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Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 04/2018, Volume 16, Issue 4, pp. 618 - 629
Thrombotic microangiopathies are rare disorders characterized by the concomitant occurrence of severe thrombocytopenia, microangiopathic hemolytic anemia, and... 
ADAMTS | 13 | thrombotic thrombocytopenic purpura | Shiga toxin | hemolytic uremic syndrome | alternative complement pathway | ADAMTS-13 | ADAMTS13-SPECIFIC IMMUNE-COMPLEXES | COMPLEMENT GENE-MUTATIONS | ESCHERICHIA-COLI | ANTI-ADAMTS13 ANTIBODIES | VON-WILLEBRAND-FACTOR | FACTOR-CLEAVING PROTEASE | CONFORMATIONAL ACTIVATION | SPACER DOMAIN | ADAMTS13 DEFICIENCY | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | UPSHAW-SCHULMAN SYNDROME | Genetic Predisposition to Disease | Prognosis | Humans | Risk Factors | Complement System Proteins - immunology | Hemolytic-Uremic Syndrome - immunology | ADAMTS13 Protein - blood | ADAMTS13 Protein - immunology | Hemolytic-Uremic Syndrome - genetics | Autoantibodies - immunology | Purpura, Thrombotic Thrombocytopenic - enzymology | Hemolytic-Uremic Syndrome - microbiology | Hemolytic-Uremic Syndrome - physiopathology | ADAMTS13 Protein - genetics | Purpura, Thrombotic Thrombocytopenic - immunology | ADAMTS13 Protein - deficiency | Complement System Proteins - genetics | Complement Pathway, Alternative - genetics | Mutation | Purpura, Thrombotic Thrombocytopenic - genetics | Purpura, Thrombotic Thrombocytopenic - physiopathology | Shiga-Toxigenic Escherichia coli - pathogenicity | Thrombocytopenic purpura | Autoimmunity | Thrombocytopenia | Thrombotic thrombocytopenic purpura | Complement activation | Autoantibodies | Hemolytic anemia | Hemolytic uremic syndrome | Ischemia | Purpura | Alternative pathway
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 02/2018, Volume 16, Issue 2, pp. 378 - 388
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 10/2017, Volume 15, Issue 10, pp. 1889 - 1900
Thrombotic thrombocytopenic purpura (TTP), a potentially fatal clinical syndrome, is primarily caused by autoantibodies against the von Willebrand factor... 
diagnosis | therapeutics | pathology | thrombotic microangiopathies | von Willebrand factor | HEMOLYTIC-UREMIC-SYNDROME | VON-WILLEBRAND-FACTOR | FACTOR-CLEAVING PROTEASE | MEDIATED GENE-THERAPY | PLASMA-EXCHANGE THERAPY | ADAMTS13 ACTIVITY | DISSEMINATED INTRAVASCULAR COAGULATION | ADVERSE-REACTIONS SONAR | RENAL-FAILURE | PERIPHERAL VASCULAR DISEASE | MALIGNANT HYPERTENSION | HEMATOLOGY | Recombinant Proteins - therapeutic use | Genetic Therapy | Predictive Value of Tests | Autoantibodies - blood | Humans | Plasma Exchange | ADAMTS13 Protein - blood | ADAMTS13 Protein - immunology | Hemostasis | Immunotherapy | Thrombocytopenia - therapy | Diagnosis, Differential | ADAMTS13 Protein - therapeutic use | Risk Factors | Treatment Outcome | Purpura, Thrombotic Thrombocytopenic - diagnosis | Purpura, Thrombotic Thrombocytopenic - epidemiology | Thrombocytopenia - blood | ADAMTS13 Protein - genetics | Anemia, Hemolytic - therapy | Anemia, Hemolytic - diagnosis | Thrombocytopenia - diagnosis | Purpura, Thrombotic Thrombocytopenic - therapy | Anemia, Hemolytic - blood | Purpura, Thrombotic Thrombocytopenic - blood | Autoimmunity | Autoantibodies | Anemia | Development and progression | Homeopathy | Materia medica and therapeutics | Thrombocytopenic purpura | Haptoglobin | Therapeutics | Von Willebrand factor | Hemoglobin | Diagnosis | Health aspects | Corticoids | Plasma | Cyclosporins | Pathogenesis | Prophylaxis | Antagonists | Splenectomy | Hemolytic anemia | Remission | Metalloproteinase | Thrombocytopenia | Thrombotic microangiopathy | Hemolytic uremic syndrome | Immunomodulation | Rituximab | Morbidity | L-Lactate dehydrogenase | Cyclophosphamide | Purpura | Lactic acid | Gene therapy | Platelets | Pathology | Thrombotic Microangiopathies | von Willebrand Factor
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 02/2017, Volume 15, Issue 2, pp. 312 - 322
Background: Thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS) are two important acute conditions to diagnose. Thrombotic... 
ADAMTS | diagnosis, differential | thrombotic thrombocytopenic purpura | thrombotic microangiopathy | thrombocytopenia | 13 protein, human | ADAMTS-13 protein, human | ANTI-ADAMTS13 ANTIBODIES | HEMOLYTIC-UREMIC-SYNDROME | IGG ANTIBODIES | FACTOR-CLEAVING PROTEASE | PLASMA-EXCHANGE | ACUTE EPISODES | THERAPY | ADAMTS13 ACTIVITY | RITUXIMAB | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | UPSHAW-SCHULMAN SYNDROME | Recurrence | Humans | ADAMTS13 Protein - blood | Fibrin - chemistry | Societies, Medical | Adult | Female | Hemolytic-Uremic Syndrome - diagnosis | Child | von Willebrand Factor - metabolism | Hemolysis | Diagnosis, Differential | Hematology - standards | Terminology as Topic | Treatment Outcome | Inflammation | Purpura, Thrombotic Thrombocytopenic - diagnosis | Remission Induction | Consensus | Complement System Proteins | Platelet Aggregation | Pregnancy | Platelet Count | Blood Platelets - metabolism | Erythrocytes - metabolism | Thrombotic Microangiopathies - diagnosis | Thrombocytopenic purpura | Enzymes | Terms and phrases | Anemia | Liver | Von Willebrand factor | Working groups | Standardization | Thrombocytopenia | Thrombotic microangiopathy | Clinical trials | Disseminated intravascular coagulation | Transplantation | Thrombotic thrombocytopenic purpura | Hemolytic anemia | Purpura | Eclampsia | Remission | Platelets | Autoimmune diseases
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2017, Volume 199, Issue 3, pp. 1021 - 1040
von Willebrand factor (VWF), a multimeric protein with a central role in hemostasis, has been shown to interact with complement components. However, results... 
PROVIDES INSIGHTS | HEMOLYTIC-UREMIC SYNDROME | FACTOR-B | ADAMTS13 ACTIVITY | SCISSILE BOND | ENDOTHELIAL-CELLS | BINDING-AFFINITY | C3 CONVERTASE | THROMBOCYTOPENIC PURPURA | FACTOR-H | IMMUNOLOGY | Complement Membrane Attack Complex - metabolism | von Willebrand Factor - immunology | Humans | Child, Preschool | Complement C5a - metabolism | Microvessels - pathology | Male | Complement Membrane Attack Complex - immunology | Microvessels - immunology | ADAMTS13 Protein - blood | Young Adult | ADAMTS13 Protein - immunology | Complement C3b - metabolism | Adult | Female | Child | Purpura, Thrombotic Thrombocytopenic - physiopathology | Infant, Newborn | von Willebrand Factor - metabolism | Complement C3-C5 Convertases - metabolism | Thrombosis - physiopathology | Endothelial Cells - metabolism | Purpura, Thrombotic Thrombocytopenic - congenital | Thrombosis - immunology | ADAMTS13 Protein - metabolism | Endothelial Cells - immunology | Adolescent | Purpura, Thrombotic Thrombocytopenic - immunology | ADAMTS13 Protein - deficiency | Complement C5a - immunology | Complement Pathway, Alternative | Endothelial Cells - pathology | Complement C3b - immunology | Complement component C3b | Complement component C5a | Activation | Complement | Thrombosis | Alternative pathway | Cell surface | Endothelial cells | Endothelium | Thrombocytopenic purpura | Thrombotic thrombocytopenic purpura | Complement activation | Perfusion | Hemostasis | Purpura | Complement component C3 | Von Willebrand factor | Microvasculature | Hemostatics | Thromboembolism
Journal Article
Blood, ISSN 0006-4971, 08/2011, Volume 118, Issue 7, pp. 1711 - 1712
Journal Article
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 10/2009, Volume 7, Issue 10, pp. 1703 - 1710
Journal Article
Journal Article