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anti-bacterial agents - pharmacology (17) 17
antibacterial activity (16) 16
acylide (15) 15
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acylides (13) 13
microbial sensitivity tests (13) 13
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structure-activity relationship (11) 11
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ketolides (10) 10
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ketolide (9) 9
clarithromycin (8) 8
antibacterial agents (7) 7
pharmacology & pharmacy (7) 7
resistant (7) 7
synthesis (7) 7
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erythromycin - chemical synthesis (6) 6
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ketolides - chemistry (6) 6
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macrolide antibiotics (6) 6
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drug design (4) 4
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gram-negative bacteria - drug effects (4) 4
gram-positive bacteria - drug effects (4) 4
highly potent (4) 4
macrolides - chemistry (4) 4
oxime (4) 4
oximes - chemistry (4) 4
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acylation (3) 3
anti-bacterial agents - pharmacokinetics (3) 3
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clarithromycin - analogs & derivatives (3) 3
clinical perspective (3) 3
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erythromycin-a (3) 3
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ketolides - chemical synthesis (3) 3
macrolides - chemical synthesis (3) 3
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oximes - chemical synthesis (3) 3
oximes - pharmacology (3) 3
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anhydrolide macrolides (2) 2
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cyclic 2',3'-carbamate derivatives (2) 2
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drug resistance, bacterial - drug effects (2) 2
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Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2013, Volume 21, Issue 17, pp. 4914 - 4922
Journal Article
Journal Article
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, ISSN 0037-9980, 05/2010, Volume 68, Issue 5, pp. 522 - 533
Journal Article
Journal Article
Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 09/2014, Volume 8, pp. 1515 - 1525
Journal Article
中国化学快报:英文版, ISSN 1001-8417, 2013, Volume 24, Issue 3, pp. 183 - 185
A series of novel acylide derivatives have been synthesized from clarithromyc|n A via a tacile procedure. The C-3 modifications involved replacing the natural... 
红霉素衍生物 | 结构修饰 | 环氧基团 | X射线晶体学 | 抗菌活性 | 克拉霉素 | 化学合成 | Synthesis | Resistance antibacterial activity | Single-crystal X-ray diffraction | Epoxide acylide erythromycin derivatives | RESISTANCE | MECHANISMS | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Journal Article
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, ISSN 0037-9980, 05/2010, Volume 68, Issue 5, pp. 522 - 533
Clarithromycin (CAM), a semi-synthetic 14-membered macrolide antibiotic, has a feature that the 6-hydroxy group of naturally occurring erythromycin A (EM-A) is... 
O-METHYLATION | NATURAL-PRODUCTS | CHEMISTRY, ORGANIC | clarithromycin | Azalide | next generation macrolide | STEREOSELECTIVE SYNTHESIS | Acylide | ANTIBACTERIAL ACTIVITY | CHIRAL SYNTHESIS | OXIME | CHEMICAL MODIFICATION | Ketolide | ERYTHROMYCIN-A | DERIVATIVES | MACROLACTONIZATION
Journal Article