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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 07/2015, Volume 112, Issue 27, pp. E3609 - E3618
Adenosine A(2A) receptor (A(2A)R)-dopamine D-2 receptor (D2R) heteromers are key modulators of striatal neuronal function. It has been suggested that the... 
GPCR heteromers | HETEROMERS | dopamine D-2 receptor | caffeine | DETERMINANTS | AFFINITY | MULTIDISCIPLINARY SCIENCES | COMPLEXES | adenosine A(2A) receptor
Journal Article
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 02/2006, Volume 26, Issue 7, pp. 2080 - 2087
The functional role of heteromers of G-protein-coupled receptors is a matter of debate. In the present study, we demonstrate that heteromerization of adenosine... 
CELL-MEMBRANE | A(2A) RECEPTORS | adenosine A receptor | DOPAMINE RELEASE | INVOLVEMENT | NEUROSCIENCES | NUCLEUS-ACCUMBENS | caffeine | INHIBITION | striatum | heteromeric receptors | RAT HIPPOCAMPUS | ENERGY-TRANSFER | adenosine A(2A) receptor | glutamate
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2012, Volume 166, Issue 6, pp. 1846 - 1859
Journal Article
EXPERIMENTAL NEUROLOGY, ISSN 0014-4886, 01/2007, Volume 203, Issue 1, pp. 241 - 245
Consumption of caffeine, an adenosine receptor antagonist, was found to be inversely associated with the incidence of Alzheimer's disease. Moreover, caffeine... 
memory | A(2A) receptor | ALZHEIMERS-DISEASE | INVOLVEMENT | RELEASE | NEUROTOXICITY | NEUROSCIENCES | NUCLEUS-ACCUMBENS | adenosine | beta-amyloid | HIPPOCAMPUS | caffeine | neuroprotection | GLUTAMATE | Alzheimer's disease | Neuroprotective Agents - therapeutic use | Phosphodiesterase Inhibitors - therapeutic use | Cognition Disorders - chemically induced | Male | Adenosine A2 Receptor Antagonists | Brain - metabolism | Amnesia - chemically induced | Amnesia - drug therapy | Neuroprotective Agents - pharmacology | Caffeine - therapeutic use | Caffeine - pharmacology | Disease Models, Animal | Triazoles - therapeutic use | Alzheimer Disease - physiopathology | Cognition Disorders - physiopathology | Maze Learning - physiology | Brain - physiopathology | Alzheimer Disease - drug therapy | Phosphodiesterase Inhibitors - pharmacology | Treatment Outcome | Avoidance Learning - physiology | Pyrimidines - pharmacology | Receptor, Adenosine A2A - metabolism | Cognition Disorders - drug therapy | Maze Learning - drug effects | Amyloid beta-Peptides - adverse effects | Brain - drug effects | Drug Synergism | Triazoles - pharmacology | Amyloid beta-Peptides - antagonists & inhibitors | Amnesia - physiopathology | Animals | Peptide Fragments - antagonists & inhibitors | Pyrimidines - therapeutic use | Alzheimer Disease - metabolism | Avoidance Learning - drug effects | Mice | Peptide Fragments - adverse effects | Index Medicus
Journal Article
BLOOD, ISSN 0006-4971, 01/2008, Volume 111, Issue 1, pp. 251 - 259
Tissue-derived adenosine, acting via the adenosine A(2A) receptor (A(2A)R), is emerging as an important negative regulator of T-cell function. In this report,... 
DANGER SIGNAL | ACTIVATION | CYTOKINE PRODUCTION | IMMUNE-SYSTEM | DENDRITIC CELLS | IN-VIVO | ADENOSINE RECEPTOR | CLONAL ANERGY | HEMATOLOGY | CUTTING EDGE | LYMPHOCYTES
Journal Article
MEDICINAL RESEARCH REVIEWS, ISSN 0198-6325, 01/2018, Volume 38, Issue 1, pp. 5 - 56
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 02/2017, Volume 114, Issue 8, pp. 2066 - 2071
The adenosine A(2A) receptor (A(2A)R) has long been implicated in cardiovascular disorders. As more selective A(2A)R ligands are being identified, its roles in... 
allosteric | COMPLEX | Parkinson's disease | MEMBRANE | MULTIDISCIPLINARY SCIENCES | HIGH-AFFINITY | structure | SOFTWARE | FEATURES | A2A adenosine receptor | PROTEIN-COUPLED RECEPTOR | GPCR | ZM241385 | DERIVATIVES | PARKINSONS-DISEASE
Journal Article
JOURNAL OF NEUROCHEMISTRY, ISSN 0022-3042, 03/2019, Volume 148, Issue 6, pp. 796 - 809
Adenosine A(2A) receptors (A(2A)R) play a key role in modulating dopamine-dependent locomotor activity, as heralded by the sensitization of locomotor activity... 
behavioral sensitization | GPR37 | BASAL GANGLIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CAFFEINE | CROSS-SENSITIZATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | NUCLEUS-ACCUMBENS | INACTIVATION | DOUBLE DISSOCIATION | WORKING-MEMORY DEFICITS | adenosine A(2A) receptor | LONG-TERM POTENTIATION | LTD | AMPHETAMINE
Journal Article
JOURNAL OF CONTROLLED RELEASE, ISSN 0168-3659, 08/2018, Volume 283, pp. 135 - 142
G protein-coupled adenosine receptors are promising therapeutic targets for a wide range of neuropathological conditions, including Parkinson's disease (PD).... 
Photopharmacology | Parkinson's disease | Tremor | RAT | OPTOGENETICS | Catalepsy | Adenosine A(2A) receptor | CAFFEINE | RELEASE | CHEMISTRY, MULTIDISCIPLINARY | SCH442416 | Movement disorder | CHEMISTRY | PHARMACOLOGY & PHARMACY | LIGAND | ISTRADEFYLLINE | TECHNOLOGY | Locomotor activity | PARKINSONS-DISEASE
Journal Article
EXPERT OPINION ON INVESTIGATIONAL DRUGS, ISSN 1354-3784, 11/2009, Volume 18, Issue 11, pp. 1619 - 1631
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 06/2013, Volume 135, Issue 23, pp. 8749 - 8759
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 08/2008, Volume 105, Issue 31, pp. 10744 - 10749
Structural studies on mammalian integral membrane proteins have long been hampered by their instability in detergent. This is particularly true for the agonist... 
G protein-coupled receptor | CRYSTALLIZATION | ACTIVATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | MEMBRANE-PROTEIN | MICELLES | SIDE-CHAINS | PROTEIN-COUPLED RECEPTOR | PURIFICATION | RHODOPSIN | conformational thermostabilization | membrane protein | Adenosine | Cell receptors | G proteins | Properties | Membrane proteins
Journal Article
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