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SCIENCE, ISSN 0036-8075, 04/2011, Volume 332, Issue 6027, pp. 322 - 327
Activation of G protein-coupled receptors upon agonist binding is a critical step in the signaling cascade for this family of cell surface proteins. We report... 
SUBTYPE-SELECTIVITY | COMPLEX | CONFORMATIONAL-CHANGES | ANTAGONIST | CRYSTAL-STRUCTURE | LIGAND RECOGNITION | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | ALLOSTERIC MODULATION | RESIDUES | PROTEIN-COUPLED-RECEPTOR | Adenosine | Research | Properties | Protein binding
Journal Article
SCIENCE, ISSN 0036-8075, 11/2008, Volume 322, Issue 5905, pp. 1211 - 1217
The adenosine class of heterotrimeric guanine nucleotide- binding protein ( G protein)- coupled receptors ( GPCRs) mediates the important role of extracellular... 
MUTAGENESIS | PROTEIN-COUPLED RECEPTOR | LIGAND RECOGNITION | PHARMACOLOGY | MULTIDISCIPLINARY SCIENCES | RHODOPSIN | THERAPEUTIC TARGETS | MECHANISMS | RESIDUES | PARKINSONS-DISEASE | INSIGHTS | Adenosine | G proteins | Research | Structure
Journal Article
TRENDS IN NEUROSCIENCES, ISSN 0166-2236, 11/2006, Volume 29, Issue 11, pp. 647 - 654
The adenosine A(2A) receptor has emerged as an attractive non-dopaminergic target in the pursuit of improved therapy for Parkinson's disease (PD), based in... 
DOPA-INDUCED DYSKINESIA | TURNING BEHAVIOR | GLOBUS-PALLIDUS | BIOLUMINESCENCE ENERGY-TRANSFER | CENTRAL-NERVOUS-SYSTEM | 6-HYDROXYDOPAMINE-LESIONED RATS | BINDING CHARACTERISTICS | DOPAMINE-D-2 RECEPTORS | NEUROSCIENCES | C-FOS EXPRESSION | SYNERGISTIC INTERACTION | Neurosciences | Adenosine | Parkinson's disease | Research | Drug therapy
Journal Article
AMERICAN JOURNAL OF PATHOLOGY, ISSN 0002-9440, 05/2011, Volume 178, Issue 5, pp. 2136 - 2145
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 06/2015, Volume 112, Issue 25, pp. 7833 - 7838
The consumption of caffeine (an adenosine receptor antagonist) correlates inversely with depression and memory deterioration, and adenosine A(2A) receptor... 
DEPRESSION | COFFEE | MULTIDISCIPLINARY SCIENCES | mood dysfunction | RATS | CHRONIC MILD STRESS | MODEL | caffeine | MICE | chronic stress | adenosine A(2A) receptor | synaptic dysfunction | SYNAPTOTOXICITY | NEUROBIOLOGY | ANTAGONISTS | BRAIN | Mood (Psychology) | Physiological aspects | Adenosine | Stress (Psychology) | Health aspects | Memory
Journal Article
by Lee, Y and Choi, S and Hyeon, C
PLOS COMPUTATIONAL BIOLOGY, ISSN 1553-734X, 02/2015, Volume 11, Issue 2
Dynamics and functions of G-protein coupled receptors (GPCRs) are accurately regulated by the type of ligands that bind to the orthosteric or allosteric... 
SIGNAL-TRANSDUCTION | ALLOSTERIC TRANSITIONS | CRYSTAL-STRUCTURE | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | DYNAMICS | RHODOPSIN | LIGHT-DEPENDENT CHANGES | DIMERIZATION | MODEL | PROTEIN-COUPLED-RECEPTOR | STRUCTURAL FEATURES | Proteins | Physiological aspects | Adenosine | G proteins | Structure | Identification and classification
Journal Article
MOLECULAR PSYCHIATRY, ISSN 1359-4184, 01/2016, Volume 21, Issue 1, pp. 97 - 107
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 02/2017, Volume 114, Issue 8, pp. 2066 - 2071
The adenosine A(2A) receptor (A(2A)R) has long been implicated in cardiovascular disorders. As more selective A(2A)R ligands are being identified, its roles in... 
allosteric | COMPLEX | Parkinson's disease | MEMBRANE | MULTIDISCIPLINARY SCIENCES | HIGH-AFFINITY | structure | SOFTWARE | FEATURES | A2A adenosine receptor | PROTEIN-COUPLED RECEPTOR | GPCR | ZM241385 | DERIVATIVES | PARKINSONS-DISEASE
Journal Article
NATURE NEUROSCIENCE, ISSN 1097-6256, 12/2008, Volume 11, Issue 12, pp. 1402 - 1409
Abnormalities of striatal function have been implicated in several major neurological and psychiatric disorders, including Parkinson's disease, schizophrenia... 
SIGNAL-TRANSDUCTION | ACTIVATION | INVOLVEMENT | DOPAMINE | FIBROBLAST-GROWTH-FACTOR | LONG-TERM POTENTIATION | PC12 CELLS | EXPRESSION | NEUROSCIENCES | MODULATION | ERK | Neurites - physiology | Embryo, Mammalian | Cercopithecus aethiops | Neurons - cytology | Receptor, Adenosine A2A - physiology | Patch-Clamp Techniques - methods | Fibroblast Growth Factors - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Transfection - methods | Long-Term Potentiation - drug effects | Neurons - physiology | Long-Term Potentiation - physiology | Neurons - drug effects | Cell Differentiation - physiology | Cyclic AMP - metabolism | Neurites - drug effects | Triazines - pharmacology | Phenethylamines - pharmacology | Immunoprecipitation - methods | Synapses - physiology | Cells, Cultured | Rats | Fibroblast Growth Factors - pharmacology | Adenosine - pharmacology | Hippocampus - cytology | Receptor Protein-Tyrosine Kinases - metabolism | Long-Term Potentiation - radiation effects | Rats, Sprague-Dawley | Adenosine A2 Receptor Agonists | Triazoles - pharmacology | Two-Hybrid System Techniques | Animals | Cell Differentiation - drug effects | Adenosine - analogs & derivatives | In Vitro Techniques | Receptors, Fibroblast Growth Factor - physiology | Neuroplasticity | Physiological aspects | Neural receptors | Fibroblast growth factors | Research
Journal Article
ChemBioChem, ISSN 1439-4227, 10/2016, Volume 17, Issue 20, pp. 1951 - 1960
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 06/2013, Volume 135, Issue 23, pp. 8749 - 8759
Journal Article
AMERICAN JOURNAL OF CLINICAL NUTRITION, ISSN 0002-9165, 07/2007, Volume 86, Issue 1, pp. 240 - 244
Background: Caffeine is the most widely consumed stimulant in the world, and individual differences in response to its stimulating effects may explain some of... 
cytochrome p450 1A2 | COFFEE-DRINKING | CONTRIBUTE | MYOCARDIAL-INFARCTION | VOLUNTEERS | adenosine A(2A) receptor gene | RISK | ADENOSINE A(2A) RECEPTOR | BLOOD-PRESSURE | genotype | epidemiology | caffeine | NUTRITION & DIETETICS | ADORA2A | CYP1A2 | DISEASE | dependence | Cytochromes | Adenosine | Research | Health aspects | Genetic polymorphisms | Caffeine
Journal Article
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 08/2008, Volume 105, Issue 31, pp. 10744 - 10749
Structural studies on mammalian integral membrane proteins have long been hampered by their instability in detergent. This is particularly true for the agonist... 
G protein-coupled receptor | CRYSTALLIZATION | ACTIVATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | MEMBRANE-PROTEIN | MICELLES | SIDE-CHAINS | PROTEIN-COUPLED RECEPTOR | PURIFICATION | RHODOPSIN | conformational thermostabilization | membrane protein | Adenosine | Cell receptors | G proteins | Properties | Membrane proteins
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2017, Volume 127, Issue 3, pp. 929 - 941
Journal Article
by Lee, JY and Lyman, E
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 10/2012, Volume 134, Issue 40, pp. 16512 - 16515
Molecular dynamics simulations of the A(2A) adenosine receptor totaling 1.4 mu s show clear evidence for specific sites mediating interactions between... 
PROTEIN-COUPLED RECEPTOR | CRYSTAL-STRUCTURE | RESOLUTION | DYNAMICS | MICELLES | SIMULATIONS | CHEMISTRY, MULTIDISCIPLINARY | LIPIDS | Adenosine | Usage | Analysis | Molecular dynamics | Chemical properties | Research | Cholesterol | Binding sites (Biochemistry) | Peptide bonds
Journal Article
Journal Article
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