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1. Full Text Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1
by Lu, Jia and Ye, Xiangcang and Fan, Fan and Xia, Ling and Bhattacharya, Rajat and Bellister, Seth and Tozzi, Federico and Sceusi, Eric and Zhou, Yunfei and Tachibana, Isamu and Maru, Dipen M and Hawke, David H and Rak, Janusz and Mani, Sendurai A and Zweidler-McKay, Patrick and Ellis, Lee M
Cancer cell, ISSN 1535-6108, 02/2013, Volume 23, Issue 2, pp. 171 - 185
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | ADAM17 Protein | RNA, Small Interfering - genetics | Immunoprecipitation | Receptors, Notch - metabolism | Colorectal Neoplasms - genetics | Humans | Calcium-Binding Proteins - antagonists & inhibitors | Culture Media, Conditioned - pharmacology | Drug Resistance, Neoplasm | Immunoblotting | Peptide Fragments - pharmacology | Intercellular Signaling Peptides and Proteins - metabolism | Neoplastic Stem Cells - metabolism | Serrate-Jagged Proteins | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Tumor Cells, Cultured | Liver Neoplasms - secondary | Colorectal Neoplasms - metabolism | Jagged-1 Protein | Biomarkers - metabolism | Calcium-Binding Proteins - metabolism | ADAM Proteins - antagonists & inhibitors | Liver Neoplasms - genetics | Signal Transduction | Endothelial Cells - metabolism | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Cell Communication | Xenograft Model Antitumor Assays | ADAM Proteins - metabolism | Phenotype | Animals | Membrane Proteins - antagonists & inhibitors | Mice, Nude | Liver Neoplasms - metabolism | Mice | ADAM Proteins - genetics | Colorectal Neoplasms - pathology | Endothelial Cells - pathology | Calcium-Binding Proteins - genetics | Genetic aspects | Colorectal cancer | Stem cells | Endothelium | Index Medicus
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2. Full Text An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin
by Lo Sardo, Valentina and Zuccato, Chiara and Gaudenzi, Germano and Vitali, Barbara and Ramos, Catarina and Tartari, Marzia and Myre, Michael A and Walker, James A and Pistocchi, Anna and Conti, Luciano and Valenza, Marta and Drung, Binia and Schmidt, Boris and Gusella, James and Zeitlin, Scott and Cotelli, Franco and Cattaneo, Elena
Nature neuroscience, ISSN 1097-6256, 05/2012, Volume 15, Issue 5, pp. 713 - 721
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Body Patterning - drug effects | Guanylate Kinases - genetics | Amyloid Precursor Protein Secretases - genetics | RNA, Small Interfering - genetics | Wnt1 Protein - genetics | Brain - embryology | PAX2 Transcription Factor - metabolism | Cadherins - metabolism | Apoptosis - drug effects | Embryo, Mammalian | Hedgehog Proteins - metabolism | Apoptosis - genetics | Green Fluorescent Proteins - genetics | Brain - metabolism | NFI Transcription Factors - metabolism | Cadherins - genetics | Tissue Inhibitor of Metalloproteinase-1 - pharmacology | Discs Large Homolog 1 Protein | Membrane Proteins - genetics | Gene Expression Regulation, Developmental - drug effects | PAX2 Transcription Factor - genetics | Cell Adhesion - drug effects | Mutation - genetics | Biological Evolution | Brain - drug effects | Huntingtin Protein | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Analysis of Variance | Membrane Proteins - antagonists & inhibitors | Cell Adhesion - physiology | Embryo, Nonmammalian | Guanylate Kinases - metabolism | Neuroepithelial Cells - physiology | Mice | Zebrafish Proteins - genetics | ADAM Proteins - genetics | Cerebral Ventricles - cytology | Drosophila melanogaster | Neuroepithelial Cells - drug effects | Embryonic Stem Cells - metabolism | Nestin | Immunoprecipitation | Gene Expression Regulation, Developmental - genetics | Wnt1 Protein - metabolism | Zebrafish - embryology | Cell Differentiation - genetics | Transfection | Hedgehog Proteins - genetics | Intermediate Filament Proteins - genetics | Neurons - physiology | Membrane Proteins - metabolism | Cerebral Ventricles - embryology | Neurons - drug effects | Nuclear Proteins - genetics | Hydroxamic Acids - pharmacology | Green Fluorescent Proteins - metabolism | Brain - cytology | ADAM Proteins - antagonists & inhibitors | Animals, Genetically Modified | Zebrafish Proteins - metabolism | Dipeptides - pharmacology | Cells, Cultured | ADAM10 Protein | Morpholines - pharmacology | Nuclear Proteins - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Dictyostelium | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Body Patterning - genetics | Huntington's chorea | Physiological aspects | Cadherins | Genetic aspects | Research | Embryonic stem cells | Risk factors | Index Medicus
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3. Full Text Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease
by Epis, Roberta and Marcello, Elena and Gardoni, Fabrizio and Vastagh, Csaba and Malinverno, Matteo and Balducci, Claudia and Colombo, Alessio and Borroni, Barbara and Vara, Hugo and Dell'Agli, Mario and Cattabeni, Flamino and Giustetto, Maurizio and Borsello, Tiziana and Forloni, Gianluigi and Padovani, Alessandro and Di Luca, Monica
Brain (London, England : 1878), ISSN 0006-8950, 11/2010, Volume 133, Issue 11, pp. 3323 - 3335
amyloid precursor protein metabolism | SAP97 | NMDA | synaptopathy | animal models | Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Biological and medical sciences | Medical sciences | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Alzheimer Disease - etiology | Molecular Sequence Data | Male | Protein Transport - physiology | Multiprotein Complexes - antagonists & inhibitors | Multiprotein Complexes - metabolism | Neural Inhibition - physiology | Synapses - metabolism | Time Factors | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Membrane Proteins - metabolism | Disease Models, Animal | Amino Acid Sequence | Nerve Tissue Proteins - antagonists & inhibitors | Alzheimer Disease - physiopathology | ADAM Proteins - antagonists & inhibitors | Discs Large Homolog 1 Protein | Mice, Inbred C57BL | ADAM10 Protein | Synapses - enzymology | Nerve Tissue Proteins - metabolism | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Guanylate Kinases | Membrane Proteins - antagonists & inhibitors | Alzheimer Disease - metabolism | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus | Abridged Index Medicus
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4. Full Text The ADAM10 Prodomain Is a Specific Inhibitor of ADAM10 Proteolytic Activity and Inhibits Cellular Shedding Events
by Marcia L. Moss and Martha Bomar and Qian Liu and Harvey Sage and Peter Dempsey and Patricia M. Lenhart and Patricia A. Gillispie and Alexander Stoeck and Dirk Wildeboer and Jörg W. Bartsch and Ralf Palmisano and Pei Zhou
The Journal of biological chemistry, ISSN 0021-9258, 12/2007, Volume 282, Issue 49, pp. 35712 - 35721
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | ADAM17 Protein | ADAM Proteins - therapeutic use | Humans | Cercopithecus aethiops | Membrane Proteins - therapeutic use | Antigens, CD - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Amyloid beta-Protein Precursor - metabolism | Disintegrins - therapeutic use | Enzyme Precursors - antagonists & inhibitors | Membrane Proteins - metabolism | ADAM Proteins - antagonists & inhibitors | Disintegrins - metabolism | ADAM10 Protein | Neoplasms - enzymology | Neoplasms - drug therapy | Amyloid Precursor Protein Secretases - therapeutic use | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Enzyme Precursors - metabolism | Animals | Betacellulin | Membrane Proteins - antagonists & inhibitors | Enzyme Precursors - therapeutic use | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Disintegrins - antagonists & inhibitors | COS Cells | Protein Structure, Tertiary - physiology | Index Medicus
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5. Full Text Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α-converting enzyme
by Schaal, Justin B and Maretzky, Thorsten and Tran, Dat Q and Tran, Patti A and Tongaonkar, Prasad and Blobel, Carl P and Ouellette, André J and Selsted, Michael E
The Journal of biological chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 8, pp. 2725 - 2734
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Tumor Necrosis Factor-alpha - metabolism | Amyloid Precursor Protein Secretases - genetics | Intestinal Mucosa - metabolism | ADAM10 Protein - genetics | Humans | Colon - drug effects | ADAM10 Protein - metabolism | Cercopithecus aethiops | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Colon - immunology | Monocytes - metabolism | Macaca mulatta | Monocytes - immunology | Defensins - chemistry | Intestinal Mucosa - drug effects | ADAM17 Protein - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Leukocytes - immunology | Proteolysis - drug effects | ADAM10 Protein - antagonists & inhibitors | ADAM17 Protein - antagonists & inhibitors | Intestinal Mucosa - immunology | Protein Isoforms - chemistry | Defensins - pharmacology | Membrane Proteins - metabolism | Toll-Like Receptors - metabolism | Escherichia coli - physiology | Recombinant Proteins - metabolism | Cell Line | Lipopolysaccharides - toxicity | Membrane Proteins - genetics | Solubility | Escherichia coli - immunology | Recombinant Proteins - chemistry | Colon - metabolism | Toll-Like Receptors - agonists | Monocytes - drug effects | Protein Isoforms - pharmacology | ADAM17 Protein - genetics | Amyloid Precursor Protein Secretases - metabolism | Animals | Tumor Necrosis Factor-alpha - chemistry | Membrane Proteins - antagonists & inhibitors | Leukocytes - drug effects | Protein Conformation | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Leukocytes - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus | cytokine | tumor necrosis factor (TNF) | proteolytic enzyme | theta defensin | TACE | shedding | ADAM | ADAM17 | Immunology | enzyme inhibitor | inflammation | defensin | sheddase inhibitors
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6. Full Text The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?
by Saftig, Paul and Reiss, Karina
European journal of cell biology, ISSN 0171-9335, 2011, Volume 90, Issue 6, pp. 527 - 535
Shedding | Neurodegeneration | ADAMs | Cell adhesion | Inflammation | Signalling | Cancer | Life Sciences & Biomedicine | Science & Technology | Cell Biology | ADAM17 Protein | Amyloid Precursor Protein Secretases - genetics | ADAM Proteins - antagonists & inhibitors | Membrane Proteins - genetics | Humans | ADAM10 Protein | Mice, Knockout | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Membrane Proteins - antagonists & inhibitors | Membrane Proteins - metabolism | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | ADAM Proteins - genetics | Molecular Targeted Therapy - methods | Drugs | Enzymes | Antiinflammatory agents | Immune response | Neurodegenerative diseases | Proteinase | Clinical trials | Cell surface | Infection | ADAM10 protein | Proteolysis | Metalloproteinase | Cardiovascular diseases | Tumor necrosis factor- alpha | Index Medicus
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7. Full Text Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway
by Milosch, N and Tanriöver, G and Kundu, A and Rami, A and François, J.-C and Baumkötter, F and Weyer, S.W and Samanta, A and Jäschke, A and Brod, F and Buchholz, C.J and Kins, S and Behl, C and Müller, U.C and Kögel, D
Cell death & disease, ISSN 2041-4889, 2014, Volume 5, Issue 8, pp. e1391 - e1391
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Humans | Phosphatidylinositol 3-Kinases - metabolism | Recombinant Proteins - biosynthesis | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Amyloid beta-Protein Precursor - metabolism | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Hydroxamic Acids - pharmacology | Amyloid beta-Protein Precursor - deficiency | Cell Line | Cell Survival - drug effects | ADAM Proteins - antagonists & inhibitors | Dipeptides - pharmacology | Mice, Inbred C57BL | ADAM10 Protein | Hippocampus - pathology | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Amino Acid Motifs | Mice, Knockout | Hippocampus - metabolism | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | In Vitro Techniques | Pertussis Toxin - toxicity | Index Medicus | Original
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8. Full Text Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines
by Colombo, Alessio and Wang, Huanhuan and Kuhn, Peer-Hendrik and Page, Richard and Kremmer, Elisabeth and Dempsey, Peter J and Crawford, Howard C and Lichtenthaler, Stefan F
Neurobiology of disease, ISSN 0969-9961, 2012, Volume 49, Issue 1, pp. 137 - 147
Neurology | Beta-secretase | Alpha-secretase | Alzheimer's disease | Amyloid precursor protein | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Amyloid Precursor Protein Secretases - genetics | Humans | Aspartic Acid Endopeptidases - genetics | Gene Knockdown Techniques | Protease Inhibitors - pharmacology | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Membrane Proteins - metabolism | Cerebral Cortex - drug effects | Neurons - drug effects | Cerebral Cortex - enzymology | ADAM Proteins - antagonists & inhibitors | Aspartic Acid Endopeptidases - antagonists & inhibitors | Membrane Proteins - genetics | Cells, Cultured | ADAM10 Protein | Mice, Knockout | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Membrane Proteins - antagonists & inhibitors | Aspartic Acid Endopeptidases - metabolism | Neurons - enzymology | Cell Line, Tumor | Amyloid Precursor Protein Secretases - antagonists & inhibitors | ADAM Proteins - genetics | Index Medicus | Alzheimer’s disease
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