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science & technology (29) 29
life sciences & biomedicine (28) 28
animals (23) 23
ae2 (20) 20
slc4a proteins (16) 16
humans (15) 15
rats (9) 9
male (8) 8
mice (8) 8
anion transport proteins (7) 7
antiporters - genetics (7) 7
biochemistry & molecular biology (7) 7
membrane proteins - genetics (7) 7
chloride-bicarbonate antiporters (6) 6
female (6) 6
physiology (6) 6
ae2, anion exchanger 2 (5) 5
anion transport proteins - genetics (5) 5
antiporters (5) 5
antiporters - metabolism (5) 5
bicarbonate (5) 5
bicarbonates - metabolism (5) 5
biomedicine (5) 5
biophysics (5) 5
cell biology (5) 5
chloride-bicarbonate antiporters - metabolism (5) 5
cholestasis (5) 5
gastroenterology & hepatology (5) 5
hydrogen-ion concentration (5) 5
mice, knockout (5) 5
stomatognathic diseases (5) 5
stomatognathic system (5) 5
anion exchangers (4) 4
anion transport proteins - metabolism (4) 4
biological and medical sciences (4) 4
cell proliferation (4) 4
chloride-bicarbonate antiporters - genetics (4) 4
cholangiocytes (4) 4
cloning, molecular (4) 4
genetic predisposition to disease (4) 4
immune response (4) 4
liver cirrhosis, biliary - genetics (4) 4
molecular medicine (4) 4
molecular sequence data (4) 4
pharmacology & pharmacy (4) 4
review (4) 4
rna, messenger - genetics (4) 4
sodium-bicarbonate symporters - metabolism (4) 4
sodium-hydrogen exchangers - metabolism (4) 4
transfection (4) 4
amino acid sequence (3) 3
anion exchanger ae2 (3) 3
antiporters - physiology (3) 3
base sequence (3) 3
bile acids (3) 3
biochemistry (3) 3
biological transport (3) 3
carbonates (3) 3
cd8-positive t-lymphocytes - immunology (3) 3
cd8-positive t-lymphocytes - metabolism (3) 3
cell line (3) 3
cells, cultured (3) 3
cholangitis - pathology (3) 3
cl (3) 3
cystic fibrosis transmembrane conductance regulator (3) 3
cystic fibrosis transmembrane conductance regulator - metabolism (3) 3
digestive system (3) 3
disease models, animal (3) 3
dna methylation (3) 3
epigenesis, genetic (3) 3
fxr, farnesoid x receptor (3) 3
gastroenterology and hepatology (3) 3
glutathione (3) 3
immunohistochemistry (3) 3
immunology (3) 3
liver - metabolism (3) 3
liver cirrhosis, biliary - immunology (3) 3
medical sciences (3) 3
mice, inbred balb c (3) 3
mrp2 (3) 3
pbc (3) 3
pbc, primary biliary cirrhosis (3) 3
physiological aspects (3) 3
psc, primary sclerosing cholangitis (3) 3
rats, wistar (3) 3
research (3) 3
rna, messenger - metabolism (3) 3
rodents (3) 3
sodium-hydrogen exchanger 1 (3) 3
sodium-hydrogen exchanger 3 (3) 3
udca, ursodeoxycholic acid (3) 3
ae1 (2) 2
ae2 gene (2) 2
age factors (2) 2
age-related changes (2) 2
alternative splicing (2) 2
ameloblasts - metabolism (2) 2
analysis (2) 2
anion exchanger (2) 2
anion transport proteins - physiology (2) 2
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1. Full Text Anion exchanger 2 is critical for CD8(+) T cells to maintain pHi homeostasis and modulate immune responses
by Concepcion, Axel R and Salas, January T and Sarvide, Sarai and Sáez, Elena and Ferrer, Alex and López, María and Portu, Ainhoa and Banales, Jesús M and Hervás-Stubbs, Sana and Oude Elferink, Ronald P. J and Prieto, Jesús and Medina, Juan F
European journal of immunology, ISSN 0014-2980, 2014, Volume 44, Issue 5, pp. 1341 - 1351
AE2 (Slc4a2) | T‐cell activation | IL‐2 signals | IL-2 signals | T-cell activation | Life Sciences & Biomedicine | Immunology | Science & Technology | CD8-Positive T-Lymphocytes - cytology | Chloride-Bicarbonate Antiporters - genetics | Cell Proliferation | Interleukin-2 Receptor alpha Subunit - biosynthesis | CD4-Positive T-Lymphocytes - immunology | Interleukin-2 - immunology | Interleukin-2 Receptor alpha Subunit - genetics | CD8-Positive T-Lymphocytes - metabolism | Interleukin-2 Receptor alpha Subunit - immunology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | CD4-Positive T-Lymphocytes - cytology | Chloride-Bicarbonate Antiporters - immunology | CD4-Positive T-Lymphocytes - metabolism | Mice, Knockout | Interleukin-2 - genetics | Chloride-Bicarbonate Antiporters - metabolism | Animals | Homeostasis - physiology | Mice | CD8-Positive T-Lymphocytes - immunology | Interleukin-2 - biosynthesis | Ion Transport - physiology | Lymphocyte Activation - physiology | Hydrogen-Ion Concentration | Homeostasis | T cells | Immune response | Index Medicus
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2. Full Text Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma
by Shiozaki, Atsushi and Hikami, Shoichiro and Ichikawa, Daisuke and Kosuga, Toshiyuki and Shimizu, Hiroki and Kudou, Michihiro and Yamazato, Yuzo and Kobayashi, Toshiyuki and Shoda, Katsutoshi and Arita, Tomohiro and Konishi, Hirotaka and Komatsu, Shuhei and Kubota, Takeshi and Fujiwara, Hitoshi and Okamoto, Kazuma and Kishimoto, Mitsuo and Konishi, Eiichi and Marunaka, Yoshinori and Otsuji, Eigo
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 40, pp. 25993 - 26006
Esophageal squamous cell carcinoma | Cellular physiology | Migration | AE2 | MMPs
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3. Full Text Bile acid transporters and regulatory nuclear receptors in the liver and beyond
by Halilbasic, Emina and Claudel, Thierry and Trauner, Michael
Journal of hepatology, ISSN 0168-8278, 2012, Volume 58, Issue 1, pp. 155 - 168
Gastroenterology and Hepatology | Gallstones | Liver cancer | Bile acids | Fatty liver disease | Cholestasis | Liver regeneration | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Animals | Carrier Proteins - metabolism | Cholestasis - metabolism | Membrane Glycoproteins - metabolism | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Liver Diseases - metabolism | Liver Regeneration - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Drug resistance in microorganisms | Corticosteroids | Glucagon | Calcifediol | Ursodiol | Deoxycholic acid | Epidermal growth factor | Vitamin D | Physiological aspects | Fibroblast growth factors | Alfacalcidol | Index Medicus | IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 | PFIC, progressive familial intrahepatic cholestasis | TNFα, tumor necrosis factor α | 3 (human) | SRC2, p160 steroid receptor coactivator | NAFLD, non-alcoholic fatty liver disease | BA, bile acid | bile acid receptor | 8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5 | UDCA, ursodeoxycholic acid | LRH-1 (NR5A2), liver receptor homolog-1 | LCA, lithocholic acid | LXRα (NR1H3), liver X receptor alpha | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | OSTαβ, organic solute transporter alpha | ABCG5 | AMPK, AMP activated protein kinase | NASH, non-alcoholic steatohepatitis | SHP (NR0B2), short heterodimer partner | OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 | EGFR, epidermal growth factor receptor | IL6, interleukin 6 | TGR5, G protein-coupled bile acid receptor | PH, partial hepatectomy | AE2, anion exchanger 2 | PSC, primary sclerosing cholangitis | OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 | RARα (NR1B1), retinoic acid receptor alpha | GLP-1, glucagon like peptide 1 | VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents | MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 | NTCP (SLC10A1), sodium | CAR (NR1I3), constitutive androstane receptor | taurocholate cotransporting polypeptide, solute carrier family 10, member 1 | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | GR (NR3C1), glucocorticoid receptor | Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer | 19, fibroblast growth factor 15 | Mdr2 | ICP, intrahepatic cholestasis of pregnancy | BRIC, benign recurrent intrahepatic cholestasis | OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 | MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 | beta | MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 | norUDCA, norursodeoxycholic acid | 6-ECDCA, 6-ethylchenodeoxycholic acid | FXR (NR1H4), farnesoid X receptor | BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 | HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha | PBC, primary biliary cirrhosis | MDR3 (ABCB4), multidrug resistance protein 2 (rodents) | HNF1α, hepatocyte nuclear factor 1 alpha | NR, nuclear receptor | FGF15 | RXRα (NR2B1), retinoid X receptor alpha | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | HCC, hepatocellular carcinoma | MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 | TPN, total parenteral nutrition
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4. Full Text The anion exchanger Ae2 is required for enamel maturation in mouse teeth
by Lyaruu, D.M and Bronckers, A.L.J.J and Mulder, L and Mardones, P and Medina, J.F and Kellokumpu, S and Oude Elferink, R.P.J and Everts, V
Matrix biology, ISSN 0945-053X, 2008, Volume 27, Issue 2, pp. 119 - 127
Anion exchanger Ae2 | Ameloblasts | Knockout | Enamel mineralisation | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Tooth - growth & development | SLC4A Proteins | Ameloblasts - metabolism | Incisor - metabolism | Antiporters - genetics | Dental Enamel - ultrastructure | Molar - metabolism | Tooth Calcification - physiology | Dentin - chemistry | Microscopy, Electron, Scanning | Bone and Bones - chemistry | Dental Enamel - metabolism | Dental Enamel - growth & development | Minerals - analysis | Mice, Inbred Strains | Tooth Calcification - genetics | Protein Isoforms - physiology | Mice, Knockout | Animals | Models, Biological | Amelogenesis - physiology | Mice | Anion Transport Proteins - physiology | Tooth - metabolism | Antiporters - physiology | Amelogenesis - genetics | Anion Transport Proteins - genetics | Protein Isoforms - genetics | Anion exchangers (Biology) | Index Medicus | knockout | enamel mineralisation | ameloblasts
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5. Full Text MiRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation
by Erice, Oihane and Munoz-Garrido, Patricia and Vaquero, Javier and Perugorria, Maria J and Fernandez-Barrena, Maite G and Saez, Elena and Santos-Laso, Alvaro and Arbelaiz, Ander and Jimenez-Agüero, Raul and Fernandez-Irigoyen, Joaquin and Santamaria, Enrique and Torrano, Verónica and Carracedo, Arkaitz and Ananthanarayanan, Meenakshisundaram and Marzioni, Marco and Prieto, Jesus and Beuers, Ulrich and Oude Elferink, Ronald P and LaRusso, Nicholas F and Bujanda, Luis and Marin, Jose J. G and Banales, Jesus M
Hepatology (Baltimore, Md.), ISSN 0270-9139, 2018, Volume 67, Issue 4, pp. 1420 - 1440
microRNAs | pathogenesis | cholangiocytes | pyruvate dehydrogenase complex E2 (PDC-E2) | anion exchanger 2 (AE2)
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6. Full Text Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization
by Boris E. Shmukler and Christine E. Kurschat and Gabriele E. Ackermann and Lianwei Jiang and Yi Zhou and Bruce Barut and Alan K. Stuart-Tilley and Jinhua Zhao and Leonard I. Zon and Iain A. Drummond and David H. Vandorpe and Barry H. Paw and Seth L. Alper
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 10/2005, Volume 289, Issue 4, pp. 835 - 849
Chloride/bicarbonate exchanger | AE2 | Physiology | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Humans | DNA, Complementary - genetics | Molecular Sequence Data | SLC4A Proteins | RNA, Messenger - biosynthesis | In Situ Hybridization | Chlorides - metabolism | Antiporters - genetics | Cloning, Molecular | Chloride-Bicarbonate Antiporters | DNA, Complementary - biosynthesis | Amino Acid Sequence | Cell Line | Introns - genetics | Oocytes - metabolism | RNA, Messenger - genetics | Xenopus laevis | Exons - genetics | Zebrafish | Chromosome Mapping | Reverse Transcriptase Polymerase Chain Reaction | Subcellular Fractions - metabolism | Blotting, Western | Animals | Embryo, Nonmammalian | Bicarbonates - metabolism | Anion Transport Proteins - genetics | Index Medicus
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7. Full Text Clinical application of transcriptional activators of bile salt transporters
by Baghdasaryan, Anna and Chiba, Peter and Trauner, Michael
Molecular aspects of medicine, ISSN 0098-2997, 06/2014, Volume 37, Issue 100, pp. 57 - 76
Nuclear receptors | ATB-binding cassette transporters | Cholestasis | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Cholestasis - genetics | Transcriptional Activation - genetics | Cholestasis - therapy | Humans | Gene Expression Regulation | Bile Acids and Salts - metabolism | Symporters - metabolism | Organic Anion Transporters, Sodium-Dependent - genetics | Cholestasis - pathology | ATP-Binding Cassette Transporters - genetics | Biological Transport | ATP Binding Cassette Subfamily B Member 11 | Membrane Transport Proteins - genetics | Symporters - genetics | ATP-Binding Cassette Transporters - metabolism | Membrane Transport Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | Genetic aspects | Genetic transcription | Index Medicus | MAF, musculo-aponeurotic fibrosacroma | TNF-α, tumor necrosis factor alpha | NDRG2, NMYC downstrean-regulated gene 2 | RARα (NR1B1), retinoic acid receptor | IL-6, interleukin 6 | ABC, ATP-binding cassette | DCA, deoxycholic acid | GGT, gamma-glutamyl transpeptidase | CARM1, co-activator-associated arginine methyltransferase 1 | SRC2, steroid receptor co-activator 2 | TCDCA, taurochenodeoxycholic acid | MRP2 (ABCC2), multidrug resistance-associated protein 2 | SREBP1, sterol regulatory element-binding protein 1 | ASBT (SLC10A2), apical sodium-dependent bile acid transporter | CA, cholic acid | UDCA, ursodeoxycholic acid | FGF15, fibroblast growth factor 19 | MARE, MAF recognition element | TβMCA, β-tauromuricholic acid | VDR (NR1I1), vitamin D receptor | CBDL, common bile duct ligation | STAT-5, signal transducer and activator of transcription 5 | MCL-1, myeloid cell leukemia factor 1 | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | FXRE, FXR response element | LXR (NR1H3), liver X receptor | CtBP, C-terminal binding protein | 15 | OSTβ (SLC51A | SHP (NR0B2), short heterodimer partner | PL, phospholipid | BCRP (ABCG2), breast cancer resistance protein | TUDCA, tauroursodeoxycholic acid | OATP, organic anion transporting polypeptide | TCA, taurocholic acid | NTCP (SLC10A1), Na+-taurocholate cotransporting polypeptide solute carrier family 10 member 1 | PSC, primary sclerosing cholangitis | LRH1 (NR5A2), liver receptor homologue 1 | LPS, lipopolysaccharide | MRP3 (ABCC3), multidrug resistance-associated protein 3 | SLC51B), organic solute transporter alpha | TGR5, G protein coupled bile acid receptor | MDR2 (ABCB4), multidrug resistance protein 2 | FXR, farnesoid X receptor (NR1H4) | IR-1, inverse repeat 1 | OCA, obeticholic acid | MRP4 (ABCC4), multidrug resistance-associated protein 4 | AE2 (SLC4A2), anion exchanger 2 | NF-κB, nuclear factor kappa-B | CCl4, carbone tetrachloride | AMPK, AMP-activated protein kinase | ALP, alkaline phosphatase | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | DILI, drug-induced liver injury | JNK, c-Jun N-terminal kinase | GR (NR3C1), glucocorticoid receptor | BS, bile salt | IL-1β, interleukin-1 beta | cAMP, cyclic adenosine monophosphate | PGC-1α, peroxisome proliferator-activated receptor gamma coactivator-1 alpha | RXRα (NR2B1), retinoid X receptor | VPAC-1, vasoactive intestinal polypeptide activated receptor | ASCOM, activating signal cointegrator-2-containing complex | ICP, intrahepatic cholestasis of pregnancy | GCA, glycocholic acid | MDR1 (ABCB1), multidrug resistance protein 1 | NRF2, nuclear factor erythroid 2-related factor 2 | beta | ALT, alanine aminotransferase | LCA, litocholic acid | BRIC2, benign recurrent intrahepatic cholestasis type 2 | OSTα | CDCA, chenodeoxycholic acid | PBC, primary biliary cirrhosis | HNF1α, hepatocyte nuclear factor 1 alpha | GRE, glucocorticoid response element | TαMCA, α-tauromuricholic acid | FGF19 | PFIC2, progressive familial intrahepatic cholestasis type 2 | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | TPN, total parenteral nutrition | HNF4α, hepatocyte nuclear factor 4 alpha
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