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7/2017, Volume 9, Issue 7, 12
The disease course of BRAF (v-raf murine sarcoma viral oncogene homolog B1)-mutant melanoma has been drastically improved by the arrival of targeted therapies. NRAS... 
NRAS -mutant melanoma | clinical trials | targeted therapies | metastatic melanoma | PROTEIN TRANSFERASE INHIBITOR | MUTANT MELANOMA | ORAL MEK INHIBITOR | IB DOSE-ESCALATION | NRAS-mutant melanoma | PHASE-II TRIAL | ONCOLOGY | THERAPEUTIC TARGET | 1ST-LINE THERAPY | UNRESECTABLE STAGE-III | CLINICAL ACTIVITY | TRAMETINIB GSK1120212 | Reviews
Book Review
Clinical Cancer Research, ISSN 1078-0432, 10/2017, Volume 23, Issue 20, pp. 6203 - 6215
Purpose: NRAS mutations in malignant melanoma are associated with aggressive disease requiring rapid antitumor intervention, but there is no approved targeted therapy for this subset of patients... 
METASTATIC MELANOMA | MULTICENTER | UNFOLDED PROTEIN RESPONSE | THERAPY | ONCOLOGY | MUTATION | RESISTANCE | OPEN-LABEL | ENDOPLASMIC-RETICULUM STRESS | COMBINATION | CELL-DEATH | Phosphorylation | Caspase 9 - metabolism | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Melanoma - genetics | MAP Kinase Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Endoplasmic Reticulum Stress - drug effects | Membrane Proteins - genetics | Activating Transcription Factor 4 - genetics | Bcl-2-Like Protein 11 - genetics | MAP Kinase Kinase Kinases - metabolism | Melanoma - pathology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Bcl-2-Like Protein 11 - metabolism | Activating Transcription Factor 4 - metabolism | Signal Transduction - drug effects | GTP Phosphohydrolases - genetics | Models, Biological | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Mutation | Cell Cycle - drug effects | Clinical trials | Raf protein | Activation | Skin cancer | Anticancer properties | Mitochondria | Inhibition | Stresses | Medical research | MEK inhibitors | Melanoma | Extracellular signal-regulated kinase | MAP kinase | siRNA | Spheroids | Stress | Inhibitors | Experimental design | Antitumor activity | In vivo methods and tests | Endoplasmic reticulum | BIM protein | Cancer | Apoptosis
Journal Article
Molecular cancer therapeutics, ISSN 1538-8514, 2017, Volume 16, Issue 1, pp. 57 - 67
Journal Article
Blood, ISSN 1528-0020, 2013, Volume 122, Issue 16, pp. 2864 - 2876
Journal Article
Anti-Cancer Agents in Medicinal Chemistry, ISSN 1871-5206, 2015, Volume 15, Issue 3, pp. 353 - 362
Journal Article
Indian Journal of Biochemistry and Biophysics, ISSN 0301-1208, 02/2018, Volume 55, Issue 1, pp. 62 - 66
Journal Article
British Journal of Dermatology, ISSN 0007-0963, 10/2014, Volume 171, Issue 4, pp. 754 - 759
.... Objectives The main objective of this study was to investigate clinical, histopathological and dermoscopic characteristics of primary melanomas according to BRAF or NRAS mutational status... 
ANTITUMOR-ACTIVITY | IMMUNOTHERAPY | FEATURES | INFILTRATION | DERMATOLOGY | Skin Neoplasms - pathology | Humans | Middle Aged | Dermoscopy | Male | Melanoma - pathology | Mutation - genetics | Melanoma - genetics | Proto-Oncogene Proteins B-raf - genetics | Skin Neoplasms - genetics | Female | Retrospective Studies | Genes, ras - genetics | Genetic aspects | Gene mutations | Analysis | Melanoma | Dermis | MAP kinase | Mutation
Journal Article