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adamts-4 (84) 84
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osteoarthritis (51) 51
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ACS Medicinal Chemistry Letters, ISSN 1948-5875, 08/2015, Volume 6, Issue 8, pp. 888 - 893
The aggrecan degrading metalloprotease ADAMTS-4 has been identified as a novel therapeutic target for osteoarthritis. Here, we use DNA-encoded Library... 
DNA-encoded library | inhibitors | ADAMTS-4 | CHEMISTRY, MEDICINAL | AGGRECAN DEGRADATION
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 10/2016, Volume 17, Issue 10, pp. 1522 - 1522
Journal Article
American Journal of Translational Research, ISSN 1943-8141, 2018, Volume 10, Issue 8, pp. 2277 - 2289
Using a rabbit model of early-stage osteoarthritis (OA) and a sampling patients with OA, we evaluated the diagnostic utility of a fluorogenic... 
Cartilage injury | ADAMTS-4 | Gold nanoparticle probe | MEDICINE, RESEARCH & EXPERIMENTAL | gold nanoparticle probe | CLEAVAGE | DEGENERATION | IN-VITRO | REPAIR | ONCOLOGY | cartilage injury | SITES | DEGRADATION | AGGRECANASE-1 ADAMTS-4 | EXPRESSION
Journal Article
Schizophrenia Research, ISSN 0920-9964, 2017, Volume 215, pp. 506 - 513
Abstract Disrupted in Schizophrenia 1 ( DISC1 ) is a prominent gene in mental illness research, encoding a scaffold protein known to be of importance in the... 
Psychiatry | Schizophrenia | Neurodevelopment | Transgenic mouse | Reelin | DISC1 | ADAMTS-4 | NEURONAL MIGRATION | PSYCHIATRY | ISOFORM | PROTEIN COMPLEX | FAMILY | IMPACT | MUTATION | AGGRECANASE-1 | EXPRESSION | MORPHOLOGY
Journal Article
Spine, ISSN 0362-2436, 11/2007, Volume 32, Issue 23, pp. 2596 - 2603
Study Design. A comparative study of aggrecanases and aggrecan fragmentation profile in the human intervertebral disc at early and advanced stages of disc... 
Aggrecanolysis | Matrix metalloproteinases | Proteoglycans | ADAMTS-5 | Disc degeneration | ADAMTS-4 | Intervertebral disc | Aggrecanases | proteoglycans | NUCLEUS PULPOSUS | INTERGLOBULAR DOMAIN | ADAMTS-4 AGGRECANASE-1 | aggrecanases | HUMAN SYNOVIAL-FLUID | aggrecanolysis | CLEAVAGE | END-PLATE | CLINICAL NEUROLOGY | IN-VITRO | ARTICULAR-CARTILAGE | intervertebral | disc degeneration | DEGRADATION | disc | ORTHOPEDICS | matrix metalloproteinases | Aggrecans - chemistry | Humans | Middle Aged | Male | Thoracic Vertebrae - enzymology | Body Water - metabolism | Procollagen N-Endopeptidase - metabolism | ADAM Proteins - analysis | Female | Endopeptidases - analysis | Thoracic Vertebrae - pathology | Intervertebral Disc - pathology | Extracellular Matrix Proteins - metabolism | Intervertebral Disc - enzymology | Severity of Illness Index | ADAMTS5 Protein | Endopeptidases - metabolism | Extracellular Matrix Proteins - chemistry | Spinal Diseases - enzymology | Proteoglycans - metabolism | Aggrecans - metabolism | Spinal Diseases - pathology | ADAMTS4 Protein | Peptide Fragments - analysis | ADAM Proteins - metabolism | Cathepsins - metabolism | Hyaluronic Acid - metabolism | Aged | Lumbar Vertebrae - pathology | Matrix Metalloproteinases - metabolism | Procollagen N-Endopeptidase - analysis | Lumbar Vertebrae - enzymology
Journal Article
Journal Article
Journal Article
by Mei, J and Sun, J and Wu, J and Zheng, XN
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, ISSN 1943-8141, 2019, Volume 11, Issue 8, pp. 4800 - 4808
Osteoarthritis (OA) is a major global health problem; however, the etiology of the disease remains unknown and a reliable treatment strategy has yet to be... 
liraglutide | TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | purinergic receptor | GLP-1 receptor | OBESITY | NF-kappa B | ONCOLOGY | ADAMTS-4 | cartilage degradation | Osteoarthritis | NF-KAPPA-B | EXPRESSION
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2015, Volume 23, Issue 9, pp. 1622 - 1626
Journal Article
Journal of Orthopaedic Research, ISSN 0736-0266, 05/2016, Volume 34, Issue 5, pp. 860 - 864
Journal Article