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Science, ISSN 0036-8075, 2/2011, Volume 331, Issue 6018, pp. 768 - 772
Endocrine tumors such as aldosterone-producing adrenal adenomas (APAs), a cause of severe hypertension, feature constitutive hormone production and... 
Depolarization | Hypertension | Somatic mutation | Cell growth | Hyperaldosteronism | REPORTS | Loss of heterozygosity | Adenoma | Genetic mutation | Sequencing | Tumors | REMEDIABLE ALDOSTERONISM | HUMAN BREAST | COLORECTAL CANCERS | ADRENOCORTICAL-CELLS | MULTIDISCIPLINARY SCIENCES | CONDUCTION | GLOMERULOSA CELLS | IDENTIFICATION | MOLECULAR-BASIS | SELECTIVITY | POTASSIUM CHANNEL | Adrenal Glands - pathology | Potassium - metabolism | Cell Proliferation | Humans | Hyperaldosteronism - pathology | Hyperplasia | Protein Multimerization | Zona Glomerulosa - pathology | Male | Hyperaldosteronism - metabolism | Sodium - metabolism | Aldosterone - metabolism | Adrenocortical Adenoma - genetics | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Female | Hypertension - genetics | Adrenal Cortex Neoplasms - metabolism | Cell Line | G Protein-Coupled Inwardly-Rectifying Potassium Channels - chemistry | Hyperaldosteronism - genetics | Mutant Proteins - genetics | Mutant Proteins - metabolism | Zona Glomerulosa - metabolism | Adrenal Cortex Neoplasms - pathology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Adrenocortical Adenoma - pathology | Adrenocortical Adenoma - metabolism | Hypertension - metabolism | Adrenal Cortex Neoplasms - genetics | Mutant Proteins - chemistry | Mutation | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Hypertension, ISSN 0194-911X, 01/2014, Volume 63, Issue 1, pp. 188 - 195
Journal Article
Clinical Endocrinology, ISSN 0300-0664, 02/2008, Volume 68, Issue 2, pp. 264 - 270
Journal Article
HUMAN MOLECULAR GENETICS, ISSN 0964-6906, 02/2014, Volume 23, Issue 4, pp. 889 - 905
Primary aldosteronism (PA) is the main cause of secondary hypertension, resulting from adrenal aldosterone-producing adenomas (APA) or bilateral hyperplasia.... 
CANCER-CELLS | FREQUENT EPIGENETIC INACTIVATION | ADRENAL-CORTEX | ZONA GLOMERULOSA | COLORECTAL-CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | GENE-EXPRESSION | KCNJ5 MUTATIONS | BETA-CATENIN | ADRENOCORTICAL TUMORS | SOMATIC MUTATIONS | Adrenal Cortex Neoplasms - complications | Aldosterone - biosynthesis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Hyperaldosteronism - metabolism | Mice, 129 Strain | Nuclear Receptor Subfamily 4, Group A, Member 2 - genetics | Hyperaldosteronism - etiology | Adult | Female | Membrane Proteins - metabolism | Adrenal Cortex Neoplasms - metabolism | Cytochrome P-450 CYP11B2 - metabolism | Wnt Signaling Pathway | Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics | Membrane Proteins - genetics | Down-Regulation | Mice, Inbred C57BL | Aldosterone - blood | Aldosterone - secretion | Adrenocortical Adenoma - metabolism | Mice, Knockout | Animals | Cell Line, Tumor | Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism | Mice | Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism | Adrenocortical Adenoma - complications | Cytochrome P-450 CYP11B2 - genetics | Index Medicus | Animal genetics | Cytochrome P-450 CYP11B2 | Hyperaldosteronism | Genomics | Nuclear Receptor Subfamily 4, Group A, Member 1 | Nuclear Receptor Subfamily 4, Group A, Member 2 | Aldosterone | Embryology and Organogenesis | Life Sciences | Genetics | Endocrinology and metabolism | Biochemistry, Molecular Biology | Adrenocortical Adenoma | Membrane Proteins | Human health and pathology | Adrenal Cortex Neoplasms | Development Biology | Molecular biology | Cancer
Journal Article
Nature Genetics, ISSN 1061-4036, 09/2013, Volume 45, Issue 9, pp. 1050 - 1054
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 01/2016, Volume 6, Issue 1, pp. 19546 - 19546
Journal Article
Nature Genetics, ISSN 1061-4036, 04/2013, Volume 45, Issue 4, pp. 440 - 444
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 08/2015, Volume 411, Issue C, pp. 146 - 154
Journal Article
Journal Article
Endocrinology, ISSN 0013-7227, 12/2015, Volume 156, Issue 12, pp. 4582 - 4591
Aldosterone-producing adenoma (APA) is a major cause of primary aldosteronism, leading to secondary hypertension. Somatic mutations in the gene for the α1... 
NA/K-ATPASE | SEVERE HYPERALDOSTERONISM | ENDOCRINOLOGY & METABOLISM | NCI-H295 CELLS | ADRENOCORTICAL CELL-LINE | KCNJ5 MUTATIONS | ANGIOTENSIN-II | K+ CHANNEL | SOMATIC MUTATIONS | ZONA GLOMERULOSA CELLS | POTASSIUM CHANNEL | Sodium-Potassium-Exchanging ATPase - genetics | Adrenal Cortex Neoplasms -