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Scientific Reports, ISSN 2045-2322, 09/2015, Volume 5, Issue 1, p. 13928
MuSK antibody-positive myasthenia gravis (MuSK-MG) accounts for 5 to 15% of autoimmune MG. MuSK and LRP4 are coreceptors for agrin in the signaling pathway... 
POSITIVE MG | ANCHORING ACETYLCHOLINESTERASE | SERONEGATIVE MYASTHENIA-GRAVIS | CRYSTAL-STRUCTURE | WNT RECEPTOR | MULTIDISCIPLINARY SCIENCES | PLATE ACETYLCHOLINESTERASE DEFICIENCY | HEPARIN-BINDING DOMAINS | TAIL SUBUNIT | NEUROMUSCULAR-JUNCTION | RECEPTOR TYROSINE KINASE | LDL-Receptor Related Proteins - metabolism | Neuromuscular Junction - metabolism | Humans | Receptor Protein-Tyrosine Kinases - immunology | Agrin - metabolism | Acetylcholinesterase - genetics | Autoantibodies - pharmacology | Epitopes - immunology | Immunoglobulin G - immunology | Muscle Proteins - metabolism | Neuromuscular Junction - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Collagen - genetics | Protein Interaction Domains and Motifs | Cell Line | Receptors, Nicotinic - metabolism | Receptors, Cholinergic - metabolism | Receptors, Cholinergic - chemistry | Receptor Protein-Tyrosine Kinases - metabolism | Mice, Knockout | Gene Expression Regulation - drug effects | Muscle Proteins - genetics | Collagen - metabolism | Autoantibodies - immunology | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Models, Biological | Immunization, Passive | Protein Binding | Receptors, Cholinergic - immunology | Mice | Receptors, Nicotinic - genetics | Acetylcholinesterase - metabolism | Receptor Protein-Tyrosine Kinases - chemistry | Immunoglobulin G - metabolism | Receptors, Cholinergic - genetics | Immunoglobulin G | Antibodies | Acetylcholinesterase | Signal transduction | Myasthenia gravis | Agrin | Collagen | Rodents | MUSK protein | Acetylcholine receptors | Basal lamina | Neuromuscular junctions | Receptor density | Myasthenia
Journal Article
Journal of Neurology, ISSN 0340-5354, 3/2012, Volume 259, Issue 3, pp. 427 - 435
Myasthenia gravis (MG) is an autoimmune disorder characterized by a defect in synaptic transmission at the neuromuscular junction causing fluctuating muscle... 
Neurology | Neurosciences | Myasthenia gravis | Low-density lipoprotein receptor-related protein | Autoimmune disorder | Medicine & Public Health | LRP4 | Neuroradiology | AGRIN | MOUSE | MUSCLE | ACETYLCHOLINE-RECEPTOR ANTIBODIES | NEUROMUSCULAR-JUNCTION FORMATION | CLINICAL NEUROLOGY | IN-VIVO | TYROSINE KINASE MUSK | HEPARAN-SULFATE | EXPRESSION | LDL-Receptor Related Proteins - metabolism | Neuromuscular Junction - metabolism | Autoantibodies - blood | Humans | Middle Aged | Receptor Protein-Tyrosine Kinases - immunology | Male | Muscle Fibers, Skeletal - drug effects | Agrin - metabolism | LDL-Receptor Related Proteins - genetics | Autoantibodies - pharmacology | Young Adult | Transfection | Adult | Female | Bungarotoxins - metabolism | Neuromuscular Junction - pathology | Myasthenia Gravis - pathology | Green Fluorescent Proteins - metabolism | Receptors, Nicotinic - metabolism | Myasthenia Gravis - blood | Cells, Cultured | Receptors, Nicotinic - immunology | Animals | Neurologic Examination | Adolescent | Muscle Fibers, Skeletal - cytology | Aged | Mice | Myasthenia Gravis - immunology | LDL-Receptor Related Proteins - immunology | Receptors | Physiological aspects | Low density lipoprotein receptors | Acetylcholine | Research | Diagnosis | Comparative analysis | Autoantibodies | Myotubes | Antisera | Skeletal muscle | Lipoproteins | Specialization | Synaptic transmission | agrin | Acetylcholine receptors | MUSK protein | Nerves | Plasma membranes | Acetylcholine receptors (nicotinic) | Neuromuscular junctions | Autoimmune diseases | Protein-tyrosine kinase | EMG
Journal Article
Annals of Neurology, ISSN 0364-5134, 02/2011, Volume 69, Issue 2, pp. 418 - 422
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2013, Volume 110, Issue 51, pp. 20783 - 20788
Myasthenia gravis (MG) is a severely debilitating autoimmune disease that is due to a decrease in the efficiency of synaptic transmission at neuromuscular... 
Phosphorylation | Receptors | Nervous system diseases | Myasthenia gravis | Autoantibodies | 3T3 cells | Enzyme linked immunosorbent assay | Antibodies | Autoimmune diseases | Synapses | PROTEIN 4 | TYROSINE KINASE | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | SEGMENTAL FLEXIBILITY | ACETYLCHOLINE-RECEPTOR | MUSCLE-SPECIFIC KINASE | activation loop | EXPERIMENTAL AUTOIMMUNE MYASTHENIA | neuromuscular junction | Dok7 | IN-VIVO | insulin receptor | MAIN IMMUNOGENIC REGION | NEUROMUSCULAR-JUNCTION | Rapsyn | Humans | Middle Aged | Receptor Protein-Tyrosine Kinases - immunology | Child, Preschool | Protein Multimerization - immunology | Male | LDL-Receptor Related Proteins - antagonists & inhibitors | Autoantibodies - pharmacology | Epitopes - immunology | Immunoglobulin G - immunology | Aged, 80 and over | Immunoglobulin G - pharmacology | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Phosphorylation - immunology | Phosphorylation - drug effects | Child | Myasthenia Gravis - pathology | Cell Line | Receptors, LDL - antagonists & inhibitors | Receptors, LDL - immunology | Myasthenia Gravis - chemically induced | Autoantibodies - immunology | Animals | Adolescent | Agrin - immunology | Immunization, Passive | Receptors, Cholinergic - immunology | Aged | Mice | Myasthenia Gravis - immunology | LDL-Receptor Related Proteins - immunology | Protein Multimerization - drug effects | Insulin receptor | Neuromuscular junction | Activation loop | Causes of | Research | Health aspects | Binding sites (Biochemistry) | Biological Sciences
Journal Article
Muscle & Nerve, ISSN 0148-639X, 11/2017, Volume 56, Issue 5, pp. 938 - 942
ABSTRACT Introduction We assessed antibodies against low‐density lipoprotein receptor‐related protein 4 (LRP4‐Ab) in a Chinese population with myasthenia... 
myasthenia gravis | clinic presentation | acetylcholine receptor autoantibodies | pathogenic mechanism | low‐density lipoprotein receptor‐related protein 4 autoantibodies | muscle‐specific tyrosine kinase receptor autoantibodies | low-density lipoprotein receptor-related protein 4 autoantibodies | muscle-specific tyrosine kinase receptor autoantibodies | PROTEIN 4 | AGRIN | CLINICAL CHARACTERISTICS | LRP4 | NEUROSCIENCES | ACETYLCHOLINE-RECEPTOR | MUSK ANTIBODY | CLINICAL NEUROLOGY | MUSCLE-SPECIFIC KINASE | Severity of Illness Index | Myasthenia Gravis - blood | Autoantibodies - blood | Humans | Middle Aged | Receptor Protein-Tyrosine Kinases - immunology | Male | Young Adult | Asian Continental Ancestry Group | Adolescent | Anti-Inflammatory Agents - therapeutic use | Adult | Female | Receptors, Cholinergic - immunology | Retrospective Studies | Cholinesterase Inhibitors - therapeutic use | Myasthenia Gravis - immunology | LDL-Receptor Related Proteins - immunology | Myasthenia Gravis - drug therapy | Prednisone - therapeutic use | Autoimmunity | Tyrosine | Enzymes | Corticosteroids | Autoantibodies | Enzyme inhibitors | Myasthenia gravis | Low density lipoproteins | Immunoglobulins | Antibodies | Prednisone | Acetylcholinesterase | Kinases | Patients | MUSK protein | Acetylcholine receptors | Protein-tyrosine kinase receptors | Sampling methods | Neuromuscular junctions | Receptor density | Remission | Myasthenia | Protein-tyrosine kinase
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, p. e0135378
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e29976
Neuromuscular junction (NMJ) formation requires the highly coordinated communication of several reciprocal signaling processes between motoneurons and their... 
MOTOR-NEURONS | NEUROTRANSMITTER | POSTSYNAPTIC DIFFERENTIATION | AGRIN | ACETYLCHOLINESTERASE | BIOLOGY | GENE-EXPRESSION | MUSCLE | SYNAPSE FORMATION | RECEPTOR | KINASE MUSK | Phosphorylation | Wnt4 Protein - metabolism | Vertebrates - genetics | Neuromuscular Junction - metabolism | Humans | Vertebrates - embryology | Cercopithecus aethiops | Wnt4 Protein - deficiency | Muscles - pathology | Embryo, Mammalian - metabolism | Neuromuscular Junction - embryology | Wnt4 Protein - genetics | Gene Expression Regulation, Developmental | HEK293 Cells | Neuromuscular Junction - pathology | Biomarkers - metabolism | Muscle Cells - pathology | Muscles - ultrastructure | Receptors, Cholinergic - metabolism | Muscles - embryology | Muscle Cells - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Neuromuscular Junction - ultrastructure | Animals | Muscles - innervation | Protein Binding | Mice | Body Patterning - genetics | COS Cells | Cluster Analysis | Proteins | Cell differentiation | Analysis | Target recognition | Wnt protein | Synaptogenesis | Innervation | Differentiation (biology) | Kinases | Acetylcholinesterase | Signal transduction | Immunology | Rodents | Clusters | Localization | Rapsyn | Cues | Nerve endings | Motor neurons | Phenotypes | Myotubes | Muscles | Polymerase chain reaction | Vertebrates | Axons | Signaling | Microscopy | Neural networks | Acetylcholine receptors | Low density lipoprotein receptors | Neuromuscular junctions | Receptor density | Biological Markers | Embryo, Mammalian | Biochemistry, Molecular Biology | Receptor Protein-Tyrosine Kinases | Life Sciences | Neuromuscular Junction | Body Patterning | Muscle Cells | Molecular biology | Receptors, Cholinergic | Wnt4 Protein
Journal Article
Neuron, ISSN 0896-6273, 2008, Volume 60, Issue 2, pp. 285 - 297
Neuromuscular junction (NMJ) formation requires agrin, a factor released from motoneurons, and MuSK, a transmembrane tyrosine kinase that is activated by... 
CELLBIO | MOLNEURO | SIGNALING | ADULT-RAT BRAIN | POSTSYNAPTIC DIFFERENTIATION | TYROSINE PHOSPHORYLATION | ACETYLCHOLINE-RECEPTOR AGGREGATION | IN-VIVO | SYNAPSE FORMATION | NEUROMUSCULAR-JUNCTION | BETA-CATENIN | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | MUSCLE-SPECIFIC KINASE | Phosphorylation | Synaptic Transmission - genetics | Neuromuscular Junction - metabolism | Humans | Muscle Fibers, Skeletal - metabolism | Presynaptic Terminals - ultrastructure | Agrin - metabolism | Motor Neurons - ultrastructure | Neuromuscular Junction - embryology | Receptor Aggregation - genetics | Muscle Fibers, Skeletal - ultrastructure | Neuromuscular Junction - genetics | Agrin - genetics | Cell Line | Receptors, LDL - genetics | Receptors, Cholinergic - metabolism | Receptors, LDL - metabolism | Signal Transduction - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Synaptic Membranes - ultrastructure | Motor Neurons - metabolism | Tyrosine - metabolism | Animals | Receptor Protein-Tyrosine Kinases - genetics | Receptors, Cholinergic - ultrastructure | Presynaptic Terminals - metabolism | Mice | Synaptic Membranes - metabolism | Protein Binding - physiology | Receptors, Cholinergic - genetics | Synaptic Membranes - genetics | Tyrosine | Neurons | Autonomic drugs | Low density lipoproteins | Proteins | Software | Epidermal growth factor | Muscular system
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 02/2018, Volume 1413, Issue 1, pp. 143 - 153
Journal Article
Journal Article
The Journal of Physiology, ISSN 0022-3751, 09/2010, Volume 588, Issue 17, pp. 3217 - 3229
The postsynaptic muscle‐specific kinase (MuSK) coordinates formation of the neuromuscular junction (NMJ) during embryonic development. Here we have studied the... 
MOUSE NEUROMUSCULAR SYNAPSE | RAPSYN | LOCALIZATION | ANTI-MUSK ANTIBODIES | ACETYLCHOLINE-RECEPTORS | COMPLEX | PHYSIOLOGY | AGRIN | PHOSPHORYLATION | PASSIVE TRANSFER | NEUROSCIENCES | JUNCTION | Immunoglobulin G - physiology | Neuromuscular Junction - metabolism | Humans | Immunoglobulin G - toxicity | Receptor Protein-Tyrosine Kinases - immunology | Synapses - genetics | Myasthenia Gravis - etiology | Myasthenia Gravis - enzymology | Receptors, Cholinergic - deficiency | Myasthenia Gravis - metabolism | Synapses - metabolism | Neuromuscular Junction - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Neuromuscular Junction - enzymology | Disease Models, Animal | Receptor Protein-Tyrosine Kinases - deficiency | Receptors, Cholinergic - metabolism | Mice, Inbred C57BL | Cells, Cultured | Receptors, Cholinergic - chemistry | Synapses - enzymology | Receptor Protein-Tyrosine Kinases - metabolism | Matrix Attachment Regions - physiology | Animals | Autoantibodies - physiology | Autoantibodies - toxicity | Receptors, Cholinergic - immunology | Mice | Autoimmunity | Tyrosine | Embryonic development | Autoantibodies | Myasthenia gravis | Immunoglobulin G | Physiological aspects | Fluorescence | Acetylcholine | Non-governmental organizations | Autoimmune diseases | Patients | Immunoglobulins | Phosphorylation | Muscles | fluorescence resonance energy transfer | Embryogenesis | scaffolds | Packing | Dispersal | Acetylcholine receptors | MUSK protein | Plasma membranes | Neuromuscular junctions | Receptor density | Neuroscience
Journal Article