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1. Full Text The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase
by Slade, Dea and Dunstan, Mark S and Barkauskaite, Eva and Weston, Ria and Lafite, Pierre and Dixon, Neil and Ahel, Marijan and Leys, David and Ahel, Ivan
Nature (London), ISSN 0028-0836, 09/2011, Volume 477, Issue 7366, pp. 616 - 622
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Glycoside Hydrolases - genetics | Humans | Adenosine Diphosphate Ribose - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Phylogeny | Pyrrolidines - pharmacology | Adenosine Diphosphate Ribose - chemistry | Glycoside Hydrolases - chemistry | Glycoside Hydrolases - antagonists & inhibitors | Amino Acid Sequence | Catalytic Domain | Biocatalysis | Models, Molecular | Actinomycetales - enzymology | Adenosine Diphosphate - pharmacology | Poly Adenosine Diphosphate Ribose - chemistry | Hydrolysis | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Poly(ADP-ribose) Polymerases - genetics | Proteins - metabolism | Protein Conformation | Glycoside Hydrolases - metabolism | Poly (ADP-Ribose) Polymerase-1 | Adenosine Diphosphate - analogs & derivatives | Evolution, Molecular | Physiological aspects | Enzymes | Hydrolases | Catalysis | Research | Microbial metabolism | Proteins | Bacteria | Genomes | Mutation | Mass spectrometry | Crystal structure | Index Medicus
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2. Full Text Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal
by DaRosa, Paul A and Wang, Zhizhi and Jiang, Xiaomo and Pruneda, Jonathan N and Cong, Feng and Klevit, Rachel E and Xu, Wenqing
Nature (London), ISSN 0028-0836, 01/2015, Volume 517, Issue 7533, pp. 223 - 226
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protein Structure, Tertiary | Biocatalysis | Allosteric Regulation | Humans | Adenosine Diphosphate Ribose - metabolism | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Substrate Specificity | Crystallography, X-Ray | Ubiquitin-Protein Ligases - chemistry | Ubiquitin-Conjugating Enzymes - chemistry | Poly Adenosine Diphosphate Ribose - chemistry | Poly Adenosine Diphosphate Ribose - metabolism | Ubiquitination | Animals | Tankyrases - metabolism | Ubiquitin-Conjugating Enzymes - metabolism | Adenosine Diphosphate Ribose - chemistry | Protein Binding | Ligands | Mice | Protein Processing, Post-Translational | Enzyme Activation | Enzymes | Signal transduction | Mutation | Binding sites | Crystal structure | Index Medicus | Wnt signaling | protein turnover | Protein poly(ADP-ribosyl)ation | ubiquitination | substrate specificity | E3 ubiquitin ligase | allosteric regulation | PARylation
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3. Full Text Poly(ADP-ribose): novel functions for an old molecule
by Schreiber, Valérie and Ame, Jean-Christophe and Dantzer, Françoise and de Murcia, Gilbert
Nature reviews. Molecular cell biology, ISSN 1471-0072, 07/2006, Volume 7, Issue 7, pp. 517 - 528
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Multigene Family | Humans | Models, Molecular | Poly Adenosine Diphosphate Ribose - chemistry | Cell Division - physiology | Poly Adenosine Diphosphate Ribose - genetics | Inflammation - metabolism | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Protein Isoforms - metabolism | Cell Death - physiology | Protein Isoforms - chemistry | DNA Repair | NAD - biosynthesis | Protein Conformation | DNA Damage | Diphtheria Toxin - chemistry | Poly(ADP-ribose) Polymerases - chemistry | Protein Isoforms - genetics | Index Medicus
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4. Full Text New PARP targets for cancer therapy
by Vyas, Sejal and Chang, Paul
Nature reviews. Cancer, ISSN 1474-175X, 2014, Volume 14, Issue 7, pp. 502 - 509
Life Sciences & Biomedicine | Oncology | Science & Technology | Humans | Adenosine Diphosphate Ribose - metabolism | Neoplasms - enzymology | Substrate Specificity | Poly(ADP-ribose) Polymerase Inhibitors | Neoplasms - drug therapy | Poly Adenosine Diphosphate Ribose - chemistry | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Neoplasms - genetics | Adenosine Diphosphate Ribose - chemistry | Poly(ADP-ribose) Polymerases - chemistry | Antimitotic agents | Transferases | Physiological aspects | Research | Antineoplastic agents | Drug therapy | Health aspects | Cancer | Index Medicus
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5. Full Text Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium
by Huang, Yihe and Winkler, Paige A and Sun, Weinan and Lü, Wei and Du, Juan
Nature (London), ISSN 0028-0836, 10/2018, Volume 562, Issue 7725, pp. 145 - 149
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Apoproteins - chemistry | Calcium - metabolism | Humans | Adenosine Diphosphate Ribose - metabolism | Adenosine Diphosphate Ribose - pharmacology | Apoproteins - ultrastructure | TRPM Cation Channels - ultrastructure | Neurodegenerative Diseases - drug therapy | Calcium - chemistry | Zebrafish Proteins - ultrastructure | Adenosine Diphosphate Ribose - chemistry | Protein Domains | Binding Sites | Apoproteins - metabolism | Calcium - pharmacology | Zebrafish Proteins - chemistry | Zebrafish Proteins - metabolism | TRPM Cation Channels - chemistry | Models, Molecular | Zebrafish | Pyrophosphatases - chemistry | Cryoelectron Microscopy | Animals | Edetic Acid - chemistry | Signal Transduction - drug effects | Ligands | TRPM Cation Channels - metabolism | Ion Channel Gating - drug effects | Calcium channels | Usage | Cryoelectron microscopy | Zebra fish | Physiological aspects | Research | Structure | Oxidative stress | Temperature | Calcium | Thermoregulation | Bipolar disorder | Activation | Crystallography | Calcium influx | Proteins | Transient receptor potential proteins | Signal transduction | Reperfusion | Microprocessors | Ischemia | Metabolites | Ribose | Temperature effects | Ion channels | Alzheimer's disease | Immune system | Automation | Immune response | Neurodegenerative diseases | Body temperature | Adenosine diphosphate | Pharmacology | Electron microscopy | Chemical compounds | Neurological diseases | Domains | NAD | Microscopy | Binding sites | Calcium ions | Index Medicus
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6. Full Text Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans
by Cho, Chao-Cheng and Chien, Chia-Yu and Chiu, Yi-Chih and Lin, Meng-Hsuan and Hsu, Chun-Hua
Nature communications, ISSN 2041-1723, 04/2019, Volume 10, Issue 1, pp. 1491 - 1491
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Biocatalysis | Glycoside Hydrolases - genetics | Adenosine Diphosphate Ribose - metabolism | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Substrate Specificity | Poly ADP Ribosylation - radiation effects | Deinococcus - metabolism | Poly Adenosine Diphosphate Ribose - chemistry | Deinococcus - genetics | Deinococcus - radiation effects | Poly Adenosine Diphosphate Ribose - metabolism | Ultraviolet Rays | Adenosine Diphosphate Ribose - chemistry | Glycoside Hydrolases - chemistry | Bacterial Proteins - metabolism | Deinococcus - enzymology | Glycoside Hydrolases - metabolism | U.V. radiation | Genotoxicity | Adenosine diphosphate | Ultraviolet radiation | Eukaryotes | Ribose | Post-translation | Irradiation | Bacteria | Disruption | Ribosylation | Damage accumulation | Radiation damage | Radioactivity | Crystal structure | ADP-ribosylation | Index Medicus
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7. Full Text PARPs and ADP-Ribosylation: 50 Years … and Counting
by Kraus, W. Lee
Molecular cell, ISSN 1097-2765, 06/2015, Volume 58, Issue 6, pp. 902 - 910
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Niacinamide - metabolism | Humans | Adenosine Diphosphate Ribose - metabolism | Nicotinamide Mononucleotide - metabolism | Biomedical Research - trends | Biosynthetic Pathways | Forecasting | Poly Adenosine Diphosphate Ribose - chemistry | NAD - chemistry | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Time Factors | Niacinamide - chemistry | Adenosine Diphosphate Ribose - chemistry | Biomedical Research - methods | Interviews as Topic | Molecular Structure | Protein Processing, Post-Translational | Nicotinamide Mononucleotide - chemistry | NAD - metabolism | Transferases | Gene expression | Sugars | Stem cells | Monosaccharides | Index Medicus
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