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Genome Biology, ISSN 1474-7596, 05/2015, Volume 16, Issue 1, p. 113
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases... 
HUMAN ARTICULAR-CARTILAGE | EMERGING ROLES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CELL-MIGRATION | GENETICS & HEREDITY | INTERDIGITAL WEB REGRESSION | TUMOR-SUPPRESSOR | EXTRACELLULAR-MATRIX | OLIGOMERIC MATRIX PROTEIN | THROMBOTIC THROMBOCYTOPENIC PURPURA | VON-WILLEBRAND-FACTOR | WEILL-MARCHESANI-SYNDROME | Endopeptidases - metabolism | Catalytic Domain | Multigene Family | Disintegrins - metabolism | Thrombospondins - genetics | Humans | Gene Expression Regulation | Extracellular Matrix - metabolism | Substrate Specificity | Arthritis - genetics | Cardiovascular Diseases - genetics | Disintegrins - genetics | ADAM Proteins - metabolism | Animals | Endopeptidases - genetics | Neoplasms - genetics | ADAM Proteins - genetics | Thrombospondins - metabolism | Disease Models, Animal | Evolution, Molecular | Peptides | Genes | Proteinase | Genomes | Arthritis | Metastasis | Cartilage oligomeric matrix protein | Metastases | Cell adhesion & migration | Proteins | Morphogenesis | Cartilage | Epidermal growth factor | Substrate specificity | Phylogenetics | Extracellular matrix | Physiology | Tumorigenesis | Matrix protein | Localization | Thrombospondin | Enzymes | ADAM protein | ADAMTS-1 protein | Procollagen | Proteoglycans | Therapeutic applications | Maximum likelihood method | Insects | Collagen | Chondroitin sulfate | Cardiovascular diseases | Cancer | Structure-function relationships | Protein Family Review
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 10/2017, Volume 27, Issue 12, pp. 874 - 911
Significance: In contrast to structural elements of the extracellular matrix, matricellular proteins appear transiently during development and injury... 
Comprehensive Invited Review | Hydrogen sulfide | Thrombospondin-1 | Reactive oxygen species | CD47 | Matricellular proteins | Nitric oxide | INNATE IMMUNE CHECKPOINT | nitric oxide | PULMONARY ARTERIAL-HYPERTENSION | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | THIOREDOXIN-INTERACTING PROTEIN | INTEGRIN-ASSOCIATED PROTEIN | ISCHEMIA-REPERFUSION INJURY | EXTRACELLULAR-MATRIX PROTEINS | GROWTH-FACTOR-BETA | hydrogen sulfide | reactive oxygen species | ENDOCRINOLOGY & METABOLISM | SMOOTH-MUSCLE-CELLS | C-TERMINAL DOMAIN | thrombospondin-1 | matricellular proteins | Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Signal Transduction | Reactive Nitrogen Species - metabolism | Humans | Marfan Syndrome - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | CD47 Antigen - metabolism | Cysteine-Rich Protein 61 - metabolism | ADAMTS1 Protein - metabolism | Extracellular Matrix Proteins - metabolism | Immunology | Blood vessels | Extracellular matrix | Cellular signal transduction | Research | Cancer | Marfan's syndrome | Pathogenesis | Clinical trials | Transgenic | Cardiovascular disease | Cell surface | Marfan syndrome | Proteins | Signal transduction | Receptors | Vascular diseases | Pathways | Bioindicators | Inhibition | Chronic illnesses | Thrombospondin | Medical research | ADAMTS-1 protein | Structural members | Oxygen | Superoxide | Nitrogen | Patients | Side effects | Molecular modelling | Biomarkers | Cardiovascular diseases
Journal Article
Nature, ISSN 0028-0836, 06/2010, Volume 465, Issue 7299, pp. 813 - 817
Down's syndrome (DS) is a genetic disorder caused by full or partial trisomy of human chromosome 21 and presents with many clinical phenotypes including a... 
CADHERIN | APOPTOSIS | ADAMTS-1 | ENDOTHELIAL-CELL PROLIFERATION | GENE | VEGF | MULTIDISCIPLINARY SCIENCES | GROWTH | DSCR1 | MICE | ETS2 | Transcriptional Regulator ERG | Neoplasm Transplantation | Oncogene Proteins - genetics | Cell Adhesion Molecules - genetics | Chromosomes, Mammalian - genetics | Humans | Cell Adhesion Molecules - antagonists & inhibitors | Male | Down Syndrome - physiopathology | Vascular Endothelial Growth Factor A - metabolism | Immunoglobulins - genetics | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Carcinoma, Lewis Lung - blood supply | Neovascularization, Pathologic - pathology | Immunoglobulins - metabolism | Carcinoma, Lewis Lung - complications | Proto-Oncogene Protein c-ets-2 - genetics | Down Syndrome - complications | Female | Proto-Oncogene Protein c-ets-2 - metabolism | Vascular Endothelial Growth Factor A - pharmacology | ADAMTS1 Protein | Disease Models, Animal | Gene Dosage - genetics | Melanoma, Experimental - blood supply | Oncogene Proteins - metabolism | Melanoma, Experimental - complications | Melanoma, Experimental - pathology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Cell Adhesion Molecules - metabolism | Carrier Proteins - genetics | ADAM Proteins - metabolism | Animals | Carcinoma, Lewis Lung - genetics | Carrier Proteins - metabolism | Melanoma, Experimental - genetics | Trisomy - genetics | Down Syndrome - genetics | Carcinoma, Lewis Lung - pathology | Neovascularization, Pathologic - genetics | Mice | Transcription Factors | ADAM Proteins - genetics | Complications and side effects | Physiological aspects | Development and progression | Genetic aspects | Down syndrome | Neovascularization | Research | Risk factors | Tumors | Proteins | Studies | Angiogenesis | Genotype & phenotype | Rodents | Blood vessels | Genetic engineering | Gene therapy | Vascular endothelial growth factor
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 04/2019, Volume 9, Issue 1, pp. 6044 - 15
Journal Article
by Kunkle, BW and Grenier-Boley, B and Sims, R and Bis, JC and Damotte, V and Naj, AC and Boland, A and Vronskaya, M and van der Lee, SJ and Amlie-Wolf, A and Bellenguez, C and Frizatti, A and Chouraki, V and Martin, ER and Sleegers, K and Badarinarayan, N and Jakobsdottir, J and Hamilton-Nelson, KL and Moreno-Grau, S and Olaso, R and Raybould, R and Chen, YN and Kuzma, AB and Hiltunen, M and Morgan, T and Ahmad, S and Vardarajan, BN and Epelbaum, J and Hoffmann, P and Boada, M and Beecham, GW and Garnier, JG and Harold, D and Fitzpatrick, AL and Valladares, O and Moutet, ML and Gerrish, A and Smith, AV and Qu, LM and Bacq, D and Denning, N and Jian, XQ and Zhao, Y and Del Zompo, M and Fox, NC and Choi, SH and Mateo, I and Hughes, JT and Adams, HH and Malamon, J and Sanchez-Garcia, F and Patel, Y and Brody, JA and Dombroski, BA and Naranjo, MCD and Daniilidou, M and Eiriksdottir, G and Mukherjee, S and Wallon, D and Uphill, J and Aspelund, T and Cantwell, LB and Garzia, F and Galimberti, D and Hofer, E and Butkiewicz, M and Fin, B and Scarpini, E and Sarnowski, C and Bush, WS and Meslage, S and Kornhuber, J and White, CC and Song, Y and Barber, RC and Engelborghs, S and Sordon, S and Voijnovic, D and Adams, PM and Vandenberghe, R and Mayhaus, M and Cupples, LA and Albert, MS and De Deyn, PP and Gu, W and Himali, JJ and Beekly, D and Squassina, A and Hartmann, AM and Orellana, A and Blacker, D and Rodriguez-Rodriguez, E and Lovestone, S and Garcia, ME and Doody, RS and Munoz-Fernadez, C and Sussams, R and Lin, HH and Fairchild, TJ and Benito, YA and ... and Cohorts Heart Aging Res Genomic Ep and Alzheimer Dis Genetics Consortium and European Alzheimers Dis Initiative and Genetic Environm Risk AD Defining and Alzheimer Disease Genetics Consortium (ADGC) and Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) and European Alzheimer’s Disease Initiative (EADI) and Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES)
NATURE GENETICS, ISSN 1061-4036, 03/2019, Volume 51, Issue 3, pp. 414 - 414
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e35128
Journal Article
Cancer Letters, ISSN 0304-3835, 01/2018, Volume 412, pp. 208 - 215
Recent gastric cancer clinical trials have aimed to establish the efficacy of combination therapy over monotherapy, however, the role for genomic biomarkers in... 
NanoString | GC301/TOP-002 trial | IRI plus S-1 | Gastric cancer | S-1 | Gene signatures | 1ST-LINE TREATMENT | PLUS CISPLATIN | ADENOCARCINOMA | INTRINSIC SUBTYPES | CXCL12/CXCR4 AXIS | ONCOLOGY | DOUBLE-BLIND | IRINOTECAN | UP-REGULATION | EXPRESSION | Stomach Neoplasms - genetics | Wnt-5a Protein - genetics | Humans | Middle Aged | Neoplasm Recurrence, Local - drug therapy | Male | Stomach Neoplasms - pathology | Oxonic Acid - administration & dosage | Stomach Neoplasms - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Tegafur - administration & dosage | Adult | Camptothecin - administration & dosage | Female | Neoplasm Recurrence, Local - genetics | Aged | Liver Neoplasms - secondary | Stomach Neoplasms - mortality | Drug Combinations | Camptothecin - analogs & derivatives | Liver cancer | Relapse | Chemotherapy | Stem cells | Clinical trials | Genetic aspects | Metastasis | Stomach cancer | Cancer | Diseases | Protein binding | CXCL12 protein | Wnt protein | CCL19 protein | Mesenchyme | Liver | Genomics | Genomes | Kinases | CD14 antigen | Cancer therapies | Metastases | Gastroenterology | Bioindicators | Lesions | Signatures | Medical research | ADAMTS-1 protein | Effectiveness | Histology | Breast cancer | Gene expression | Patients | Survival | CD4 antigen | Studies | Irinotecan | Signaling | Medical prognosis | Biomarkers | Tumors | Peritoneum
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2015, Volume 10, Issue 1, p. e0115861
Congenital heart valve defects in humans occur in approximately 2% of live births and are a major source of compromised cardiac function. In this study we... 
PROTEOLYTIC CLEAVAGE | ADAMTS5 | TGF-BETA | MULTIDISCIPLINARY SCIENCES | O-GLYCOSYLATION | DISEASE | VERSICAN CLEAVAGE | EXTRACELLULAR-MATRIX | MICE | DIFFERENTIATION | FAMILY | ADAMTS5 Protein | Cell Proliferation | Humans | Heart Defects, Congenital - pathology | Heart Valves - pathology | MAP Kinase Signaling System | Heart Defects, Congenital - genetics | ADAM Proteins - metabolism | Animals | Embryo, Mammalian - physiopathology | N-Acetylgalactosaminyltransferases - genetics | Heart Defects, Congenital - physiopathology | Mice | N-Acetylgalactosaminyltransferases - metabolism | Extracellular Matrix Proteins - metabolism | Heart Valves - physiopathology | ADAMTS1 Protein | Disease Models, Animal | Proteins | Heart | Congenital heart disease | Genetic disorders | Cardiology | Proteases | Cell proliferation | Laboratories | Stenosis | Kinases | Defects | Signal transduction | Cell growth | Ultrasonic imaging | Regurgitation | Aorta | Outflow | Extracellular matrix | Bone morphogenetic proteins | Rheumatic heart disease | Heart diseases | Versican | Medical research | ADAMTS-1 protein | Pulmonary arteries | Developmental biology | Lung diseases | MAP kinase | Glycosylation | Ablation | Coronary artery disease | Heart valves | Signaling | Mucin | Coronary vessels | Stem cells | Aberration | Cancer | Ejection | Veins & arteries
Journal Article
Journal Article