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American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 03/2010, Volume 298, Issue 3, pp. E395 - E402
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2013, Volume 451, Issue 2, pp. 329 - 342
The aPKC [atypical PKC (protein kinase C)] isoforms iota and zeta play crucial roles in the formation and maintenance of cell polarity and represent attractive... 
ATP pocket | Protein kinase A/protein kinase G/protein kinase C family kinase (AGC kinase) | Atypical protein kinase C | Madin-Darby canine kidney (MDCK) cell | Cell polarity | Cell-based assay | Crystallography | Cell migration | Chemical inhibitor | CANCER-CELLS | LAMBDA/IOTA | COMPLEX | protein kinase A/protein kinase G/protein kinase C family kinase (AGC kinase) | POLARITY | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | atypical protein kinase C | ZETA | crystallography | INVASION | cell-based assay | TRANSFORMED GROWTH | cell migration | APKC | PKC-IOTA | cell polarity | chemical inhibitor | Phosphorylation | Humans | Molecular Sequence Data | Crystallography, X-Ray | Pyrimidines - chemistry | Molecular Mimicry | Protein Kinase Inhibitors - chemistry | Protein Kinase C - metabolism | Adenosine Triphosphate - metabolism | Inhibitory Concentration 50 | Cytoskeletal Proteins - metabolism | Binding Sites | Amino Acid Sequence | Cell Line | Cell Survival - drug effects | Drug Evaluation, Preclinical - methods | Protein Kinase Inhibitors - chemical synthesis | Thiophenes - pharmacology | Protein Kinase C - antagonists & inhibitors | Pyrimidines - pharmacology | Cell Movement - drug effects | Animals | High-Throughput Screening Assays | Protein Kinase C - chemistry | Dogs | Adenosine - metabolism | Protein Kinase Inhibitors - pharmacology | Adenosine Triphosphate - chemistry | Thiophenes - chemistry | Isoenzymes - antagonists & inhibitors | Protein Kinase Inhibitors - metabolism
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2010, Volume 285, Issue 6, pp. 3825 - 3832
Phosphorylation of the activation loop is one of the most common mechanisms for regulating protein kinase activity. The catalytic subunit of cAMP-dependent... 
CATALYTIC SUBUNIT | DOMAIN | MECHANISM | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CAMP-DEPENDENT KINASE | CONFORMATION | EXCHANGE | AUTOPHOSPHORYLATION | THREONINE | Phosphorylation | Isotope | Stability | Threonine | Serine | Kinases | Activation Loop | Protein | AGC kinase | Exchange | Allosteric | Enzyme Catalysis and Regulation | Protein Kinase A
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SUBSTRATE-SPECIFICITY | HYDROPHOBIC MOTIF PHOSPHORYLATION | cancer | serum and glucocorticoid protein kinase (SGK) | COMPLEX 2 | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 25, pp. 22017 - 22027
Pkh1, -2, and -3 are the yeast orthologs of mammalian 3-phosphoinositide- dependent protein kinase-1 (PDK1). Although essential for viability, their... 
AGC KINASES | CATALYTIC SUBUNIT | PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | BINDING POCKET | SACCHAROMYCES-CEREVISIAE | ADENYLATE-CYCLASE | RAS PROTEINS | DOCKING SITE | Protein-Serine-Threonine Kinases - deficiency | Sequence Deletion | Phosphorylation | Cyclic AMP-Dependent Protein Kinases - chemistry | Saccharomyces cerevisiae - drug effects | Saccharomyces cerevisiae Proteins - biosynthesis | Saccharomyces cerevisiae - metabolism | Nitrogen - pharmacology | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Catalytic Domain | Proto-Oncogene Proteins c-akt - chemistry | Protein-Serine-Threonine Kinases - genetics | Cell Size | Saccharomyces cerevisiae Proteins - genetics | Protein-Serine-Threonine Kinases - biosynthesis | Saccharomyces cerevisiae - cytology | Sequence Homology, Amino Acid | Animals | Mutagenesis | Saccharomyces cerevisiae Proteins - metabolism | Hydrophobic and Hydrophilic Interactions | Protein Binding | Saccharomyces cerevisiae - enzymology | Protein-Serine-Threonine Kinases - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Index Medicus | Site-directed Mutagenesis | Protein Kinase A (PKA) | Yeast | Signal Transduction | Protein Kinases | PKB | Sch9 | Protein Phosphorylation | Saccharomyces cerevisiae | PDK1 | Pkh1–3
Journal Article