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index medicus (361) 361
adamts5 protein (273) 273
humans (255) 255
animals (215) 215
osteoarthritis (173) 173
adam proteins - metabolism (157) 157
male (133) 133
mice (129) 129
adamts4 protein (126) 126
adam proteins - genetics (113) 113
cartilage (113) 113
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female (92) 92
adamts5 (90) 90
chondrocytes - metabolism (90) 90
expression (90) 90
middle aged (84) 84
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biochemistry & molecular biology (77) 77
procollagen n-endopeptidase - metabolism (73) 73
aggrecans - metabolism (72) 72
aged (70) 70
cartilage, articular - metabolism (70) 70
chondrocytes (70) 70
aggrecanase (69) 69
in-vitro (68) 68
gene expression (67) 67
degradation (64) 64
arthritis (62) 62
orthopedics (61) 61
adult (59) 59
aggrecan (56) 56
matrix metalloproteinase 13 - metabolism (56) 56
cell biology (55) 55
chondrocytes - drug effects (55) 55
osteoarthritis - metabolism (53) 53
adamts (51) 51
adamts5 protein - metabolism (51) 51
osteoarthritis - pathology (50) 50
articular-cartilage (48) 48
cartilage, articular - pathology (47) 47
extracellular matrix (47) 47
rats (47) 47
immunohistochemistry (46) 46
mice, inbred c57bl (44) 44
rna, messenger - metabolism (44) 44
extracellular-matrix (43) 43
abridged index medicus (42) 42
disease models, animal (42) 42
gene-expression (41) 41
procollagen n-endopeptidase - genetics (41) 41
matrix metalloproteinase 13 - genetics (40) 40
adamts-5 (39) 39
adamts5 protein - genetics (39) 39
article (38) 38
adam proteins - antagonists & inhibitors (37) 37
collagen type ii - metabolism (37) 37
adam proteins (36) 36
chondrocytes - pathology (36) 36
mice, knockout (36) 36
analysis (34) 34
collagen (34) 34
osteoarthritis - genetics (34) 34
proteoglycans - metabolism (34) 34
cytokines (33) 33
proteins (33) 33
enzymes (32) 32
extracellular matrix - metabolism (32) 32
gene expression regulation (32) 32
interglobular domain (32) 32
reverse transcriptase polymerase chain reaction (32) 32
rodents (32) 32
aggrecans - genetics (31) 31
cartilage - metabolism (31) 31
endopeptidases - metabolism (31) 31
matrix metalloproteinases (30) 30
rats, sprague-dawley (30) 30
adamts1 protein (29) 29
blotting, western (29) 29
cattle (29) 29
cleavage (29) 29
human synovial-fluid (29) 29
metalloproteinase (29) 29
osteoarthritis - drug therapy (29) 29
proteases (29) 29
rna, messenger - genetics (29) 29
in-vivo (28) 28
chondrocytes - cytology (27) 27
family (27) 27
inflammation (27) 27
osteoarthritis, knee - metabolism (27) 27
interleukin-1beta - pharmacology (26) 26
aged, 80 and over (25) 25
signal transduction (25) 25
activation (24) 24
adam proteins - biosynthesis (24) 24
cartilage diseases (24) 24
cartilage, articular - drug effects (24) 24
human articular-cartilage (24) 24
matrix metalloproteinase (24) 24
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Matrix Biology, ISSN 0945-053X, 12/2016, Volume 56, pp. 57 - 73
Matrix metalloproteinase 13 (MMP-13) degrades collagenous extracellular matrix and its aberrant activity associates with diseases such as arthritis, cancer,... 
Cartilage | Endocytosis | Collagenase | Matrix metalloproteinases | Extracellular trafficking | Osteoarthritis | ACTIVATED PROTEIN-KINASE | MATRIX METALLOPROTEINASE-13 | BIOCHEMISTRY & MOLECULAR BIOLOGY | METALLOPROTEINASE 13-DEFICIENT MICE | FUNCTIONAL DIFFERENCES | HUMAN COLLAGENASE-3 MMP-13 | PROTEOLYTIC ACTIVITIES | CELL BIOLOGY | NONCATALYTIC DOMAINS | GROWTH-FACTOR-BETA | OSTEOARTHRITIC CARTILAGE | COLLAGENOLYTIC ACTIVITY | Binding, Competitive | Matrix Metalloproteinase 13 - chemistry | Humans | Low Density Lipoprotein Receptor-Related Protein-1 - chemistry | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Tissue Inhibitor of Metalloproteinase-3 - chemistry | ADAMTS5 Protein - chemistry | ADAMTS5 Protein - metabolism | Matrix Metalloproteinase 13 - metabolism | Matrix Metalloproteinase 13 - secretion | Protein Transport | Chondrocytes - enzymology | Tissue Inhibitor of Metalloproteinase-3 - metabolism | HEK293 Cells | Protein Binding | Protein Interaction Domains and Motifs | Physiological aspects | Low density lipoproteins | Atherosclerosis | Lymphocyte receptors | Lipoproteins (low density) | Tissue engineering | Proteinase | Hemopexin | Tissue inhibitor of metalloproteinase 3 | Arthritis | Matrix metalloproteinase | Collagenase 3 | Proteins | Clonal deletion | Proteolysis | Arteriosclerosis | Collagen | Internalization | Extracellular levels | Chondrocytes | Fibrosis | Extracellular matrix | Receptor density | Cancer | Index Medicus | Hpx, hemopexin domain | ECM, extracellular matrix | RAP, receptor-associated protein | EEA1, early endosome antigen 1 | LRP, LDL receptor-related protein | RPLP0, the 60S acidic ribosomal protein P0 | DMEM, Dulbecco's modified Eagle's medium | FBS, foetal bovine serum | OA, osteoarthritis | ADAMTS, adamalysin-like metalloproteinase with thrombospondin motifs | TIMP, tissue inhibitor of metalloproteinases | LDL, low-density lipoprotein | MMP, matrix metalloproteinase
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 06/2017, Volume 69, Issue 6, pp. 1246 - 1256
ObjectiveThe aggrecanase ADAMTS-5 and the collagenase matrix metalloproteinase 13 (MMP-13) are constitutively secreted by chondrocytes in normal cartilage, but... 
LRP1 | ARTICULAR-CARTILAGE | ADAMTS-5 | METALLOPROTEINASE | EXOSITE INHIBITOR | ESCHERICHIA-COLI | ECTODOMAIN | TISSUE INHIBITOR | RHEUMATOLOGY | EXPRESSION | PROTEOLYTIC ACTIVITIES | Humans | Middle Aged | Male | Collagenases - drug effects | Low Density Lipoprotein Receptor-Related Protein-1 - physiology | Osteoarthritis - drug therapy | ADAMTS5 Protein - metabolism | Low Density Lipoprotein Receptor-Related Protein-1 - drug effects | Osteoarthritis - physiopathology | ADAM17 Protein - metabolism | Young Adult | Proteolysis - drug effects | Chondrocytes - physiology | Collagen - drug effects | Cartilage, Articular - metabolism | ADAM17 Protein - analysis | Adult | Female | Aggrecans - drug effects | Child | Matrix Metalloproteinase 14 - analysis | Antibodies, Monoclonal - pharmacology | Endocytosis - drug effects | Matrix Metalloproteinase 14 - metabolism | Matrix Metalloproteinase 13 - metabolism | Adolescent | Explants | Shedding | ADAM protein | Profiling | Proteinase | Hydroxyproline | Collagenase | Matrix metalloproteinase | Cell surface | Collagenase 3 | Degradation | Cartilage | Gene silencing | Endocytosis | Proteolysis | Collagen | Chondrocytes | Monoclonal antibodies | Receptor density | Biocompatibility | Inhibition | Aggrecan | Osteoarthritis | Cartilage diseases | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 03/2016, Volume 6, Issue 1, pp. 23117 - 23117
Journal Article
Scientific Reports, ISSN 2045-2322, 11/2015, Volume 5, Issue 1, pp. 17014 - 17014
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 2017, Volume 44, Issue 1, pp. 38 - 52
Background/Aims: Aggrecanase-1 (ADAMTS-4) and aggrecanase-2 (ADAMTS-5) are secreted enzymes belonging to the ADAMTS (a disintegrin and metalloproteinase with... 
Mirna-92a-3p | Aggrecanase-1 | Aggrecanase-2 | Chondrogenesis | Osteoarthritis | Chondrocytes | INTERLEUKIN-1 | PHYSIOLOGY | MESENCHYMAL STEM-CELLS | CARTILAGE | CELL BIOLOGY | ADAMTS4 AGGRECANASE-1 | RESPONSES | MMP ACTIVITY | HUMAN OSTEOARTHRITIC CHONDROCYTES | DEGRADATION | NF-KAPPA-B | PROGRESSION | Chondrocytes - cytology | Chondrogenesis - drug effects | Interleukin-1beta - pharmacology | ADAMTS4 Protein - genetics | MicroRNAs - antagonists & inhibitors | Gene Expression - drug effects | Chondrogenesis - genetics | Humans | Middle Aged | ADAMTS4 Protein - antagonists & inhibitors | Male | MicroRNAs - metabolism | NF-kappa B - metabolism | ADAMTS5 Protein - genetics | ADAMTS5 Protein - metabolism | Chondrocytes - drug effects | Cartilage, Articular - metabolism | Mesenchymal Stem Cells - cytology | Mesenchymal Stem Cells - drug effects | Adult | Female | Mesenchymal Stem Cells - metabolism | Chondrocytes - metabolism | NF-kappa B - antagonists & inhibitors | Bone Marrow Cells - cytology | ADAMTS5 Protein - antagonists & inhibitors | Cells, Cultured | ADAMTS4 Protein - metabolism | Cartilage, Articular - pathology | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Osteoarthritis, Knee - pathology | Osteoarthritis, Knee - genetics | Aged | MicroRNAs - genetics | Antagomirs - metabolism | Osteoarthritis, Knee - metabolism | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 7, pp. 3197 - 3208
The metalloproteinase ADAMTS-5 (A disintegrin and metalloproteinase with thrombospondin motifs) degrades aggrecan, a proteoglycan essential for cartilage... 
SYNOVIAL-FLUID | BIOCHEMISTRY & MOLECULAR BIOLOGY | cartilage | FUNCTIONAL DIFFERENCES | oligomer | ADAMTS | AGGRECAN INTERGLOBULAR DOMAIN | cartilage biology | VON-WILLEBRAND-FACTOR | PROTEOLYTIC ACTIVITIES | aggrecan | ADAMTS5 | NONCATALYTIC DOMAINS | OSTEOARTHRITIC CARTILAGE | oligomerization | PROCOLLAGEN N-PROTEINASE | ARTICULAR-CARTILAGE | IN-VIVO | metalloprotease | Recombinant Fusion Proteins - isolation & purification | Molecular Weight | Humans | Knee Joint - enzymology | Recombinant Fusion Proteins - metabolism | Arthritis, Experimental - pathology | Knee Joint - pathology | Knee Joint - immunology | Mice, Mutant Strains | Proteolysis | Gene Deletion | HEK293 Cells | Protein Interaction Domains and Motifs | Dimerization | Peptide Fragments - genetics | ADAMTS5 Protein | Catalytic Domain | Peptide Fragments - metabolism | Cross-Linking Reagents - chemistry | ADAM Proteins - chemistry | Peptide Fragments - isolation & purification | Mice, Inbred C57BL | Arthritis, Experimental - immunology | ADAM Proteins - isolation & purification | Aggrecans - isolation & purification | Aggrecans - metabolism | Recombinant Fusion Proteins - chemistry | Mutant Proteins | ADAM Proteins - metabolism | Peptide Fragments - chemistry | Animals | Arthritis, Experimental - enzymology | Enzyme Activation | ADAM Proteins - genetics | Crosses, Genetic | Index Medicus | Molecular Bases of Disease
Journal Article
Journal Article
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 10/2018, Volume 49, Issue 6, pp. 2414 - 2426
Journal Article
Journal Article