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Biochemical Pharmacology, ISSN 0006-2952, 11/2019, Volume 169, p. 113627
Parathyroid hormone (PTH)-related protein (PTHrP) (gene name ) was discovered as the factor responsible for the humoral hypercalcemia of malignancy. It shares... 
Endocytosis | Adenylyl cyclase | PTHrP | PTH | Receptor
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 10/2014, Volume 86, Issue 4, pp. 417 - 429
The dopamine D-1 receptor-D-3 receptor (D1R-D3R) heteromer is being considered as a potential therapeutic target for neuropsychiatric disorders. Previous... 
FORMS | INTERFACE | ADENYLYL-CYCLASE | RELEVANCE | TARGETS | D-1 | PHARMACOLOGY & PHARMACY | BRAIN | HETEROMERIZATION
Journal Article
Neuroscience, ISSN 0306-4522, 2005, Volume 135, Issue 1, pp. 247 - 261
Opiates produce analgesia by activating μ opioid receptor-linked inhibitory G protein signaling cascades and related ion channel interactions that suppress... 
adenylyl cyclase | withdrawal | antinociception | signal transduction | morphine | Signal transduction | Antinociception | Morphine | Adenylyl cyclase | Withdrawal
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2019, pp. 568 - 585
Adenylyl cyclases type 1 (AC1) and 8 (AC8) are group 1 transmembrane adenylyl cyclases (AC) that are stimulated by Ca /calmodulin. Studies have shown that mice... 
1,3,4-Oxadiazole | Adenylyl cyclase inhibitors | Chronic pain treatment | Molecular modeling
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2015, Volume 194, Issue 11, pp. 5472 - 5487
PGE(2) is a potent lipid mediator involved in maintaining homeostasis but also promotion of acute inflammation or immune suppression in chronic inflammation... 
PROTEIN-KINASE-A | INTERLEUKIN-1 PRODUCTION | PROSTANOID RECEPTORS | IL-1-BETA PRODUCTION | ADENYLYL-CYCLASE | SILICA CRYSTALS | PERITONEAL-MACROPHAGES | PHOSPHOLIPASE A | IMMUNOLOGY | NALP3 INFLAMMASOME | CUTTING EDGE
Journal Article
STRUCTURE, ISSN 0969-2126, 06/2008, Volume 16, Issue 6, pp. 897 - 905
The role of cholesterol in eukaryotic membrane protein function has been attributed primarily to an influence on membrane fluidity and curvature. We present... 
CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-ADRENOCEPTOR | BENZODIAZEPINE-RECEPTOR | IDENTIFICATION | CELL BIOLOGY | BIOPHYSICS | PROTEIN-COUPLED RECEPTOR | ADENYLYL-CYCLASE | SEQUENCE | MEMBRANE-PROTEINS | AGONIST | LIPIDS
Journal Article
NATURE, ISSN 0028-0836, 09/2011, Volume 477, Issue 7364, pp. 349 - U129
The human mind and body respond to stress(1), a state of perceived threat to homeostasis, by activating the sympathetic nervous system and secreting the... 
ACTIVATION | GENE | BETA-ARRESTINS | ADENYLYL-CYCLASE | MULTIDISCIPLINARY SCIENCES | NUCLEAR EXPORT SIGNAL | SHORT-INTERFERING RNAS | N-DOMAIN | RECEPTOR | MAMMALIAN-CELLS | EXPRESSION
Journal Article
Journal of Cardiovascular Pharmacology, ISSN 0160-2446, 03/2018, Volume 71, Issue 3, pp. 147 - 154
Journal Article
Brain Research, ISSN 0006-8993, 2015, Volume 1645, pp. 71 - 74
Abstract In 1991 we demonstrated that chronic morphine exposure increased levels of adenylyl cyclase and protein kinase A (PKA) in several regions of the rat... 
Neurology | Protein kinase A | CREB | Stimulants | Adenylyl cyclase | Addiction | Opiates | Drugs of abuse | G alpha subunits | drugs of abuse | stimulants | addiction | adenylyl cyclase | protein kinase A | opiates
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 07/2012, Volume 8, Issue 7, pp. 622 - 630
Functional selectivity of G protein-coupled receptor (GPCR) ligands toward different downstream signals has recently emerged as a general hallmark of this... 
PATHWAYS | ACTIVATION | CONFORMATIONAL-CHANGES | BETA-ARRESTIN-2 | ADENYLYL-CYCLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INCREASES | PROTEIN-COUPLED RECEPTORS | FUNCTIONAL SELECTIVITY | BETA-ARRESTIN | SIGNALING COMPLEXES
Journal Article
ANNUAL REVIEW OF BIOCHEMISTRY, ISSN 0066-4154, 2007, Volume 76, pp. 481 - 511
Although cyclic nucleotide phosphodiesterases (PDEs) were described soon after the discovery of cAMP, their complexity and functions in signaling is only... 
CAMP-SPECIFIC PHOSPHODIESTERASE | TERM FEEDBACK-REGULATION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PDEs | DEPENDENT PROTEIN-KINASE | RESONANCE ENERGY-TRANSFER | SACCHAROMYCES-CEREVISIAE | second messengers | RAT CARDIAC MYOCYTES | GPCRs | CYANOBACTERIAL ADENYLYL-CYCLASE | MEMORY GENE DUNCE | TANDEM GAF DOMAINS
Journal Article
Biochimica et Biophysica Acta - General Subjects, ISSN 0304-4165, 12/2015, Volume 1850, Issue 12, pp. 2518 - 2529
Background: Two major soluble blood platelet activators are thrombin and ADP. Of these two, only thrombin can induce mitochondrial collapse and programmed cell... 
Calcium signaling | Mitochondria | Adenylyl cyclase | Differential equations | Cyclic AMP | Phospholipase C
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2006, Volume 103, Issue 30, pp. 11288 - 11293
Heterogeneity of heart failure (HF) phenotypes indicates contributions from underlying common polymorphisms. We considered polymorphisms in the β₁-adrenergic... 
Homozygotes | Heart | Drug carriers | Receptors | Phenotypes | Mortality | Placebos | Agonists | Hospitalization | Genotypes | G protein-coupled receptor | Myocardium | Signaling | Genetics | Adenylyl cyclase | adenylyl cyclase | Biological Sciences | myocardium | genetics | signaling
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 03/2017, Volume 13, Issue 3, pp. 259 - 259
Cells express several G-protein-coupled receptors (GPCRs) at their surfaces, transmitting simultaneous extracellular hormonal and chemical signals into cells.... 
PROTEIN-KINASE-A | ACTIVATION | PHOSPHORYLATION | ADENYLYL-CYCLASE | ARRESTIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | PKA | DYNAMICS | SUBUNITS | HORMONAL-STIMULATION | CAMP
Journal Article
Anesthesiology, ISSN 0003-3022, 12/2011, Volume 115, Issue 6, pp. 1363 - 1381
Journal Article