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The FEBS Journal, ISSN 1742-464X, 12/2011, Volume 278, Issue 23, pp. 4683 - 4700
Journal Article
PLoS Pathogens, ISSN 1553-7366, 10/2009, Volume 5, Issue 10, pp. e1000626 - e1000626
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 16, pp. 3792 - 3800
Immunotoxins based on Pseudomonas exotoxin A (PE) are promising anticancer agents that combine a variable fragment (Fv) from an antibody to a tumor-associated... 
Immunoglobulin Variable Region - adverse effects | Virulence Factors - genetics | Exotoxins - pharmacokinetics | Humans | Antibodies, Monoclonal - adverse effects | Bacterial Toxins - pharmacokinetics | Immunotoxins - adverse effects | Immunotoxins - pharmacology | Endosomes - metabolism | Exotoxins - adverse effects | Lysosomes - metabolism | Virulence Factors - pharmacokinetics | ADP Ribose Transferases - pharmacokinetics | Bacterial Toxins - genetics | Female | Sialic Acid Binding Ig-like Lectin 2 | ADP Ribose Transferases - adverse effects | Antibodies, Monoclonal - pharmacology | Antibodies, Monoclonal - pharmacokinetics | Clinical Trials as Topic | Exotoxins - pharmacology | Bacterial Toxins - adverse effects | Xenograft Model Antitumor Assays | ADP Ribose Transferases - genetics | Antibodies, Monoclonal - genetics | Immunotoxins - genetics | Animals | Bacterial Toxins - pharmacology | Mice, Nude | ADP Ribose Transferases - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Exotoxins - genetics | Immunoglobulin Variable Region - pharmacology | Immunoglobulin Variable Region - genetics | Immunotoxins - pharmacokinetics | Mice | Mice, Inbred BALB C | Virulence Factors - adverse effects | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Mutation | Virulence Factors - pharmacology | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2011, Volume 17, Issue 1, pp. 100 - 110
Purpose: Designed ankyrin repeat proteins (DARPins) hold great promise as a new class of binding molecules to overcome the limitations of antibodies for... 
RECOMBINANT ANTIBODY | IMMUNOTOXIN | ONCOLOGY | EP-CAM | STABILITY | ANTICANCER AGENT | AERUGINOSA EXOTOXIN-A | PHASE-I | PSEUDOMONAS EXOTOXIN | CARCINOMA | CANCER STEM-CELLS | Cell Adhesion Molecules - chemistry | Injections, Intravenous | Cell Adhesion Molecules - administration & dosage | Recombinant Fusion Proteins - pharmacology | Humans | Antineoplastic Agents - administration & dosage | Recombinant Fusion Proteins - metabolism | Exotoxins - metabolism | Antineoplastic Agents - metabolism | ADP Ribose Transferases - administration & dosage | Exotoxins - administration & dosage | Protein Engineering | Cell Adhesion Molecules - pharmacology | Female | Antineoplastic Agents - pharmacology | Recombinant Fusion Proteins - administration & dosage | ADP Ribose Transferases - chemistry | ADP Ribose Transferases - metabolism | Cell Survival - drug effects | Exotoxins - chemistry | Ankyrin Repeat | Exotoxins - pharmacology | Virulence Factors - chemistry | Recombinant Fusion Proteins - chemistry | Antineoplastic Agents - chemistry | Cell Adhesion Molecules - metabolism | Bacterial Toxins - chemistry | Xenograft Model Antitumor Assays | Bacterial Toxins - metabolism | Animals | Pseudomonas aeruginosa - genetics | Bacterial Toxins - pharmacology | Mice, Nude | ADP Ribose Transferases - pharmacology | Cell Line, Tumor | Bacterial Toxins - administration & dosage | Virulence Factors - metabolism | Mice | Neoplasms, Experimental - drug therapy | Virulence Factors - administration & dosage | Virulence Factors - pharmacology
Journal Article
Journal Article
Journal Article
Glia, ISSN 0894-1491, 04/2019, Volume 67, Issue 4, pp. 703 - 717
Clostridium botulinum C3 transferase (C3bot) ADP‐ribosylates rho proteins to change cellular functions in a variety of cell types including astrocytes and... 
vimentin | astrocytes | axonotrophic | C3 transferase | exosomes | RECRUITMENT | EXOENZYME | INTEGRIN | CELL-SURFACE | NEUROSCIENCES | MEMBRANE-VESICLES | GROWTH | RHO | SPINAL-CORD-INJURY | CENTRAL-NERVOUS-SYSTEM | Protein Binding - genetics | Extracellular Vesicles - ultrastructure | Vimentin - metabolism | Rats, Inbred Lew | Male | Microscopy, Immunoelectron | Spinal Cord Injuries - pathology | Subcellular Fractions - ultrastructure | Botulinum Toxins - pharmacology | Neurons - ultrastructure | Time Factors | Vimentin - genetics | Protein Binding - drug effects | Extracellular Vesicles - physiology | Neurons - metabolism | Spinal Cord - cytology | Neurons - drug effects | ADP Ribose Transferases - metabolism | Disease Models, Animal | Botulinum Toxins - metabolism | Spinal Cord Injuries - metabolism | Subcellular Fractions - drug effects | Mice, Inbred C57BL | Cells, Cultured | Rats | Mice, Transgenic | Subcellular Fractions - metabolism | Astrocytes - ultrastructure | Animals | ADP Ribose Transferases - pharmacology | Mice | Astrocytes - metabolism | Neurons | Intermediate filament proteins | Analysis | Integrins | Protein binding | Vimentin | Binding | Neuroprotection | Brain | Membranes | Spinal cord | Astrocytes | RhoA protein | Spinal cord injury | Exosomes | ADP | Cell surface | Proteins | Plasticity (spinal) | Internalization | Synaptosomes | Ribosylation | Recombinant
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 06/2015, Volume 26, Issue 6, pp. 1120 - 1128
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 10/2011, Volume 10, Issue 10, pp. 1829 - 1838
A novel anticancer agent was constructed by fusing a gene encoding the scFV that targets both glycosylated and unglycosylated forms of CD133 to a gene fragment... 
RECOMBINANT IMMUNOTOXIN | STEM-CELLS | IMMUNOGENICITY | ONCOLOGY | IN-VIVO | DIFFERENTIATION | IDENTIFICATION | AC133 | CARCINOMA | LIGAND-DIRECTED TOXIN | CD133 | Antigens, CD - immunology | Virulence Factors - genetics | Recombinant Fusion Proteins - pharmacology | Antigens, CD - biosynthesis | Neoplastic Stem Cells - drug effects | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Exotoxins - pharmacokinetics | Humans | Bacterial Toxins - pharmacokinetics | Peptides - genetics | Immunotoxins - pharmacology | Antigens, CD - genetics | Head and Neck Neoplasms - metabolism | Transfection | Virulence Factors - pharmacokinetics | ADP Ribose Transferases - pharmacokinetics | Bacterial Toxins - genetics | Female | Glycoproteins - genetics | Cell Survival - drug effects | Cell Growth Processes - drug effects | Peptides - immunology | Head and Neck Neoplasms - drug therapy | Exotoxins - pharmacology | AC133 Antigen | Immunoglobulin Fragments - pharmacology | Head and Neck Neoplasms - pathology | Glycoproteins - biosynthesis | Xenograft Model Antitumor Assays | ADP Ribose Transferases - genetics | Glycoproteins - immunology | Immunotoxins - genetics | Animals | Carcinoma, Squamous Cell - drug therapy | Bacterial Toxins - pharmacology | Mice, Nude | ADP Ribose Transferases - pharmacology | Recombinant Fusion Proteins - pharmacokinetics | Exotoxins - genetics | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Head and Neck Neoplasms - genetics | Immunoglobulin Fragments - genetics | Immunotoxins - pharmacokinetics | Mice | Mice, Inbred BALB C | Virulence Factors - pharmacology | xenograft model | cancer stem cells | head and neck cancer | pseudomonas exotoxin
Journal Article