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International Journal of Molecular Sciences, ISSN 1661-6596, 11/2016, Volume 17, Issue 11, pp. 1869 - 1869
Tumor necrosis factor receptor-associated factor 2 (TRAF2) is a critical mediator of tumor necrosis factor-alpha (TNF-alpha) signaling. However, the regulatory... 
TRAF2 | JNK | Tumor necrosis factor-α (TNF-α) | BIG1 | Apoptosis | APOPTOSIS | LOCALIZATION | ACTIVATION | PROTEIN | NECROPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | tumor necrosis factor-alpha (TNF-alpha); apoptosis | CHEMISTRY, MULTIDISCIPLINARY | CELL-DEATH | ADP-RIBOSYLATION FACTORS | RECYCLING ENDOSOMES | ARF-FAMILY | NF-KAPPA-B | RNA, Small Interfering - genetics | Luciferases - metabolism | Apoptosis - drug effects | Humans | TNF Receptor-Associated Factor 2 - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | Luciferases - genetics | Proteolysis - drug effects | Ubiquitination - drug effects | Guanine Nucleotide Exchange Factors - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Genes, Reporter | Guanine Nucleotide Exchange Factors - genetics | NF-kappa B - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Gene Expression Regulation | TNF Receptor-Associated Factor 2 - metabolism | Signal Transduction - genetics | Receptors, Tumor Necrosis Factor, Type I - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type I - genetics | Protein Transport | TNF Receptor-Associated Factor 2 - antagonists & inhibitors | Tumor Necrosis Factor-alpha - pharmacology | Guanine Nucleotide Exchange Factors - antagonists & inhibitors | NF-kappa B - genetics | Cell Line, Tumor | Protein Binding | HeLa Cells | RNA, Small Interfering - metabolism | Signal transduction | Tumor necrosis factor-TNF | Adenosine triphosphatase | apoptosis | tumor necrosis factor-α (TNF-α)
Journal Article
The Journal of cell biology, ISSN 0021-9525, 01/2019, Volume 218, Issue 1, pp. 285 - 298
Differential inclusion or skipping of microexons is an increasingly recognized class of alternative splicing events. However, the functional significance of... 
ACTIVATION | COMPLEX | DOMAIN | G-PROTEINS | KINASE | MET | CANCER | EPITHELIAL MORPHOGENESIS DOWNSTREAM | C-SRC | FAMILY | CELL BIOLOGY | Proto-Oncogene Proteins c-met - metabolism | RNA, Small Interfering - antagonists & inhibitors | RNA, Small Interfering - genetics | Phosphatidylinositol Phosphates - metabolism | Alternative Splicing | Exons | Humans | Cytosol - drug effects | Hepatocyte Growth Factor - pharmacology | Phosphatidylinositol Phosphates - chemistry | Phosphatidylinositol 4,5-Diphosphate - metabolism | Protein Isoforms - metabolism | ADP-Ribosylation Factors - antagonists & inhibitors | Guanine Nucleotide Exchange Factors - metabolism | Protein Isoforms - chemistry | HEK293 Cells | Hepatocyte Growth Factor - genetics | Cell Membrane - metabolism | ADP-Ribosylation Factors - metabolism | ADP-Ribosylation Factors - genetics | Binding Sites | Phosphatidylinositol 4,5-Diphosphate - chemistry | Cell Membrane - drug effects | Guanine Nucleotide Exchange Factors - genetics | Protein Structure, Secondary | Signal Transduction | Introns | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Models, Molecular | Amino Acid Motifs | Hepatocyte Growth Factor - metabolism | Proto-Oncogene Proteins c-met - genetics | Cell Movement - drug effects | Guanine Nucleotide Exchange Factors - antagonists & inhibitors | Protein Binding | Cytosol - metabolism | HeLa Cells | Protein Isoforms - antagonists & inhibitors | Guanine Nucleotide Exchange Factors - chemistry | Protein Isoforms - genetics | RNA, Small Interfering - metabolism
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2007, Volume 104, Issue 25, pp. 10370 - 10375
Small molecules that produce nonfunctional protein-protein complexes are an alternative to competitive inhibitors for the inhibition of protein functions. Here... 
Molecules | Microscopy | Anisotropy | Fluorescence | Small interfering RNA | HeLa cells | Kinetics | Gross domestic product | Binding sites | Crystal structure | Guanine nucleotide exchage factor | Inhibition | Arf1 factor | GTPase | Protein-protein interactions | GUANINE-NUCLEOTIDE-EXCHANGE | MECHANISM | MULTIDISCIPLINARY SCIENCES | inhibition | ADP-RIBOSYLATION FACTOR-1 | protein-protein interactions | INTERFACE | SMALL-MOLECULE INHIBITORS | FACTOR ARNO | guanine nucleotide exchage factor | BREFELDIN-A | RAC1 | DOWNSTREAM ACTIVATION | BINDING | Humans | Brefeldin A - pharmacology | Structure-Activity Relationship | GTPase-Activating Proteins - metabolism | Dose-Response Relationship, Drug | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Computer Simulation | Sensitivity and Specificity | ADP-Ribosylation Factor 1 - metabolism | Guanosine Diphosphate - metabolism | Protein Synthesis Inhibitors - pharmacology | Protein Structure, Tertiary | Cell Line | Aniline Compounds - pharmacology | Models, Molecular | ADP-Ribosylation Factor 1 - antagonists & inhibitors | Cell Movement - drug effects | Animals | Dogs | Benzimidazoles - pharmacology | GTPase-Activating Proteins - genetics | HeLa Cells | Mutation | Proteins - antagonists & inhibitors | ADP-Ribosylation Factor 1 - chemistry | Guanine Nucleotide Exchange Factors - chemistry | RNA, Small Interfering - metabolism | Research | G proteins | Guanosine triphosphatase | Guanine | Benzimidazoles | Aniline Compounds | Brefeldin A | Guanosine Diphosphate | Cellular Biology | Proteins | Life Sciences | ADP-Ribosylation Factor 1 | Protein Synthesis Inhibitors | GTPase-Activating Proteins | Biochemistry, Molecular Biology | Guanine Nucleotide Exchange Factors | RNA, Small Interfering | Hela Cells | Cell Movement | protein–protein interactions | Biological Sciences
Journal Article
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2014, Volume 111, Issue 34, pp. 12378 - 12383
Guanine nucleotide exchange factors (GEFs) of the exchange factor for Arf6 (EFA6), brefeldin A-resistant Arf guanine nucleotide exchange factor (BRAG), and... 
Negative feedback | Guanine nucleotide exchange factors | Control loops | Nuclear membrane | Lipids | Cell membranes | Liposomes | Nucleotides | Kinetics | Positive feedback | Membrane traffic | Endocytosis | Autoinhibition | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | POSITIVE FEEDBACK | MEMBRANE | MULTIDISCIPLINARY SCIENCES | G-PROTEINS | PH DOMAIN | autoinhibition | membrane traffic | FAMILY | STRUCTURAL BASIS | NUCLEOTIDE EXCHANGE FACTOR | endocytosis | kinetics | BINDING | CONFORMATIONAL SWITCH | Cell Adhesion Molecules - chemistry | Cell Adhesion Molecules - genetics | Membrane Glycoproteins - metabolism | Humans | Membrane Glycoproteins - chemistry | Guanosine Triphosphate - metabolism | Nerve Tissue Proteins - chemistry | Guanine Nucleotide Exchange Factors - metabolism | ADP-Ribosylation Factor 1 - metabolism | Sulfotransferases - metabolism | Protein Interaction Domains and Motifs | ADP-Ribosylation Factor 1 - genetics | ADP-Ribosylation Factors - metabolism | Guanosine Diphosphate - metabolism | ADP-Ribosylation Factors - genetics | Recombinant Proteins - metabolism | Sulfotransferases - genetics | Cell Line | Cricetinae | Guanine Nucleotide Exchange Factors - genetics | Mutagenesis, Site-Directed | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cell Adhesion Molecules - metabolism | Nerve Tissue Proteins - genetics | Membrane Glycoproteins - genetics | Nerve Tissue Proteins - metabolism | ADP-Ribosylation Factors - chemistry | Feedback, Physiological | Animals | Models, Biological | Enzyme Activation | ADP-Ribosylation Factor 1 - chemistry | Sulfotransferases - chemistry | Amino Acid Substitution | Guanine Nucleotide Exchange Factors - chemistry | Physiological aspects | Protein research | Research | Guanosine triphosphatase | Protein-protein interactions | Membrane proteins | Biological Sciences
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2008, Volume 414, Issue 2, pp. 189 - 194
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, p. e0148097
High reactive oxygen species (ROS) levels and enhanced vascular smooth muscle cells (VSMC) proliferation are observed in numerous cardiovascular diseases. The... 
MIGRATION | PATHWAYS | COMPLEX | PROTEIN | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | GROWTH | CARDIOVASCULAR-DISEASE | RECEPTOR | RAC1 | DOWNSTREAM ACTIVATION | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | Reactive Oxygen Species - metabolism | Muscle, Smooth, Vascular - metabolism | Receptor, Angiotensin, Type 1 - genetics | Receptor, Epidermal Growth Factor - metabolism | MAP Kinase Kinase 4 - metabolism | ADP-Ribosylation Factors - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | ADP-Ribosylation Factors - metabolism | Myocytes, Smooth Muscle - drug effects | NADH, NADPH Oxidoreductases - metabolism | ADP-Ribosylation Factors - genetics | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Muscle, Smooth, Vascular - drug effects | Vasoconstrictor Agents - pharmacology | Cell Line | NADH, NADPH Oxidoreductases - genetics | Angiotensin II - pharmacology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Gene Expression Regulation | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Muscle, Smooth, Vascular - cytology | NADPH Oxidase 1 | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Receptor, Angiotensin, Type 1 - metabolism | MAP Kinase Kinase 4 - genetics | Cell Proliferation - drug effects | rac1 GTP-Binding Protein - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | rac1 GTP-Binding Protein - genetics | Cell proliferation | Angiotensin | Physiological aspects | Smooth muscle | Genetic aspects | Research | Guanosine triphosphatase | ADP-ribosylation factor | Molecular machines | GTP-binding protein | Oxidase | Intracellular signalling | Activation | Hormones | Kinases | ADP-ribosylation factor 6 | NAD(P)H oxidase | Cell adhesion & migration | Proteins | Signal transduction | Cell growth | Epidermal growth factor | Rodents | Aorta | Ribosylation | Angiotensin II | Heart diseases | ADP-ribosylation | Enzymes | Immunoglobulins | Epidermal growth factor receptors | RNA-mediated interference | Muscles | Extracellular signal-regulated kinase | Adenosine diphosphate | MAP kinase | Rac1 protein | JNK protein | Superoxide | Pharmacology | Gene expression | Ribonucleic acid--RNA | Medicine | Cardiovascular diseases | Guanosinetriphosphatase | RNA | Ribonucleic acid
Journal Article