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Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SUBSTRATE-SPECIFICITY | HYDROPHOBIC MOTIF PHOSPHORYLATION | cancer | serum and glucocorticoid protein kinase (SGK) | COMPLEX 2 | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | Index Medicus | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2010, Volume 427, Issue 1, pp. 69 - 78
More than 200 phosphorylated 14-3-3-binding sites in the literature were analysed to define 14-3-3 specificities, identify relevant protein kinases, and give... 
Evolution | 14-3-3 protein | Disrupted-in-schizophrenia 1 (DISC1) | calmodulin-dependent protein kinase | AGC protein kinase | NEURONAL MIGRATION | SIGNALING PATHWAYS | MEMBRANE H+-ATPASE | REGULATING 14-3-3 BINDING | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | EUKARYOTIC PROTEIN-KINASES | evolution | NUCLEAR-LOCALIZATION | EXOENZYME-S | STRUCTURAL BASIS | Ca2+/calmodulin-dependent protein kinase | disrupted-in-schizophrenia 1 (DISC1) | ENDOPLASMIC-RETICULUM | Protein Kinases - metabolism | Phosphorylation | Immunoprecipitation | Humans | RNA, Messenger - genetics | Cells, Cultured | Computational Biology | Kidney - cytology | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | 14-3-3 Proteins - metabolism | Nerve Tissue Proteins - metabolism | Kidney - metabolism | Carrier Proteins - metabolism | Protein Binding | Binding Sites | Dimerization | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | 14-3-3 Proteins - genetics | Index Medicus | Bcl-2-associated death promoter | AANAT, serotonin acetyltransferase | FOXO, Forkhead box O | KLC, kinesin light chain | CDK5, cyclin-dependent kinase 5 | HEK, human embryonic kidney | MARK, microtubule affinity-regulating kinase | AMPK, AMP-activated protein kinase | EST, expressed sequence tag | PKB, protein kinase B | RSK, ribosomal S6 kinase | CaMK, Ca2 | GLUT4, glucose transporter 4 | protein kinase G | GST, glutathione transferase | HDAC, histone deacetylase | HAP1A, Huntingtin-associated protein 1A | DIG, digoxigenin | PKC, protein kinase C | BAD, Bcl-XL | PP2A, protein phosphatase 2A | DSTT, Division of Signal Transduction Therapy | HA, haemagglutinin | AGC, protein kinase A | Ca2 | PI4K, phosphoinositide 4-kinase | DISC1, disrupted-in-schizophrenia 1 | protein kinase C family kinase | YAP1, yes-associated protein 1
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2007, Volume 407, Issue 2, pp. 231 - 241
AS 160 (Akt substrate of 160 kDa) mediates insulin-stimulated GLUT4 (glucose transporter 4) translocation, but is widely expressed in insulin-insensitive... 
14-3-3 | Akt/protein kinase B (PKB) | GTPase-activating protein (GAP) | p90 ribosomal S6 kinase (RSK) | Akt substrate of 160 kDa (AS160) | Serum- and glucocorticoid-induced protein kinase (SGK) | MOUSE SKELETAL-MUSCLE | MAMMALIAN TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | Akt substrate of 160kDa (AS160) | AKT SUBSTRATE | CELL-GROWTH | GTPASE-ACTIVATING PROTEIN | INSULIN-STIMULATED PHOSPHORYLATION | GLUT4 TRANSLOCATION | S6 KINASE | PROTEOMIC ANALYSIS | RAB-GAP | serum- and glucocorticoid-induced protein kinase (SGK) | Cell Line | Insulin-Like Growth Factor I - pharmacology | Phosphorylation | Humans | GTPase-Activating Proteins - metabolism | Insulin | Amino Acids | Aminoimidazole Carboxamide - pharmacology | Hypoglycemic Agents - pharmacology | 14-3-3 Proteins - metabolism | Ribonucleotides - pharmacology | Aminoimidazole Carboxamide - analogs & derivatives | Protein Binding | Epidermal Growth Factor - pharmacology | Binding Sites | Index Medicus | ACC, acetyl-CoA carboxylase | AGC kinase, protein kinase A | AICAR, 5-amino-4-imidazolecarboxamide1-β-D-ribofuranoside | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | TOS motif, mTOR signalling motif | PAS, phospho-Akt substrate | pSer, phosphorylated serine | TSC, tuberous sclerosis complex | AS160, Akt substrate of 160 kDa | PKB, protein kinase B (also known as Akt) | AMPK, AMP-activated protein kinase | RSK, p90 ribosomal S6 kinase | DSP, dithiobis(succinimidyl propionate) | protein kinase C-family | ERK, extracellular-signal-regulated kinase | PDK1, phosphoinositide-dependent kinase 1 | protein kinase B (PKB) | IGF-1, insulin-like growth factor-1 | Akt substrate of 160 kDa (AS160) | GLUT4, glucose transporter 4 | protein kinase G | mTOR, mammalian target of rapamycin | TORC1, mTOR–raptor (regulatory associated protien of mTOR) complex | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | GST, glutathione S-transferase | PKC, protein kinase C | PP2A, protein phosphatase 2A | Akt | SGK, serum- and glucocorticoid-induced protein kinase | HA, haemagglutinin | GSV, GLUT4 storage vesicle | p70S6K, p70 S6 kinase | PTB, phosphotyrosine binding domain | pThr, phosphorylated threonine | GAP, GTPase-activating protein | HEK-293, human embryonic kidney-293 | IRAP, insulin-responsive aminopeptidase | Rheb, Ras enriched in brain | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2013, Volume 451, Issue 2, pp. 329 - 342
The aPKC [atypical PKC (protein kinase C)] isoforms iota and zeta play crucial roles in the formation and maintenance of cell polarity and represent attractive... 
ATP pocket | Protein kinase A/protein kinase G/protein kinase C family kinase (AGC kinase) | Atypical protein kinase C | Madin-Darby canine kidney (MDCK) cell | Cell polarity | Cell-based assay | Crystallography | Cell migration | Chemical inhibitor | CANCER-CELLS | LAMBDA/IOTA | COMPLEX | protein kinase A/protein kinase G/protein kinase C family kinase (AGC kinase) | POLARITY | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | atypical protein kinase C | ZETA | crystallography | INVASION | cell-based assay | TRANSFORMED GROWTH | cell migration | APKC | PKC-IOTA | cell polarity | chemical inhibitor | Phosphorylation | Humans | Molecular Sequence Data | Crystallography, X-Ray | Pyrimidines - chemistry | Molecular Mimicry | Protein Kinase Inhibitors - chemistry | Protein Kinase C - metabolism | Adenosine Triphosphate - metabolism | Inhibitory Concentration 50 | Cytoskeletal Proteins - metabolism | Binding Sites | Amino Acid Sequence | Cell Line | Cell Survival - drug effects | Drug Evaluation, Preclinical - methods | Protein Kinase Inhibitors - chemical synthesis | Thiophenes - pharmacology | Protein Kinase C - antagonists & inhibitors | Pyrimidines - pharmacology | Cell Movement - drug effects | Animals | High-Throughput Screening Assays | Protein Kinase C - chemistry | Dogs | Adenosine - metabolism | Protein Kinase Inhibitors - pharmacology | Adenosine Triphosphate - chemistry | Thiophenes - chemistry | Isoenzymes - antagonists & inhibitors | Protein Kinase Inhibitors - metabolism | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2007, Volume 402, Issue 3, pp. 491 - 501
MSK 1 (mitogen- and stress-activated kinase 1) is a dual kinase domain protein that acts downstream of the ERK1/2 (extracellular-signal-regulated kinase 1/2)... 
Precursor ion scanning MS | cAMP-response-element-binding protein (CREB) | p90 ribosomal S6 kinase (RSK) | p38 | Extracellular-signal-regulated kinase (ERK) | Mitogen-activated protein kinase (MAPK) | precursor ion scanning MS | ACTIVATED PROTEIN-KINASE | STRESS-INDUCED PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | BINDING PROTEIN | DOCKING SITE | extracellular-signal-regulated kinase (ERK) | TUMOR-NECROSIS-FACTOR | LYSOPHOSPHATIDIC ACID | EMBRYONIC STEM-CELLS | HYDROPHOBIC MOTIF PHOSPHORYLATION | MAPKAP KINASE-2 | RIBOSOMAL S6 KINASE | Amino Acid Sequence | Cell Line | Phosphorylation | Humans | Molecular Sequence Data | Phosphoserine - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Sequence Alignment | Mutagenesis | Mass Spectrometry | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Conserved Sequence | Protein Binding | Enzyme Activation | Phosphoserine - chemistry | Mitogen-Activated Protein Kinases - metabolism | Index Medicus | 2, MAPK | RSK, p90 ribosomal S6 kinase | MSK, mitogen- and stress-activated kinase | AGC-type kinases, protein kinase A | ERK, extracellular-signal-regulated kinase | PDK1, phosphoinositide-dependent kinase 1 | protein kinase C-family kinases | LC, liquid chromatography | ERK kinase 1 | MNK, MAPK-integrating kinase | PKI, protein kinase A inhibitor | protein kinase G | CREB, cAMP-response-element-binding | GST, glutathione S-transferase | MS, tandem MS | ATF, activating transcription factor | MAPKAPK2 | MEK1 | MRM, multiple reaction monitoring | 3, MAPK-activated protein kinase-2 | MAPK, mitogen-activated protein kinase
Journal Article
Journal Article
Journal Article
BMC Genomics, ISSN 1471-2164, 09/2015, Volume 16, Issue 1, pp. 719 - 719
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 02/2014, Volume 42, Issue 1, pp. 35 - 41
Journal Article