X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (21284) 21284
Book Chapter (93) 93
Dissertation (75) 75
Publication (24) 24
Book / eBook (13) 13
Government Document (12) 12
Conference Proceeding (11) 11
Web Resource (9) 9
Magazine Article (4) 4
Book Review (3) 3
Newspaper Article (3) 3
Trade Publication Article (2) 2
Journal / eJournal (1) 1
Streaming Video (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
science & technology (16472) 16472
life sciences & biomedicine (15092) 15092
humans (12569) 12569
animals (9731) 9731
poly polymerases - metabolism (7564) 7564
apoptosis (5693) 5693
biochemistry & molecular biology (4707) 4707
mice (4459) 4459
oncology (4090) 4090
poly polymerase (3992) 3992
female (3731) 3731
apoptosis - drug effects (3492) 3492
cell biology (3492) 3492
male (3273) 3273
cell line, tumor (3258) 3258
cancer (2648) 2648
proteins (2538) 2538
poly polymerase inhibitors (2518) 2518
dna damage (2470) 2470
dna repair (2336) 2336
rats (2297) 2297
poly polymerase-1 (2124) 2124
cell line (1931) 1931
poly polymerases - genetics (1832) 1832
pharmacology & pharmacy (1679) 1679
signal transduction (1658) 1658
cells, cultured (1602) 1602
gene expression (1599) 1599
ribose (1593) 1593
research (1581) 1581
deoxyribonucleic acid--dna (1578) 1578
research article (1563) 1563
caspases - metabolism (1545) 1545
mutation (1534) 1534
poly-adp-ribose binding proteins (1512) 1512
antineoplastic agents - pharmacology (1482) 1482
enzyme inhibitors - pharmacology (1470) 1470
cell survival - drug effects (1455) 1455
cell death (1413) 1413
analysis (1374) 1374
cell cycle (1359) 1359
science & technology - other topics (1346) 1346
breast cancer (1327) 1327
caspase (1310) 1310
multidisciplinary sciences (1309) 1309
caspase 3 - metabolism (1292) 1292
blotting, western (1286) 1286
adp ribose transferases (1233) 1233
dose-response relationship, drug (1225) 1225
cell proliferation - drug effects (1206) 1206
phosphorylation (1191) 1191
caspase-3 (1182) 1182
tumors (1165) 1165
molecular sequence data (1155) 1155
oxidative stress (1108) 1108
chemotherapy (1088) 1088
kinases (1087) 1087
flow cytometry (1062) 1062
genetic aspects (1049) 1049
dna (1048) 1048
enzymes (1047) 1047
tumor cells, cultured (1036) 1036
poly polymerase 1 (1026) 1026
adenosine diphosphate (1018) 1018
medicine (1004) 1004
middle aged (1002) 1002
amino acid sequence (979) 979
nad - metabolism (972) 972
time factors (967) 967
enzyme activation (951) 951
monosaccharides (950) 950
cell proliferation (945) 945
sugars (944) 944
hela cells (920) 920
cytotoxicity (919) 919
health aspects (917) 917
biology (897) 897
caspase 3 (892) 892
protein binding (883) 883
mitochondria (877) 877
virulence factors (876) 876
biophysics (870) 870
immunology (864) 864
signal transduction - drug effects (859) 859
adp ribose transferases - metabolism (858) 858
adult (856) 856
adenosine diphosphate ribose - metabolism (851) 851
genetics & heredity (842) 842
physiological aspects (839) 839
reactive oxygen species - metabolism (835) 835
neurosciences (831) 831
poly (820) 820
kinetics (814) 814
science (813) 813
neurosciences & neurology (809) 809
parp (809) 809
cancer therapies (796) 796
aged (789) 789
medicine, research & experimental (782) 782
research & experimental medicine (781) 781
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (21234) 21234
Japanese (201) 201
Chinese (186) 186
French (78) 78
Russian (76) 76
German (43) 43
Korean (16) 16
Polish (14) 14
Portuguese (11) 11
Norwegian (9) 9
Spanish (7) 7
Hungarian (6) 6
Italian (4) 4
Ukrainian (4) 4
Turkish (2) 2
Czech (1) 1
Danish (1) 1
Dutch (1) 1
Hebrew (1) 1
Romanian (1) 1
Swedish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


The FEBS journal, ISSN 1742-464X, 09/2016, Volume 283, Issue 18, pp. 3371 - 3388
ADP‐ribosylation is a conserved post‐translational protein modification that plays a role in all major cellular processes, particularly DNA repair,... 
PAR | poly(ADP‐ribose) | PARP1 | protein ADP‐ribosylation | ENPP1 | mass spectrometry | phosphodiesterase | post‐translational modification | Post-translational modification | Protein ADP-ribosylation | Poly(ADP-ribose) | Mass spectrometry | Phosphodiesterase | protein ADP-ribosylation | poly(ADP-ribose) | post-translational modification | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Humans | Adenosine Diphosphate Ribose - metabolism | Pyrophosphatases - genetics | Proto-Oncogene Proteins - chemistry | Tandem Mass Spectrometry | Protein Domains | Poly(ADP-ribose) Polymerases - chemistry | Binding Sites | ADP Ribose Transferases - metabolism | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Phosphoric Diester Hydrolases - metabolism | Recombinant Proteins - chemistry | Poly (ADP-Ribose) Polymerase-1 - metabolism | Proto-Oncogene Proteins - genetics | Phosphoric Diester Hydrolases - genetics | Pyrophosphatases - chemistry | Recombinant Proteins - genetics | Phosphoric Diester Hydrolases - chemistry | Pyrophosphatases - metabolism | Sequence Homology, Amino Acid | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Poly (ADP-Ribose) Polymerase-1 - chemistry | Mice | Protein Processing, Post-Translational | In Vitro Techniques | Poly (ADP-Ribose) Polymerase-1 - genetics | Phosphates | Enzymes | Nervous system diseases | Physiological aspects | Sugars | Protein binding | Monosaccharides | Proteins | Molecular biology | Index Medicus | Original
Journal Article
Nature (London), ISSN 0028-0836, 07/2018, Volume 559, Issue 7713, pp. 285 - 289
The observation that BRCA1-and BRCA2-deficient cells are sensitive to inhibitors of poly(ADP-ribose) polymerase (PARP) has spurred the development of cancer... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | Genome - genetics | Male | Synthetic Lethal Mutations | DNA Repair - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Ribonucleotides - genetics | Neoplasms - genetics | Poly (ADP-Ribose) Polymerase-1 - deficiency | Female | Genes, BRCA1 | BRCA1 Protein - deficiency | Prostatic Neoplasms - drug therapy | Ribonuclease H - genetics | DNA Damage - drug effects | Cell Line | Prostatic Neoplasms - pathology | DNA Topoisomerases, Type I - metabolism | Ribonuclease H - deficiency | Neoplasms - enzymology | DNA Replication | Poly (ADP-Ribose) Polymerase-1 - metabolism | Piperazines - pharmacology | Gene Editing | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Animals | CRISPR-Cas Systems | Prostatic Neoplasms - enzymology | Mice | HeLa Cells | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Neoplasms - pathology | Poly (ADP-Ribose) Polymerase-1 - genetics | Ribonuclease H - metabolism | DNA polymerases | Physiological aspects | Ribonucleotides | Genetic aspects | Toxicity | Leukemia | Genomics | Homologous recombination | Genes | DNA damage | Poly(ADP-ribose) | Cytotoxicity | Homology | Genomes | Kinases | Metastases | Ribonuclease H2 | Proteins | Dwarfism | Genotype & phenotype | Clonal deletion | Ribose | Cell cycle | Inhibition | Lesions | Repair | Deoxyribonucleic acid--DNA | Adducts | BRCA2 protein | CRISPR | Enzymes | Chronic lymphatic leukemia | BRCA1 protein | Anemia | Hypersensitivity | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Breast cancer | Screens | Substrates | DNA biosynthesis | Poly(ADP-ribose) Polymerase 1 | Trapping | Inhibitors | Mutation | DNA adducts | Prostate cancer | Prostate | Cancer | Index Medicus
Journal Article
Journal of cellular physiology, ISSN 0021-9541, 12/2017, Volume 232, Issue 12, pp. 3744 - 3761
Strategies to treat cachexia are still at its infancy. Enhanced muscle protein breakdown and ubiquitin‐proteasome system are common features of cachexia... 
muscle atrophy and myosin loss | muscle anabolism and catabolism and mitochondrial content | PARP activity | Parp‐1−/− and Parp‐2−/− mice | cancer‐induced cachexia | Parp-1 | cancer-induced cachexia | and Parp-2 | mice | Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Diaphragm - pathology | Oxidative Stress | Mitochondria, Muscle - metabolism | Lung Neoplasms - pathology | NF-kappa B - metabolism | Mice, 129 Strain | Ubiquitination | Time Factors | Proteolysis | Cachexia - etiology | Muscle Proteins - metabolism | Poly (ADP-Ribose) Polymerase-1 - deficiency | Female | Biomarkers - metabolism | Lung Neoplasms - genetics | Muscle, Skeletal - enzymology | Cachexia - genetics | Lung Neoplasms - enzymology | Signal Transduction | Mitochondria, Muscle - pathology | Mice, Inbred C57BL | Organ Size | Genotype | Poly (ADP-Ribose) Polymerase-1 - metabolism | Diaphragm - enzymology | Lung Neoplasms - complications | Mice, Knockout | Phenotype | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Cachexia - enzymology | Cachexia - pathology | Muscle Fibers, Skeletal - pathology | Cell Line, Tumor | Poly(ADP-ribose) Polymerases - deficiency | Mice, Inbred BALB C | Muscle, Skeletal - pathology | Proteasome Endopeptidase Complex - metabolism | Poly (ADP-Ribose) Polymerase-1 - genetics | Apoptosis | Muscle Fibers, Skeletal - enzymology | Ubiquitin | Tyrosine | Oxidative stress | Lung cancer | Cachexia | Mitochondrial DNA | Muscle proteins | Monosaccharides | Ligases | Myosin | Genetic aspects | Sugars | Adenocarcinoma | Chromatin | Poly(ADP-ribose) | AKT protein | Nuclei | Body composition | Fibers | Proteins | Degradation | Atrophy | Genotype & phenotype | Signal transduction | Protein composition | Body composition (biology) | Ribose | Rodents | Diaphragm (anatomy) | Oxidation | Polymers | Deoxyribonucleic acid--DNA | NF-κB protein | Markers | Muscles | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Inflammation | Metabolism | Muscle contraction | Chronic conditions | Poly(ADP-ribose) Polymerase 1 | Proteasomes | Catabolism | Nuclei (cytology) | Mice | Diaphragm | Cancer | Index Medicus | 62D05 Sampling theory, sample surveys | 92D Genetics and population dynamics | 62H Multivariate analysis | 92 Biology and other natural sciences | Anàlisi multivariable | Matemàtica aplicada a les ciències | Classificació AMS | Multivariate analysis | Parp-1-/- and Parp-2-/- mice | Anàlisi numèrica | Genètica | Sampling (Statistics) | Mostreig (Estadística) | Matemàtiques i estadística | Genetics | Probabilitat | 62 Statistics | Àrees temàtiques de la UPC
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 06/2017, Volume 24, Issue 20, pp. 2156 - 2173
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that plays a critical role in diverse cellular functions, such as DNA damage detection and repair,... 
Biomarker | Synthetic lethality | Gastrointestinal cancer | Carcinogenesis | PARP inhibitors | Poly (ADP-ribose) polymerase-1 (PARP-1) | Poly (ADP-Ribose) Polymerase-1 - analysis | Gastrointestinal Neoplasms - genetics | Gastrointestinal Neoplasms - drug therapy | Humans | Gastrointestinal Tract - drug effects | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Drug Discovery | Gastrointestinal Tract - metabolism | Gastrointestinal Tract - pathology | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | Gastrointestinal Neoplasms - pathology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Animals | Antineoplastic Agents - pharmacology | Polymorphism, Single Nucleotide | Poly (ADP-Ribose) Polymerase-1 - genetics | Transcription | Gastrointestinal tract diseases | Pathogenesis | Liver | Gene regulation | DNA damage | Poly(ADP-ribose) | Disorders | Clinical trials | Single-nucleotide polymorphism | DNA repair | Inflammatory diseases | Enzymatic activity | Ribose | Pancreas | Deoxyribonucleic acid--DNA | Medical research | Neurodegenerative diseases | Medical treatment | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Esophagus | Neurological diseases | Poly(ADP-ribose) Polymerase 1 | Damage detection | Cell death | Tumors | Cancer | Polymorphism
Journal Article
Journal Article