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Journal Article
Clinical Science, ISSN 0143-5221, 04/2009, Volume 116, Issue 8, pp. 607 - 620
AMPK (AMP-activated protein kinase) is a heterotrimetric enzyme that is expressed in many tissues, including the heart and vasculature, and plays a central... 
Obesity | Cardiovascular disease | Insulin resistance | 5-Amino-4-imidazole carboxamideriboside-1-β-D-ribofuranoside (AICAR) | Metformin | AMP-activated protein kinase (AMPK) | MEDICINE, RESEARCH & EXPERIMENTAL | cardiovascular disease | AORTIC ENDOTHELIAL-CELLS | COENZYME-A REDUCTASE | NITRIC-OXIDE SYNTHESIS | metformin | ACETYL-COA CARBOXYLASE | PARKINSON-WHITE-SYNDROME | ISCHEMIA-REPERFUSION INJURY | FATTY-ACID OXIDATION | IN-VIVO | 5-amino-4-imidazolecarboxamide riboside-1-beta-D-ribofuranoside (AICAR) | INSULIN-RESISTANCE SYNDROME | insulin resistance | obesity | CORONARY-ARTERY-DISEASE | Metabolic Syndrome - enzymology | Metformin - therapeutic use | Enzyme Activators - therapeutic use | Aminoimidazole Carboxamide - therapeutic use | Cardiovascular Diseases - drug therapy | Humans | Cardiovascular Diseases - enzymology | Enzyme Activation - drug effects | Metabolic Syndrome - drug therapy | AMP-Activated Protein Kinases - physiology | Ribonucleotides - therapeutic use | Thiazolidinediones - therapeutic use | Aminoimidazole Carboxamide - analogs & derivatives | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Signal Transduction - physiology | Enzyme Activation - physiology | ACC, acetyl-CoA carboxylase | CVD, cardiovascular disease | HMG-CoA, 3-hydroxy-3-methyl-CoA | AMPK, AMP-activated protein kinase | Review | MI, myocardial infarction | MO25, mouse protein 25 | CPT-1, carnitine palmitoyltransferase-1 | CaMK, Ca2 | IL-6, interleukin-6 | PDH, pyruvate dehydrogenase | HF, heart failure | 5-amino-4-imidazolecarboxamide riboside-1-β-D-ribofuranoside (AICAR) | CHF, chronic HF | mTOR, mammalian target of rapamycin | NEFA, non-esterified fatty acid (‘free fatty acid’) | PFK-2, phosphofructokinase-2 | STRAD, Ste20-related adaptor | p70RSK, p70 ribosomal protein S6 kinase | calmodulin-dependent protein kinase | GLUT-4, glucose transporter-4 | TNF-α, tumour necrosis factor-α | PROactive, PROspective pioglitAzone Clinical Trial In macroVascular Events | eNOS, endothelial NO synthase | LV, left ventricular | TZD, thiazolinedione | eEF2, eukaryotic elongation factor 2 | MF, metformin | PPAR-γ, peroxisome-proliferator-activated receptor-γ | AICAR, 5-amino-4-imidazolecarboxamide riboside-1-β-D-ribofuranoside
Journal Article
Oncotarget, ISSN 1949-2553, 01/2019, Volume 10, Issue 7, pp. 749 - 759
Although radiotherapy is often used to treat localized disease and for palliative care in prostate cancer patients, novel methods are required to improve the... 
AMPK | Radiosensitizer | AICAR | Prostate cancer
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 9/2017, Volume 54, Issue 7, pp. 5427 - 5439
The metabolic disease, type 2 diabetes mellitus (T2DM), is a major risk factor for Alzheimer’s disease (AD). This suggests that drugs such as metformin that... 
Neurology | Neurosciences | C. elegans | Biomedicine | Oligomerization | Alzheimer’s disease | Neurobiology | AICAR | Metformin | Cell Biology
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 06/2019, Volume 476, pp. 1725 - 1740
AMP-activated protein kinase (AMPK) is a heterotrimer of alpha-catalytic and beta- and gamma-regulatory subunits that acts to regulate cellular and whole-body... 
METFORMIN | HOMEOSTASIS | ISOFORMS | COMPOUND-C | METABOLISM | ADIPONECTIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADIPOCYTE DIFFERENTIATION | INHIBITS ADIPOGENESIS | AICAR | ADIPOSE-TISSUE
Journal Article
Immunology and Cell Biology, ISSN 0818-9641, 10/2010, Volume 88, Issue 7, pp. 754 - 760
  Activation of nuclear factor-kappa B (NF-κB) is one of the most important pro-inflammatory mechanisms in disease. In this study, we show that... 
NF-κB | AICAR | BAEC | AMP-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2004, Volume 384, Issue 2, pp. 295 - 305
AMPK (AMP-activated protein kinase) responds to intracellular ATP depletion, while PPARalpha (peroxisome proliferator-activated receptor alpha) induces the... 
5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) | Peroxisome proliferator-activated receptor α (PPARα) | ATP/AMP ratio | Nuclear translocation | Transcription | AMP-activated protein kinase (AMPK) | MUTAGENESIS | peroxisome proliferator-activated receptor alpha (PPAR alpha) | STIMULATION | transcription | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | CASCADE | BETA | REGION | LIVER-CELLS | nuclear translocation | GLUCOSE | 5-aminoimidazole-4-carboxamide ribonucleoside | AICAR | RIBOSIDE | EXPRESSION | Phosphotransferases - metabolism | Transcription, Genetic - drug effects | COS Cells - chemistry | Kidney - embryology | Humans | Transcriptional Activation - drug effects | Cercopithecus aethiops | Multienzyme Complexes - metabolism | HeLa Cells - metabolism | Hepatocytes - metabolism | AMP-Activated Protein Kinases | Protein Subunits - metabolism | Aminoimidazole Carboxamide - pharmacology | COS Cells - metabolism | Ribonucleotides - pharmacology | Transfection | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Protein-Serine-Threonine Kinases - physiology | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Rats | PPAR alpha - genetics | Kidney - cytology | Multienzyme Complexes - genetics | Multienzyme Complexes - antagonists & inhibitors | HeLa Cells - chemistry | Transcription, Genetic - physiology | Animals | Aminoimidazole Carboxamide - analogs & derivatives | Multienzyme Complexes - physiology | Cell Line, Tumor | Hepatocytes - chemistry | Transcriptional Activation - physiology | PPAR alpha - metabolism | AOX, peroxisomal acyl-CoA oxidase | GFP, green fluorescent protein | GST, glutathione S-transferase | PGC-1, PPARγ co-activator-1 | PPRE, peroxisome proliferator-responsive element | PPAR, peroxisome proliferator-activated receptor | the prefixes h, m and r denote human, mouse and rat respectively | RXR, retinoid X receptor | AMPK, AMP-activated protein kinase | HNF, hepatocyte nuclear factor | LBD, ligand-binding domain | ZMP, AICAR monophosphate | AMP ratio | DMEM, Dulbecco's modified Eagle's medium | CAT, chloramphenicol acetyltransferase | RT-PCR, reverse transcription–PCR | ATP | peroxisome proliferator-activated receptor α (PPARα) | AICAR, 5-aminoimidazole-4-carboxamide ribonucleoside
Journal Article
Neuroscience Letters, ISSN 0304-3940, 2009, Volume 455, Issue 3, pp. 191 - 194
We have previously demonstrated that Leptin reduces extracellular amyloid β (Aβ) protein both and , and intracellular tau phosphorylation . Further, we have... 
GSK-3β | Tau | AICAR | Alzheimer's disease | Leptin | ALZHEIMERS-DISEASE | GSK-3 beta | LITHIUM | NEUROSCIENCES | tau | Alzheimer’s disease
Journal Article
Molecular Oncology, ISSN 1574-7891, 11/2018, Volume 12, Issue 11, pp. 1917 - 1934
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2019, Volume 294, Issue 42, pp. 15257 - 15270
Metabolic pathways play important roles in proliferation and differentiation of malignant cells. 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr), a... 
Index Medicus | AML | Molecular Bases of Disease | leukemia | cell differentiation | cell cycle | DNA damage response | nucleotide | AMP-activated kinase (AMPK) | AICAr | Chk1 | pyrimidine
Journal Article