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The FEBS Journal, ISSN 1742-464X, 09/2016, Volume 283, Issue 18, pp. 3371 - 3388
ADP ‐ribosylation is a conserved post‐translational protein modification that plays a role in all major cellular processes, particularly DNA repair,... 
PAR | protein | ribosylation | poly | ribose | ENPP | mass spectrometry | PARP | phosphodiesterase | ADP | post‐translational modification | Post-translational modification | Protein ADP-ribosylation | PARP1 | Poly(ADP-ribose) | ENPP1 | Mass spectrometry | Phosphodiesterase | protein ADP-ribosylation | poly(ADP-ribose) | post-translational modification | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUDIX HYDROLASES | RIBOSE | BONE MINERALIZATION | SPINDLE STRUCTURE | NUCLEOTIDE PYROPHOSPHATASES/PHOSPHODIESTERASES | POLY(ADP-RIBOSE) GLYCOHYDROLASE | CELLULAR FUNCTIONS | PURIFICATION | EXPRESSION | Humans | Adenosine Diphosphate Ribose - metabolism | Pyrophosphatases - genetics | Proto-Oncogene Proteins - chemistry | Tandem Mass Spectrometry | Protein Domains | Poly(ADP-ribose) Polymerases - chemistry | Binding Sites | ADP Ribose Transferases - metabolism | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Phosphoric Diester Hydrolases - metabolism | Recombinant Proteins - chemistry | Poly (ADP-Ribose) Polymerase-1 - metabolism | Proto-Oncogene Proteins - genetics | Phosphoric Diester Hydrolases - genetics | Pyrophosphatases - chemistry | Recombinant Proteins - genetics | Phosphoric Diester Hydrolases - chemistry | Pyrophosphatases - metabolism | Sequence Homology, Amino Acid | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Poly (ADP-Ribose) Polymerase-1 - chemistry | Mice | Protein Processing, Post-Translational | In Vitro Techniques | Poly (ADP-Ribose) Polymerase-1 - genetics | Phosphates | Enzymes | Nervous system diseases | Physiological aspects | Sugars | Protein binding | Monosaccharides | Proteins | Molecular biology | Index Medicus | poly(ADP‐ribose) | protein ADP‐ribosylation | Original
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 2, pp. 645 - 652
PARylation [poly(ADP-ribosyl)ation] is involved in the maintenance of genomic methylation patterns through its control of Dram 1 [DNA... 
DNA methylation | Epigenetics | Poly(ADP-ribosyl)ation (PARylation) | DNA methyltranferase 1 (Dnmt1) | CCCTC-binding factor (Ctcf) | Poly(ADP-ribose) polymerase 1 (Parp1) | POLY(ADP-RIBOSYL)ATION REACTIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | poly(ADP-ribosyl)ation (PARylation) | epigenetics | HUMAN GENOME | GENE | EMBRYONIC STEM-CELLS | INSULATOR PROTEIN CTCF | UNMETHYLATED STATE | TUMOR-SUPPRESSOR | poly(ADP-ribose) polymerase 1 (Parp1) | CPG ISLANDS | BINDING | DNA (Cytosine-5-)-Methyltransferases - metabolism | Multiprotein Complexes - metabolism | DNA Methylation | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | DNA (Cytosine-5-)-Methyltransferase 1 | CCCTC-Binding Factor | Epigenesis, Genetic | CpG Islands - physiology | Repressor Proteins - metabolism | Index Medicus | poly(ADP-ribose) polymerase 1 | DNMT1 protein | genomics | Promoters | ADP-ribosylation | CpG islands | Life Sciences | Poly(ADP-ribose) Polymerases | DNA (Cytosine-5-)-Methyltransferase | Multiprotein Complexes | Repressor Proteins | Biochemistry, Molecular Biology | CpG Islands | Poly Adenosine Diphosphate Ribose | Molecular biology | DMR1, differentially methylated region 1 | Ab, antibody | poly(ADPribosyl)ation (PARylation) | H2B, histone 2B | PARG, poly(ADP-ribose) glycohydrolase | Ctcf, CCCTC-binding factor | IP, immunoprecipitation | DTT, dithiothreitol | ChIP, chromatin immunoprecipitation | TBST, Tris-buffered saline plus 0.05% Tween 20 | Dnmt1, DNA (cytosine-5)-methyltransferase 1 | Parp1, poly(ADP-ribose) polymerase 1 | H1, histone 1 | CGI, CpG island | dsDNA, double-stranded DNA | PARylation, poly(ADP-ribosyl)ation | PARs, poly(ADP-ribose) polymers | RE-ChIP, sequential ChIP
Journal Article
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 12/2017, Volume 232, Issue 12, pp. 3744 - 3761
The study findings imply that activation of either PARP‐1 or ‐2 is likely to play a relevant role in muscle protein catabolism via oxidative stress, NF‐κB... 
| Parp‐1 | and Parp‐2 | muscle atrophy and myosin loss | muscle anabolism and catabolism and mitochondrial content | PARP activity | mice | cancer‐induced cachexia | Parp-1 | cancer-induced cachexia | and Parp-2 | POLY(ADP-RIBOSE) POLYMERASE | PHYSIOLOGY | LIMB MUSCLES | ADP-RIBOSE-POLYMERASE | THORACIC-SURGERY | CELL BIOLOGY | SKELETAL-MUSCLE | INHIBITION | EXPERIMENTAL-MODEL | MITOCHONDRIAL DYSFUNCTION | EXPRESSION | Diaphragm - pathology | Oxidative Stress | Mitochondria, Muscle - metabolism | Lung Neoplasms - pathology | NF-kappa B - metabolism | Mice, 129 Strain | Ubiquitination | Time Factors | Proteolysis | Cachexia - etiology | Muscle Proteins - metabolism | Poly (ADP-Ribose) Polymerase-1 - deficiency | Female | Biomarkers - metabolism | Lung Neoplasms - genetics | Muscle, Skeletal - enzymology | Cachexia - genetics | Lung Neoplasms - enzymology | Signal Transduction | Mitochondria, Muscle - pathology | Mice, Inbred C57BL | Organ Size | Genotype | Poly (ADP-Ribose) Polymerase-1 - metabolism | Diaphragm - enzymology | Lung Neoplasms - complications | Mice, Knockout | Phenotype | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Cachexia - enzymology | Cachexia - pathology | Muscle Fibers, Skeletal - pathology | Cell Line, Tumor | Poly(ADP-ribose) Polymerases - deficiency | Mice, Inbred BALB C | Muscle, Skeletal - pathology | Proteasome Endopeptidase Complex - metabolism | Poly (ADP-Ribose) Polymerase-1 - genetics | Apoptosis | Muscle Fibers, Skeletal - enzymology | Ubiquitin | Tyrosine | Oxidative stress | Lung cancer | Cachexia | Mitochondrial DNA | Muscle proteins | Monosaccharides | Ligases | Myosin | Genetic aspects | Sugars | Adenocarcinoma | Chromatin | Poly(ADP-ribose) | AKT protein | ADP | Nuclei | Body composition | Fibers | Proteins | Degradation | Atrophy | Genotype & phenotype | Signal transduction | Protein composition | Body composition (biology) | Ribose | Rodents | Diaphragm (anatomy) | Oxidation | Polymers | Deoxyribonucleic acid--DNA | NF-κB protein | Markers | Contractility | Muscles | Poly(ADP-ribose) polymerase | Inflammation | Metabolism | Muscle contraction | Chronic conditions | Poly(ADP-ribose) Polymerase 1 | Proteasomes | Catabolism | Nuclei (cytology) | Mice | Diaphragm | Cancer | Index Medicus | 62D05 Sampling theory, sample surveys | 92D Genetics and population dynamics | 62H Multivariate analysis | 92 Biology and other natural sciences | Anàlisi multivariable | Matemàtica aplicada a les ciències | Classificació AMS | Multivariate analysis | Parp-1-/- and Parp-2-/- mice | Anàlisi numèrica | Genètica | Sampling (Statistics) | Mostreig (Estadística) | Matemàtiques i estadística | Genetics | Probabilitat | 62 Statistics | Àrees temàtiques de la UPC
Journal Article
DNA Repair, ISSN 1568-7864, 11/2014, Volume 23, pp. 4 - 16
Poly(ADP-ribosyl)ation is a post-translational modification of proteins involved in regulation of many cellular pathways. Poly(ADP-ribose) (PAR) consists of... 
Macrodomain | PARP | PARG | DNA damage response | Poly(ADP-ribose) | MACRO DOMAINS | DNA-DAMAGE RESPONSE | CRYSTAL-STRUCTURE | SULFOLOBUS-SOLFATARICUS | MONO-ADP-RIBOSYLTRANSFERASE | FINGER ANTIVIRAL PROTEIN | STRUCTURAL BASIS | GENETICS & HEREDITY | VIRAL MESSENGER-RNAS | TOXICOLOGY | POLYMERASE-ACTIVITY | IONIZING-RADIATION | Viruses - genetics | Humans | Eukaryotic Cells - metabolism | Proto-Oncogene Proteins - chemistry | Phylogeny | Tankyrases - metabolism | Plant Proteins - chemistry | Fishes | DNA Repair Enzymes - metabolism | Archaeal Proteins - genetics | Plant Proteins - metabolism | Poly(ADP-ribose) Polymerases - chemistry | Insect Proteins - metabolism | DNA Repair Enzymes - chemistry | Archaeal Proteins - metabolism | Hydrolases - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Catalytic Domain | Signal Transduction | Viruses - metabolism | Tankyrases - chemistry | Poly Adenosine Diphosphate Ribose - chemistry | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Prokaryotic Cells - metabolism | DNA Repair | Insect Proteins - chemistry | Hydrolases - chemistry | Evolution, Molecular | Index Medicus | TARG1, terminal ADP-ribose protein glycohydrolase | ARH, ADP-ribosylhydrolase | PARG, poly(ADP-ribose) glycohydrolase | PAR, poly(ADP-ribose) | PARP, poly(ADP-ribose) polymerase | ADPr, ADP-ribose
Journal Article
2002, Pharmacology and toxicology., ISBN 0849300738, 338
Book
Journal of Molecular Biology, ISSN 0022-2836, 03/2011, Volume 407, Issue 1, pp. 149 - 170
Poly(ADP-ribose)polymerase-1 (PARP-1) is a highly abundant chromatin-associated enzyme present in all higher eukaryotic cell nuclei, where it plays key roles... 
solution structure | DNA single-strand breaks | poly(ADP ribose)polymerase-1 | zinc finger | DNA repair | poly(ADP ribose) polymerase-1 | CHROMATIN-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | IDENTIFICATION | HUMAN POLY(ADP-RIBOSE) POLYMERASE | REPAIR | ENZYME ACTIVATION | ADP-RIBOSYLATION | LIGASE-III | DIPOLAR COUPLINGS | PROTEINS | Chromatin - metabolism | Zinc Fingers | Magnetic Resonance Spectroscopy | Humans | DNA - metabolism | Mutation - genetics | DNA Breaks, Single-Stranded | Poly(ADP-ribose) Polymerases - metabolism | Poly(ADP-ribose) Polymerases - genetics | DNA Repair | Protein Binding | Electrophoretic Mobility Shift Assay | Poly (ADP-Ribose) Polymerase-1 | Poly(ADP-ribose) Polymerases - chemistry | Ligases | DNA | Genetic research | Nuclear magnetic resonance spectroscopy | Disease susceptibility | Zinc finger proteins | DNA binding proteins | Sugars | Monosaccharides | Index Medicus | F1, finger 1 | BER, base excision repair | EMSA, electromobility shift assay | RDC, residual dipolar coupling | BRCT, breast cancer susceptibility protein C-terminal domain | NOE, nuclear Overhauser effect | PARP-1, poly(ADP-ribose)polymerase-1 | DL3, DNA ligase IIIα | ssDNA, single-stranded DNA | HSQC, heteronuclear single-quantum coherence | F2, finger 2 | NOESY, NOE spectroscopy | SSBR, single-strand break repair | PAR, poly(ADP-ribose) | SV-AUC, sedimentation velocity analytical ultracentrifugation
Journal Article