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ag014699 (17) 17
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Molecular cancer therapeutics, ISSN 1535-7163, 12/2011, Volume 10, Issue 12, pp. 2320 - 2329
AG014699 was the first inhibitor of the DNA-repair enzyme Poly(ADP-ribose) polymerase-1 (PARP-1) to enter clinical trial in cancer patients. In addition to... 
cardiotoxicity | PARP | AG014699 | perfusion | doxorubicin
Journal Article
The Lancet Oncology, ISSN 1470-2045, 10/2018, Volume 19, Issue 10, pp. 1269 - 1270
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2012, Volume 18, Issue 2, pp. 510 - 523
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e60408
Exposure to genotoxic agents, such as irradiation produces DNA damage, the toxicity of which is augmented when the DNA repair is impaired. Poly (ADP-ribose)... 
CARCINOMA-CELLS | LYMPHOMA-CELLS | AG014699 | GENOTOXIC STRESS | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | HOMOLOGOUS RECOMBINATION | IONIZING-RADIATION | TUMORS | PROGRESSION | POLY(ADP-RIBOSE) POLYMERASE INHIBITOR | Transcriptional Regulator ERG | Cell Line | Cell Survival - drug effects | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - metabolism | Humans | Trans-Activators | Cellular Senescence - drug effects | Morpholines - pharmacology | PTEN Phosphohydrolase - metabolism | Male | Cell Survival - radiation effects | Recombinant Fusion Proteins | Poly(ADP-ribose) Polymerases - metabolism | Poly(ADP-ribose) Polymerases - genetics | Cellular Senescence - radiation effects | Fluorescent Antibody Technique | Cell Line, Tumor | Indoles - pharmacology | Serine Endopeptidases | Chromones - pharmacology | DNA damage | Analysis | Genetic aspects | Research | DNA repair | Prostate cancer | Cancer | Cell culture | Protein kinase C | Radiosensitivity | Homologous recombination | Lung cancer | Genotoxicity | Radiation | Galactosidase | Phosphatase | ADP | Mimicry | Proteins | Fusion protein | Deoxyribonucleic acid--DNA | Sensitivity analysis | BRCA1 protein | Gene expression | Survival | Radiation dosage | ERG gene | Inhibitors | Irradiation | Sensitivity enhancement | Lymphomas | Mutation | Radiation damage | ETS protein | Senescence | Toxicity | Homology | Biology | Activation | Ribose | Rodents | Cell cycle | Brachytherapy | BRCA2 protein | Cell survival | Poly(ADP-ribose) polymerase | Breast cancer | Radiation therapy | Polymerase | Sensitivity | DNA-dependent protein kinase | Cell lines | Prostate | PTEN protein | Tumors | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 01/2015, Volume 32, Issue 1, pp. 37 - 46
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 8/2014, Volume 74, Issue 2, pp. 257 - 265
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, p. e0118187
Therapeutic inhibition of poly(ADP-ribose) polymerase (PARP), as monotherapy or to supplement the potencies of other agents, is a promising strategy in cancer... 
SMOOTH-MUSCLE | RADIOSENSITIZATION | AG014699 | EFFICACY | NICOTINAMIDE | MULTIDISCIPLINARY SCIENCES | DEPENDENT PROTEIN-KINASE | MICE | DNA-REPAIR | CHEMOPOTENTIATION | POLY(ADP-RIBOSE) POLYMERASE-1 INHIBITORS | Rats, Wistar | Myosin-Light-Chain Kinase - metabolism | Aorta - drug effects | Humans | Enzyme Inhibitors - pharmacology | Rats | Male | Myosin-Light-Chain Kinase - antagonists & inhibitors | Aorta - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Receptors, Purinergic P2 - metabolism | Poly(ADP-ribose) Polymerases - deficiency | Indoles - pharmacology | Mice | Poly (ADP-Ribose) Polymerase-1 | Vasodilation - drug effects | Aorta - physiology | Carcinoma, Renal Cell - blood supply | Kidney Neoplasms - blood supply | Niacinamide | Ionizing radiation | Dilatation | Analysis | Nitric oxide | Myosin | Blood vessels | Muscle proteins | Health aspects | NADPH | Suramin | Purine receptors | Xenotransplantation | Poly(ADP-ribose) | Smooth muscle | Kinases | Phosphatase | ADP | Experiments | Myosin-light-chain kinase | Vasodilation | Complexity | Windows (intervals) | Poisons | Receptors | Ribose | Rodents | Xenografts | Purine P2 receptors | Inhibition | Deoxyribonucleic acid--DNA | Medical research | Enzymes | Muscles | Poly(ADP-ribose) polymerase | Pharmacology | Gene expression | Muscle contraction | Polymerase | NAD | Poly(ADP-ribose) Polymerase 1 | Inhibitors | Perfusion | Pharmacy | Dilation | Nicotinamide | Temozolomide | Tumors | Cancer | Veins & arteries | Deoxyribonucleic acid | DNA
Journal Article
Molecular Oncology, ISSN 1574-7891, 06/2013, Volume 7, Issue 3, pp. 308 - 322
Cancer cells may use PARP enzymes and Homologous Recombination to repair single and double strand breaks caused by genotoxic insults. In this study, the PARP-1... 
Gemcitabine | Rucaparib | Chemoradiotherapy | Pancreatic cancer | PARP inhibitor | SURVIVAL | CELLS | CURATIVE RESECTION | RADIATION | CHEMOTHERAPY | BREAST-CANCER | TRIAL | AG014699 | ONCOLOGY | CARCINOMA | POLY(ADP-RIBOSE) POLYMERASE INHIBITOR | Chemoradiotherapy - methods | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Apoptosis - radiation effects | Cell Cycle - radiation effects | Humans | Pancreatic Neoplasms - pathology | Pancreas - drug effects | Pancreas - pathology | Pancreas - metabolism | Poly(ADP-ribose) Polymerase Inhibitors | Antimetabolites, Antineoplastic - therapeutic use | Deoxycytidine - therapeutic use | Cell Line, Tumor | Indoles - therapeutic use | Cell Proliferation - drug effects | Cell Cycle - drug effects | Pancreas - radiation effects | Deoxycytidine - analogs & derivatives | Cell Proliferation - radiation effects | Pancreatic Neoplasms - therapy | Enzymes | Care and treatment | Analysis | Oncology, Experimental | Research | Tumor proteins | Radiotherapy | Health aspects | Cancer | Flow cytometry | Immunocytochemistry | Mitosis | p53 Protein | Homologous recombination | Genotoxicity | Cytotoxicity | AKT protein | Cancer therapies | DNA repair | Western blotting | Ovarian cancer | Surgery | Deoxyribonucleic acid--DNA | Poly(ADP-ribose) polymerase | Breast cancer | Radiation therapy | Tumor cell lines | Studies | Chemotherapy | Cell lines | Biomarkers | Mutation | Apoptosis | Papers | Paper
Journal Article