytokines | Iodides | Traditional Chinese medicine | Caspase | Inflammation | Survivin | Gene expression | Zinc | Nuclear transport | Oxygenase | Cytometry | Hospitals | Inhibitors | Natural products | Prostate cancer | Deoxyribonucleic acid | DNA
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 2/2014, Volume 73, Issue 2, pp. 249 - 257
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 03/2003, Volume 9, Issue 3, pp. 1136 - 1144
Journal Article
FEBS Letters, ISSN 0014-5793, 08/2015, Volume 589, Issue 17, pp. 2233 - 2240
Immunomodulatory drugs such as thalidomide, lenalidomide, and pomalidomide exhibit high responsive rates for newly identified or relapsed multiple myeloma... 
Degradation | Ubiquitination | IKZF1 | Kinase inhibitor | Multiple myeloma | Apoptosis | poly(ADP-ribose) polymerase 1 | Tris(hydroxymethyl)aminomethane hydrochloride | CRL4 | cereblon | CHX | UPP | GSK3 | RING | FBS | ethylenediaminetetraacetic acid | IMiDs | SDS | damage-specific DNA-binding protein 1 | PARP1 | Tris–HCl | casein kinase II | ubiquitin–proteasome pathway | green fluorescent protein | DDB1 | fetal bovine serum | really interesting new gene | CDKs | GAPDH | CK2 | Rosc | roscovitine | chloroquine | regulator of cullins-1 | GFP | sodium dodecyl sulfate | glyceraldehyde-3-phosphate dehydrogenase | lenalidomide | 5,6-dichlorobenzimidazole riboside | Tris buffered saline with 0.1% Tween 20 | CRBN | TBST | EDTA | ROC1 | cycloheximide | cyclin-dependent kinases | Len | DRB | immunomodulatory drugs | glycogen synthase kinase 3 | cullin-4 RING E3 ligase | COMPLEX | PHOSPHORYLATION | IKAROS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | CDK INHIBITOR | CEREBLON | BETA-CATENIN | CELL BIOLOGY | R-ROSCOVITINE | BIOPHYSICS | LENALIDOMIDE | E3 UBIQUITIN LIGASE | Cell Survival - drug effects | Apoptosis - drug effects | Purines - pharmacology | Humans | Immunoblotting | Dichlororibofuranosylbenzimidazole - pharmacology | Multiple Myeloma - metabolism | Proteolysis - drug effects | Multiple Myeloma - pathology | Ubiquitination - drug effects | Time Factors | Protein Stability - drug effects | HEK293 Cells | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Ikaros Transcription Factor - metabolism | Ubiquitin | Phosphates | Glycogen | Fluorescence | DNA binding proteins | Sulfates | Monosaccharides | Synthesis | Surface active agents | Casein | Ligases | Cyclohexane | Sugars | Protein binding
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e29554
Journal Article