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Publication DateAnalytical Chemistry, ISSN 0003-2700, 07/2014, Volume 86, Issue 13, pp. 6454 - 6460
A method was created on the basis of ultrafast affinity extraction to determine both the dissociation rate constants and equilibrium constants for drug–protein...
CHEMISTRY, ANALYTICAL | HUMAN-SERUM-ALBUMIN | PEAK DECAY ANALYSIS | CHROMATOGRAPHIC ANALYSIS | CHIRAL SEPARATION MECHANISMS | LIGAND-BINDING | (S)-WARFARIN BINDING | SILICA MONOLITHS | DISSOCIATION RATES | HPLC COLUMNS | RAPID ANALYSIS | Pharmaceutical Preparations - isolation & purification | Pharmaceutical Preparations - metabolism | Humans | Serum Albumin - isolation & purification | Solubility | Protein Binding | Chromatography, Affinity - economics | Kinetics | Chromatography, Affinity - methods | Serum Albumin - metabolism
CHEMISTRY, ANALYTICAL | HUMAN-SERUM-ALBUMIN | PEAK DECAY ANALYSIS | CHROMATOGRAPHIC ANALYSIS | CHIRAL SEPARATION MECHANISMS | LIGAND-BINDING | (S)-WARFARIN BINDING | SILICA MONOLITHS | DISSOCIATION RATES | HPLC COLUMNS | RAPID ANALYSIS | Pharmaceutical Preparations - isolation & purification | Pharmaceutical Preparations - metabolism | Humans | Serum Albumin - isolation & purification | Solubility | Protein Binding | Chromatography, Affinity - economics | Kinetics | Chromatography, Affinity - methods | Serum Albumin - metabolism
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Loading RightsELECTROPHORESIS, ISSN 0173-0835, 04/2017, Volume 38, Issue 8, pp. 1188 - 1200
To optimize chiral separation conditions and to improve the knowledge of enantioseparation, it is important to know the binding constants K between analytes...
Cyclodextrin | Capillary electrophoresis | Binding constant | Enantiomer separation | Ephedrine | CHIRAL SEPARATION | CHEMISTRY, ANALYTICAL | RECTANGULAR HYPERBOLAE | INCLUSION COMPLEXATION | NUCLEAR-MAGNETIC-RESONANCE | SELECTORS COMPARATIVE CE | BIOCHEMICAL RESEARCH METHODS | EPHEDRINE DERIVATIVES | ISOTHERMAL TITRATION CALORIMETRY | ALKALOID ENANTIOMERS | ZONE-ELECTROPHORESIS | MONTE-CARLO-SIMULATION | Thermodynamics | beta-Cyclodextrins - chemistry | Stereoisomerism | Phenethylamines - chemistry | Calorimetry | Electrophoretic Mobility Shift Assay | Electrophoresis, Capillary - methods | Binding | Mathematical analysis | Electrophoresis | Cyclodextrins | Derivatives | Enantiomers | Buffers
Cyclodextrin | Capillary electrophoresis | Binding constant | Enantiomer separation | Ephedrine | CHIRAL SEPARATION | CHEMISTRY, ANALYTICAL | RECTANGULAR HYPERBOLAE | INCLUSION COMPLEXATION | NUCLEAR-MAGNETIC-RESONANCE | SELECTORS COMPARATIVE CE | BIOCHEMICAL RESEARCH METHODS | EPHEDRINE DERIVATIVES | ISOTHERMAL TITRATION CALORIMETRY | ALKALOID ENANTIOMERS | ZONE-ELECTROPHORESIS | MONTE-CARLO-SIMULATION | Thermodynamics | beta-Cyclodextrins - chemistry | Stereoisomerism | Phenethylamines - chemistry | Calorimetry | Electrophoretic Mobility Shift Assay | Electrophoresis, Capillary - methods | Binding | Mathematical analysis | Electrophoresis | Cyclodextrins | Derivatives | Enantiomers | Buffers
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Loading RightsELECTROPHORESIS, ISSN 0173-0835, 01/2019, Volume 40, Issue 2, pp. 289 - 295
An open‐tubular capillary electrochromatography method has been developed for the determination of binding constants between β2‐adrenergic receptor (β2‐AR) and...
Drug activity | Affinity interaction | Oriented covalent immobilization | Open‐tubular capillary electrochromatography | Binding | Drugs | Electrochromatography | Norepinephrine | Lead compounds | Propanolol hydrochloride | Augmented reality
Drug activity | Affinity interaction | Oriented covalent immobilization | Open‐tubular capillary electrochromatography | Binding | Drugs | Electrochromatography | Norepinephrine | Lead compounds | Propanolol hydrochloride | Augmented reality
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Loading RightsJournal of the American Chemical Society, ISSN 0002-7863, 09/2007, Volume 129, Issue 36, pp. 11177 - 11184
Carbohydrate−protein interactions on surface and in solution were quantitatively measured by a glycan microarray. Assessing carbohydrate affinities is...
CONCANAVALIN-A | LECTIN | LIGANDS | AFFINITY | TITRATION MICROCALORIMETRY | ANTIBODY | INTERACTION NETWORKS | CHEMISTRY, MULTIDISCIPLINARY | BINDING-PROTEINS | ARRAYS | PLASMON RESONANCE | Protein Array Analysis | Fluorescein-5-isothiocyanate - chemistry | Proteins - chemistry | Carbohydrates - chemistry | Carbohydrate Conformation | Concanavalin A - chemistry | Ionization constants | DNA microarrays | Analysis | Protein-protein interactions
CONCANAVALIN-A | LECTIN | LIGANDS | AFFINITY | TITRATION MICROCALORIMETRY | ANTIBODY | INTERACTION NETWORKS | CHEMISTRY, MULTIDISCIPLINARY | BINDING-PROTEINS | ARRAYS | PLASMON RESONANCE | Protein Array Analysis | Fluorescein-5-isothiocyanate - chemistry | Proteins - chemistry | Carbohydrates - chemistry | Carbohydrate Conformation | Concanavalin A - chemistry | Ionization constants | DNA microarrays | Analysis | Protein-protein interactions
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Loading RightsANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 01/2014, Volume 53, Issue 4, pp. 988 - 993
Hostguest complexes between cucurbit[7] (CB[7]) or CB[8] and diamantane diammonium ion guests 3 or 6 were studied by (HNMR)-H-1 spectroscopy and X-ray...
affinity pairs | HIGH-ENERGY WATER | host-guest systems | STREPTAVIDIN | STABILITY | cucurbit[n]uril | X-ray diffraction | CHEMISTRY, MULTIDISCIPLINARY | avidin-biotin | HOST-GUEST COMPLEXES | AFFINITY | CHEMISTRY | CUCURBITURIL HOMOLOGS | AVIDIN | DERIVATIVES | DRIVING-FORCE | Competition | Binding | Receptors | X-rays | Constants | Buffers | Optimization | Crystal structure
affinity pairs | HIGH-ENERGY WATER | host-guest systems | STREPTAVIDIN | STABILITY | cucurbit[n]uril | X-ray diffraction | CHEMISTRY, MULTIDISCIPLINARY | avidin-biotin | HOST-GUEST COMPLEXES | AFFINITY | CHEMISTRY | CUCURBITURIL HOMOLOGS | AVIDIN | DERIVATIVES | DRIVING-FORCE | Competition | Binding | Receptors | X-rays | Constants | Buffers | Optimization | Crystal structure
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Loading RightsTetrahedron, ISSN 0040-4020, 2004, Volume 60, Issue 49, pp. 11205 - 11209
In our continuing efforts into designing boronic acid-based sensors that recognize cell-surface carbohydrates, it has been necessary to examine various factors...
pK a | Boronic acids | Binding constants | pH | pK | DESIGN | SUPPORTED LIQUID-MEMBRANES | CHEMISTRY, ORGANIC | PHYSIOLOGICAL PH | binding constants | SENSORS | AQUEOUS-SOLUTION | TRANSPORT | FRUCTOSE | LIGANDS | pK(a) | AFFINITY-CHROMATOGRAPHY | COMPLEXATION | boronic acids
pK a | Boronic acids | Binding constants | pH | pK | DESIGN | SUPPORTED LIQUID-MEMBRANES | CHEMISTRY, ORGANIC | PHYSIOLOGICAL PH | binding constants | SENSORS | AQUEOUS-SOLUTION | TRANSPORT | FRUCTOSE | LIGANDS | pK(a) | AFFINITY-CHROMATOGRAPHY | COMPLEXATION | boronic acids
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Loading RightsAngewandte Chemie International Edition, ISSN 1433-7851, 01/2014, Volume 53, Issue 4, pp. 988 - 993
Host⋅guest complexes between cucurbit[7] (CB[7]) or CB[8] and diamantane diammonium ion guests 3 or 6 were studied by 1H NMR spectroscopy and X‐ray...
cucurbit[n]uril | affinity pairs | avidin–biotin | X‐ray diffraction | host‐guest systems | X-ray diffraction | host-guest systems | avidin-biotin | Bridged-Ring Compounds - chemistry | Imidazoles - chemistry | Models, Molecular | Crystallography, X-Ray | Molecular Structure | Imidazoles - chemical synthesis | Bridged-Ring Compounds - chemical synthesis
cucurbit[n]uril | affinity pairs | avidin–biotin | X‐ray diffraction | host‐guest systems | X-ray diffraction | host-guest systems | avidin-biotin | Bridged-Ring Compounds - chemistry | Imidazoles - chemistry | Models, Molecular | Crystallography, X-Ray | Molecular Structure | Imidazoles - chemical synthesis | Bridged-Ring Compounds - chemical synthesis
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Loading RightsJournal of Chromatography A, ISSN 0021-9673, 07/2016, Volume 1455, pp. 163 - 171
The performances of three neutral static coatings (hydroxypropyl cellulose, polyethylene oxide and poly(N,N-dimethylacrylamide) have been evaluated in order to...
Hydroxypropyl cellulose | Neutral coating | Affinity capillary electrophoresis | Poly(N,N-dimethylacrylamide) | Cyclodextrin | Polyethylene oxide | CHEMISTRY, ANALYTICAL | COATED CAPILLARY | RESOLUTION | BIOCHEMICAL RESEARCH METHODS | TACRINE | BETA-CYCLODEXTRIN | POLYACRYLAMIDE | INCLUSION | SEPARATION | PROTEINS | COMPLEXATION | Cytokinins | Cyclodextrins | Adsorption | Coatings | Binding | Capillarity | Electrophoresis | Constants | Affinity | Derivatives | Analytical chemistry | Chemical Sciences
Hydroxypropyl cellulose | Neutral coating | Affinity capillary electrophoresis | Poly(N,N-dimethylacrylamide) | Cyclodextrin | Polyethylene oxide | CHEMISTRY, ANALYTICAL | COATED CAPILLARY | RESOLUTION | BIOCHEMICAL RESEARCH METHODS | TACRINE | BETA-CYCLODEXTRIN | POLYACRYLAMIDE | INCLUSION | SEPARATION | PROTEINS | COMPLEXATION | Cytokinins | Cyclodextrins | Adsorption | Coatings | Binding | Capillarity | Electrophoresis | Constants | Affinity | Derivatives | Analytical chemistry | Chemical Sciences
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Loading RightsProgress in Nuclear Magnetic Resonance Spectroscopy, ISSN 0079-6565, 2007, Volume 51, Issue 4, pp. 219 - 242
The use of NMR to determine quantitatively the dissociation constants of protein-ligand complexes is firmly established. The opportunity to observe cleanly the...
Protein-ligand interactions | Quantitative methods | Binding affinity | Drug discovery | NMR spectroscopy | protein-ligand interactions | binding affinity | WEAK MOLECULAR-COMPLEXES | HUMAN SERUM-ALBUMIN | quantitative methods | NUCLEAR-MAGNETIC-RESONANCE | STUDYING RECOGNITION PROCESSES | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | WHEAT-GERM-AGGLUTININ | CARBOHYDRATE INTERACTIONS | drug discovery | HIGH-AFFINITY LIGANDS | BIFUNCTIONAL KEY ENZYME | SPECTROSCOPY | TRANSFER DIFFERENCE NMR | SIALIC-ACID BIOSYNTHESIS
Protein-ligand interactions | Quantitative methods | Binding affinity | Drug discovery | NMR spectroscopy | protein-ligand interactions | binding affinity | WEAK MOLECULAR-COMPLEXES | HUMAN SERUM-ALBUMIN | quantitative methods | NUCLEAR-MAGNETIC-RESONANCE | STUDYING RECOGNITION PROCESSES | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | WHEAT-GERM-AGGLUTININ | CARBOHYDRATE INTERACTIONS | drug discovery | HIGH-AFFINITY LIGANDS | BIFUNCTIONAL KEY ENZYME | SPECTROSCOPY | TRANSFER DIFFERENCE NMR | SIALIC-ACID BIOSYNTHESIS
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Loading RightsJournal of Chromatography A, ISSN 0021-9673, 09/2018, Volume 1568, pp. 197 - 204
Affinity capillary electrophoresis (ACE) is typically used for the determination of stability constant, , of weak to moderately strong complexes. Sensitive...
Crown ether complexes | Affinity capillary electrophoresis | Stability constant | Mass spectrometry | Electrospray ionization | CE-MS interface | BINDING CONSTANT | CHEMISTRY, ANALYTICAL | RECTANGULAR HYPERBOLAE | COMPLEXATION CONSTANTS | BIOCHEMICAL RESEARCH METHODS | SEPARATION TECHNIQUES | ERROR PROPAGATION | CE-ICP-MS | METHODOLOGY | ESI | MONTE-CARLO-SIMULATION | DISSOCIATION-CONSTANTS | Electrophoresis | Comparative analysis | Crown ethers
Crown ether complexes | Affinity capillary electrophoresis | Stability constant | Mass spectrometry | Electrospray ionization | CE-MS interface | BINDING CONSTANT | CHEMISTRY, ANALYTICAL | RECTANGULAR HYPERBOLAE | COMPLEXATION CONSTANTS | BIOCHEMICAL RESEARCH METHODS | SEPARATION TECHNIQUES | ERROR PROPAGATION | CE-ICP-MS | METHODOLOGY | ESI | MONTE-CARLO-SIMULATION | DISSOCIATION-CONSTANTS | Electrophoresis | Comparative analysis | Crown ethers
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Acidity Constants of the Hematite–Liquid Water Interface from Ab Initio Molecular Dynamics
The Journal of Physical Chemistry Letters, ISSN 1948-7185, 09/2018, Volume 9, Issue 18, pp. 5574 - 5582
The interface between transition metal oxides (TMO) and liquid water plays a crucial role in environmental chemistry, catalysis, and energy science. Yet, the...
INTRINSIC PROTON AFFINITY | SOLID-SOLUTION INTERFACE | TEMPERATURE-DEPENDENCE | METAL (HYDR)OXIDES | MATERIALS SCIENCE, MULTIDISCIPLINARY | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | REACTIVE FORCE-FIELD | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | PK(A) PREDICTION | SOLVATION STRUCTURE | REAXFF | BOND-VALENCE METHODS | SURFACE PROTONATION
INTRINSIC PROTON AFFINITY | SOLID-SOLUTION INTERFACE | TEMPERATURE-DEPENDENCE | METAL (HYDR)OXIDES | MATERIALS SCIENCE, MULTIDISCIPLINARY | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | REACTIVE FORCE-FIELD | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | PK(A) PREDICTION | SOLVATION STRUCTURE | REAXFF | BOND-VALENCE METHODS | SURFACE PROTONATION
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Loading RightsELECTROPHORESIS, ISSN 0173-0835, 01/2010, Volume 31, Issue 1, pp. 17 - 27
In the past two decades, CE has been used frequently for the measurement of apparent binding/association constants. CE has numerous advantages, including short...
Association constant | Affinity CE | Hummel–Dreyer method | Binding constant | Frontal analysis | Hummel-Dreyer method | ALA TERMINUS PEPTIDES | CHEMISTRY, ANALYTICAL | ASSOCIATION CONSTANTS | AFFINITY CAPILLARY-ELECTROPHORESIS | BIOCHEMICAL RESEARCH METHODS | SERUM TRANSPORT PROTEINS | EQUILIBRIUM MIXTURES | BETA-CYCLODEXTRIN | COMPUTER-SIMULATION | ZONE-ELECTROPHORESIS | MONTE-CARLO-SIMULATION | Proteins - metabolism | Computer Simulation | Protein Binding | Kinetics | Miniaturization | Proteins - chemistry | Electrophoresis, Capillary - methods | Binding | Electrophoresis | Constants
Association constant | Affinity CE | Hummel–Dreyer method | Binding constant | Frontal analysis | Hummel-Dreyer method | ALA TERMINUS PEPTIDES | CHEMISTRY, ANALYTICAL | ASSOCIATION CONSTANTS | AFFINITY CAPILLARY-ELECTROPHORESIS | BIOCHEMICAL RESEARCH METHODS | SERUM TRANSPORT PROTEINS | EQUILIBRIUM MIXTURES | BETA-CYCLODEXTRIN | COMPUTER-SIMULATION | ZONE-ELECTROPHORESIS | MONTE-CARLO-SIMULATION | Proteins - metabolism | Computer Simulation | Protein Binding | Kinetics | Miniaturization | Proteins - chemistry | Electrophoresis, Capillary - methods | Binding | Electrophoresis | Constants
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Stability, metastability and spectroscopic constants of electronic states of NH− and CH
Molecular Physics, ISSN 0026-8976, 03/2015, Volume 113, Issue 6, pp. 622 - 629
Highly correlated ab initio methods were used in order to calculate potential energy curves (PECs) of the bound electronic states of CH − and NH − anions and...
metastability | spectroscopic constants | MRCI/AV6Z | electron affinity | potential energy curves | Potential energy curves | Electron affinity | Spectroscopic constants | Metastability | BORON | CORRELATED MOLECULAR CALCULATIONS | DIATOMIC HYDRIDES | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | IONS | LIFETIMES | ROTATION-VIBRATION SPECTRUM | NEON | CONTINUUM | AFFINITIES | GAUSSIAN-BASIS SETS | Superconductivity
metastability | spectroscopic constants | MRCI/AV6Z | electron affinity | potential energy curves | Potential energy curves | Electron affinity | Spectroscopic constants | Metastability | BORON | CORRELATED MOLECULAR CALCULATIONS | DIATOMIC HYDRIDES | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | IONS | LIFETIMES | ROTATION-VIBRATION SPECTRUM | NEON | CONTINUUM | AFFINITIES | GAUSSIAN-BASIS SETS | Superconductivity
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Loading RightsJournal of Separation Science, ISSN 1615-9306, 03/2016, Volume 39, Issue 5, pp. 980 - 985
Enantiomers of Tröger's base were separated by capillary electrophoresis using 2I‐O‐, 3I‐O‐, and 6I‐O‐carboxymethyl‐α‐, β‐, and γ‐cyclodextrin and native α‐,...
Regioisomers | Cyclodextrin | Stability constants | Capillary electrophoresis | Chiral separation | CHEMISTRY, ANALYTICAL | COMPLETE-SETS | AFFINITY CAPILLARY-ELECTROPHORESIS | ENANTIOSELECTIVITY | RECOGNITION | SINGLE-ISOMER | ENANTIOSEPARATIONS | METHANOLIC BACKGROUND ELECTROLYTES | CHIRAL RESOLVING AGENTS | SEPARATION | C6 POSITIONS | Capillarity | Mathematical analysis | Electrolytes | Electrophoresis | Holes | Derivatives | Enantiomers
Regioisomers | Cyclodextrin | Stability constants | Capillary electrophoresis | Chiral separation | CHEMISTRY, ANALYTICAL | COMPLETE-SETS | AFFINITY CAPILLARY-ELECTROPHORESIS | ENANTIOSELECTIVITY | RECOGNITION | SINGLE-ISOMER | ENANTIOSEPARATIONS | METHANOLIC BACKGROUND ELECTROLYTES | CHIRAL RESOLVING AGENTS | SEPARATION | C6 POSITIONS | Capillarity | Mathematical analysis | Electrolytes | Electrophoresis | Holes | Derivatives | Enantiomers
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Loading RightsEcology Letters, ISSN 1461-023X, 03/2019, Volume 22, Issue 3, pp. 558 - 560
The two parameters of the Michaelis–Menten model, the maximum uptake rate and the half‐saturation constant, are not stochastically independent, and the...
nutrient affinity | Defence | trade‐off | trade-off | COMPETITION | RESISTANCE | ECOLOGY | TRADE-OFFS | TRAITS | Nutrients | Dinoflagellida | Kinetics | Toxins, Biological - metabolism | Affinity | Dinoflagellates | Saturation
nutrient affinity | Defence | trade‐off | trade-off | COMPETITION | RESISTANCE | ECOLOGY | TRADE-OFFS | TRAITS | Nutrients | Dinoflagellida | Kinetics | Toxins, Biological - metabolism | Affinity | Dinoflagellates | Saturation
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