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Gene Therapy, ISSN 0969-7128, 03/2005, Volume 12, Issue 5, pp. 437 - 445
Journal Article
Cancer Cell, ISSN 1535-6108, 12/2004, Volume 6, Issue 6, pp. 611 - 623
ONYX-015 is an adenovirus that lacks the E1B-55K gene product for p53 degradation. Thus, ONYX-015 was conceived as an oncolytic virus that would selectively... 
NUCLEAR-LOCALIZATION | ADENOVIRUS REPLICATION | CHROMOSOME-TRANSLOCATION | MESSENGER-RNA | ONCOLOGY | E1B 55-KILODALTON PROTEIN | INFECTED-CELLS | TIME QUANTITATIVE PCR | SV40-TRANSFORMED CELLS | NUCLEOPORIN GENE | NECK-CANCER | Gene Expression - genetics | Virus Replication - genetics | Humans | Viral Proteins - metabolism | Cytopathogenic Effect, Viral - genetics | Caspase 3 | RNA Transport | Capsid Proteins - metabolism | HCT116 Cells | Cell Cycle Proteins - metabolism | In Situ Hybridization, Fluorescence | Caspase Inhibitors | Blotting, Western | Proto-Oncogene Proteins c-mdm2 | Models, Biological | Adenovirus E1A Proteins - genetics | Epithelial Cells - virology | Viral Nonstructural Proteins - metabolism | Adenoviruses, Human - genetics | Adenoviridae - metabolism | Mutation | Adenoviruses, Human - metabolism | Capsid Proteins - genetics | Neoplasms - metabolism | Epithelial Cells - metabolism | DNA, Viral - biosynthesis | Neoplasms - virology | Caspases - metabolism | Neoplasms - genetics | Adenovirus E1A Proteins - metabolism | Polymerase Chain Reaction | Adenoviridae - genetics | Cell Cycle Proteins - genetics | Protein Biosynthesis - genetics | RNA, Viral - metabolism | Adenovirus E1B Proteins - metabolism | Nuclear Proteins - genetics | Adenovirus E1B Proteins - genetics | Proto-Oncogene Proteins - metabolism | Epithelial Cells - radiation effects | Cyclin-Dependent Kinase Inhibitor p21 | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Viral Nonstructural Proteins - genetics | Viral Plaque Assay | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | bcl-2-Associated X Protein | Poly(ADP-ribose) Polymerases - metabolism | Viral Vaccines | Tumor Suppressor Protein p14ARF - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2000, Volume 6, Issue 8, pp. 879 - 885
Journal Article
Gene Therapy, ISSN 0969-7128, 2001, Volume 8, Issue 10, pp. 746 - 759
Journal Article
Molecular Therapy, ISSN 1525-0016, 11/2004, Volume 10, Issue 5, pp. 958 - 966
Journal Article
Current Cancer Drug Targets, ISSN 1568-0096, 03/2007, Volume 7, Issue 2, pp. 133 - 139
The current field of oncolytic virus development has evolved from, and been educated by, the route adenoviruses have taken to Phase 111 development in the... 
VIRAL GENE-THERAPY | ONCOLOGY | PHASE-I TRIAL | PANCREATIC-CANCER | GEMCITABINE POTENTIATE | ATTENUATED ADENOVIRUS | REPLICATION-SELECTIVE ADENOVIRUS | MALIGNANT-MELANOMA | HUMAN TUMOR-CELLS | NECK-CANCER | DELETED ADENOVIRUS
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 2000, Volume 60, Issue 22, pp. 6359 - 6366
Journal Article