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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 30, pp. 13473 - 13478
Staphylococcus aureus α-hemolysin (Hla), a potent cytotoxin, plays an important role in the pathogenesis of staphylococcal diseases, including those caused by... 
Receptors | Epithelial cells | Cell lines | Erythrocytes | Small interfering RNA | Cytotoxicity | Toxins | Cell membranes | Focal adhesions | Staphylococcus aureus | Cellular receptor | Pore-forming cytotoxin | CELLS | INFECTIONS | TYROSINE PHOSPHORYLATION | PROTECTION | pore-forming cytotoxin | TOXIN | MULTIDISCIPLINARY SCIENCES | P130(CAS) | MURINE MODEL | ERYTHROCYTES | PORE | BINDING | cellular receptor | Amyloid Precursor Protein Secretases - genetics | Epithelial Cells - metabolism | Hemolysin Proteins - pharmacology | Staphylococcus aureus - physiology | Hemolysin Proteins - genetics | Humans | Focal Adhesions | Molecular Sequence Data | Immunoblotting | RNA Interference | Membrane Proteins - metabolism | Staphylococcus aureus - metabolism | Staphylococcus aureus - genetics | Amino Acid Sequence | Cell Line | Cell Survival - drug effects | Rabbits | Membrane Proteins - genetics | Electrophoresis, Polyacrylamide Gel | Bacterial Proteins - genetics | ADAM10 Protein | Epithelial Cells - pathology | Host-Pathogen Interactions | Integrin beta1 - metabolism | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Bacterial Proteins - pharmacology | Animals | Epithelial Cells - microbiology | Erythrocytes - metabolism | Cell Line, Tumor | Protein Binding | Bacterial Proteins - metabolism | Mutation | ADAM Proteins - genetics | Integrin beta1 - genetics | Hemolysin Proteins - metabolism | Biological Sciences
Journal Article
Blood, ISSN 0006-4971, 12/2012, Volume 120, Issue 26, pp. 5217 - 5223
Journal Article
Cell Death and Disease, ISSN 2041-4889, 2014, Volume 5, Issue 8, pp. e1391 - e1391
Journal Article
Nature Neuroscience, ISSN 1097-6256, 07/2011, Volume 14, Issue 7, pp. 857 - 865
Tumor necrosis factor-alpha-converting enzyme (TACE; also known as ADAM17) is a proteolytic sheddase that is responsible for the cleavage of several... 
ALPHA-SECRETASE | BACE1 | PERIPHERAL-NERVE MYELINATION | LIPID RAFTS | NEUROTROPHIN RECEPTOR P75(NTR) | REMYELINATION | AMYLOID PRECURSOR PROTEIN | NEUREGULIN-1 | EXPRESSION | NEUROSCIENCES | CONVERTING-ENZYME | ADAM17 Protein | Embryo, Mammalian | Homeodomain Proteins - metabolism | Humans | Ganglia, Spinal - cytology | Femoral Nerve - pathology | Disease Models, Animal | Gene Expression Regulation, Developmental - physiology | Animals, Newborn | Motor Neurons - physiology | Myelin Basic Protein - metabolism | Gene Expression Regulation, Developmental - drug effects | Rats | Polyradiculoneuropathy - genetics | Signal Transduction - genetics | Coculture Techniques - methods | Mice, Knockout | Amyloid Precursor Protein Secretases - metabolism | Schwann Cells - ultrastructure | Aspartic Acid Endopeptidases - metabolism | Axons - pathology | Ascorbic Acid - pharmacology | Mice | Myelin Sheath - ultrastructure | ADAM Proteins - genetics | Neurofilament Proteins - metabolism | Femoral Nerve - ultrastructure | Age Factors | Gene Expression Regulation, Developmental - genetics | Myelin Sheath - drug effects | Polyradiculoneuropathy - metabolism | ADAM Proteins - pharmacology | Myelin Sheath - metabolism | Polyradiculoneuropathy - pathology | Transfection - methods | Axons - ultrastructure | Femoral Nerve - metabolism | Schwann Cells - physiology | Motor Neurons - drug effects | Schwann Cells - drug effects | Microscopy, Electron, Transmission | RNA, Small Interfering - pharmacology | Cells, Cultured | ADAM Proteins - deficiency | Axons - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods | Antioxidants - pharmacology | Transcription Factors - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Animals | Neuregulin-1 - metabolism | Physiological aspects | Myelination | Research | Tumor necrosis factor | Proteases | Schwann cells
Journal Article
Journal Article
Cellular Signalling, ISSN 0898-6568, 2012, Volume 24, Issue 2, pp. 532 - 538
During the progression of prostate cancer, the epithelial adhesion molecule E-cadherin is cleaved from the cell surface by ADAM15 proteolytic processing,... 
ADAM10 | Soluble E-cadherin | EGFR | ACTIVATION | MESENCHYMAL TRANSITION | CANCER | CELL BIOLOGY | GROWTH-FACTOR RECEPTOR | ADHESION | INVASION | BENIGN | FRAGMENT | DISINTEGRIN/METALLOPROTEINASE ADAM10 | PROGRESSION | Amyloid Precursor Protein Secretases - genetics | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | Epithelial Cells - metabolism | Recombinant Fusion Proteins - pharmacology | Epithelial Cells - drug effects | Humans | Male | Amphiregulin | Glycoproteins - pharmacology | Cadherins - biosynthesis | Prostate - metabolism | Antibodies, Monoclonal, Humanized | Receptor, Epidermal Growth Factor - metabolism | EGF Family of Proteins | Immunoglobulin G - pharmacology | Prostate - drug effects | Membrane Proteins - metabolism | Phosphorylation - drug effects | Cetuximab | Epithelial Cells - cytology | Cell Line | Gene Expression | ADAM Proteins - antagonists & inhibitors | Membrane Proteins - genetics | Antibodies, Monoclonal - pharmacology | Enzyme Inhibitors - pharmacology | Solubility | ADAM10 Protein | Cadherins - secretion | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Immunoglobulin G - genetics | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Prostate - cytology | Protein Binding | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Recombinant Fusion Proteins - genetics | Cell Proliferation - drug effects | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Epidermal Growth Factor - pharmacology | ADAM Proteins - genetics | RNA, Small Interfering - metabolism | Monoclonal antibodies | Immunoglobulins | Epidermal growth factor | soluble E-cadherin
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2011, Volume 286, Issue 8, pp. 6801 - 6807
A characteristic of malignant cells is their capacity to invade their surrounding and to metastasize to distant organs. During these processes, proteolytic... 
EGG INTEGRIN ALPHA-6-BETA-1 | ADHESION | INVASION | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | COLLAGEN-I | GROWTH-FACTOR | METALLOPROTEINASES | EXPRESSION | CANCER | BINDING | Humans | Gene Expression Regulation, Neoplastic | Extracellular Matrix - metabolism | Melanoma - enzymology | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - pharmacology | Membrane Proteins - pharmacology | Neoplasm Proteins - metabolism | ADAM Proteins - pharmacology | ADAM Proteins - biosynthesis | Neoplasm Metastasis | Neoplasm Proteins - genetics | Matrix Metalloproteinase 1 - genetics | Fibroblasts - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Cell Adhesion - genetics | ADAM Proteins - antagonists & inhibitors | Matrix Metalloproteinase 2 - metabolism | Membrane Proteins - genetics | Neoplasm Invasiveness | Neoplasm Proteins - biosynthesis | Matrix Metalloproteinase 13 - genetics | Cell Communication | Recombinant Proteins - genetics | Melanoma - pathology | Recombinant Proteins - pharmacology | Cell Adhesion - drug effects | Fibroblasts - pathology | Amino Acid Motifs | Matrix Metalloproteinase 13 - metabolism | Gene Expression Regulation, Enzymologic | Integrin beta1 - metabolism | Matrix Metalloproteinase 2 - genetics | Membrane Proteins - biosynthesis | Animals | Membrane Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | ADAM Proteins - genetics | Integrin beta1 - genetics | Matrix Metalloproteinase 1 - metabolism | Extracellular Matrix - pathology | Cell Movement | Melanoma Cells | ADAM ADAMTS | Cell-Cell Interaction | Cell Surface Receptor | Cell Adhesion | Fibroblast | Cell Biology
Journal Article
Journal Article
Cell Reports, ISSN 2211-1247, 02/2016, Volume 14, Issue 7, pp. 1761 - 1773
Interleukin (IL)-11 has been shown to be a crucial factor for intestinal tumorigenesis, lung carcinomas, and asthma. IL-11 is thought to exclusively mediate... 
ADAM10 | ADAM17 | interleukin-11 | signal transduction | proteolysis | Signal transduction | Interleukin-11 | Proteolysis | MURINE INTERLEUKIN-11 | INFLAMMATION | GLYCOPROTEIN 130 | FAMILY CYTOKINE | SOLUBLE IL-6 | RECEPTOR ALPHA-CHAIN | EXPRESSION | TUMORIGENESIS | IL-6 RECEPTOR | CELL BIOLOGY
Journal Article
Blood, ISSN 0006-4971, 07/2004, Volume 104, Issue 1, pp. 100 - 106
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 10/2015, Volume 5, Issue 1, p. 15150
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 04/2013, Volume 201, Issue 2, pp. 279 - 292
Notch regulates cell-cell contact-dependent signaling and is activated by hypoxia, a micro-environmental condition that promotes cellular invasion during both... 
INDUCIBLE FACTOR-I | MESSENGER-RNA | BREAST-CANCER METASTASIS | CELL-MIGRATION | E-CADHERIN EXPRESSION | GENE-EXPRESSION | LUNG CARCINOMAS | GROWTH-FACTOR | TUMOR-GROWTH | BINDING | CELL BIOLOGY | Epithelial Cells - metabolism | Receptors, Notch - metabolism | Epithelial Cells - drug effects | Humans | Intercellular Signaling Peptides and Proteins - chemistry | ADAM12 Protein | Intercellular Signaling Peptides and Proteins - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Membrane Proteins - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Protein Structure, Tertiary | Epithelium - drug effects | Cell Hypoxia - drug effects | Epithelium - pathology | Epithelium - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Membrane Proteins - genetics | Epithelial Cells - pathology | Signal Transduction - genetics | Cell Communication - genetics | Heparin-binding EGF-like Growth Factor | ADAM Proteins - metabolism | Pseudopodia - metabolism | Signal Transduction - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Models, Biological | Cell Communication - drug effects | Cell Line, Tumor | ADAM Proteins - genetics | Epidermal growth factor | Proteases | Cellular control mechanisms | Cancer cells | Hypoxia | Cellular signal transduction | Genetic aspects | Research | Properties | Observations
Journal Article