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Neuropsychopharmacology, ISSN 0893-133X, 11/2015, Volume 40, Issue 12, pp. 2696 - 2704
  Cocaine dependence is characterized by compulsive drug taking and reduced involvement in social, occupational, or recreational activities. Unraveling the... 
Journal Article
Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 01/2006, Volume 117, Issue 1, pp. 18 - 24
The human β -adrenoceptor is a member of the 7-transmembrane family of receptors, encoded by a gene on chromosome 5, and widely distributed in the respiratory... 
agonists | Desensitization | Adrenergic receptor | Polymorphisms
Journal Article
Circulation Research, ISSN 0009-7330, 11/2006, Volume 99, Issue 10, pp. 1084 - 1091
β1- and β2-adrenergic receptors (βARs) are known to differentially regulate cardiomyocyte contraction and growth. We tested the hypothesis that these... 
FRET | β-adrenergic receptor | cAMP | Cardiomyocyte
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2019, Volume 514, Issue 1, pp. 295 - 300
Neuroblastoma (NB), the most common extracranial solid tumor in childhood, always leads to an unfavorable prognosis. β3-adrenergic receptor (β3-AR) signaling... 
mTOR | Neuroblastoma | β3-adrenergic receptor | Proliferation
Journal Article
Circulation Research, ISSN 0009-7330, 06/2011, Volume 108, Issue 12, pp. 1448 - 1458
RATIONALE:Exercise training confers sustainable protection against ischemia–reperfusion injury in animal models and has been associated with improved survival... 
cardioprotection | exercise | nitric oxide | nitrite | β3-adrenergic receptor | nitrosothiol
Journal Article
NATURE, ISSN 0028-0836, 10/2013, Volume 502, Issue 7472, pp. 575 - 575
G-protein-coupled receptors (GPCRs) are integral membrane proteins that have an essential role in human physiology, yet the molecular processes through which... 
ADRENOCEPTOR | COMPLEX | DISPLAY | LIGAND-BINDING | SERINE | PROTEIN-COUPLED RECEPTOR | MULTIDISCIPLINARY SCIENCES | RHODOPSIN | STATE | ADRENERGIC-RECEPTOR | AGONIST
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2014, Volume 111, Issue 48, pp. 17296 - 17301
Journal Article
NATURE, ISSN 0028-0836, 09/2011, Volume 477, Issue 7366, pp. 549 - U311
G protein-coupled receptors (GPCRs) are responsible for the majority of cellular responses to hormones and neurotransmitters as well as the senses of sight,... 
CRYSTALLIZATION | LIPIDIC MESOPHASES | ALPHA-SUBUNIT | MULTIDISCIPLINARY SCIENCES | COUPLED RECEPTOR | MEDIATED ACTIVATION | MEMBRANE-PROTEINS | ADENYLATE-CYCLASE | BINDING | BETA-ADRENERGIC RECEPTOR | INSIGHTS
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 08/2010, Volume 132, Issue 33, pp. 11443 - 11445
G protein-coupled receptors (GPCRs) represent a large fraction of current pharmaceutical targets, and of the GPCRs, the beta(2) adrenergic receptor (beta(2)AR)... 
CONFORMATIONAL-CHANGES | PROTEIN-COUPLED RECEPTOR | LIGAND | CHEMISTRY, MULTIDISCIPLINARY | BETA-ADRENERGIC RECEPTOR | PREDICTION
Journal Article
NATURE, ISSN 0028-0836, 08/2015, Volume 524, Issue 7565, pp. 315 - 315
Activation of the mu-opioid receptor (mu OR) is responsible for the efficacy of the most effective analgesics. To shed light on the structural basis for mu OR... 
CRYSTALLIZING MEMBRANE-PROTEINS | COMPLEX | LIPIDIC MESOPHASES | PROTEIN-COUPLED RECEPTOR | MULTIDISCIPLINARY SCIENCES | FORCE-FIELD | ADRENERGIC-RECEPTOR | MOLECULAR-DYNAMICS SIMULATIONS | CHARMM | MICE LACKING | MUSCARINIC ACETYLCHOLINE-RECEPTOR
Journal Article
BJU INTERNATIONAL, ISSN 1464-4096, 06/2018, Volume 121, Issue 6, pp. 821 - 821
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/1997, Volume 100, Issue 12, pp. 3184 - 3188
Journal Article
SCIENCE, ISSN 0036-8075, 11/2007, Volume 318, Issue 5854, pp. 1258 - 1265
Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors constitute the largest family of eukaryotic signal transduction proteins that... 
MOLECULAR-MECHANISM | CRYSTALLIZATION | ACTIVATION | HUMAN GENOME | LIGAND-BINDING | BETA-ADRENERGIC-RECEPTOR | MEMBRANE | MULTIDISCIPLINARY SCIENCES | RHODOPSIN | HUMAN BETA-2-ADRENERGIC RECEPTOR | AGONIST
Journal Article
NATURE, ISSN 0028-0836, 11/2007, Volume 450, Issue 7168, pp. 383 - U4
Structural analysis of G-protein-coupled receptors (GPCRs) for hormones and neurotransmitters has been hindered by their low natural abundance, inherent... 
CRYSTALLIZATION | AGONIST ACTIVATION | DOMAIN | CONFORMATIONAL-CHANGES | LIGAND-BINDING | BOVINE RHODOPSIN | MULTIDISCIPLINARY SCIENCES | INTERMEDIATE | CRYSTALLOGRAPHY | BACTERIORHODOPSIN | BETA-ADRENERGIC RECEPTOR
Journal Article
NATURE, ISSN 0028-0836, 05/2016, Volume 533, Issue 7602, pp. 265 - 265
Conformational selection and induced fit are two prevailing mechanisms(1,2) to explain the molecular basis for ligand-based activation of receptors.... 
DYNAMIC PROCESS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | EQUILIBRIUM | RHODOPSIN | PICHIA-PASTORIS | LANDSCAPES | BINDING | EXPRESSION | BETA-ADRENERGIC RECEPTOR | PROPAGATION
Journal Article
01/2012
To interfere with the drug-cue memory processes of addicts such as reconsolidation by the administration of the β-adrenergic receptor (β-AR) of norepinephrine... 
β-adrenergic receptor | Conditioned place preference | Memory | Opioid | Acquisition Retrieval
Web Resource
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 04/2010, Volume 181, Issue 7, pp. 676 - 687
Journal Article
NATURE, ISSN 0028-0836, 08/2015, Volume 524, Issue 7565, pp. 375 - 375
mu-Opioid receptors (mu ORs) are G-protein-coupled receptors that are activated by a structurally diverse spectrum of natural and synthetic agonists including... 
DYNAMIC PROCESS | COMPLEX | EFFICACY | PROTEIN-COUPLED RECEPTOR | CRYSTAL-STRUCTURE | NMR-SPECTROSCOPY | MULTIDISCIPLINARY SCIENCES | RHODOPSIN | BETA-ADRENERGIC RECEPTOR | ANALGESIA | AGONIST
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 03/2008, Volume 376, Issue 5, pp. 1305 - 1319
G protein-coupled receptor (GPCR) instability represents one of the most profound obstacles in the structural study of GPCRs that bind diffusible ligands. The... 
adrenergic receptor | GPCR | membrane | mutagenesis | stability
Journal Article
SCIENCE, ISSN 0036-8075, 03/2012, Volume 335, Issue 6072, pp. 1106 - 1110
Extracellular ligand binding to G protein-coupled receptors (GPCRs) modulates G protein and beta-arrestin signaling by changing the conformational states of... 
PARTIAL AGONISTS | BETA-2-ADRENERGIC RECEPTOR | BETA ADRENERGIC-RECEPTOR | CONFORMATIONAL-CHANGES | LIGAND-BINDING | PROTEIN-COUPLED RECEPTOR | TRANSMEMBRANE RECEPTORS | CRYSTAL-STRUCTURE | NMR-SPECTROSCOPY | MULTIDISCIPLINARY SCIENCES | A(2A) ADENOSINE RECEPTOR
Journal Article
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