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Nature Cell Biology, ISSN 1465-7392, 2009, Volume 11, Issue 2, pp. 162 - 171
EpCAM was found to be overexpressed on epithelial progenitors, carcinomas and cancer-initiating cells. The role of EpCAM in proliferation, and its association... 
BREAST-CANCER | TARGET | STEM-CELLS | ADHESION MOLECULE | DEPENDENT GAMMA-SECRETASE | EP-CAM | COLORECTAL-CANCER | C-MYC | CELL-PROLIFERATION | BETA-CATENIN | CELL BIOLOGY | ADAM17 Protein | NIH 3T3 Cells | Cell Adhesion Molecules - genetics | Colonic Neoplasms - genetics | Cell Proliferation | Active Transport, Cell Nucleus - physiology | Homeodomain Proteins - metabolism | Humans | Lymphoid Enhancer-Binding Factor 1 - genetics | Male | Presenilin-2 - metabolism | Cell Membrane - genetics | Colonic Neoplasms - metabolism | Epithelial Cell Adhesion Molecule | Cell Nucleus - metabolism | Cell Transformation, Neoplastic - genetics | Muscle Proteins - metabolism | Antigens, Neoplasm - metabolism | Cell Membrane - metabolism | Protein Structure, Tertiary | Antigens, Neoplasm - genetics | Transcription Factors - genetics | Cell Adhesion Molecules - metabolism | Cell Transformation, Neoplastic - metabolism | Lymphoid Enhancer-Binding Factor 1 - metabolism | beta Catenin - metabolism | Homeodomain Proteins - genetics | beta Catenin - genetics | Muscle Proteins - genetics | Transcription Factors - metabolism | ADAM Proteins - metabolism | Animals | Cell Nucleus - genetics | Mitosis - physiology | Carcinoma - genetics | LIM-Homeodomain Proteins | Signal Transduction - physiology | Mice | Carcinoma - metabolism | Tumor antigens | Physiological aspects | Genetic aspects | Research | Health aspects | Cell adhesion molecules | Membrane proteins
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2017, Volume 292, Issue 15, pp. 6339 - 6351
We previously showed that the cell adhesion molecule Nectin-4 is overexpressed in ovarian cancer tumors, and its cleaved extracellular domain can be detected... 
BREAST-CANCER | CARCINOMA ASCITES SPHEROIDS | METALLOPROTEASE-17 ADAM17 | L-SELECTIN | GROWTH-FACTOR-RECEPTOR | LYSOPHOSPHATIDIC ACID | PERITONEAL MESOTHELIAL CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | TNF-ALPHA | CONVERTING-ENZYME | Amyloid Precursor Protein Secretases - genetics | Cell Adhesion Molecules - genetics | ADAM10 Protein - genetics | Humans | Ovarian Neoplasms - pathology | ADAM10 Protein - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | RNA, Neoplasm - metabolism | Proto-Oncogene Proteins c-akt - genetics | ADAM17 Protein - metabolism | Ovarian Neoplasms - genetics | Neoplasm Metastasis | MAP Kinase Signaling System - genetics | Protein Domains | Female | Membrane Proteins - metabolism | Ovarian Neoplasms - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Membrane Proteins - genetics | Proto-Oncogene Proteins c-jun - genetics | RNA, Messenger - genetics | Cell Adhesion Molecules - metabolism | ADAM17 Protein - genetics | Amyloid Precursor Protein Secretases - metabolism | Proto-Oncogene Proteins c-jun - metabolism | Cell Line, Tumor | RNA, Neoplasm - genetics | Nectin-4 | ADAM | ADAM17 | ovarian cancer | cell migration | ADAM10 | cancer biology | biomarker | Cell Biology
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2013, Volume 23, Issue 2, pp. 171 - 185
We report a paracrine effect whereby endothelial cells (ECs) promote the cancer stem cell (CSC) phenotype of human colorectal cancer (CRC) cells. We showed... 
COLON-CANCER | METASTASIS | ONCOLOGY | NOTCH | NICHE | SELF-RENEWAL | RECEPTOR | GROWTH-FACTOR | TUMOR ANGIOGENESIS | DIFFERENTIATION | ANGIOCRINE FACTORS | CELL BIOLOGY | ADAM17 Protein | RNA, Small Interfering - genetics | Immunoprecipitation | Receptors, Notch - metabolism | Colorectal Neoplasms - genetics | Humans | Calcium-Binding Proteins - antagonists & inhibitors | Culture Media, Conditioned - pharmacology | Drug Resistance, Neoplasm | Immunoblotting | Peptide Fragments - pharmacology | Intercellular Signaling Peptides and Proteins - metabolism | Neoplastic Stem Cells - metabolism | Serrate-Jagged Proteins | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Tumor Cells, Cultured | Liver Neoplasms - secondary | Colorectal Neoplasms - metabolism | Jagged-1 Protein | Biomarkers - metabolism | Calcium-Binding Proteins - metabolism | ADAM Proteins - antagonists & inhibitors | Liver Neoplasms - genetics | Signal Transduction | Endothelial Cells - metabolism | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Cell Communication | Xenograft Model Antitumor Assays | ADAM Proteins - metabolism | Phenotype | Animals | Membrane Proteins - antagonists & inhibitors | Mice, Nude | Liver Neoplasms - metabolism | Mice | ADAM Proteins - genetics | Colorectal Neoplasms - pathology | Endothelial Cells - pathology | Calcium-Binding Proteins - genetics | Genetic aspects | Colorectal cancer | Stem cells | Endothelium
Journal Article
Nature Communications, ISSN 2041-1723, 03/2011, Volume 2, Issue 1, p. 229
The fibroblast growth factor receptor 2-IIIb (FGFR2b) and the vascular endothelial growth factor receptor 2 (VEGFR2) are tyrosine kinases that can promote cell... 
FACTOR-RECEPTOR | CANCER-CELLS | HB-EGF | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | TACE | NECROSIS-FACTOR-ALPHA | ANGIOTENSIN-II | POTENTIAL ROLE | KERATINOCYTE MIGRATION | CONVERTING-ENZYME | ADAM17 Protein | Receptor, Epidermal Growth Factor - genetics | Phosphorylation | Cell Proliferation | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Transcriptional Activation | Phosphatidylinositol 3-Kinases - metabolism | Vascular Endothelial Growth Factor Receptor-2 - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Fibroblast Growth Factor 7 - metabolism | Receptor, Epidermal Growth Factor - metabolism | Transfection | Mitogen-Activated Protein Kinase 1 - genetics | src-Family Kinases - metabolism | Female | Fetus | p38 Mitogen-Activated Protein Kinases - metabolism | Endothelial Cells - physiology | Cell Line | Gene Expression | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Epidermal Growth Factor - genetics | Intercellular Signaling Peptides and Proteins - genetics | Vascular Endothelial Growth Factor Receptor-2 - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | Epidermal Growth Factor - metabolism | Mice, Transgenic | Keratinocytes - cytology | Fibroblast Growth Factor 7 - genetics | Phosphatidylinositol 3-Kinases - genetics | Heparin-binding EGF-like Growth Factor | ADAM Proteins - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Endothelial Cells - cytology | Mice | ADAM Proteins - genetics | src-Family Kinases - genetics | Fetal Blood | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Cell Movement | Keratinocytes - physiology | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 10/2017, Volume 9, Issue 10, pp. 1356 - 1365
Sequence variations occurring in the gene encoding the triggering receptor expressed on myeloid cells 2 ( TREM 2) support an essential function of microglia... 
neurodegeneration | phagocytosis | TREM | regulated intramembrane proteolysis | Alzheimer's disease | TREM2 | MEDICINE, RESEARCH & EXPERIMENTAL | MICROGLIAL RESPONSE | FLUID SOLUBLE TREM2 | INTRAMEMBRANE PROTEOLYSIS | GOLGI-APPARATUS | AMYLOID PRECURSOR PROTEIN | APOLIPOPROTEIN-E | DISEASE | BETA-PROTEIN | MYELOID CELLS-2 TREM2 | GAMMA-SECRETASE | Amyloid Precursor Protein Secretases - genetics | Membrane Glycoproteins - metabolism | ADAM10 Protein - genetics | Humans | ADAM10 Protein - metabolism | Histidine - metabolism | Mutation, Missense | Phagocytosis - genetics | ADAM17 Protein - metabolism | Sequence Analysis, Protein | HEK293 Cells | Cell Membrane - metabolism | Membrane Proteins - metabolism | Membrane Proteins - genetics | Phagocytosis - physiology | THP-1 Cells | Immunity, Innate | Serine - metabolism | Membrane Glycoproteins - genetics | Microglia | ADAM17 Protein - genetics | Amyloid Precursor Protein Secretases - metabolism | Alzheimer Disease - metabolism | Alzheimer Disease - genetics | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Histidine | Proteases | Proteolysis | Mass spectrometry | Immunoglobulins | Myeloid cells | Neurodegenerative diseases | Serine | Innate immunity | Mass spectroscopy | Cell surface | Phagocytes | Missense mutation | Coding | Mutation | Alzheimers disease | Endoplasmic reticulum | Phagocytosis | Neuroscience | Immunology | Report | Reports | Genetics, Gene Therapy & Genetic Disease
Journal Article
Journal Article
Cell Reports, ISSN 2211-1247, 02/2016, Volume 14, Issue 7, pp. 1761 - 1773
Interleukin (IL)-11 has been shown to be a crucial factor for intestinal tumorigenesis, lung carcinomas, and asthma. IL-11 is thought to exclusively mediate... 
ADAM10 | ADAM17 | interleukin-11 | signal transduction | proteolysis | Signal transduction | Interleukin-11 | Proteolysis | MURINE INTERLEUKIN-11 | INFLAMMATION | GLYCOPROTEIN 130 | FAMILY CYTOKINE | SOLUBLE IL-6 | RECEPTOR ALPHA-CHAIN | EXPRESSION | TUMORIGENESIS | IL-6 RECEPTOR | CELL BIOLOGY
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