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European journal of human genetics, ISSN 1018-4813, 2011, Volume 19, Issue 6, pp. 655 - 661
In view of the population-specific heterogeneity in reported genetic risk factors for Parkinson's disease (PD), we conducted a genome-wide association study... 
BST1 | MAPT | HLA | GAK/DGKQ | SNCA | DOPAMINERGIC FUNCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA-SYNUCLEIN PROMOTER | REACTIVE MICROGLIA | MAPT REGION | SUBSTANTIA-NIGRA | POSITRON-EMISSION-TOMOGRAPHY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | GENETICS & HEREDITY | TAU-GENE HAPLOTYPE | NIGRA PARS COMPACTA | SPORADIC PARKINSONS-DISEASE | ADP-ribosyl Cyclase - biosynthesis | Antigens, CD - biosynthesis | DNA Fingerprinting | Humans | Middle Aged | GPI-Linked Proteins - biosynthesis | Male | Genetic Loci | Antigens, CD - genetics | Case-Control Studies | tau Proteins - biosynthesis | Netherlands | tau Proteins - genetics | alpha-Synuclein - biosynthesis | Aged, 80 and over | Adult | Female | alpha-Synuclein - genetics | Intracellular Signaling Peptides and Proteins - genetics | ADP-ribosyl Cyclase - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Gene Frequency | Risk Factors | Protein-Serine-Threonine Kinases - genetics | Genotype | Parkinson Disease - genetics | Protein-Serine-Threonine Kinases - biosynthesis | Adolescent | Age of Onset | Aged | Polymorphism, Single Nucleotide | GPI-Linked Proteins - genetics | Haplotypes | Parkinson's disease | Neurodegenerative diseases | Genomics | Linkage disequilibrium | Parkinsons disease | Genomes | Single-nucleotide polymorphism | Kinases | Gene expression | Risk factors | Cell adhesion & migration | Neurology | Rheumatoid arthritis | Quality control | Population | Genetics | Replication | Histocompatibility antigen HLA | Chromosomes | Age | Movement disorders | GAK | DGKQ
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 07/2003, Volume 112, Issue 2, pp. 286 - 297
  The generation of Ig-secreting cells (ISCs) from memory B cells requires interactions between antigen-specific (Ag-specific) B cells, T cells, and dendritic... 
Journal Article
Leukemia, ISSN 0887-6924, 05/2005, Volume 19, Issue 5, pp. 750 - 758
Prognostic predictions in B-cell chronic lymphocytic leukemia (B-CLL) at early clinical stage are based on biological disease parameters, such as ZAP-70 and... 
cDNA microarray analysis | B-cell chronic lymphocytic leukemia (B-CLL) | Genomic aberrations | CD38 antigen | IgV | Protein tyrosine kinase ZAP-70 | status | PROTOCOLS | CLL PATIENTS | IMMUNOGLOBULIN | IgV(H) status | CLASSIFICATION | protein tyrosine kinase ZAP-70 | genomic aberrations | PROGNOSTIC-FACTOR | ONCOLOGY | ABC-TRANSPORTER TAP | GENES | RESISTANCE | MICROARRAYS | VARIABLE-REGION MUTATIONS | HEMATOLOGY | Predictive Value of Tests | ADP-ribosyl Cyclase - biosynthesis | Antigens, CD - biosynthesis | Humans | Middle Aged | ZAP-70 Protein-Tyrosine Kinase | Male | ADP-ribosyl Cyclase 1 | Gene Expression Profiling | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Antigens, CD - genetics | Antigens, CD - analysis | Protein-Tyrosine Kinases - genetics | Aged, 80 and over | Adult | Female | Membrane Glycoproteins | Protein-Tyrosine Kinases - biosynthesis | ADP-ribosyl Cyclase - genetics | Immunoglobulin Heavy Chains - analysis | Reproducibility of Results | Oligonucleotide Array Sequence Analysis - methods | Gene Expression Regulation, Leukemic | Disease Progression | Gene Expression Regulation, Enzymologic | ADP-ribosyl Cyclase - analysis | Chromosome Aberrations | Survival Analysis | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - mortality | Mutation | Protein-Tyrosine Kinases - analysis | In Situ Hybridization, Fluorescence - methods | Immunoglobulin Heavy Chains - genetics
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 07/2003, Volume 112, Issue 2, pp. 286 - 297
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 09/2004, Volume 200, Issue 5, pp. 587 - 599
Journal Article
The Journal of Immunology, ISSN 0022-1767, 08/2004, Volume 173, Issue 4, pp. 2410 - 2418
Journal Article
Molecular and Cellular Biochemistry, ISSN 0300-8177, 7/2012, Volume 366, Issue 1, pp. 69 - 80
Cyclic ADP-ribose (cADPR), a metabolite of NAD+, is known to function as a second messenger for intracellular Ca2+ mobilization in various vertebrate and... 
Life Sciences | Biochemistry, general | Cyclic ADP-ribose hydrolase | Xenopus laevis | Medical Biochemistry | Oncology | CD38 | Cardiology | CD157 | ADP-ribosyl cyclase | ACTIVE-SITE | SCHISTOSOMA-MANSONI | BETA-CELLS | CYCLASE ACTIVITY | CELL BIOLOGY | INOSITOL 1,4,5-TRISPHOSPHATE | CALCIUM-MOBILIZING METABOLITES | 2ND-MESSENGER ENZYME | SURFACE GLYCOPROTEIN | NAD(+) GLYCOHYDROLASE | LEUKOCYTE ANTIGEN CD38 | ADP-ribosyl Cyclase - biosynthesis | NAD - analogs & derivatives | Xenopus Proteins - genetics | Antigens, CD - biosynthesis | Humans | Brain - enzymology | Cercopithecus aethiops | GPI-Linked Proteins - biosynthesis | Molecular Sequence Data | Phylogeny | Antigens, CD - genetics | Xenopus Proteins - chemistry | NAD - chemistry | Inosine Nucleotides - chemistry | Base Sequence | Cloning, Molecular | Conserved Sequence | Xenopus Proteins - biosynthesis | Antigens, CD - chemistry | Xenopus laevis - genetics | ADP-ribosyl Cyclase - genetics | Recombinant Fusion Proteins - biosynthesis | Amino Acid Sequence | ADP-ribosyl Cyclase 1 - genetics | Recombinant Fusion Proteins - chemistry | ADP-ribosyl Cyclase - chemistry | Organ Specificity | Sequence Analysis, DNA | Cyclic ADP-Ribose - biosynthesis | Hydrolysis | ADP-ribosyl Cyclase 1 - chemistry | Animals | GPI-Linked Proteins - chemistry | ADP-ribosyl Cyclase 1 - biosynthesis | Recombinant Fusion Proteins - genetics | Kinetics | COS Cells | Cyclic ADP-Ribose - metabolism | Evolution, Molecular | GPI-Linked Proteins - genetics | Frogs | Enzymes | Metabolites | Polyacrylamide | Physiological aspects | Amino acids | Hydrolases | Sugars | Monosaccharides | Signal transduction | Biosynthesis | Evolution & development
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2013, Volume 288, Issue 36, pp. 25938 - 25949
NAD(+) is mainly synthesized in human cells via the "salvage" pathways starting from nicotinamide, nicotinic acid, or nicotinamide riboside (NR). The... 
NAMPT INHIBITION | IN-VITRO | CYCLIC-ADP-RIBOSE | CHS 828 | ENZYME | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE | CD38 | FK866 | LYMPHOCYTES | 5'-Nucleotidase - genetics | Gene Expression Regulation, Enzymologic - drug effects | Humans | Membrane Glycoproteins - biosynthesis | GPI-Linked Proteins - biosynthesis | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors | Neoplasms - genetics | Nicotinamide Phosphoribosyltransferase - metabolism | Piperidines - pharmacology | NAD - biosynthesis | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Acrylamides - pharmacology | Cytokines - genetics | Gene Expression Regulation, Neoplastic - genetics | 5'-Nucleotidase - biosynthesis | NAD - genetics | ADP-ribosyl Cyclase 1 - genetics | Cytokines - metabolism | Gene Silencing | Neoplasms - enzymology | Down-Regulation - drug effects | Down-Regulation - genetics | Membrane Glycoproteins - genetics | Neoplasms - drug therapy | Nicotinamide Phosphoribosyltransferase - genetics | Gene Expression Regulation, Enzymologic - genetics | ADP-ribosyl Cyclase 1 - biosynthesis | Cell Line, Tumor | Cytokines - antagonists & inhibitors | Nicotinamide Mononucleotide - biosynthesis | Nicotinamide Mononucleotide - genetics | GPI-Linked Proteins - genetics | NAD | Cancer Therapy | CD73 | Nicotinamide Riboside | NAD Biosynthesis | Signal Transduction | Cell Death | Nicotinamide Mononucleotide | Nicotinamide
Journal Article
Cancer Research, ISSN 0008-5472, 10/2015, Volume 75, Issue 19, pp. 4074 - 4085
Myeloid-derived suppressor cells (MDSC) are an immunosuppressive population of immature myeloid cells found in advanced-stage cancer patients and mouse tumor... 
CYCLIC ADP-RIBOSE | GENE | MICROENVIRONMENT | ONCOLOGY | IMMUNE SUPPRESSION | INFLAMMATION | MOUSE MODEL | TRANSCRIPTION | NITRIC-OXIDE | CD38 |