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Cancer Cell, ISSN 1535-6108, 02/2013, Volume 23, Issue 2, pp. 171 - 185
We report a paracrine effect whereby endothelial cells (ECs) promote the cancer stem cell (CSC) phenotype of human colorectal cancer (CRC) cells. We showed... 
COLON-CANCER | METASTASIS | ONCOLOGY | NOTCH | NICHE | SELF-RENEWAL | RECEPTOR | GROWTH-FACTOR | TUMOR ANGIOGENESIS | DIFFERENTIATION | ANGIOCRINE FACTORS | CELL BIOLOGY | ADAM17 Protein | RNA, Small Interfering - genetics | Immunoprecipitation | Receptors, Notch - metabolism | Colorectal Neoplasms - genetics | Humans | Calcium-Binding Proteins - antagonists & inhibitors | Culture Media, Conditioned - pharmacology | Drug Resistance, Neoplasm | Immunoblotting | Peptide Fragments - pharmacology | Intercellular Signaling Peptides and Proteins - metabolism | Neoplastic Stem Cells - metabolism | Serrate-Jagged Proteins | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Tumor Cells, Cultured | Liver Neoplasms - secondary | Colorectal Neoplasms - metabolism | Jagged-1 Protein | Biomarkers - metabolism | Calcium-Binding Proteins - metabolism | ADAM Proteins - antagonists & inhibitors | Liver Neoplasms - genetics | Signal Transduction | Endothelial Cells - metabolism | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Cell Communication | Xenograft Model Antitumor Assays | ADAM Proteins - metabolism | Phenotype | Animals | Membrane Proteins - antagonists & inhibitors | Mice, Nude | Liver Neoplasms - metabolism | Mice | ADAM Proteins - genetics | Colorectal Neoplasms - pathology | Endothelial Cells - pathology | Calcium-Binding Proteins - genetics | Genetic aspects | Colorectal cancer | Stem cells | Endothelium | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2008, Volume 283, Issue 51, pp. 35507 - 35516
The receptor for advanced glycation end products (RAGE) is a 55-kDa type I membrane glycoprotein of the immunoglobulin superfamily. Ligand-induced... 
ALPHA-SECRETASE | RAGE RECEPTOR | MATRIX METALLOPROTEINASES | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYLOID PRECURSOR PROTEIN | BLOOD-BRAIN-BARRIER | SPLICE VARIANTS | MULTILIGAND RECEPTOR | EXPRESSION | SOLUBLE RECEPTOR | Amyloid Precursor Protein Secretases - genetics | RNA, Small Interfering - genetics | Tetradecanoylphorbol Acetate - pharmacology | Humans | Cell Membrane - genetics | Protease Inhibitors - pharmacology | Matrix Metalloproteinase 9 - metabolism | Carcinogens - pharmacology | Protein Isoforms - metabolism | Cell Membrane - metabolism | Diabetes Complications - genetics | Membrane Proteins - metabolism | Hydroxamic Acids - pharmacology | Receptor for Advanced Glycation End Products | Ionophores - pharmacology | Cell Line | ADAM Proteins - antagonists & inhibitors | Membrane Proteins - genetics | Alternative Splicing - genetics | Diabetes Complications - metabolism | ADAM10 Protein | Protein Structure, Tertiary - genetics | Calcimycin - pharmacology | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Alternative Splicing - drug effects | Membrane Proteins - antagonists & inhibitors | Alzheimer Disease - metabolism | Matrix Metalloproteinase Inhibitors | Amyloid Precursor Protein Secretases - antagonists & inhibitors | ADAM Proteins - genetics | Alzheimer Disease - genetics | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Protein Isoforms - genetics | Index Medicus
Journal Article
International Journal of Cancer, ISSN 0020-7136, 10/2013, Volume 133, Issue 7, pp. 1557 - 1566
The interaction of the MHC class I-related chain molecules A and B (MICA and MICB) with the corresponding natural killer group 2, member D (NKG2D) receptor... 
ADAM10 | ADAM17 | shedding | NKG2D ligands | MICA | MICB | ACTIVATION | CANCER | CUTTING EDGE | RECEPTOR NKG2D | NK CELLS | ONCOLOGY | ENGAGEMENT | SOLUBLE MICA | CYTOTOXICITY | T-CELLS | ADAM17 Protein | Immunologic Surveillance | Neoplasms - metabolism | T-Lymphocyte Subsets - immunology | Amyloid Precursor Protein Secretases - genetics | Prostatic Neoplasms - metabolism | Pancreatic Neoplasms - metabolism | Breast Neoplasms - immunology | Humans | Carcinoma, Pancreatic Ductal - metabolism | Male | Exosomes | Breast Neoplasms - metabolism | Prostatic Neoplasms - immunology | Histocompatibility Antigens Class I - metabolism | NK Cell Lectin-Like Receptor Subfamily K - metabolism | RNA Interference | Killer Cells, Natural - immunology | Female | Membrane Proteins - metabolism | Carcinoma, Pancreatic Ductal - immunology | Tumor Escape - immunology | ADAM Proteins - antagonists & inhibitors | Membrane Proteins - genetics | Dipeptides - pharmacology | Histocompatibility Antigens Class I - immunology | ADAM10 Protein | Matrix Metalloproteinase Inhibitors - pharmacology | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Membrane Proteins - antagonists & inhibitors | Neoplasms - immunology | Pancreatic Neoplasms - immunology | Cell Line, Tumor | RNA, Small Interfering | Amyloid Precursor Protein Secretases - antagonists & inhibitors | ADAM Proteins - genetics | Tetraspanin-29 - metabolism | Cytokines - biosynthesis | T cells | Proteases | Analysis | Enzyme-linked immunosorbent assay | Tumors | Ligands | Immunology | Immune system | Index Medicus | ADAM10 protein
Journal Article
Brain, ISSN 0006-8950, 11/2010, Volume 133, Issue 11, pp. 3323 - 3335
We describe here an innovative, non-transgenic animal model of Alzheimer's disease. This model mimics early stages of sporadic disease, which represents the... 
amyloid precursor protein metabolism | SAP97 | NMDA | synaptopathy | animal models | SECRETASE CLEAVAGE | AMYLOID-PRECURSOR-PROTEIN | COGNITIVE IMPAIRMENT | TRIPLE-TRANSGENIC MODEL | NMDA RECEPTOR TRAFFICKING | NEUROSCIENCES | OLIGOMERS | CLINICAL NEUROLOGY | INTRACELLULAR A-BETA | MOUSE MODEL | IN-VIVO | PLASTICITY | Alzheimer Disease - etiology | Molecular Sequence Data | Male | Protein Transport - physiology | Multiprotein Complexes - antagonists & inhibitors | Multiprotein Complexes - metabolism | Neural Inhibition - physiology | Synapses - metabolism | Time Factors | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Membrane Proteins - metabolism | Disease Models, Animal | Amino Acid Sequence | Nerve Tissue Proteins - antagonists & inhibitors | Alzheimer Disease - physiopathology | ADAM Proteins - antagonists & inhibitors | Discs Large Homolog 1 Protein | Mice, Inbred C57BL | ADAM10 Protein | Synapses - enzymology | Nerve Tissue Proteins - metabolism | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Guanylate Kinases | Membrane Proteins - antagonists & inhibitors | Alzheimer Disease - metabolism | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 07/2014, Volume 74, Issue 13, pp. 3429 - 3440
Journal Article
Cell Death and Disease, ISSN 2041-4889, 2014, Volume 5, Issue 8, pp. e1391 - e1391
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2007, Volume 282, Issue 49, pp. 35712 - 35721
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 8, pp. 2725 - 2734
Theta-defensins (theta-defensins) are macrocyclic peptides expressed exclusively in granulocytes and selected epithelia of Old World monkeys. They contribute... 
ADAM17 | EPITHELIAL-CELLS | ANTIMICROBIAL ACTIVITIES | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCED ARTHRITIS | TACE | THERAPEUTIC TARGETS | NF-KAPPA-B | CYCLIC-PEPTIDES | EGFR | Tumor Necrosis Factor-alpha - metabolism | Amyloid Precursor Protein Secretases - genetics | Intestinal Mucosa - metabolism | ADAM10 Protein - genetics | Humans | Colon - drug effects | ADAM10 Protein - metabolism | Cercopithecus aethiops | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Colon - immunology | Monocytes - metabolism | Macaca mulatta | Monocytes - immunology | Defensins - chemistry | Intestinal Mucosa - drug effects | ADAM17 Protein - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Leukocytes - immunology | Proteolysis - drug effects | ADAM10 Protein - antagonists & inhibitors | ADAM17 Protein - antagonists & inhibitors | Intestinal Mucosa - immunology | Protein Isoforms - chemistry | Defensins - pharmacology | Membrane Proteins - metabolism | Toll-Like Receptors - metabolism | Escherichia coli - physiology | Recombinant Proteins - metabolism | Cell Line | Lipopolysaccharides - toxicity | Membrane Proteins - genetics | Solubility | Escherichia coli - immunology | Recombinant Proteins - chemistry | Colon - metabolism | Toll-Like Receptors - agonists | Monocytes - drug effects | Protein Isoforms - pharmacology | ADAM17 Protein - genetics | Amyloid Precursor Protein Secretases - metabolism | Animals | Tumor Necrosis Factor-alpha - chemistry | Membrane Proteins - antagonists & inhibitors | Leukocytes - drug effects | Protein Conformation | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Leukocytes - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus | cytokine | tumor necrosis factor (TNF) | proteolytic enzyme | theta defensin | shedding | ADAM | Immunology | enzyme inhibitor | inflammation | defensin | sheddase inhibitors
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2012, Volume 49, Issue 1, pp. 137 - 147
Journal Article
Circulation Research, ISSN 0009-7330, 05/2008, Volume 102, Issue 10, pp. 1192 - 1201
Journal Article
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