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Endocrinology, ISSN 0013-7227, 11/2015, Volume 156, Issue 11, pp. 3895 - 3908
Adrenocortical carcinoma (ACC) is a rare malignancy that harbors a dismal prognosis in advanced stages. Mitotane is approved as an orphan drug for treatment of... 
ADJUVANT MITOTANE | ACTIVATION | UNFOLDED PROTEIN RESPONSE | CHOLESTERYL ESTER | METABOLISM | QUANTIFICATION | MITOCHONDRIA | ENDOCRINOLOGY & METABOLISM | ACAT | CANCER | EXPRESSION | Immunohistochemistry | Transcription Factor CHOP - genetics | Gas Chromatography-Mass Spectrometry | Oligonucleotide Array Sequence Analysis | Apoptosis - drug effects | Humans | Immunoblotting | Endoplasmic Reticulum Stress - genetics | Mitotane - pharmacology | Adrenocortical Carcinoma - drug therapy | Antineoplastic Agents, Hormonal - therapeutic use | Adrenocortical Carcinoma - metabolism | HEK293 Cells | Sterol O-Acyltransferase - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Adrenal Cortex Neoplasms - metabolism | Cell Survival - drug effects | Antineoplastic Agents, Hormonal - pharmacology | Endoplasmic Reticulum Stress - drug effects | Adrenocortical Carcinoma - genetics | Transcriptome - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Mitotane - therapeutic use | Hep G2 Cells | Adrenal Cortex Neoplasms - drug therapy | Adrenal Cortex Neoplasms - genetics | Disease-Free Survival | Cell Line, Tumor | Sterol O-Acyltransferase - genetics | HeLa Cells | Lipids - analysis | Transcription Factor CHOP - metabolism | Sterol O-Acyltransferase - antagonists & inhibitors | Index Medicus | Abridged Index Medicus
Journal Article
Endocrine-Related Cancer, ISSN 1351-0088, 04/2016, Volume 23, Issue 4, pp. 1 - 19
Adrenocortical carcinoma (ACC) generally has poor prognosis. Existing treatments provide limited benefit for most patients with locally advanced or metastatic... 
Adrenalytic activity | Mitochondrial oxidative phosphorylation | Experimental therapy | Adrenocortical carcinoma | Reactive oxygen release | HUMAN NEUROBLASTOMA-CELLS | reactive oxygen release | MITOTANE | LIPID-PEROXIDATION | BEAGLE DOGS | adrenocortical carcinoma | COA-CHOLESTEROL ACYLTRANSFERASE | ALPHA-TOCOPHEROL | ACYL-COA | CANCER | adrenalytic activity | experimental therapy | PD-132301-2 | ONCOLOGY | ENDOCRINOLOGY & METABOLISM | ACAT INHIBITOR | mitochondrial oxidative phosphorylation | Cell Survival - drug effects | Guinea Pigs | Reactive Oxygen Species - metabolism | Humans | Adrenal Cortex - metabolism | Phenylurea Compounds - therapeutic use | Antineoplastic Agents - therapeutic use | Adrenal Cortex Neoplasms - pathology | Mitochondria - drug effects | Membrane Potential, Mitochondrial - drug effects | Mice, SCID | Rats, Sprague-Dawley | Adrenal Cortex Neoplasms - drug therapy | Adrenocortical Carcinoma - pathology | Adrenocortical Carcinoma - drug therapy | Animals | Tumor Burden - drug effects | Adrenocortical Carcinoma - metabolism | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Phenylurea Compounds - pharmacology | Adrenal Cortex - drug effects | Mitochondria - physiology | Adrenal Cortex Neoplasms - metabolism | Index Medicus | Apoptosis of adrenocortical carcinoma cells in culture and in xenografts | Hyperpolarization of mitochondrial membranes and reactive oxygen production | Roles of reactive oxygen in adrenalytic activity | Suppression of cytotoxicity by lipophilic antioxidants | Inhibition of F1F0-ATPase activity and oxidative phosphorylation
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, pp. e103744 - e103744
Insulin-like growth factor 2 (IGF2) overexpression is an important molecular marker of adrenocortical carcinoma (ACC), which is a rare but devastating... 
INSULIN | MALIGNANCY | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | FACTOR SYSTEM | RECEPTOR | LARGE COHORT | TUMORS | EXPRESSION | TUMORIGENESIS | FACTOR-II GENE | Genomic Imprinting | Cell Proliferation | Prognosis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Apoptosis - genetics | Male | Genetic Loci | RNA, Messenger - metabolism | Gene Knockdown Techniques | Young Adult | Adrenocortical Carcinoma - pathology | Insulin-Like Growth Factor II - genetics | Aged, 80 and over | G1 Phase Cell Cycle Checkpoints | Adult | Female | Adrenocortical Carcinoma - genetics | RNA, Messenger - genetics | Chromosomes, Human, Pair 11 - genetics | DNA Methylation - genetics | Signal Transduction - genetics | Insulin-Like Growth Factor II - metabolism | Phenotype | Adolescent | Cell Line, Tumor | Aged | Epigenetic inheritance | Platelet-derived growth factor | Carcinoma | Growth | Development and progression | Fibroblast growth factors | Comparative analysis | Cancer | Adrenal glands | Fibroblast growth factor receptor 9 | Insulin-like growth factors | Kinases | Proteins | Pathways | Cattle | Chromosome 11 | Tumorigenesis | Insulin-like growth factor II | Growth factors | Protein-tyrosine kinase | G1 phase | Tyrosine | Therapeutic applications | Cell division | Gene expression | Insulin | Loci | Uniparental disomy | Medical prognosis | Mutation | Tumors | Apoptosis | Index Medicus | Life Sciences | Biochemistry, Molecular Biology
Journal Article
Toxicological sciences : an official journal of the Society of Toxicology, ISSN 1096-6080, 01/2015, Volume 143, Issue 1, pp. 126 - 135
Several pesticides suspected or known to have endocrine disrupting effects were screened for pro- or antiandrogenic properties by determining their effects on... 
CYP17 | H295R | androgen receptor | LNCaP | pesticides | SRD5A1 | ENDOCRINE-DISRUPTING CHEMICALS | CANCER CELLS | MALE-RAT | ANDROGEN RECEPTOR PHOSPHORYLATION | IN-VITRO | FUNGICIDE PROCHLORAZ | GROWTH | TOXICOLOGY | DERIVATIVES | VINCLOZOLIN | EXPOSURE | Prostatic Neoplasms - metabolism | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Humans | Receptors, Androgen - metabolism | Male | Dose-Response Relationship, Drug | Adrenocortical Carcinoma - pathology | Adrenocortical Carcinoma - drug therapy | Prostatic Neoplasms - genetics | Receptors, Androgen - drug effects | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Adrenocortical Carcinoma - metabolism | Dihydrotestosterone - pharmacology | Membrane Proteins - metabolism | Prostate-Specific Antigen - metabolism | Adrenal Cortex Neoplasms - metabolism | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Antineoplastic Agents, Hormonal - pharmacology | Adrenocortical Carcinoma - genetics | Membrane Proteins - genetics | Androgen Antagonists - pharmacology | Imidazoles - pharmacology | Adrenal Cortex Neoplasms - pathology | Adrenal Cortex Neoplasms - drug therapy | Adrenal Cortex Neoplasms - genetics | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Membrane Proteins - antagonists & inhibitors | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Benomyl - pharmacology | Cell Line, Tumor | Steroid 17-alpha-Hydroxylase - genetics | Cell Proliferation - drug effects | Oxazoles - pharmacology | Steroid 17-alpha-Hydroxylase - metabolism | Kallikreins - metabolism | Pesticides - pharmacology | Index Medicus | Life Sciences
Journal Article
Endocrine, ISSN 1355-008X, 12/2014, Volume 47, Issue 3, pp. 943 - 951
Journal Article
Journal Article
Cancer Cell International, ISSN 1475-2867, 03/2018, Volume 18, Issue 1, pp. 29 - 29
Background: New disease progression despite surgery and adjuvant therapy with mitotane. In this study, we aimed to investigate the in vitro effects of... 
Nilotinib | Adrenocortical carcinoma cells | Spheroid cell culture | Mitotane | PATHWAYS | ACTIVATION | RECEPTOR | TUMORS | MODELS | ONCOLOGY | GROWTH | IMATINIB | SUNITINIB | RESISTANCE | EXPRESSION
Journal Article
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 03/2009, Volume 300, Issue 1-2, pp. 115 - 120
Adrenocortical carcinoma is an uncommon malignancy and feminizing symptoms secondary to adrenal estrogen-secretion are extremely rare. The direct secretion of... 
17β-Hydroxysteroid dehydrogenase type 5 | Estrogen biosynthesis | Aromatase | AKR1C3 | CYP19 | Human adrenal cortex | Human adrenocortical H295 cells | 17 beta-Hydroxysteroid dehydrogenase type 5 | MODEL | BREAST | CELL BIOLOGY | LINE | ENDOCRINOLOGY & METABOLISM | RECEPTORS | EXPRESSION | AROMATASE CYP19 | Vasoactive Intestinal Peptide - metabolism | Progesterone Reductase - metabolism | Humans | Aromatase - metabolism | Steroid 11-beta-Hydroxylase - genetics | Aromatase - genetics | Hydroxyprostaglandin Dehydrogenases | Colforsin - metabolism | Adult | Female | 3-Hydroxysteroid Dehydrogenases | Adrenal Cortex Neoplasms - metabolism | Cytochrome P-450 CYP11B2 - metabolism | Promoter Regions, Genetic | Estrogens - biosynthesis | Adrenal Cortex Neoplasms - pathology | Progesterone Reductase - genetics | Steroid 11-beta-Hydroxylase - metabolism | Aldo-Keto Reductase Family 1 Member C3 | 17-Hydroxysteroid Dehydrogenases - genetics | Cell Line, Tumor | Steroid 17-alpha-Hydroxylase - genetics | Steroid 17-alpha-Hydroxylase - metabolism | 17-Hydroxysteroid Dehydrogenases - metabolism | Cytochrome P-450 CYP11B2 - genetics | Immunohistochemistry | Care and treatment | Messenger RNA | Carcinoma | Cytochrome P-450 | Physiological aspects | Phenols | Vasoactive intestinal peptides | Estradiol | Cancer | Index Medicus | human adrenocortical H295 cells | aromatase | human adrenal cortex | estrogen biosynthesis | 17β-hydroxysteroid dehydrogenase type 5
Journal Article