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phosphorylation (34) 34
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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2010, Volume 426, Issue 1, pp. 109 - 118
Activation of AMPK (AMP-activated protein kinase) by phosphorylation at Thr(172) is catalysed by at least two distinct upstream kinases, i.e... 
calmodulin-dependent protein kinase (CaMK) | AMP-activated protein kinase-related kinase (ARK) | calmodulin-dependent protein kinase kinase (CaMKK) | AMP-activated protein kinase (AMPK) | TUMOR-SUPPRESSOR LKB1 | LOCALIZATION | MECHANISM | Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | CASCADE | UPSTREAM KINASE | Ca2+/calmodulin-dependent protein kinase (CaMK) | SUBSTRATE-SPECIFICITY | INHIBITION | CLONING | Amino Acid Sequence | Cell Line | AMP-Activated Protein Kinases - metabolism | Immunoprecipitation | Calcium - metabolism | Humans | Molecular Sequence Data | Calcimycin - pharmacology | Phenformin - pharmacology | Cyclic AMP - pharmacology | Sequence Homology, Amino Acid | Calcium - physiology | Adenosine Triphosphate - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism | Protein Binding | Adenosine Diphosphate - metabolism | HeLa Cells | Phosphorylation - drug effects | Ionophores - pharmacology | ACC, acetyl-CoA carboxylase | calmodulin-dependent protein kinase kinase | HEK, human embryonic kidney | MARK, microtubule affinity-regulating kinase | AMPK, AMP-activated protein kinase | TBS, Tris-buffered saline | BRSK, brain-specific kinase | UBA, ubiquitin-associated | MO25, mouse protein 25 | CaMK, Ca2 | ARK, AMPK-related kinase | NUAK, SNF1 (sucrose-non-fermenting kinase-1)-like kinase | AMPactivated protein kinase-related kinase (ARK) | GST, glutathione transferase | STRAD, Ste20-related adaptor | GFP, green fluorescent protein | calmodulin-dependent protein kinase | SIK, salt-inducible kinase | calmodulindependent protein kinase (CaMK) | Ca2 | AICAR, 5-amino-4-imidazolecarboxamide riboside | FBS, foetal bovine serum | CaMKK, Ca2
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2010, Volume 427, Issue 1, pp. 69 - 78
More than 200 phosphorylated 14-3-3-binding sites in the literature were analysed to define 14-3-3 specificities, identify relevant protein kinases, and give insights into how cellular 14-3-3... 
Evolution | 14-3-3 protein | Disrupted-in-schizophrenia 1 (DISC1) | calmodulin-dependent protein kinase | AGC protein kinase | Ca | NEURONAL MIGRATION | SIGNALING PATHWAYS | MEMBRANE H+-ATPASE | REGULATING 14-3-3 BINDING | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | EUKARYOTIC PROTEIN-KINASES | evolution | NUCLEAR-LOCALIZATION | EXOENZYME-S | STRUCTURAL BASIS | Ca2+/calmodulin-dependent protein kinase | disrupted-in-schizophrenia 1 (DISC1) | ENDOPLASMIC-RETICULUM | Protein Kinases - metabolism | Phosphorylation | Immunoprecipitation | Humans | RNA, Messenger - genetics | Cells, Cultured | Computational Biology | Kidney - cytology | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | 14-3-3 Proteins - metabolism | Nerve Tissue Proteins - metabolism | Kidney - metabolism | Carrier Proteins - metabolism | Protein Binding | Binding Sites | Dimerization | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | 14-3-3 Proteins - genetics | Bcl-2-associated death promoter | AANAT, serotonin acetyltransferase | FOXO, Forkhead box O | KLC, kinesin light chain | CDK5, cyclin-dependent kinase 5 | HEK, human embryonic kidney | MARK, microtubule affinity-regulating kinase | AMPK, AMP-activated protein kinase | EST, expressed sequence tag | PKB, protein kinase B | RSK, ribosomal S6 kinase | CaMK, Ca2 | GLUT4, glucose transporter 4 | protein kinase G | GST, glutathione transferase | HDAC, histone deacetylase | HAP1A, Huntingtin-associated protein 1A | DIG, digoxigenin | PKC, protein kinase C | BAD, Bcl-XL | PP2A, protein phosphatase 2A | DSTT, Division of Signal Transduction Therapy | HA, haemagglutinin | AGC, protein kinase A | Ca2 | PI4K, phosphoinositide 4-kinase | DISC1, disrupted-in-schizophrenia 1 | protein kinase C family kinase | YAP1, yes-associated protein 1
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2014, Volume 457, Issue 1, pp. 215 - 225
The related NUAK1 and NUAK2 are members of the AMPK (AMP-activated protein kinase... 
AMPK-related kinase 5 (ARK5) | AMP-activated protein kinase (AMPK) | Sucrose-non-fermenting protein kinase/AMPKrelated protein kinase (SNARK) | Liver kinase B1 (LKB1) | Kinase profiling | Kinase inhibitor | Myosin phosphate-targeting subunit 1(MYPT1) | CELLS | liver kinase B1 (LKB1) | PHOSPHORYLATION | ARK5 | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | sucrose-non-fermenting protein kinase/AMPK-related protein kinase (SNARK) | kinase inhibitor | INVASION | PATHWAY | ROLES | kinase profiling | AMPK | myosin phosphate-targeting subunit 1(MYPT1) | ASSOCIATION | EXPRESSION | Protein Kinases - genetics | Humans | Substrate Specificity | Heterocyclic Compounds, 4 or More Rings - pharmacology | Repressor Proteins - antagonists & inhibitors | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Drug Evaluation, Preclinical | Protein-Serine-Threonine Kinases - metabolism | Protein-Serine-Threonine Kinases - physiology | Benzodiazepinones - pharmacology | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Repressor Proteins - agonists | Pyrimidines - pharmacology | Enzyme Activation - drug effects | Cell Movement - drug effects | Tumor Suppressor Proteins - physiology | Animals | Anilides - pharmacology | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | ACC, acetyl-CoA carboxylase | AMPKrelated protein kinase (SNARK) | SIK, salt-induced kinase | NF-κB, nuclear factor κB | HEK, human embryonic kidney | AMPK, AMP-activated protein kinase | HA, haemagglutinin | BRSK, brain-specific kinase | sucrose-non-fermenting protein kinase | DMEM, Dulbecco’s modified Eagle’s medium | PP1, protein phosphatase 1 | MEF, mouse embryonic fibroblast | PEI, polyethylenimine | MARK, microtubule-affinity-regulating kinase | MYPT1, myosin phosphate-targeting subunit 1 | LKB1, liver kinase B1
Journal Article
Biochemical journal, ISSN 0264-6021, 02/2014, Volume 458, Issue 1, pp. 41 - 56
The LKB1 tumour suppressor protein kinase functions to activate two isoforms of AMPK... 
Amino Acid Sequence | Phosphorylation | Humans | Protein-Serine-Threonine Kinases - genetics | Molecular Sequence Data | Protein Prenylation | Serine - metabolism | Animals | Adenylate Kinase - metabolism | HEK293 Cells | Cysteine - metabolism | Mice | Protein-Serine-Threonine Kinases - metabolism | STRAD, STE20-related kinase adaptor | ACC, acetyl-CoA carboxylase | PI3K, phosphoinositide 3-kinase | SIK3, salt-inducible kinase 3 | HEK, human embryonic kidney | AMPK, AMP-activated protein kinase | ARK5, AMPK-related protein kinase 5 | EDL, extensor digitorum longus | ERK, extracellular-signal-regulated kinase | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | RSK, ribosomal S6 kinase | DMEM, Dulbecco's modified Eagle's medium | NUAK1, NUAK family, SNF1-like kinase | phenformin | BRSK, BR serine | SAD-A | threonine kinase | mTOR, mammalian target of rapamycin | Bub2 | HSP90, heat-shock protein 90 | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | SAD-B kinase | MARK4, MAP | signal transduction | 5-amino-4-imidazolecarboxamide riboside (AICAR) | PKA, cAMP-dependent protein kinase | HA, haemagglutinin | BiP, immunoglobulin heavy-chain-binding protein | PH, pleckstrin homology | raptor, regulatory associated protein of mTOR | Cdc16) domain family, member 1 | TBC1D1, TBC (Tre-2 | BDNF, brain-derived neurotrophic factor | ACTH, adrenocorticotropic hormone | MAPKAPK, MAPKAP (MAPK-activated protein) kinase | MEF, mouse embryonic fibroblast | AICAR, 5-amino-4-imidazolecarboxamide riboside | AMP-activated protein kinase-related kinase (AMPK-related kinase) | monoclonal antibody | microtubule affinity-regulating kinase 4 | ER, endoplasmic reticulum | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2006, Volume 394, Issue 3, pp. 545 - 555
Recent work indicates that the LKB1 tumour suppressor protein kinase. which is mutated in Peutz-Jeghers cancer syndrome, phosphorylates and activates a group of protein kinases that are related to AMPK... 
LKB1 tumour suppressor protein kinase | Ubiquitination | Peutz-Jeghers syndrome (PJS) | Small-angle X-ray scattering analysis (SAXS analysis) | AMP-activated protein kinase (AMPK) | LYS48-LINKED POLYUBIQUITIN CHAIN | PROTEIN | RECOGNITION | DETERMINANTS | UPSTREAM | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LKB1 | UBA DOMAIN | small-angle X-ray scattering analysis (SAXS analysis) | ubiquitination | SOLUTION SCATTERING | TUMOR-SUPPRESSOR | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Phosphorylation | Escherichia coli | Humans | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Ubiquitin - metabolism | Models, Molecular | Molecular Sequence Data | Multienzyme Complexes - metabolism | Multienzyme Complexes - genetics | AMP-Activated Protein Kinases | Multienzyme Complexes - chemistry | Protein Transport | Sequence Homology, Amino Acid | Sequence Alignment | Protein-Serine-Threonine Kinases - chemistry | Enzyme Activation | Protein-Serine-Threonine Kinases - metabolism | AMPK, AMP-activated protein kinase | BRSK, brain-specific kinase | MO25, mouse protein 25 | NSD, normalized spatial discrepancy | Rhp23, a functional homologue of the human excision repair enzyme Hhr23A | SNRK, sucrose-non-fermenting-related kinase | SNF1, sucrose-non-fermenting kinase-1 | TAP, tandem affinity purification | PJS, Peutz–Jegher's syndrome | SAKS1, stress-activated-kinase substrate-1 | GFP, green fluorescent protein | GST, glutathione S-transferase | SIK, salt-induced kinase | SUMO1, small ubiquitin-related modifier-1 | SAXS, small-angle X-ray scattering | STRAD, STE20-related adaptor | UBA, ubiquitin-associated domain | HA, haemagglutinin | QIK, Qin-induced kinase | NUAK1 kinase, ARK5 (AMPK-related kinase 1) | Peutz–Jeghers syndrome (PJS) | MARK, microtubule-affinity-regulating kinase | NEDD8, neural precursor cell-expressed developmentally down-regulated 8
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 04/2007, Volume 27, Issue 16, pp. 4413 - 4423
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2010, Volume 430, Issue 3, pp. 393 - 404
LRRK2 (leucine-rich repeat protein kinase 2) is mutated in a significant number of Parkinson's disease patients, but still little is understood about how it is regulated or functions... 
Pathogenic mutation | 14-3-3 protein | Phosphorylation | Cytoplasmic localization | Parkinson's disease | Leucine-rich repeat protein kinase 2 (LRRK2) | KINASE-ACTIVITY | leucine-rich repeat protein kinase 2 (LRRK2) | cytoplasmic localization | pathogenic mutation | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPHOSPHORYLATION | PROTEINS | phosphorylation | 14-3-3-PROTEINS | Immunoprecipitation | Humans | Swiss 3T3 Cells | Molecular Sequence Data | Cytoplasm - metabolism | Green Fluorescent Proteins - genetics | Brain - metabolism | Kidney - metabolism | Protein-Serine-Threonine Kinases - metabolism | 14-3-3 Proteins - genetics | Amino Acid Sequence | Cell Line | Green Fluorescent Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Serine - genetics | Binding Sites - genetics | Parkinson Disease - genetics | Serine - metabolism | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Mice, Knockout | 14-3-3 Proteins - metabolism | Sequence Homology, Amino Acid | Animals | Spleen - metabolism | Protein Binding | Mice | Mutation | Microscopy, Fluorescence | DIG, digoxigenin | GFP, green fluorescent protein | COR, C-terminal of ROC | FBS, fetal bovine serum | SILAC, stable isotope labelling of amino acids | TBST, Tris-buffered saline with Tween 20 | DTT, dithiothreitol | HEK-293, human embryonic kidney | Hsp90, heat-shock protein 90 | PD, Parkinson's disease | DMEM, Dulbecco's modified Eagle's medium | IPI, International Protein Index | MARK3, microtubule affinity-regulating kinase 3 | CDC, cell division cycle | LRRK2, leucine-rich repeat protein kinase 2 | ROC, Ras of complex GTPase domain | KLH, keyhole-limpet haemocyanin
Journal Article