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Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7654, pp. 299 - 304
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2004, Volume 101, Issue 51, pp. 17699 - 17704
Journal Article
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 06/2006, Volume 396, Issue 3, pp. 419 - 429
PAR [poly(ADP-ribose)] is a structural and regulatory component of multiprotein complexes in eukaryotic cells. PAR catabolism is accelerated under genotoxic... 
APOPTOSIS | RNA interference | NUCLEAR | RAT | DNA damage response | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-methyl-N '-nitro-N-nitrosoguanidine (MNNG) | DNA-DAMAGE | poly(ADP-ribose) glycohydrolase (PARG) | H2O2 | IDENTIFICATION | PARP-1 | silencing | NECROSIS | POLYMERASE-1 | HYDROGEN-PEROXIDE | GALLOTANNIN | Cell Survival - drug effects | Apoptosis - drug effects | Glycoside Hydrolases - physiology | Glycoside Hydrolases - genetics | Humans | Cells, Cultured | Hydrogen Peroxide - pharmacology | Mice, Knockout | Methylnitronitrosoguanidine - pharmacology | Poly Adenosine Diphosphate Ribose - metabolism | Animals | RNA Interference | Mice | HeLa Cells | MNNG, N-methyl-N′-nitro-N-nitrosoguanidine | RNAi, RNA interference | PI3K, phosphoinositide 3-kinase | PCNA, proliferating-cell nuclear antigen | ADP-HPD, ADP (hydroxymethyl)pyrrolidinediol | DTT, dithiothreitol | DMEM, Dulbecco's modified Eagle's medium | SVPDE, snake venom phosphodiesterase | PARP, PAR polymerase | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | 3-AB, 3-aminobenzamide | N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) | PARG, PAR glycohydrolase | FBS, fetal bovine serum | NLS, nuclear localization signal | ARH3, ADP-ribosyl-(arginine)-hydrolase 3 | siRNA, small interfering RNA | MEF, mouse embryonic fibroblast | DTNB, 5,5′-dithiobis-(2-nitrobenzoic acid) | PAR, poly(ADP-ribose)
Journal Article
Journal Article
Journal Article
Journal Article
Pure and Applied Chemistry, ISSN 0033-4545, 01/2002, Volume 74, Issue 5, pp. 703 - 785
The future of medicinal chemistry as both a pure and an applied science has been considered relative to trends that are already having a significant impact... 
ADENOSINE-DIPHOSPHATE (HYDROXYMETHYL)PYRROLIDINEDIOL | HIV-1 PROTEASE INHIBITORS | HUMAN SERUM-ALBUMIN | DRUG DISCOVERY | FLOW HELIUM CRYOSTAT | PLANT ANTITUMOR AGENTS | DNA TOPOISOMERASE-I | RECEPTOR BLOCKING-AGENTS | MULTIDRUG-RESISTANCE | CHEMISTRY, MULTIDISCIPLINARY | MUSCARINIC ACETYLCHOLINE-RECEPTORS
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/1995, Volume 38, Issue 2, pp. 389 - 393
Adenosine diphosphate (hydroxymethyl)pyrrolidinediol (ADP-HPD), an NH analog of ADP-ribose, was chemically synthesized and shown to be a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase... 
ADP-RIBOSYLATION | CELLS | CHEMISTRY, CLINICAL & MEDICINAL | Animals | NAD+ Nucleosidase - antagonists & inhibitors | Cattle | Enzyme Inhibitors - chemistry | Kinetics | Enzyme Inhibitors - chemical synthesis | Thymus Gland - enzymology | Adenosine Diphosphate - analogs & derivatives | Glycoside Hydrolases - antagonists & inhibitors | Adenosine Diphosphate - pharmacology
Journal Article