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1. Full Text Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year
by Kennedy, Elizabeth A., BS and Connolly, Jennifer, MSc and Hourihane, Jonathan O'B., DM and Fallon, Padraic G., PhD and McLean, W.H. Irwin, DSc, FRS and Murray, Deirdre, PhD and Jo, Jay-Hyun, PhD and Segre, Julia A., PhD and Kong, Heidi H., MD, MHSc and Irvine, Alan D., MD, DSc
Journal of allergy and clinical immunology, ISSN 0091-6749, 2016, Volume 139, Issue 1, pp. 166 - 172
Allergy and Immunology | skin | atopic dermatitis | longitudinal birth cohort | microbiome | Staphylococcus aureus | 16S sequencing | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Skin - microbiology | Humans | Risk Factors | Child, Preschool | Infant | Male | Dermatitis, Atopic - microbiology | Bacteria - genetics | Microbiota | Intermediate Filament Proteins - genetics | RNA, Bacterial - genetics | RNA, Ribosomal, 16S - genetics | Female | Microbiota (Symbiotic organisms) | Atopic dermatitis | Oncology, Experimental | Genomics | Skin | Research | Research institutes | Cancer | Studies | Disease | Antibiotics | Eczema | Physiology | Mutation | Dermatitis | Allergies | Asthma | Index Medicus | Abridged Index Medicus | AD, Atopic dermatitis | Nt, Nasal tip | FLG, Filaggrin | BASELINE, Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints | Atopic Dermatitis and Skin Disease | AMOVA, Analysis of molecular variance | OTU, Operational taxonomic unit | Pf, Popliteal fossa | Af, Antecubital fossa
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2. Full Text Increased Risk of Cutaneous and Systemic Infections in Atopic Dermatitis—A Cohort Study
by Langan, Sinéad M and Abuabara, Katrina and Henrickson, Sarah E and Hoffstad, Ole and Margolis, David J
Journal of investigative dermatology, ISSN 0022-202X, 06/2017, Volume 137, Issue 6, pp. 1375 - 1377
Life Sciences & Biomedicine | Dermatology | Science & Technology | Index Medicus | AD, atopic dermatitis
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3. Full Text Autoimmunity (or Not) in Atopic Dermatitis
by Roesner, Lennart M and Werfel, Thomas
Frontiers in immunology, ISSN 1664-3224, 09/2019, Volume 10, pp. 2128 - 2128
Life Sciences & Biomedicine | Immunology | Science & Technology | Autoimmunity | Care and treatment | Atopic dermatitis | Analysis | Index Medicus | atopic dermatitis (AD) | skin | allergy | autoimmunity | T cell | autoallergy
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4. Full Text The Financial and Emotional Impact of Atopic Dermatitis on Children and Their Families
by Filanovsky, Michelle G., MD and Pootongkam, Suwimon, MD and Tamburro, Joan E., DO and Smith, Mary C., CNS and Ganocy, Stephen J., PhD and Nedorost, Susan T., MD
The Journal of pediatrics, ISSN 0022-3476, 2016, Volume 169, pp. 284 - 290.e5
Pediatrics | AD Atopic dermatitis | CADIS Childhood Atopic Dermatitis Impact Scale | OTC Over-the-counter | Life Sciences & Biomedicine | Science & Technology | Family - psychology | Severity of Illness Index | Dermatitis, Atopic - psychology | Humans | Child, Preschool | Cost of Illness | Infant | Male | Emotions | Dermatitis, Atopic - economics | Health Care Costs - statistics & numerical data | Adolescent | Female | Surveys and Questionnaires | Ohio | Child | Medical colleges | Family | Hospitals | Atopic dermatitis | Index Medicus | Abridged Index Medicus
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5. Full Text Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity
by Saunders, Sean P., PhD and Moran, Tara, BSc and Floudas, Achilleas, PhD and Wurlod, Felicity, MSc and Kaszlikowska, Agnieszka, BSc and Salimi, Maryam, PhD and Quinn, Emma M., PhD and Oliphant, Christopher J., PhD and Núñez, Gabriel, MD and McManus, Ross, PhD and Hams, Emily, PhD and Irvine, Alan D., MD and McKenzie, Andrew N.J., PhD and Ogg, Graham S., MD and Fallon, Padraic G., PhD
Journal of allergy and clinical immunology, ISSN 0091-6749, 2015, Volume 137, Issue 2, pp. 482 - 491
Allergy and Immunology | Allergy | mouse | mutation | type 2 innate lymphoid cells | innate immunity | flaky tail | atopy | eczema | atopic dermatitis | asthma | filaggrin | Immunology | Life Sciences & Biomedicine | Science & Technology | Adaptive Immunity | Lymphocytes - metabolism | Dermatitis, Atopic - genetics | Pneumonia - etiology | Skin - metabolism | Pneumonia - pathology | Mice, Transgenic | Dermatitis, Atopic - pathology | Immunity, Innate | Dermatitis, Atopic - complications | Lymphocytes - pathology | Phenotype | Animals | Lymphocytes - immunology | Intermediate Filament Proteins - deficiency | Dermatitis, Atopic - immunology | Intermediate Filament Proteins - genetics | Mice | Mutation | Skin - pathology | Disease Models, Animal | Skin - immunology | Skin | Hospitals | Research institutes | Atopic dermatitis | Analysis | Inflammation | Chlorophyll | Compliance | Laboratories | Patients | Proteins | Human subjects | Pathology | Lungs | Rodents | Suctioning | Software | Index Medicus | Abridged Index Medicus | NF-κB, Nuclear factor κB | AD, Atopic dermatitis | RL, Lung resistance | non-T cell | CFP, Cerulean fluorescent protein | FLG, Human filaggrin gene | Cdyn, Dynamic lung compliance | nILC2, Natural type 2 innate lymphoid cell | Flg, Murine filaggrin gene | dLN, Draining lymph node | AHR, Airway hyperresponsiveness | IL-7Rα, IL-7 receptor α | Atopic Dermatitis and Skin Disease | WT, Wild-type | eGFP, Enhanced green fluorescent protein | TSLP, Thymic stromal lymphopoietin | NBNT, Non-B | ILC2, Type 2 innate lymphoid cell | ROR, Retinoic acid–related orphan receptor | iILC2, Inflammatory type 2 innate lymphoid cells
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6. Full Text Raman profiles of the stratum corneum define 3 filaggrin genotype–determined atopic dermatitis endophenotypes
by O'Regan, Gráinne M., MRCPI and Kemperman, Patrick M.J.H., MD and Sandilands, Aileen, PhD and Chen, Huijia, MD and Campbell, Linda E., BSc and Kroboth, Karin, PhD and Watson, Rosemarie, MD and Rowland, Marion, MB, PhD and Puppels, Gerwin J., PhD and McLean, W.H. Irwin, DSc, FMedSci and Caspers, Peter J., PhD and Irvine, Alan D., MD, FRCPI
Journal of allergy and clinical immunology, ISSN 0091-6749, 2010, Volume 126, Issue 3, pp. 574 - 580.e1
Allergy and Immunology | hyperlinearity | transepidermal water loss | confocal Raman spectroscopy | Atopic dermatitis | eczema | tyrosine | filaggrin | natural moisturizing factor | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | Fundamental immunology | Immunopathology | Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis | Skin allergic diseases. Stinging insect allergies | Biological and medical sciences | Allergic diseases | Medical sciences | Dermatitis, Atopic - genetics | Genetic Predisposition to Disease | Skin - metabolism | Humans | Genotype | Male | Phenotype | Ireland | Intermediate Filament Proteins - genetics | Female | Spectrum Analysis, Raman | Mutation | Child | Medical colleges | Proteins | Hydration | Spectrum analysis | Homeostasis | Amino acids | Skin | Index Medicus | Abridged Index Medicus | SC, Stratum corneum | AD, Atopic dermatitis | TEWL, Transepidermal water loss | FLG, Filaggrin | Atopic Dermatitis and Skin Disease | HLP, Hyperlinear palms | ROC, Receiver operating characteristic | AUC, Area under the curve | NMF, Natural moisturizing factor
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7. Full Text Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy
by Brough, Helen A., MSc, FRCPCH and Liu, Andrew H., MD and Sicherer, Scott, MD and Makinson, Kerry, MSc and Douiri, Abdel, PhD and Brown, Sara J., MD and Stephens, Alick C., PhD and Irwin McLean, W.H., PhD, DSc, FRSE, FMedSci and Turcanu, Victor, PhD and Wood, Robert A., MD and Jones, Stacie M., MD and Burks, Wesley, MD and Dawson, Peter, PhD and Stablein, Donald, PhD and Sampson, Hugh, MD and Lack, Gideon, MD
Journal of allergy and clinical immunology, ISSN 0091-6749, 2014, Volume 135, Issue 1, pp. 164 - 170.e4
Allergy and Immunology | peanut sensitization | peanut allergy | Atopic dermatitis | environmental peanut exposure | dust | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Antigens, Plant - analysis | Dust - analysis | Allergens - analysis | Skin Tests | Dermatitis, Atopic - epidemiology | Humans | Antigens, Plant - immunology | Dust - immunology | Infant | Male | Plant Proteins - immunology | Plant Proteins - analysis | Environmental Exposure - analysis | Peanut Hypersensitivity - immunology | Housing | Environmental Exposure - adverse effects | Peanut Hypersensitivity - diagnosis | Allergens - immunology | Peanut Hypersensitivity - epidemiology | Arachis - immunology | Dermatitis, Atopic - immunology | Female | Odds Ratio | Allergens | Medical colleges | Skin | Inflammation | Dermatitis | Peanut allergy | Studies | Food allergies | Mutation | Peanuts | Allergies | Children & youth | Index Medicus | Abridged Index Medicus | LR, Logistic regression | AD, Atopic dermatitis | PA, Peanut allergy | SPT, Skin prick test | FLG, Filaggrin | sIgE, Specific IgE | Atopic Dermatitis and Skin Disease | CoFAR, Consortium of Food Allergy Research | IQR, Interquartile range | OR, Odds ratio | LLQ, Lower limit of quantitation | EPE, Environmental peanut exposure
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8. Full Text Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year
by Kelleher, Maeve, MB and Dunn-Galvin, Audrey, PhD and Hourihane, Jonathan O'B., DM and Murray, Deirdre, MD and Campbell, Linda E., BSc and McLean, W.H. Irwin, DSc, FRS and Irvine, Alan D., MD
Journal of allergy and clinical immunology, ISSN 0091-6749, 2015, Volume 135, Issue 4, pp. 930 - 935.e1
Allergy and Immunology | skin barrier | TEWL | atopic dermatitis | Infant | predictor | biomarker | filaggrin | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Dermatitis, Atopic - genetics | Prognosis | Skin - metabolism | Humans | Genotype | Male | Risk | Dermatitis, Atopic - physiopathology | Dermatitis, Atopic - diagnosis | Time Factors | DNA Mutational Analysis | Intermediate Filament Proteins - genetics | Female | Skin - physiopathology | Intermediate Filament Proteins - metabolism | Infant, Newborn | Atopic dermatitis | Skin | Babies | Food allergies | Medical research | Mutation | Dermatitis | Allergies | Index Medicus | Abridged Index Medicus | LR, Logistic regression | AD, Atopic dermatitis | FLG, Filaggrin gene | TEWL, Transepidermal water loss | Atopic Dermatitis and Skin Disease | BASELINE, Babies After Scope: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints | SCOPE, Screening for Pregnancy Endpoints | AUC, Area under the ROC curve | ROC, Receiver operating characteristic | ΔTEWL, Change in TEWL measurement between one timepoint and another | OR, Odds ratio
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9. Full Text Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis
by Cole, Christian, PhD and Kroboth, Karin, MSc and Schurch, Nicholas J., PhD and Sandilands, Aileen, PhD and Sherstnev, Alexander, PhD and O'Regan, Grainne M., MRCPI and Watson, Rosemarie M., MD and Irwin McLean, W.H., DSc and Barton, Geoffrey J., PhD and Irvine, Alan D., MD and Brown, Sara J., MD
Journal of allergy and clinical immunology, ISSN 0091-6749, 2014, Volume 134, Issue 1, pp. 82 - 91
Allergy and Immunology | single molecule | Atopic dermatitis | transcriptome | eczema | skin | tissue | filaggrin | direct RNA sequencing | gene expression | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | Fundamental immunology | Immunopathology | Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis | Skin allergic diseases. Stinging insect allergies | Biological and medical sciences | Allergic diseases | Medical sciences | Dermatitis, Atopic - genetics | Intermediate Filament Proteins - immunology | Skin - metabolism | Humans | Gene Expression Regulation | Male | Dermatitis, Atopic - pathology | Lipid Metabolism - immunology | Case-Control Studies | Extracellular Space - immunology | Young Adult | Adolescent | Dermatitis, Atopic - immunology | Intermediate Filament Proteins - genetics | Transcription, Genetic - immunology | Female | High-Throughput Nucleotide Sequencing | Child | Dermatitis, Atopic - metabolism | Skin - pathology | Skin - immunology | Pediatrics | Care and treatment | Skin | Analysis | Proteins | Genotype & phenotype | Biopsy | Quality control | Lipids | Genomes | Mutation | Stress response | Gene expression | Dermatitis | Deoxyribonucleic acid--DNA | Apoptosis | Index Medicus | Abridged Index Medicus | eQTL, Expression quantitative trait loci | AD, Atopic dermatitis | FLG, Filaggrin gene | CILP, Cartilage intermediate layer protein gene | DRS, Direct RNA sequencing | FDR, False discovery rate | GO, Gene ontology | STAT, Signal transducer and activator of transcription | Atopic Dermatitis and Skin Disease
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