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1. Full Text Biopolymers augment viral vectors based gene delivery
by Balakrishnan, Balaji and David, Ernest
Journal of Biosciences, ISSN 0250-5991, 9/2019, Volume 44, Issue 4, pp. 1 - 8
The success of viral vectors mediated gene therapy is still hampered by immunogenicity and insufficient transgene expression. Alternatively, non-viral vectors... 
Life Sciences | Biomedicine, general | gene delivery | vectors | Life Sciences, general | Microbiology | Zoology | gene therapy | Plant Sciences | Biopolymers | virus | Cell Biology | CELLS | TRANSDUCTION | ADENOVIRAL VECTORS | MAGNETIC NANOPARTICLES | LIPOSOMES ENHANCE | LENTIVIRAL VECTORS | ADENOASSOCIATED VIRUSES | IN-VITRO | THERAPY | IMMUNE-RESPONSES | BIOLOGY | Anopheles | Genetic vectors | Gene therapy | Gene expression | Genes | Therapy | Immunogenicity | Gene transfer | Product development | Vectors | Vectors (Biology) | Expression vectors
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2. Full Text Viral vectors for gene therapy and gene modification approaches
by Merten, Otto-Wilhelm and Gaillet, Bruno
Biochemical Engineering Journal, ISSN 1369-703X, 04/2016, Volume 108, pp. 98 - 115
Presently, viral vectors are widespread biological products, some of which have already been commercialized. They are derived from viruses modified to render... 
Viral vectors | Gene addition | Gene transfer | Protein transduction | AAV | MLV | AV | LV | HELPER-DEPENDENT ADENOVIRUS | ADENOASSOCIATED VIRUS | TITER RETROVIRAL VECTORS | NUCLEAR-LOCALIZATION SIGNAL | SITE-SPECIFIC INTEGRATION | ENGINEERING, CHEMICAL | PRODUCER CELL-LINES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | LENTIVIRAL VECTOR | ROUS-SARCOMA-VIRUS | VIRUS-LIKE PARTICLES | LARGE-SCALE PRODUCTION | Genetic vectors | Gene therapy | Genes | Leukemia | Genetically modified organisms
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3. Full Text Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors
by Münch, Robert C and Muth, Anke and Muik, Alexander and Friedel, Thorsten and Schmatz, Julia and Dreier, Birgit and Trkola, Alexandra and Plückthun, Andreas and Büning, Hildegard and Buchholz, Christian J
Nature Communications, ISSN 2041-1723, 02/2015, Volume 6, Issue 1, pp. 6246 - 6246
We describe receptor-targeted adeno-associated viral (AAV) vectors that allow genetic modification of rare cell types ex vivo and in vivo while showing no... 
ADENOASSOCIATED VIRUS TYPE-2 | LIBRARIES | AAV VECTORS | CELLS | THERAPY | TROPISM | MULTIDISCIPLINARY SCIENCES | RIBOSOME DISPLAY | DARPINS | SULFATE PROTEOGLYCAN BINDING | PEPTIDE | Gene Transfer Techniques | Luciferases - metabolism | Transduction, Genetic | Dependovirus - metabolism | Serum - metabolism | Cell Count | Humans | Receptor, ErbB-2 - metabolism | Genetic Vectors - metabolism | Ankyrin Repeat | Cell Adhesion Molecules - metabolism | Epithelial Cell Adhesion Molecule | CD4-Positive T-Lymphocytes - immunology | Animals | Chromatography, Affinity | Neoplasms - blood | Mice, Nude | Neoplasms - immunology | HEK293 Cells | Antigens, Neoplasm - metabolism | Female | Mice | Neoplasms - pathology | Index Medicus
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4. Full Text Enhancing titres of therapeutic viral vectors using the transgene repression in vector production (TRiP) system
by Maunder, H.E and Wright, J and Kolli, B.R and Vieira, C.R and Mkandawire, T.T and Tatoris, S and Kennedy, V and Iqball, S and Devarajan, G and Ellis, S and Lad, Y and Clarkson, N.G and Mitrophanous, K.A and Farley, D.C
Nature Communications, ISSN 2041-1723, 03/2017, Volume 8, Issue 1, pp. 14834 - 14834
A key challenge in the field of therapeutic viral vector/vaccine manufacturing is maximizing production. For most vector platforms, the 'benchmark' vector... 
HIV-1 | CELLS | BINDING ATTENUATION PROTEIN | BACILLUS-SUBTILIS | ADENOASSOCIATED VIRUS | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | CANCER GENE-THERAPY | PROTEOMIC ANALYSIS | EXPRESSION | LENTIVIRAL VECTORS | Protein Biosynthesis | Codon | Cyclooxygenase 2 - genetics | Humans | HEK293 Cells | Adenoviridae - genetics | Green Fluorescent Proteins - genetics | Genetic Vectors | Transgenes | Bacillus subtilis - genetics | RNA - genetics | Index Medicus
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5. Full Text Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors
by Zolotukhin, Irene and Zolotukhin, Sergei and Potter, Mark and Sakai, Yoshihisa and Loiler, Scott and Fraites, Thomas J and Chiodo, Vince A and Phillipsberg, Tina and Muzyczka, Nicholas and Hauswirth, William W and Flotte, Terance R and Byrne, Barry J and Snyder, Richard O
Methods, ISSN 1046-2023, 2002, Volume 28, Issue 2, pp. 158 - 167
Recombinant adeno-associated viral (rAAV) vectors based on serotype 2 are currently being evaluated most extensively in animals and human clinical trials. rAAV... 
Adeno-associated virus | Purification | Serotype | Gene therapy | Chromatography | EFFICIENT TRANSDUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | gene therapy | GENE-THERAPY VECTORS | adeno-associated virus | SITE-SPECIFIC INTEGRATION | TITER | CLONING | purification | AAV | chromatography | ADENOASSOCIATED VIRUS VECTORS | REP | TYPE-2 | serotype | CELL-LINE | Cell Line | DNA, Recombinant - genetics | Adenoviridae Infections - virology | Sepharose | Humans | Rats, Inbred F344 | Rats | Male | Genetic Vectors - genetics | Plasmids - isolation & purification | Genetic Vectors - isolation & purification | Animals | Virion | Virus Replication | Gene Expression Regulation, Viral | Adenoviridae - growth & development | Plasmids - genetics | Adenoviridae - genetics | Adenoviridae - classification | Anion Exchange Resins | Genetic Therapy - methods | Index Medicus
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6. Full Text Development of selective cytotoxic viral vectors for concentration of undifferentiated cells in cardiomyocytes derived from human induced pluripotent stem cells
by Kono, K and Sawada, R and Kuroda, T and Yasuda, S and Matsuyama, S and Matsuyama, A and Mizuguchi, H and Sato, Y
SCIENTIFIC REPORTS, ISSN 2045-2322, 03/2019, Volume 9, Issue 1, pp. 3630 - 11
Cell-processed therapeutic products (CTPs) derived from human pluripotent stem cells (hPSCs) have innovative applications in regenerative medicine. However,... 
THERAPY | RECOMBINANT ADENOASSOCIATED VIRUS | MULTIDISCIPLINARY SCIENCES | MOUSE | PURIFICATION | TRANSDUCTION | GENE-TRANSFER | DIFFERENTIATION | TUMORIGENICITY | SAFETY SWITCH | ADIPOCYTE | Regeneration | Stem cells | Cytotoxicity | Cardiomyocytes | Suicide | Suicide genes | Pluripotency | Apoptosis | Expression vectors
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7. Human gene targeting by viral vectors
by Russell, David W and Hirata, Roli K
Nature Genetics, ISSN 1061-4036, 04/1998, Volume 18, Issue 4, pp. 325 - 330
Stable transduction of mammalian cells typically involves random integration of viral vectors by non-homologous recombination. Here we report that Vectors... 
INTEGRATION | ADENOASSOCIATED VIRUS | DNA | EMBRYONIC STEM-CELLS | GENETICS & HEREDITY | INTERFERON-INDUCIBLE GENE | ADENO-ASSOCIATED VIRUS | TRANSDUCTION | HOMOLOGOUS RECOMBINATION | RETROVIRAL VECTORS | MAMMALIAN-CELLS | Gene Targeting | Gene Transfer Techniques | Humans | Genes - genetics | Male | Phosphotransferases (Alcohol Group Acceptor) - genetics | Recombinant Proteins - genetics | Mutation - genetics | Genetic Vectors - genetics | Dose-Response Relationship, Drug | Transfection - methods | Genetic Vectors - pharmacology | Hypoxanthine Phosphoribosyltransferase - genetics | Genes, Viral - genetics | Transfection - genetics | Neomycin | Adenoviridae - genetics | Tumor Cells, Cultured | Recombination, Genetic - drug effects
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8. Full Text Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display Differential Efficiency and Cell Tropism after Delivery to Different Regions of the Central Nervous System
by Burger, Corinna and Gorbatyuk, Oleg S and Velardo, Margaret J and Peden, Carmen S and Williams, Philip and Zolotukhin, Sergei and Reier, Paul J and Mandel, Ronald J and Muzyczka, Nicholas
Molecular Therapy, ISSN 1525-0016, 08/2004, Volume 10, Issue 2, pp. 302 - 317
Recombinant adeno-associated virus 2 (rAAV2) has been shown to deliver genes to neurons effectively in the brain, retina, and spinal cord. The characterization... 
gene delivery | nervous system | AAV | capsid | stereology | tropism | spinal cord | retrograde transport | brain | serotype | Tropism | Brain | Gene delivery | Spinal cord | Nervous system | Stereology | Serotype | Capsid | Retrograde transport | MEDICINE, RESEARCH & EXPERIMENTAL | TYROSINE-HYDROXYLASE | MEDIATED GENE-TRANSFER | RAT MODEL | GTP-CYCLOHYDROLASE I | GREEN FLUORESCENT PROTEIN | IMMUNOCOMPETENT MICE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | INTRAMUSCULAR INJECTION | GENETICS & HEREDITY | ADENOASSOCIATED VIRUS VECTORS | NIGROSTRIATAL SYSTEM | PARKINSONS-DISEASE | Dependovirus - genetics | Neurons - virology | Central Nervous System - metabolism | Green Fluorescent Proteins - analysis | Rats | Male | Green Fluorescent Proteins - genetics | Rats, Sprague-Dawley | Genetic Vectors - genetics | Tissue Distribution | Animals | Neurons - metabolism | Capsid - metabolism | Central Nervous System - chemistry | Transduction, Genetic - methods | Central Nervous System - virology | Genetic Therapy - methods | Index Medicus
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9. Full Text Intravascular injections of adenoassociated viral vector serotypes rh10 and PHP.B transduce murine sciatic nerve axons
by Anderson, Hans E and Schaller, Kristin L and Caldwell, John H and Weir, Richard F. ff
Neuroscience Letters, ISSN 0304-3940, 07/2019, Volume 706, pp. 51 - 55
Adenoassociated viral vectors provide a safe and robust method for expression of transgenes in nondividing cells such as neurons. Intravenous injections of... 
Peripheral nerve | Intravascular injection | Motor neuron | Mouse | Green fluorescent protein | Adenoassociated viral vector | SYSTEM | LOCALIZATION | SPINAL-CORD | ADULT MICE | NEUROSCIENCES | DELIVERY | MEDIATED GENE-EXPRESSION | THERAPY | NEURONS | INTERFACES | Fluorescence | Neurons | Genetic engineering
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10. Full Text Heart-targeted adeno-associated viral vectors selected by in vivo biopanning of a random viral display peptide library
by Ying, Y and Müller, O.J and Goehringer, C and Leuchs, B and Trepel, M and Katus, H.A and Kleinschmidt, J.A
Gene Therapy, ISSN 0969-7128, 08/2010, Volume 17, Issue 8, pp. 980 - 990
Selection of targeted vectors from virus display peptide libraries is a versatile and efficient approach to improve vector specificity and efficiency. This... 
vector targeting | AAV | heart | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSDUCTION | DIRECTED EVOLUTION | ADENOASSOCIATED VIRUS TYPE-2 | THERAPY VECTOR | AAV2 CAPSID GENE | TROPISM | CARDIAC GENE-TRANSFER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | EFFICIENT | EXPRESSION | Cell Line | Dependovirus - genetics | Gene Transfer Techniques | Transduction, Genetic | Rats | Peptide Library | Myocytes, Cardiac - virology | Animals | Sarcoglycans - genetics | Myocardium - metabolism | Myocytes, Cardiac - metabolism | Mice | Genetic Vectors | Genetic Therapy - methods | Care and treatment | Genetic vectors | Adenoviruses | Genetic aspects | Research | Gene therapy | Health aspects | Heart diseases | Heart | Viruses | Peptides | Rodents | Index Medicus
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11. Full Text Common gene therapy viral vectors do not efficiently penetrate sputum from cystic fibrosis patients
by Hida, Kaoru and Lai, Samuel K and Suk, Jung Soo and Won, Sang Y and Boyle, Michael P and Hanes, Justin
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, pp. e19919 - e19919
Norwalk virus and human papilloma virus, two viruses that infect humans at mucosal surfaces, have been found capable of rapidly penetrating human mucus... 
NONHUMAN-PRIMATES | IN-VITRO | ADENOASSOCIATED VIRUS | CILIATED AIRWAY EPITHELIUM | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | POLYMER NANOPARTICLES | DIRECTED EVOLUTION | RAPID-TRANSPORT | RECOMBINANT ADENOVIRUS | INTRACELLULAR TRAFFICKING | Cystic Fibrosis - therapy | Dependovirus - genetics | Genetic Therapy | Humans | Polyethylene Glycols - chemistry | Genetic Vectors - genetics | Polystyrenes - chemistry | Sputum - metabolism | Biological Transport | Time Factors | Models, Biological | Adenoviridae - genetics | Diffusion | Cystic fibrosis | Genetic vectors | Gene therapy | Papillomavirus infections | Adenoviruses | Epithelial cells | Lung | Mucosa | Clinical trials | Viruses | Mucus | Mucous membrane | Nanoparticles | Respiratory tract | Cf gene | Deoxyribonucleic acid--DNA | Expression vectors | Medical research | Gene transfer | Secretions | Patients | Adhesion | Vectors (Biology) | Viscous drag | Lungs | Fibrosis | Sputum | Surface area | Index Medicus | Deoxyribonucleic acid | DNA
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12. Latest trends in cancer therapy applying viral vectors
by Lundstrom, Kenneth
Future Virology, ISSN 1746-0794, 11/2017, Volume 12, Issue 11, pp. 667 - 684
Gene therapy based on viral vectors has demonstrated steady progress recently, not only in the area of cancers. A multitude of viral vectors has been... 
oncolytic viruses | cancer gene therapy | immunotherapy | HEPATOCELLULAR-CARCINOMA CELLS | ONCOLYTIC VACCINIA VIRUS | ADENOASSOCIATED VIRUS | BORNE-ENCEPHALITIS-VIRUS | SEMLIKI-FOREST-VIRUS | NEWCASTLE-DISEASE VIRUS | MEDIATED GENE-THERAPY | IN-VITRO | VIROLOGY | MEASLES-VIRUS | VESICULAR STOMATITIS-VIRUS
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13. Full Text AAV-mediated photoreceptor transduction of the pig cone-enriched retina
by Mussolino, C and Della Corte, M and Rossi, S and Viola, F and Di Vicino, U and Marrocco, E and Neglia, S and Doria, M and Testa, F and Giovannoni, R and Crasta, M and Giunti, M and Villani, E and Lavitrano, M and Bacci, M.L and Ratiglia, R and Simonelli, F and Auricchio, A and Surace, E.M
Gene Therapy, ISSN 0969-7128, 07/2011, Volume 18, Issue 7, pp. 637 - 645
Recent success in clinical trials supports the use of adeno-associated viral (AAV) vectors for gene therapy of retinal diseases caused by defects in the... 
photoreceptor transduction | biodistribution | large animal model | retina | AAV | pig | MEDICINE, RESEARCH & EXPERIMENTAL | SUBRETINAL DELIVERY | RECOMBINANT ADENOASSOCIATED VIRUS | NONHUMAN PRIMATE | VISION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN GENE-THERAPY | MODEL | VIRAL VECTORS | LEBER CONGENITAL AMAUROSIS | TRANSGENE EXPRESSION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | GENETICS & HEREDITY | Dependovirus - genetics | Gene Transfer Techniques | Promoter Regions, Genetic | Transduction, Genetic | Dependovirus - immunology | Retina | Dependovirus - classification | Photoreceptor Cells | Pigment Epithelium of Eye | Animals | Rhodopsin - genetics | Swine | Models, Animal | Genetic Vectors | Leber Congenital Amaurosis - therapy | Serotyping | Care and treatment | Physiological aspects | Photoreceptors | Genetic aspects | Research | Dependoviruses | Gene therapy | Retinal diseases | Health aspects | Hogs | Neurons | Index Medicus | Animal models | Rhodopsin | Clinical trials | Data processing | Rods | Promoters | Cones | Serotypes | retinal pigment epithelium | Transgenes | Expression vectors | Original
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