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1. Full Text Indications and Outcome of Pelvic Exenteration for Locally Advanced Primary and Recurrent Rectal Cancer
by Bhangu, Aneel and Mohammed Ali, S and Brown, Gina and Nicholls, R John and Tekkis, Paris
Annals of Surgery, ISSN 0003-4932, 02/2014, Volume 259, Issue 2, pp. 315 - 322
OBJECTIVE:The outcome of pelvic exenteration was compared in patients with locally advanced primary (LAP) cancer and recurrent rectal cancer (RRC).... 
recurrent rectal cancer | locally advanced rectal cancer | exenteration | SURGERY | MESORECTAL EXCISION | RADICAL RESECTION | CHEMORADIATION | Humans | Middle Aged | Carcinoma - mortality | Male | Chemoradiotherapy, Adjuvant | Neoplasm Recurrence, Local - mortality | Neoplasm Recurrence, Local - surgery | Neoplasm Recurrence, Local - pathology | Aged, 80 and over | Adult | Female | Neoadjuvant Therapy | Rectal Neoplasms - pathology | Carcinoma - pathology | Rectal Neoplasms - surgery | Carcinoma - surgery | Neoplasm Recurrence, Local - therapy | Treatment Outcome | Rectal Neoplasms - therapy | Rectal Neoplasms - mortality | Pelvic Exenteration | Survival Analysis | Carcinoma - therapy | Aged | Neoplasm Staging
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2. Full Text Evidence and research in rectal cancer
by Valentini, Vincenzo and Beets-Tan, Regina and Borras, Josep M and Krivokapić, Zoran and Leer, Jan Willem and Påhlman, Lars and Rödel, Claus and Schmoll, Hans Joachim and Scott, Nigel and Velde, Cornelius Van de and Verfaillie, Christine and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Kolorektalkirurgi and Institutionen för kirurgiska vetenskaper
Radiotherapy and Oncology, ISSN 0167-8140, 2008, Volume 87, Issue 3, pp. 449 - 474
Abstract The main evidences of epidemiology, diagnostic imaging, pathology, surgery, radiotherapy, chemotherapy and follow-up are reviewed to optimize the... 
Hematology, Oncology and Palliative Medicine | Adjuvant chemotherapy | Randomized clinical trial | Local recurrence | Diagnostic | Early stage | Scenario of ongoing research | Epidemiology | Follow-up | Surgery | Endorectal ultrasound | Total mesorectal excision | Advanced stage | Intraoperative radiotherapy | Acute and late toxicity | Post-operative treatment | Concomitant radiochemotherapy | Educational | Radiotherapy | Pre-operative treatment | Radiotherapy technique | Computerized tomography | Quality of life | Pathology | Chemotherapy | Magnetic resonance imaging | Combined modality therapy | Rectal cancer treatment | Local excision | Intermediate stage | adjuvant chemotherapy | magnetic resonance imaging | pathology | COMBINED-MODALITY THERAPY | intraoperative radiotherapy | LOCALLY ADVANCED PRIMARY | CIRCUMFERENTIAL RESECTION MARGIN | scenario of ongoing research | concomitant radiochemotherapy | rectal cancer treatment | chemotherapy | COURSE PREOPERATIVE RADIOTHERAPY | total mesorectal excision | intermediate stage | epidemiology | follow-up | GROWTH-FACTOR RECEPTOR | INTRAOPERATIVE RADIATION-THERAPY | radiotherapy technique | FLUOROURACIL-BASED CHEMOTHERAPY | RANDOMIZED PHASE-III | endorectal ultrasound | local excision | combined modality therapy | local recurrence | diagnostic | computerized tomography | QUALITY-OF-LIFE | educational | acute and late toxicity | randomized clinical trial | advanced stage | post-operative treatment | ONCOLOGY | radiotherapy | pre-operative treatment | quality of life | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | surgery | early stage | Rectal Neoplasms - diagnosis | Humans | Risk Factors | Combined Modality Therapy | Rectal Neoplasms - pathology | Rectal Neoplasms - epidemiology | Rectal Neoplasms - therapy | Oncology, Experimental | Research | Cancer | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICINE | MEDICIN
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3. Full Text Pelvic Exenteration for Rectal Cancer: A Systematic Review
by Yang, Timothy X and Morris, David L and Chua, Terence C
Diseases of the Colon & Rectum, ISSN 0012-3706, 04/2013, Volume 56, Issue 4, pp. 519 - 531
BACKGROUND:Pelvic exenteration is a potentially curative treatment for locally advanced primary or recurrent rectal cancer. OBJECTIVE:This systematic review... 
Rectal cancer | Pelvic exenteration | SURGERY | LOCALLY ADVANCED PRIMARY | RECONSTRUCTION | SURGICAL-MANAGEMENT | SACRAL RESECTION | RADICAL SURGERY | EXTENDED RESECTION | RECURRENT | COLORECTAL-CANCER | QUALITY-OF-LIFE | GASTROENTEROLOGY & HEPATOLOGY | CARCINOMA | Rectal Neoplasms - surgery | Humans | Pelvic Exenteration | Neoplasm Recurrence, Local | Rectal Neoplasms - pathology | Postoperative Complications | Rectal Neoplasms - mortality
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4. Full Text Novel radiomic signature as a prognostic biomarker for locally advanced rectal cancer
by Meng, Yankai and Zhang, Yuchen and Dong, Di and Li, Chunming and Liang, Xiao and Zhang, Chongda and Wan, Lijuan and Zhao, Xinming and Xu, Kai and Zhou, Chunwu and Tian, Jie and Zhang, Hongmei
Journal of Magnetic Resonance Imaging, ISSN 1053-1807, 09/2018, Volume 48, Issue 3, pp. 605 - 614
Background Locally advanced rectal cancer (LARC) patient stratification by clinicoradiologic factors may yield variable results. Therefore, more efficient... 
biomarker | prognosis | locally advanced rectal cancer | radiomic signature | disease‐free survival | disease-free survival | EXTRAMURAL VENOUS INVASION | LEUCOVORIN | STAGE | CHEMORADIATION | PREOPERATIVE CHEMORADIOTHERAPY | OXALIPLATIN | DISEASE-FREE SURVIVAL | RADIOTHERAPY | FLUOROURACIL | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | CHEMOTHERAPY | Medicine, Experimental | Medical research | Analysis | Colorectal cancer | Model testing | Segmentation | Image processing | Population studies | Multivariate analysis | Risk factors | Rank tests | Training | Confidence intervals | Time dependence | Regression models | Mathematical models | Statistical analysis | Risk groups | Lava | Gastrointestinal tract | Shrinkage | Regression analysis | Statistical tests | Risk analysis | Patients | Survival | Field strength | Itk protein | Image segmentation | Population (statistical) | Magnetic resonance imaging | Gastrointestinal system | Rectum | Biomarkers | Cancer
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5. Full Text Total neoadjuvant therapy for rectal cancer
by Goodman, K.A
Cancer / Radiothérapie, ISSN 1278-3218, 09/2018, Volume 22, Issue 5, pp. 459 - 465
While outcomes for patients with locally advanced disease have improved considerably with combined modality therapy, there is now an emphasis on developing... 
Induction chemotherapy | Locally advanced rectal cancer | Chimiothérapie d’induction | Chemoradiation | Chimioradiothérapie | Thérapie néoadjuvante totale | Cancer rectal localement évolué | Total neoadjuvant therapy | ADJUVANT CHEMOTHERAPY | CHEMORADIATION THERAPY | POSTOPERATIVE CHEMORADIOTHERAPY | FOLLOW-UP | TOTAL MESORECTAL EXCISION | PATHOLOGICAL COMPLETE RESPONSE | RADIATION-THERAPY | PHASE-III TRIAL | ONCOLOGY | PREOPERATIVE RADIOTHERAPY | NONOPERATIVE TREATMENT | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Digestive System Surgical Procedures | Humans | Quality of Life | Neoadjuvant Therapy | Clinical Trials as Topic | Rectal Neoplasms - pathology | Chemotherapy, Adjuvant | Rectal Neoplasms - therapy | Chemoradiotherapy
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6. Full Text Multicentre propensity score-matched analysis of laparoscopic versus open surgery for T4 rectal cancer
by de’Angelis, Nicola and de’Angelis, Nicola and Landi, Filippo and Landi, Filippo and Vitali, Giulio Cesare and Vitali, Giulio Cesare and Memeo, Riccardo and Memeo, Riccardo and Martínez-Pérez, Aleix and Martínez-Pérez, Aleix and Solis, Alejandro and Solis, Alejandro and Assalino, Michela and Assalino, Michela and Vallribera, Francesc and Vallribera, Francesc and Mercoli, Henry Alexis and Mercoli, Henry Alexis and Marescaux, Jacques and Marescaux, Jacques and Mutter, Didier and Mutter, Didier and Ris, Frédéric and Ris, Frédéric and Espin, Eloy and Espin, Eloy and Brunetti, Francesco and Brunetti, Francesco
Surgical Endoscopy, ISSN 0930-2794, 8/2017, Volume 31, Issue 8, pp. 3106 - 3121
The use of laparoscopy for advanced-stage rectal cancer remains controversial. This study aimed to compare the operative and oncologic outcomes of laparoscopic... 
Locally advanced rectal cancer | Rectal cancer | Gynecology | Propensity score matching | Laparoscopy | Open surgery | Medicine & Public Health | Surgery | Hepatology | Gastroenterology | Radiochemotherapy | Abdominal Surgery | Proctology | SURGERY | RANDOMIZED CLINICAL-TRIAL | PATHOLOGICAL OUTCOMES | TOTAL MESORECTAL EXCISION | CIRCUMFERENTIAL MARGIN | LOCAL RECURRENCE | LOW ANTERIOR RESECTION | COLORECTAL-CANCER | PREOPERATIVE RADIOTHERAPY | NEOADJUVANT CHEMORADIOTHERAPY | ASSISTED RESECTION | Length of Stay | Adenocarcinoma - pathology | Rectal Neoplasms - surgery | Humans | Middle Aged | Proportional Hazards Models | Male | Survival Rate | Treatment Outcome | Propensity Score | Aged, 80 and over | Adult | Female | Aged | Rectal Neoplasms - pathology | Rectum - surgery | Laparotomy | Neoplasm Staging | Elective Surgical Procedures | Adenocarcinoma - surgery | Digestive System Surgical Procedures - methods | Medical research | Analysis | Mortality | Colorectal cancer | Medicine, Experimental | Laparoscopic surgery | Health aspects | Health risk assessment
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7. Full Text Identification of a biomarker profile associated with resistance to neoadjuvant chemoradiation therapy in rectal cancer
by Garcia-Aguilar, Julio and Chen, Zhenbin and Smith, David D and Li, Wenyan and Madoff, Robert D and Cataldo, Peter and Marcet, Jorge and Pastor, Carlos
Annals of Surgery, ISSN 0003-4932, 09/2011, Volume 254, Issue 3, pp. 486 - 493
Objective: To identify a biomarker profile associated with tumor response to chemoradiation (CRT) in locally advanced rectal cancer. Background: Rectal cancer... 
SURGERY | K-RAS | CYCLIN D1 | MESORECTAL EXCISION | GENE-EXPRESSION | PREOPERATIVE CHEMORADIOTHERAPY | NONOPERATIVE TREATMENT | TUMOR-RESPONSE | PREDICTS RESPONSE | THYMIDYLATE-SYNTHASE | ADVANCED COLORECTAL-CANCER | Leucovorin - administration & dosage | Predictive Value of Tests | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Adenocarcinoma - pathology | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Prognosis | Prospective Studies | United States | Humans | Middle Aged | Male | Organoplatinum Compounds - administration & dosage | Fluorouracil - administration & dosage | Rectal Neoplasms - genetics | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Sensitivity and Specificity | Aged, 80 and over | Adult | Female | Adenocarcinoma - genetics | Rectal Neoplasms - pathology | Chemotherapy, Adjuvant | Radiotherapy, Adjuvant | Rectal Neoplasms - drug therapy | Adenocarcinoma - radiotherapy | Radiotherapy Dosage | Reproducibility of Results | Neoplasm Invasiveness | Rectal Neoplasms - surgery | Genotype | Proto-Oncogene Proteins - genetics | Treatment Outcome | Genes, p53 - genetics | Adenocarcinoma - drug therapy | Rectal Neoplasms - radiotherapy | Polymorphism, Genetic | Drug Resistance, Neoplasm - genetics | Cyclin D1 - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoadjuvant Therapy - methods | Aged | Biomarkers, Tumor - genetics | Mutation | Neoplasm Staging | Adenocarcinoma - surgery
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8. Full Text History of neoadjuvant therapy for rectal cancer
by Chan, Tiffany and Smith, Radhika K
Seminars in Colon and Rectal Surgery, ISSN 1043-1489, 06/2019, Volume 30, Issue 2, pp. 58 - 62
Management of rectal cancer has evolved extensively over the last 30 years. Treatment of locally advanced rectal cancer currently incorporates surgery,... 
Neoadjuvant therapy | Locally advanced rectal cancer | Radiation
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9. Predicting locally advanced rectal cancer response to neoadjuvant therapy with F-18-FDG PET and MRI radiomics features
by Giannini, V and Mazzetti, S and Bertotto, I and Chiarenza, C and Cauda, S and Delmastro, E and Bracco, C and Di Dia, A and Leone, F and Medico, E and Pisacane, A and Ribero, D and Stasi, M and Regge, D
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, ISSN 1619-7070, 04/2019, Volume 46, Issue 4, pp. 878 - 888
PurposePathological complete response (pCR) following neoadjuvant chemoradiotherapy or radiotherapy in locally advanced rectal cancer (LARC) is reached in... 
CT imaging | Locally advanced rectal cancer | STATISTICS | PERFORMANCE | PATHOLOGICAL RESPONSE | CHEMORADIOTHERAPY | CT TEXTURE ANALYSIS | PARAMETERS | TUMOR HETEROGENEITY | Radiomics | BIOMARKERS | F-18-FDG PET | Magnetic resonance imaging | Texture features | ASSOCIATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Prediction of treatment response
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10. Full Text An update on the multimodality of localized rectal cancer
by Artac, Mehmet and Korkmaz, Levent and El-Rayes, Bassel and Philip, Philip A
Critical Reviews in Oncology and Hematology, ISSN 1040-8428, 2016, Volume 108, pp. 23 - 32
Highlights • A multidisciplinary team is essential in the management of localized rectal cancer. • Pre-operative chemoradiotherapy is the standard for... 
Hematology, Oncology and Palliative Medicine | Neo-adjuvant | Chemo-radiotherapy | Rectal cancer | Surgery | Locally advanced | RANDOMIZED-TRIAL | WILD-TYPE KRAS | TOTAL MESORECTAL EXCISION | PATHOLOGICAL COMPLETE RESPONSE | RADIATION-THERAPY | PHASE-III TRIAL | ONCOLOGY | PREOPERATIVE RADIOTHERAPY | NEOADJUVANT CHEMORADIOTHERAPY | POSTOPERATIVE ADJUVANT CHEMOTHERAPY | SHORT-COURSE RADIOTHERAPY | HEMATOLOGY | Rectal Neoplasms - diagnosis | Digestive System Surgical Procedures | Humans | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Neoplasm Staging | Rectal Neoplasms - therapy | Colorectal cancer
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11. Full Text Adjuvant Chemotherapy Improves Survival Following Resection of Locally Advanced Rectal Cancer with Pathologic Complete Response
by Turner, Megan C and Keenan, Jeffrey E and Rushing, Christel N and Gulack, Brian C and Nussbaum, Daniel P and Benrashid, Ehsan and Hyslop, Terry and Strickler, John H and Mantyh, Christopher R and Migaly, John
Journal of Gastrointestinal Surgery, ISSN 1091-255X, 8/2019, Volume 23, Issue 8, pp. 1614 - 1622
Controversy exists over the use of adjuvant chemotherapy for locally advanced (stages II–III) rectal cancer (LARC) patients who demonstrate pathologic complete... 
Pathologic complete responders | NCCN guidelines | Locally advanced rectal cancer | Medicine & Public Health | Surgery | Chemoradiation | Gastroenterology | Adjuvant therapy | SURGERY | LEUCOVORIN | METAANALYSIS | RANDOMIZED-TRIALS | OXALIPLATIN | FLUOROURACIL | POSTOPERATIVE CHEMOTHERAPY | NEOADJUVANT CHEMORADIOTHERAPY | PREOPERATIVE CHEMO RADIOTHERAPY | GASTROENTEROLOGY & HEPATOLOGY | Comorbidity | Analysis | Colorectal cancer | Adjuvant treatment | Cancer
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12. Full Text LncRNA and mRNA signatures associated with neoadjuvant chemoradiotherapy downstaging effects in rectal cancer
by Li, Ning and Yu, Jing and Luo, Aiping and Tang, Yuan and Liu, Wenyang and Wang, Shulian and Liu, Yueping and Song, Yongwen and Fang, Hui and Chen, Bo and Qi, Shunan and Lu, Ningning and Yu, Zihao and Li, Yexiong and Liu, Zhihua and Jin, Jing
Journal of Cellular Biochemistry, ISSN 0730-2312, 04/2019, Volume 120, Issue 4, pp. 5207 - 5217
Radiotherapy plays a crucial role in combined treatment modality in local advanced rectal cancer (LARC). While neoadjuvant chemoradiotherapy responses were... 
long noncoding RNA | radiotherapy | microarray | local advanced rectal cancer | The Cancer Genome Atlas | ADJUVANT CHEMOTHERAPY | CELLS | LUNG | MECHANISM | STATISTICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COLON | CELL BIOLOGY | CETUXIMAB | INHIBITION | GENE-EXPRESSION | KRAS | Antisense RNA | Messenger RNA | Colorectal cancer | Genes | MiRNA | mRNA | Genomes | Radiation therapy | Gene expression | Patients | Computer programs | Medical prognosis | Rectum | Biomarkers | Combined treatment | Cancer
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