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index medicus (615) 615
humans (464) 464
animals (348) 348
adamts (268) 268
biochemistry & molecular biology (215) 215
adam proteins - metabolism (210) 210
adam proteins - genetics (162) 162
female (160) 160
mice (158) 158
male (154) 154
cell biology (133) 133
adamts proteins (128) 128
expression (106) 106
extracellular-matrix (98) 98
adamts family (91) 91
osteoarthritis (90) 90
adult (88) 88
adamts4 protein (84) 84
extracellular matrix (83) 83
cells, cultured (82) 82
middle aged (82) 82
cartilage (78) 78
proteases (78) 78
gene expression (75) 75
molecular sequence data (73) 73
amino acid sequence (72) 72
extracellular matrix - metabolism (70) 70
aged (69) 69
aggrecan (69) 69
matrix metalloproteinases (68) 68
thrombotic thrombocytopenic purpura (68) 68
adamts5 protein (66) 66
aggrecanase (66) 66
metalloproteinase (66) 66
adam proteins (65) 65
in-vitro (64) 64
family (61) 61
cattle (60) 60
proteoglycans - metabolism (60) 60
protein structure, tertiary (59) 59
hematology (58) 58
blotting, western (57) 57
proteolysis (57) 57
gene-expression (56) 56
articular-cartilage (55) 55
article (54) 54
mutation (54) 54
adamts13 protein (53) 53
signal transduction (53) 53
adamts proteins - metabolism (52) 52
analysis (52) 52
collagen (51) 51
endopeptidases - metabolism (51) 51
peripheral vascular disease (51) 51
rna, messenger - metabolism (51) 51
metalloprotease (50) 50
procollagen n-endopeptidase - metabolism (50) 50
reverse transcriptase polymerase chain reaction (50) 50
metalloendopeptidases - metabolism (49) 49
proteins (49) 49
gene (48) 48
interglobular domain (48) 48
von willebrand factor - metabolism (48) 48
von-willebrand-factor (48) 48
adamts1 protein (47) 47
matrix metalloproteinases - metabolism (47) 47
rheumatology (47) 47
metalloproteinases (46) 46
cartilage, articular - metabolism (45) 45
cell line, tumor (45) 45
degradation (45) 45
matrix metalloproteinase (45) 45
rats (45) 45
adam proteins - chemistry (44) 44
aggrecans - metabolism (44) 44
cell line (44) 44
factor-cleaving protease (44) 44
adamts proteins - genetics (43) 43
genetic aspects (43) 43
immunohistochemistry (43) 43
metalloendopeptidases - genetics (43) 43
adam adamts (42) 42
cloning (42) 42
disintegrin (42) 42
enzymes (42) 42
inflammation (42) 42
aggrecans (41) 41
cleavage (41) 41
extracellular matrix proteins - metabolism (41) 41
in-vivo (41) 41
orthopedics (41) 41
von willebrand factor (41) 41
arthritis (40) 40
lectins, c-type (40) 40
proteoglycan (40) 40
procollagen n-endopeptidase - genetics (39) 39
adam (38) 38
oncology (38) 38
physiological aspects (38) 38
base sequence (37) 37
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Journal of Biological Chemistry, ISSN 0021-9258, 09/2011, Volume 286, Issue 38, pp. 33335 - 33344
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2016, Volume 126, Issue 6, pp. 2167 - 2180
Lymphangiogenesis is supported by 2 homologous VEGFR3 ligands, VEGFC and VEGFD. VEGFC is required for lymphatic development, while VEGFD is not. VEGFC and... 
VASCULAR DEVELOPMENT | MEDICINE, RESEARCH & EXPERIMENTAL | EMBRYONIC LYMPHANGIOGENESIS | SKELETAL-MUSCLE | CCBE1 | LYMPHATIC VESSELS | FACTOR-C | TYROSINE KINASES | LIGAND | LYMPHEDEMA | ENDOTHELIAL GROWTH-FACTOR | Cell Proliferation | Humans | Vascular Endothelial Growth Factor D - deficiency | Vascular Endothelial Growth Factor C - deficiency | ADAMTS Proteins - deficiency | Lymphatic Vessels - metabolism | Procollagen N-Endopeptidase - metabolism | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | HEK293 Cells | Vascular Endothelial Growth Factor D - genetics | Peptide Hydrolases - metabolism | Calcium-Binding Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | ADAMTS Proteins - metabolism | Endothelial Cells - metabolism | Procollagen N-Endopeptidase - genetics | Lymphangiogenesis - physiology | Calcium-Binding Proteins - deficiency | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Vascular Endothelial Growth Factor C - genetics | Mice, Knockout | Vascular Endothelial Growth Factor D - metabolism | Animals | Endothelial Cells - cytology | Models, Biological | Vascular Endothelial Growth Factor C - metabolism | Ligands | Mice | Lymphangiogenesis - genetics | ADAMTS Proteins - genetics | Calcium-Binding Proteins - genetics | Genetic aspects | Neovascularization | Proteolysis | Vascular endothelial growth factor | Health aspects | Studies | Lymphatic system | Lymphedema | Rodents | Cloning | Zebrafish | Skin | Experiments | Defects | Index Medicus | Abridged Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 05/2014, Volume 129, Issue 19, pp. 1962 - 1971
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 20, pp. 7864 - 7879
The biomechanical properties of extracellular matrices (ECMs) are critical to many biological processes, including cell-cell communication and cell migration... 
extracellular matrix protein | cardiogenesis | PERICARDIAL CELLS | Drosophila | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADAMTSL | ADAMTS | GAG | TSR repeats | thrombospondin | ADHESION | PEPTIDES | cardiac matrix | INTEGRINS | cardiac development | Drosophila melanogaster | BINDING | Drosophila genetics | extracellular matrix | TYPE-1 REPEATS | Thrombospondins - genetics | Baculoviridae - metabolism | Heart - physiology | Extracellular Matrix - metabolism | Baculoviridae - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Extracellular Matrix - chemistry | Drosophila melanogaster - metabolism | Repetitive Sequences, Amino Acid | Sf9 Cells | Gene Expression Regulation, Developmental | Cloning, Molecular | Escherichia coli - metabolism | Protein Domains | Collagen Type IV - metabolism | Recombinant Proteins - metabolism | Gene Expression | Spodoptera - cytology | Genetic Vectors - chemistry | Signal Transduction | Heart - growth & development | Genetic Vectors - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Protein Transport | ADAM Proteins - metabolism | Animals | Escherichia coli - genetics | Organogenesis - genetics | Spodoptera - metabolism | Collagen Type IV - genetics | Drosophila melanogaster - growth & development | Drosophila Proteins - genetics | ADAM Proteins - genetics | Thrombospondins - metabolism | Index Medicus | Cell Biology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2011, Volume 286, Issue 46, pp. 39738 - 39749
Journal Article
PLoS ONE, ISSN 1932-6203, 2017, Volume 12, Issue 8, pp. e0182885 - e0182885
Purpose: To determine survival in afatinib-treated patients after treatment with first-generation EGFR tyrosine kinase inhibitors (TKIs) and to study... 
TYROSINE KINASE INHIBITORS | TRIAL | GROWTH-FACTOR RECEPTOR | 1ST-LINE TREATMENT | GEFITINIB | ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | T790M MUTATION | OPEN-LABEL | CHEMOTHERAPY | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Lung Neoplasms - mortality | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Wnt Proteins - metabolism | Tumor Suppressor Protein p53 - genetics | Exome | Receptor, Epidermal Growth Factor - metabolism | Wnt Proteins - genetics | Aged, 80 and over | Adult | Female | Microfilament Proteins - metabolism | Microfilament Proteins - genetics | Calcium-Binding Proteins - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Genome-Wide Association Study | Signal Transduction | ADAMTS Proteins - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Tumor Suppressor Protein p53 - metabolism | Carcinoma, Non-Small-Cell Lung - mortality | Disease Progression | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Erlotinib Hydrochloride - therapeutic use | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | ADAMTS Proteins - genetics | Calcium-Binding Proteins - genetics | Care and treatment | Histocompatibility antigens | Research | Lung cancer, Non-small cell | HLA histocompatibility antigens | Wnt protein | Copy number | p53 Protein | Genes | Lung cancer | AKT protein | Biology | Cancer therapies | Epidermal growth factor | Drb1 protein | Gefitinib | Protein-tyrosine kinase | Tyrosine | Cell survival | Epidermal growth factor receptors | Cloning | Survival | Patients | 1-Phosphatidylinositol 3-kinase | Pathology | Chemotherapy | Medical prognosis | Histocompatibility antigen HLA | Tumors | Cancer | Index Medicus
Journal Article
FASEB Journal, ISSN 0892-6638, 05/2016, Volume 30, Issue 5, pp. 1741 - 1756
Journal Article
by Iglesias, Adriana I and Mishra, Aniket and Vitart, Veronique and Bykhovskaya, Yelena and Höhn, René and Springelkamp, Henriët and Cuellar-Partida, Gabriel and Gharahkhani, Puya and Bailey, Jessica N. Cooke and Willoughby, Colin E and Li, Xiaohui and Yazar, Seyhan and Nag, Abhishek and Khawaja, Anthony P and Polašek, Ozren and Siscovick, David and Mitchell, Paul and Tham, Yih Chung and Haines, Jonathan L and Kearns, Lisa S and Hayward, Caroline and Shi, Yuan and Van Leeuwen, Elisabeth M and Taylor, Kent D and Wang, Jie Jin and Rochtchina, Elena and Attia, John and Scott, Rodney and Holliday, Elizabeth G and Baird, Paul N and Xie, Jing and Inouye, Michael and Viswanathan, Ananth and Sim, Xueling and Bonnemaijer, Pieter and Rotter, Jerome I and Martin, Nicholas G and Zeller, Tanja and Mills, Richard A and Staffieri, Sandra E and Jonas, Jost B and Schmidtmann, Irene and Boutin, Thibaud and Kang, Jae H and Lucas, Sionne E. M and Wong, Tien Yin and Beutel, Manfred E and Wilson, James F and Allingham, R. Rand and Brilliant, Murray H and Budenz, Donald L and Christen, William G and Fingert, John and Friedman, David S and Gaasterland, Douglas and Gaasterland, Terry and Hauser, Michael A and Kraft, Peter and Lee, Richard K and Lichter, Paul R and Liu, Yutao and Loomis, Stephanie J and Moroi, Sayoko E and Pericak-Vance, Margaret A and Realini, Anthony and Richards, Julia E and Schuman, Joel S and Scott, William K and Singh, Kuldev and Sit, Arthur J and Vollrath, Douglas and Weinreb, Robert N and Wollstein, Gadi and Zack, Donald J and Zhang, Kang and Donnelly, Peter and Barroso, Ines and Blackwell, Jenefer M and Bramon, Elvira and Brown, Matthew A and Casas, Juan P and Corvin, Aiden and Deloukas, Panos and Duncanson, Audrey and Jankowski, Janusz and Markus, Hugh S and Mathew, Christopher G and Palmer, Colin N. A and Plomin, Robert and Rautanen, Anna and Sawcer, Stephen J and Trembath, Richard C and Wood, Nicholas W and Spencer, Chris C. A and Band, Gavin and Bellenguez, Céline and Freeman, Colin and Hellenthal, Garrett and Giannoulatou, Eleni and Pirinen, Matti and ... and Blue Mountains Eye Study-GWAS Grp and NEIGHBORHOOD Consortium and Wellcome Trust Case Control Consor and Blue Mountains Eye Study—GWAS group and Wellcome Trust Case Control Consortium 2 (WTCCC2)
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 11
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide... 
DECORIN | CHROMATIN STATES | POLYMORPHISMS | RISK-FACTOR | MULTIDISCIPLINARY SCIENCES | MOUSE | GENE-EXPRESSION | MUTATIONS | HERITABILITY | LUMICAN | KERATOCONUS | Glaucoma | Cornea | Genes | Myopia | Association analysis | Genomes | Gene expression | Tissues | Connective tissues | Keratoconus | Collagen | Eye diseases | Extracellular matrix | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 42, pp. 30114 - 30124
Background: Amyloid precursor protein (APP) and ADAM10, main -secretase involved in generation of secreted APP (sAPP), are overexpressed in pancreatic cancer.... 
PLUS GEMCITABINE | ADAM ADAMTS | Amyloid Precursor Protein | Secretases | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHASE-III | ADAM10 | PROLIFERATION | Pancreatic Cancer | ADAM-10 | DISINTEGRIN METALLOPROTEASE | Protein Secretion | PROSTATE-CANCER | EXPRESSION | ALPHA-SECRETASE CLEAVAGE | Amyloid Precursor Protein Secretases - genetics | Pancreatic Neoplasms - metabolism | Phenylalanine - analogs & derivatives | Phenylalanine - pharmacology | Humans | Deoxycytidine - pharmacology | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Pancreatic Neoplasms - drug therapy | Protease Inhibitors - pharmacology | Amyloid beta-Protein Precursor - metabolism | Cytotoxins - metabolism | Antimetabolites, Antineoplastic - pharmacology | Membrane Proteins - metabolism | Neoplasm Proteins - genetics | Hydroxamic Acids - pharmacology | Protein Structure, Tertiary | ADAM Proteins - antagonists & inhibitors | Membrane Proteins - genetics | Dipeptides - pharmacology | Pancreatic Neoplasms - pathology | ADAM10 Protein | Thiophenes - pharmacology | Pancreatic Neoplasms - genetics | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Membrane Proteins - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Amyloid Precursor Protein Secretases - antagonists & inhibitors | ADAM Proteins - genetics | Cytotoxins - genetics | Deoxycytidine - analogs & derivatives | Index Medicus | Molecular Bases of Disease
Journal Article
by Marouli, Eirini and Graff, Mariaelisa and Medina-Gomez, Carolina and Lo, Ken Sin and Wood, Anew R and Kjaer, Troels R and Fine, Rebecca S and Lu, Yingchang and Schurmann, Claudia and Highland, Heather M and Rüeger, Sina and Thorleifsson, Gudmar and Justice, Anne E and Lamparter, David and Stirrups, Kathleen E and Turcot, Valérie and Young, Kristin L and Winkler, Thomas W and Esko, Tõnu and Karaderi, Tugce and Locke, Adam E and Masca, Nicholas G. D and Ng, Maggie C. Y and Mudgal, Poorva and Rivas, Manuel A and Vedantam, Sailaja and Mahajan, Anubha and Guo, Xiuqing and Abecasis, Goncalo and Aben, Katja K and Adair, Linda S and Alam, Dewan S and Albrecht, Eva and Allin, Kristine H and Allison, Matthew and Amouyel, Philippe and Appel, Emil V and Arveiler, Dominique and Asselbergs, Folkert W and Auer, Paul L and Balkau, Beverley and Banas, Bernhard and Bang, Lia E and Benn, Marianne and Bergmann, Sven and Bielak, Lawrence F and Blüher, Matthias and Boeing, Heiner and Boerwinkle, Eric and Böger, Carsten A and Bonnycastle, Lori L and Bork-Jensen, Jette and Bots, Michiel L and Bottinger, Erwin P and Bowden, Donald W and Brandslund, Ivan and Breen, Gerome and Brilliant, Murray H and Broer, Linda and Burt, Amber A and Butterworth, Adam S and Carey, David J and Caulfield, Mark J and Chambers, John C and Chasman, Daniel I and Chen, Yii-Der Ida and Chowdhury, Rajiv and Christensen, Cramer and Chu, Auey Y and Cocca, Massimiliano and Collins, Francis S and Cook, James P and Corley, Janie and Galbany, Jordi Corominas and Cox, Amanda J and Cuellar-Partida, Gabriel and Danesh, John and Davies, Gail and de Bakker, Paul I. W and de Borst, Gert J and de Denus, Simon and de Groot, Mark C. H and de Mutsert, Renée and Deary, Ian J and Dedoussis, George and Demerath, Ellen W and den Hollander, Anneke I and Dennis, Joe G and Di Angelantonio, Emanuele and nos, Fotios and Du, Mengmeng and Dunning, Alison M and Easton, Douglas F and Ebeling, Tapani and Edwards, Todd L and Ellinor, Patrick T and Elliott, Paul and Evangelou, Evangelos and Farmaki, Aliki-Eleni and Faul, Jessica D and ... and EPIC-CVD Consortium and GoT2D Genes Consortium and MAGIC Investigators and Global Lipids Genetics Consortium and EPIC-InterAct Consortium and ReproGen Consortium and ExomeBP Consortium and CHD Exome Consortium and T2D-Genes Consortium and CHD Exome+ Consortium and The EPIC-InterAct Consortium and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Enheten för biobanksforskning and Allmänmedicin and Umeå universitet and Medicin
Nature, ISSN 0028-0836, 2017, Volume 542, Issue 7640, pp. 186 - 190
Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so... 
MULTIDISCIPLINARY SCIENCES | MISSING HERITABILITY | GENETIC ARCHITECTURE | INTERLEUKIN-11 | MICE | MUTATIONS | GENOME-WIDE ASSOCIATION | Cell Adhesion Molecules - genetics | Gene Frequency - genetics | Humans | Glycoproteins - metabolism | Male | Intercellular Signaling Peptides and Proteins - metabolism | Hedgehog Proteins - genetics | Proteolysis | NADPH Oxidases - genetics | Adult | Female | Interleukin-11 Receptor alpha Subunit - genetics | Somatomedins - metabolism | Glycosaminoglycans - biosynthesis | Glycoproteins - genetics | Multifactorial Inheritance - genetics | Procollagen N-Endopeptidase - genetics | Intercellular Signaling Peptides and Proteins - genetics | Interferon Regulatory Factors - genetics | Proteoglycans - biosynthesis | NADPH Oxidase 4 | Body Height - genetics | Genome, Human - genetics | Phenotype | Receptors, Androgen - genetics | Alleles | Genetic Variation - genetics | Pregnancy-Associated Plasma Protein-A - metabolism | ADAMTS Proteins - genetics | Stature | Genetic aspects | Observations | Genetic variation | Studies | Datasets | Disease | Genes | Deoxyribonucleic acid--DNA | Index Medicus | Hälsovetenskaper | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Medical and Health Sciences | Medicin och hälsovetenskap | Public Health, Global Health, Social Medicine and Epidemiology | Health Sciences
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2010, Volume 285, Issue 14, pp. 10376 - 10384
A disintegrin and metalloproteinase 10 (ADAM10) is a type I transmembrane glycoprotein responsible for the ectodomain shedding of a number of proteins... 
ER RETENTION SIGNAL | POTASSIUM CHANNELS | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | TRANS-GOLGI NETWORK | SURFACE EXPRESSION | TRAFFICKING | CELL-SURFACE | ALPHA-SECRETASE ADAM10 | MEMBRANE-PROTEINS | Amyloid Precursor Protein Secretases - genetics | Humans | Cercopithecus aethiops | Endoplasmic Reticulum - metabolism | Cytoplasm - metabolism | Neurons - cytology | RNA, Messenger - metabolism | Receptors, Interleukin-2 - genetics | Arginine - genetics | Cell Membrane - metabolism | Membrane Proteins - metabolism | Neurons - metabolism | Discs Large Homolog 1 Protein | Hippocampus - embryology | Mutagenesis, Site-Directed | Membrane Proteins - genetics | RNA, Messenger - genetics | Cells, Cultured | ADAM10 Protein | Rats | Receptors, Interleukin-2 - metabolism | Glycosylation | Mutation - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Protein Transport | Hippocampus - metabolism | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Guanylate Kinases | Adaptor Proteins, Signal Transducing - genetics | Fluorescent Antibody Technique | Mice | ADAM Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | COS Cells | Arginine - metabolism | Index Medicus | Intracellular Processing | ADAM | Protease | Subcellular Organelles | Trafficking | ADAMts | ADAM10 | Endoplasmic Reticulum | Cell | Protein | Cell Biology | Processing
Journal Article