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Journal of the American College of Cardiology, ISSN 0735-1097, 2009, Volume 53, Issue 10, pp. 849 - 856
Objectives The aim of this prospective trial was to assess whether platelet reactivity to clopidogrel assessed with multiple electrode platelet aggregometry... 
Cardiovascular | Internal Medicine | clopidogrel | whole blood aggregometry | stent thrombosis | platelet aggregation | ADVERSE CARDIOVASCULAR EVENTS | PERCUTANEOUS CORONARY INTERVENTION | RESPONSIVENESS | CARDIAC & CARDIOVASCULAR SYSTEMS | INHIBITION | IMPLANTATION | PREDICTORS | RESISTANCE | BARE-METAL | ANTAGONISTS | AGGREGOMETRY | Prospective Studies | Platelet Function Tests - methods | Ticlopidine - pharmacology | Ticlopidine - therapeutic use | Humans | Kaplan-Meier Estimate | Male | Thrombosis - epidemiology | Coronary Artery Disease - mortality | Electric Impedance | Ticlopidine - analogs & derivatives | Drug-Eluting Stents - adverse effects | Electrodes | Coronary Artery Disease - therapy | Point-of-Care Systems | Thrombosis - etiology | Ticlopidine - adverse effects | Platelet Aggregation Inhibitors - pharmacology | Female | Platelet Function Tests - instrumentation | Aged | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Transluminal angioplasty | Coenzymes | Vasodilators | Adenosine diphosphate | Coronary heart disease | Thrombosis | Stent (Surgery) | Blood clot | Aggregation | Disease transmission | Blood platelets | Analysis | Adenosine triphosphatase | Drug therapy | Intervention | Anticoagulants | Aspirin | Heart attacks | Medical imaging | Cardiovascular disease | Studies | Confidence intervals | Coronary vessels | Acute coronary syndromes | Stents | Drug dosages | Index Medicus | Abridged Index Medicus
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 11/2015, Volume 21, Issue 48, pp. 17459 - 17465
Journal Article
2012, ISBN 1439841802, xiii, 304
Book
Journal of the American College of Cardiology, ISSN 0735-1097, 01/2008, Volume 51, Issue 3, pp. 256 - 260
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2008, Volume 359, Issue 12, pp. 1238 - 1251
In this large clinical trial, aspirin plus extended-release dipyridamole was found to have an efficacy similar to that of clopidogrel in the prevention of... 
ACTIVE CONTROLLED-TRIALS | HIGH-RISK PATIENTS | TICLOPIDINE | TRANSIENT ISCHEMIC ATTACK | DOUBLE-BLIND | PREVENTION | RANDOMIZED CONTROLLED-TRIAL | ARTERIAL ORIGIN ESPRIT | CEREBRAL-ISCHEMIA | UMCG Approved | NON-INFERIORITY TRIALS | ISSUES | MEDICINE, GENERAL & INTERNAL | PLACEBO | DESIGN | WARFARIN | REGIMENS | Myocardial Infarction - epidemiology | Benzoates - therapeutic use | Ticlopidine - therapeutic use | Humans | Middle Aged | Male | Risk | Secondary Prevention | Aspirin - administration & dosage | Vascular Diseases - mortality | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Aspirin - adverse effects | Platelet Aggregation Inhibitors - administration & dosage | Ticlopidine - adverse effects | Dipyridamole - adverse effects | Female | Stroke - epidemiology | Drug Therapy, Combination | Platelet Aggregation Inhibitors - therapeutic use | Dipyridamole - therapeutic use | Benzimidazoles - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Brain Ischemia - epidemiology | Stroke - prevention & control | Double-Blind Method | Kaplan-Meier Estimate | Proportional Hazards Models | Brain Ischemia - prevention & control | Factor Analysis, Statistical | Stroke - drug therapy | Ticlopidine - analogs & derivatives | Aged | Hemorrhage - chemically induced | Delayed-Action Preparations | Stroke (Disease) | Aspirin | Usage | Care and treatment | Dipyridamole | Clopidogrel | Health aspects | Stroke | Index Medicus | Abridged Index Medicus | Recurrence | Brain Ischemia | Benzimidazoles | Follow-Up Studies | Neurons and Cognition | Cognition | Hemorrhage | Drug Delivery Systems | Life Sciences | Angiotensin II Type 1 Receptor Blockers | Angiotensin-Converting Enzyme Inhibitors | Vascular Diseases | Mental Status Schedule | Retrospective Studies | Severity of Illness Index | Disability Evaluation | Benzoates | Drug Administration Schedule | International Cooperation | Ticlopidine | Myocardial Infarction | Platelet Aggregation Inhibitors | Santé publique et épidémiologie | Original | Dipyridamole/adverse effects/therapeutic use | Angiotensin-Converting Enzyme Inhibitors/therapeutic use | Recurrence/prevention & control | Benzoates/therapeutic use | Brain Ischemia/epidemiology/prevention & control | MEDICIN OCH HÄLSOVETENSKAP | Platelet Aggregation Inhibitors/administration & dosage/adverse | Combination | MEDICAL AND HEALTH SCIENCES | Aspirin/administration & dosage/adverse effects | Myocardial Infarction/epidemiology | Factor Analysis | Benzimidazoles/therapeutic use | Drug Therapy | Ticlopidine/adverse effects/analogs & derivatives/therapeutic use | effects/therapeutic use | Vascular Diseases/mortality | Hemorrhage/chemically induced | Stroke/drug therapy/epidemiology/prevention & control | Statistical | Kaplan-Meiers Estimate
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2009, Volume 360, Issue 4, pp. 354 - 362
The antiplatelet drug clopidogrel requires activation by cytochrome P-450 (CYP) enzymes. This study shows that CYP polymorphisms that reduce clopidogrel... 
VARIABILITY | MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | PHARMACOKINETICS | STENT THROMBOSIS | INCREASED RISK | PLATELET INHIBITION | PRASUGREL | PHARMACODYNAMICS | INDIVIDUAL RESPONSIVENESS | ATHEROTHROMBOTIC EVENTS | Ticlopidine - pharmacology | Ticlopidine - therapeutic use | Area Under Curve | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Male | Cardiovascular Diseases - genetics | Angioplasty, Balloon, Coronary | Ticlopidine - adverse effects | Ticlopidine - metabolism | Cardiovascular Diseases - epidemiology | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - metabolism | Platelet Aggregation Inhibitors - therapeutic use | Stents | Platelet Aggregation Inhibitors - adverse effects | Genotype | Thrombosis - epidemiology | Combined Modality Therapy | Ticlopidine - analogs & derivatives | Polymorphism, Genetic | Randomized Controlled Trials as Topic | Cytochrome P-450 CYP2C19 | Acute Coronary Syndrome - therapy | Heterozygote | Thrombosis - genetics | Mutation | Usage | Genetic variation | Cytochrome P-450 | Physiological aspects | Causes of | Clopidogrel | Cardiovascular diseases | Health aspects | Risk factors | Studies | Cardiovascular disease | Heart attacks | Drug therapy | Index Medicus | Abridged Index Medicus
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2012, Volume 366, Issue 15, pp. 1404 - 1413
Patients with atherosclerotic vascular disease were randomly assigned to receive the thrombin antagonist vorapaxar or placebo. Vorapaxar reduced the rate of... 
ATOPAXAR | MEDICINE, GENERAL & INTERNAL | CLOPIDOGREL | EFFICACY | SAFETY | TOLERABILITY | DOUBLE-BLIND | PRASUGREL | LESSONS | ANTAGONISTS | ASPIRIN | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | Risk | Secondary Prevention | Pyridines - adverse effects | Cardiovascular Diseases - mortality | Female | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Pyridines - therapeutic use | Double-Blind Method | Hemorrhage - epidemiology | Receptor, PAR-1 - antagonists & inhibitors | Kaplan-Meier Estimate | Peripheral Arterial Disease - drug therapy | Stroke - drug therapy | Lactones - adverse effects | Lactones - therapeutic use | Retreatment | Myocardial Infarction - drug therapy | Brain Ischemia - drug therapy | Intracranial Hemorrhages - chemically induced | Intracranial Hemorrhages - epidemiology | Aged | Hemorrhage - chemically induced | Prevention | Drugs | Aggregation | Dose-response relationship (Biochemistry) | Atheroembolism | Blood platelets | Atherosclerosis | Product/Service Evaluations | Dosage and administration | Drug therapy | Myocardial infarction | Cerebral infarction | Stroke | Aspirin | Heart attacks | Proteinase-activated receptor 1 | Thrombin | Hemorrhage | Patients | Bleeding | Disease prevention | Ischemia | Arteriosclerosis | Death | Cardiovascular diseases | Health risk assessment | Computer Science | Medical Imaging
Journal Article
Annual review of biochemistry, ISSN 0066-4154, 6/2017, Volume 86, Issue 1, pp. 27 - 68
Peptides and proteins have been found to possess an inherent tendency to convert from their native functional states into intractable amyloid aggregates. This... 
amyloidosis | quality control | protein aggregation | protein homeostasis | conformational diseases | chaperones | functional amyloid | Protein aggregation | Quality control | Functional amyloid | Amyloidosis | Chaperones | Protein homeostasis | Conformational diseases | FIBRIL FORMATION | NUCLEATED CONFORMATIONAL CONVERSION | SOLID-STATE NMR | STOP-CODON MUTATION | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FAMILIAL BRITISH DEMENTIA | ALPHA-SYNUCLEIN AGGREGATION | BETA PRECURSOR PROTEIN | APOLIPOPROTEIN AII GENE | HUMAN PRION PROTEIN | Proteostasis Deficiencies - metabolism | Molecular Chaperones - metabolism | History, 21st Century | Parkinson Disease - history | Humans | Proteostasis Deficiencies - history | Protein Aggregation, Pathological - history | Drugs, Investigational | Parkinson Disease - drug therapy | Amyloid - chemistry | Diabetes Mellitus, Type 2 - metabolism | Diabetes Mellitus, Type 2 - history | Molecular Targeted Therapy | Alzheimer Disease - pathology | Amyloid - metabolism | Protein Aggregation, Pathological - pathology | Protein Aggregation, Pathological - prevention & control | Parkinson Disease - metabolism | Immunoglobulin Light-chain Amyloidosis | Amyloid - genetics | Alzheimer Disease - history | Parkinson Disease - pathology | Amyloidosis - pathology | Amyloidosis - history | Gene Expression Regulation | Molecular Chaperones - genetics | Proteostasis Deficiencies - pathology | Alzheimer Disease - drug therapy | Amyloidosis - drug therapy | Protein Folding | Proteostasis Deficiencies - prevention & control | Alzheimer Disease - metabolism | Protein Conformation | Diabetes Mellitus, Type 2 - pathology | Proteostasis Deficiencies - drug therapy | Diabetes Mellitus, Type 2 - drug therapy | Amyloidosis - metabolism | Protein Aggregation, Pathological - metabolism | Physiological aspects | Development and progression | Genetic aspects | Protein folding | Amyloid beta-protein
Journal Article