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Medicine Today, ISSN 1443-430X, 01/2011, Volume 12, Issue 1, pp. 28 - 39
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2002, Volume 277, Issue 25, pp. 22201 - 22208
Osteoarthritis is a degenerative joint disorder characterized by breakdown of articular cartilage. Degradation of aggrecan, which together with type II... 
aggrecan
Journal Article
Endocrinology, ISSN 0013-7227, 04/2002, Volume 143, Issue 4, pp. 1467 - 1474
Previous studies in chondrogenic RCJ3.1C5.18 (C5.18) cells showed that growth of these cells at high extracellular Ca super(2+) concentrations ([Ca super(2+)]... 
aggrecan
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2002, Volume 361, Issue 3, pp. 689 - 696
Although the effects of mechanical loading on chondrocyte metabolic activities have been extensively characterized, the sequence of events through which... 
aggrecan
Journal Article
Journal of Cell Science, ISSN 0021-9533, 11/2001, Volume 114, Issue 21, pp. 3813 - 3822
Cells of the monocyte/macrophage lineage are involved in the development of inflammatory joint diseases such as rheumatoid arthritis. This disease is... 
aggrecan
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2001, Volume 358, Issue 3, pp. 615 - 626
Studies of aggrecan proteolysis in human joints have implicated both the aggrecanase [ADAMTS, a disintegrin-like and metalloprotease (reprolysin-type) with... 
aggrecan
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 11/2002, Volume 30, Issue 6, pp. 869 - 874
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2013, Volume 210, Issue 12, pp. 2569 - 2582
Journal Article
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 05/2017, Volume 18, Issue 5, p. 975
Slow growth and rapid loss of chondrogenic phenotypes are the major problems affecting chronic cartilage lesions. The role of microRNA-195 (miR-195) and its... 
Signal pathway | Col2a1/aggrecan | MiR-195 | Cartilage lesion | Chondrocyte proliferation | FGF18 | cartilage lesion | MICROFRACTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | chondrocyte proliferation | CHEMISTRY, MULTIDISCIPLINARY | MESENCHYMAL STEM-CELLS | COLLAGEN-II | ARTICULAR-CARTILAGE REPAIR | IN-VIVO | miR-195 | GENE-THERAPY | GROWTH-PLATE | signal pathway | OSTEOCHONDRITIS-DISSECANS | OSTEOARTHRITIS | EXPRESSION | Chondrocytes - cytology | Cell Proliferation | Osteochondritis - genetics | Humans | Osteochondritis - pathology | Fibroblast Growth Factors - genetics | MicroRNAs - metabolism | Case-Control Studies | Collagen Type II - metabolism | Fibroblast Growth Factors - metabolism | Chondrocytes - physiology | Osteochondritis - metabolism | HEK293 Cells | Female | 3' Untranslated Regions | Chondrogenesis | Chondrocytes - metabolism | Cells, Cultured | Rats | Aggrecans - metabolism | Aggrecans - genetics | Rats, Sprague-Dawley | Collagen Type II - genetics | Phenotype | Animals | MicroRNAs - genetics | Knee | Fibroblast growth factor | Collagen (type II) | Homeostasis | Chains | Antisense | Assaying | Cartilage | Genotype & phenotype | Transfection | Mathematical models | Fibroblast growth factor 18 | Lesions | Informatics | MiRNA | Maintenance | Ribonucleic acid--RNA | Patients | Anterior cruciate ligament | Inhibitors | 3' Untranslated regions | Chondrocytes | In vivo methods and tests | Aggrecan | Internet
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 12225 - 6
Short stature is a common pediatric disorder affecting 3% of the population. However, the clinical variability and genetic heterogeneity prevents the... 
VARIANTS | FORM | MULTIDISCIPLINARY SCIENCES | GROWTH | GUIDELINES | SPONDYLOEPIPHYSEAL DYSPLASIA | AGGRECAN GENE | IDENTIFICATION | CHILDREN | Cartilage | Aggrecan | Mutation | Genetic screening
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 16214 - 12
Journal Article
Journal of Orthopaedic Research, ISSN 0736-0266, 01/2001, Volume 19, Issue 3, pp. 478 - 481
Human adult cartilage is an inherently difficult tissue from which to isolate RNA. The RNA isolation techniques described so far have generally only been... 
aggrecan
Journal Article
蛋白质与细胞:英文版, ISSN 1674-800X, 2017, Volume 8, Issue 8, pp. 560 - 572
Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type Ⅱ... 
基质蛋白 | 胶原蛋白 | 结缔组织 | 细胞外基质 | 关节软骨 | 临床试验 | 生物学功能 | 蛋白聚糖 | Life Sciences | Biochemistry, general | Protein Science | Stem Cells | Human Genetics | arthritis | collagen | Developmental Biology | biomarker | Cell Biology | VI COLLAGEN | PERICELLULAR MATRIX | X COLLAGEN | INFLAMMATORY ARTHRITIS | XVI COLLAGEN | CELL BIOLOGY | MULTIPLE EPIPHYSEAL DYSPLASIA | IX COLLAGEN | CHONDROCYTE HYPERTROPHY | HIP-OSTEOARTHRITIS | II COLLAGEN | Aggrecans - chemistry | Humans | Collagen - chemistry | Protein Isoforms - metabolism | Protein Isoforms - classification | Cartilage, Articular - metabolism | Protein Isoforms - chemistry | Collagen - genetics | Osteoarthritis - pathology | Extracellular Matrix Proteins - metabolism | Cartilage, Articular - chemistry | Biomarkers - metabolism | Extracellular Matrix Proteins - chemistry | Gene Expression | Extracellular Matrix Proteins - genetics | Collagen - classification | Osteoarthritis - metabolism | Aggrecans - metabolism | Aggrecans - genetics | Osteoarthritis - diagnosis | Osteoarthritis - genetics | Cartilage, Articular - pathology | Collagen - metabolism | Animals | Protein Isoforms - genetics | Medicine, Experimental | Medical research | Development and progression | Arthritis | Research institutes | Collagen | Knee | Collagen (type II) | Connective tissue diseases | Clinical trials | Mechanical properties | Extracellular matrix | Cartilage (articular) | Aggrecan | Drug development | Biochemical markers | Mini-Review | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Reumatologi och inflammation | Cell and Molecular Biology | Klinisk medicin | Rheumatology and Autoimmunity | Clinical Medicine | Medicinska och farmaceutiska grundvetenskaper | Cell- och molekylärbiologi
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2000, Volume 275, Issue 9, pp. 6321 - 6327
The effect of age on the incorporation of newly synthesized aggrecan into the extracellular matrix of human articular cartilage was investigated. This property... 
aggrecan
Journal Article
Journal Article