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NATURE COMMUNICATIONS, ISSN 2041-1723, 09/2019, Volume 10, Issue 1, pp. 1 - 11
Supplementation with the NAD(+) precursor nicotinamide riboside (NR) ameliorates and prevents a broad array of metabolic and aging disorders in mice. However,... 
HEPATIC GLUCONEOGENESIS | LIFE-SPAN | HOMEOSTASIS | ACTIVATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | DISEASE | NAD(+) | MONONUCLEOTIDE | NUTRIENT | DEFICIENCY | NADPH | Therapeutic applications | Liver | DNA damage | Dietary supplements | Disorders | Metabolism | Kinases | Insulin | NAD | Glucose tolerance | Intolerance | Poly(ADP-ribose) Polymerase 1 | Mitochondria | Diet | Aging | Mice | Nicotinamide | Supplementation | Metabolic disorders | Deoxyribonucleic acid--DNA
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 04/2019, Volume 10, Issue 1, pp. 1491 - 14
Poly-ADP-ribosylation, a post-translational modification involved in various cellular processes, is well characterized in eukaryotes but thought to be devoid... 
REPAIR | PROTEIN | RECOGNITION | POLY(ADP-RIBOSE) GLYCOHYDROLASE | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | RIBOSE | IDENTIFICATION | DNA-DAMAGE-RESPONSE | DOMAINS | BINDING | U.V. radiation | Genotoxicity | ADP | Ultraviolet radiation | Eukaryotes | Ribose | Post-translation | Irradiation | Bacteria | Disruption | Ribosylation | Damage accumulation | Radiation damage | Radioactivity | Crystal structure | ADP-ribosylation
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1224 - 15
Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2... 
BARD1 | COMPLEX | TARGETS BRCA1 | PROTEIN | RECOGNITION | DNA-DAMAGE RESPONSE | MULTIDISCIPLINARY SCIENCES | STRAND-BREAK REPAIR | FOCI FORMATION | END | DOMAIN-BINDING | Whole-Body Irradiation | Ubiquitin-Specific Proteases - genetics | Humans | Intracellular Signaling Peptides and Proteins - metabolism | DNA Breaks, Double-Stranded - drug effects | MCF-7 Cells | Neoplasms - genetics | HEK293 Cells | Neoplasms, Experimental - genetics | Trans-Activators - genetics | Neoplasms, Experimental - mortality | Nuclear Proteins - genetics | Ubiquitin-Specific Proteases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Recombinational DNA Repair | Tumor Suppressor Proteins - metabolism | Mice, Inbred C57BL | Kaplan-Meier Estimate | Ubiquitin-Protein Ligases - metabolism | Neoplasms - mortality | Nuclear Proteins - metabolism | Treatment Outcome | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | Mice, Knockout | Neoplasms - drug therapy | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Trans-Activators - metabolism | Mice | Mutation | Neoplasms, Experimental - drug therapy | RNA, Small Interfering - metabolism | Enzymes | Stability | BRCA1 protein | DNA damage | Homologous recombination | Poly(ADP-ribose) polymerase | Homology | Breast cancer | ADP | Genomic instability | Polymerase | Homologous recombination repair | Inhibitors | Ribose | Biomarkers | Bioindicators | Deoxyribonucleic acid--DNA | Cancer
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1 - 15
Targeting bacterial virulence factors directly provides a new paradigm for the intervention and treatment of bacterial diseases. Pseudomonas aeruginosa... 
Interfaces | Phage display | Animal models | Complementarity | Virulence factors | p53 Protein | Clinical trials | Antibodies | Exotoxin A | Ribosylation | Apoptosis | ADP-ribosylation
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 07/2019, Volume 10, Issue 1, pp. 2954 - 16
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1182 - 14
Protein ADP-ribosylation is essential for the regulation of several cellular pathways, enabling dynamic responses to diverse pathophysiological conditions. It... 
STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | NUDIX HYDROLASES | MACRO DOMAIN | RIBOSE | DNA-REPAIR | IDENTIFICATION | POLY(ADP-RIBOSE) GLYCOHYDROLASE PARG | MASS-SPECTROMETRY | CELL-DEATH | MOLECULAR-MECHANISMS | Proteins | Dynamic control | Enzymes | Spectrometry | Ribose | Ribosylation | ADP | ADP-ribosylation
Journal Article