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Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 11, p. e0206838
Background We evaluated the safety and immunogenicity of (i) an intradermal HIV-DNA regimen given with/without intradermal electroporation (EP) as prime and... 
HUMORAL IMMUNE-RESPONSES | ELECTROPORATION | DNA VACCINE | SAFETY | MULTIDISCIPLINARY SCIENCES | BROAD | TYPE-1 | HIV Antibodies - blood | Immunogenicity, Vaccine | HIV Infections - prevention & control | Vaccines, DNA - genetics | env Gene Products, Human Immunodeficiency Virus - immunology | Humans | Viral Vaccines - genetics | AIDS Vaccines - immunology | Vaccines, DNA - immunology | Glucosides - immunology | Male | Administration, Cutaneous | Healthy Volunteers | Viral Vaccines - adverse effects | Vaccines, DNA - administration & dosage | AIDS Vaccines - adverse effects | Vaccinia virus - immunology | Young Adult | Antibodies, Neutralizing - immunology | env Gene Products, Human Immunodeficiency Virus - genetics | Lipid A - immunology | Mozambique | Vaccination - methods | HIV Antibodies - immunology | Adult | Female | Tanzania | Electroporation | Immunization, Secondary - methods | Viral Vaccines - administration & dosage | HIV-1 - immunology | Vaccines, DNA - adverse effects | AIDS Vaccines - genetics | AIDS Vaccines - administration & dosage | Viral Vaccines - immunology | Antibodies, Neutralizing - blood | AIDS vaccines | Usage | Care and treatment | Adults | Health aspects | HIV infection | Risk factors | Laboratories | Vaccination | Clinical trials | Viruses | Lipids | Infections | DNA vaccines | Vaccines | Lipid A | Proteins | Randomization | Immunology | Gag protein | Acquired immune deficiency syndrome--AIDS | Audio frequencies | Safety engineering | Human immunodeficiency virus--HIV | Safety | Public health | Deoxyribonucleic acid--DNA | Enzyme-linked immunosorbent assay | Antigens | Medical research | Immunization | Immunoglobulins | Internal medicine | Envelope protein | Priming | Medicine | Glycoprotein gp160 | Hospitals | Infectious diseases | Immunogenicity | γ-Interferon | Glycoprotein gp120 | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | DNA | Human immunodeficiency virus
Journal Article
Journal Article
Vaccine, ISSN 0264-410X, 2007, Volume 25, Issue 20, pp. 4085 - 4092
Abstract Needle-free delivery of a six-plasmid HIV-1 DNA vaccine encoding EnvA, EnvB, EnvC, and subtype B Gag, Pol, and Nef underwent open-label evaluation in 15 subjects... 
Allergy and Immunology | Promoter | Prevention | T cell response | AIDS | Envelope | Gag | Pol | Nef | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | VIRUS | SAFETY | HUMANS | IMMUNOGENICITY EVALUATION | INDUCTION | IMMUNOLOGY | ENV | envelope | promoter | MEMORY T-CELLS | prevention | HIV Infections - prevention & control | Vaccines, DNA - genetics | Gene Products, env - immunology | Humans | AIDS Vaccines - immunology | Vaccines, DNA - immunology | Male | Vaccines, Combined - administration & dosage | Vaccines, Combined - immunology | Vaccines, DNA - administration & dosage | AIDS Vaccines - adverse effects | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | HIV Antibodies - immunology | Plasmids - genetics | HIV Antibodies - biosynthesis | Vaccines, Combined - genetics | Adult | Female | Gene Products, gag - immunology | HIV Infections - virology | Plasmids - immunology | HIV-1 - genetics | Immunity, Cellular - immunology | HIV-1 - immunology | Vaccines, Combined - adverse effects | Vaccines, DNA - adverse effects | Adolescent | AIDS Vaccines - genetics | AIDS Vaccines - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Gene Products, nef - immunology | nef Gene Products, Human Immunodeficiency Virus | Proteins | AIDS vaccines | T cells | HIV (Viruses) | DNA | Enzyme-linked immunosorbent assay | Vaccines | Acquired immune deficiency syndrome--AIDS | Plasmids | Laboratories | Human immunodeficiency virus--HIV
Journal Article
Vaccine, ISSN 0264-410X, 2011, Volume 29, Issue 46, pp. 8417 - 8428
Highlights ► A phase I/II HIV vaccine trial has been conducted in Tanzania employing priming with HIV-1 DNA and boosting HIV-1 MVA... 
Allergy and Immunology | MVA boost | DNA prime | HIV vaccine | MEDICINE, RESEARCH & EXPERIMENTAL | VACCINIA VIRUS ANKARA | PHASE-1 SAFETY | IMMUNOGENICITY EVALUATION | CLADE-C | IMMUNOLOGY | DAR-ES-SALAAM | T-CELL RESPONSES | DOUBLE-BLIND | SMALLPOX VACCINATION | CANDIDATE VACCINE | MONOCLONAL-ANTIBODIES | Vaccines, DNA - genetics | Cell Proliferation | Humans | Viral Vaccines - genetics | AIDS Vaccines - immunology | Vaccines, DNA - immunology | Male | Neutralization Tests | Vaccines, Synthetic - immunology | Human Experimentation | Vaccines, DNA - administration & dosage | Vaccinia virus - genetics | Drug Carriers | Young Adult | Acquired Immunodeficiency Syndrome - immunology | Vaccination - methods | Leukocytes, Mononuclear - immunology | Adult | Female | Acquired Immunodeficiency Syndrome - virology | Placebos - administration & dosage | Injections, Intradermal | Interferon-gamma - secretion | Vaccines, Synthetic - genetics | Tanzania | Acquired Immunodeficiency Syndrome - prevention & control | Viral Proteins - genetics | Immunization, Secondary - methods | Enzyme-Linked Immunospot Assay | HIV-1 - genetics | Viral Vaccines - administration & dosage | HIV-1 - immunology | Plasmids | Adolescent | AIDS Vaccines - genetics | Vaccines, Synthetic - administration & dosage | AIDS Vaccines - administration & dosage | Genetic Vectors | Viral Vaccines - immunology | Interferon-gamma - biosynthesis | Viral antibodies | AIDS vaccines | Immune response | DNA | Vaccination | Antibodies | Universities and colleges | HIV (Viruses) | Biometry | Vaccines | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Immunization | CD8 antigen | Immune response (cell-mediated) | DNA vaccines | Lymphocytes T | Corticotropin-releasing hormone | CD4 antigen | glycoprotein gp160 | Gag protein | Immunogenicity | Interleukin 2 | Lymphocytes | Peripheral blood mononuclear cells | Serological tests | Enzyme-linked immunosorbent assay
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 2, p. e55571
.... We tested a DNA prime/adenovirus boost malaria vaccine in a Phase 1 clinical trial with controlled human malaria infection... 
APICAL MEMBRANE ANTIGEN-1 | SPOROZOITE INOCULATION | VIRUS ANKARA | IMMUNIZATION | NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | CIRCUMSPOROZOITE PROTEIN | DOUBLE-BLIND | NAIVE ADULTS | CYTOTOXIC T-LYMPHOCYTES | PHASE 2A TRIAL | Vaccines, DNA - genetics | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Humans | Middle Aged | Vaccines, DNA - immunology | Male | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Young Adult | Malaria Vaccines - adverse effects | Plasmodium falciparum - genetics | Malaria Vaccines - immunology | Adult | Female | Antigens, Protozoan - genetics | Malaria Vaccines - therapeutic use | Membrane Proteins - genetics | Adenoviruses, Human - immunology | Membrane Proteins - immunology | Vaccines, DNA - therapeutic use | Malaria, Falciparum - parasitology | Interferon-gamma - immunology | Vaccines, DNA - adverse effects | Adolescent | Malaria, Falciparum - immunology | Adenoviruses, Human - genetics | CD8-Positive T-Lymphocytes - immunology | Immunity, Cellular | Protozoan Proteins - immunology | Malaria Vaccines - genetics | Antigens | Wildlife conservation | Malaria | Liver | Vaccination | Malaria vaccine | Vaccines | T cells | Plasmodium falciparum | Advertising executives | Mosquitoes | Control | Analysis | Adenoviruses | DNA | Bites and stings | Genetic aspects | Health aspects | Enzyme-linked immunosorbent assay | Flow cytometry | Animal models | Goats | CD8 antigen | Antibodies | Leukocytes (mononuclear) | Lymphocytes T | Parasites | Aquatic insects | Immunity | Immunity (cell-mediated) | Replicating | Acquired immune deficiency syndrome--AIDS | Sporozoites | Peripheral blood mononuclear cells | Deoxyribonucleic acid--DNA | Circumsporozoite protein | Expression vectors | Vector-borne diseases | Medical research | Immunization | Statistical analysis | Diarrhea | Membrane proteins | Cytometry | Plasmids | γ-Interferon | Interferon | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS
Journal Article
Vaccine, ISSN 0264-410X, 2015, Volume 33, Issue 51, pp. 7344 - 7351
Abstract Recombinant adenoviral vector (rAd)-based vaccines are currently being developed for several infectious diseases and cancer therapy, but pre-existing seroprevalence to such vectors may prevent their use in broad human populations... 
Allergy and Immunology | Adenoviral vectors | Vaccine development | Humoral immune response | Simian adenovirus | Chimpanzee adenovirus | Cellular immune response | NONHUMAN-PRIMATES | MEDICINE, RESEARCH & EXPERIMENTAL | V3 LOOP | NEUTRALIZING ANTIBODIES | DENDRITIC CELLS | RHESUS-MONKEYS | ENVELOPE GLYCOPROTEIN | IMMUNOLOGY | IMMUNIZATION | T-CELL RESPONSES | IMMUNE-RESPONSES | GENE-TRANSFER | Vaccines, DNA - genetics | Adenoviruses, Simian - immunology | AIDS Vaccines - isolation & purification | Immunoglobulin G - blood | Viral Vaccines - genetics | AIDS Vaccines - immunology | Vaccines, DNA - immunology | Drug Discovery - methods | Vaccines, Synthetic - immunology | Antibodies, Viral - blood | Drug Carriers | Vaccines, Synthetic - isolation & purification | Adenoviruses, Simian - genetics | CD4-Positive T-Lymphocytes - immunology | Viral Vaccines - isolation & purification | Female | Vaccines, DNA - isolation & purification | SAIDS Vaccines - isolation & purification | Vaccines, Synthetic - genetics | SAIDS Vaccines - genetics | Animals | SAIDS Vaccines - immunology | AIDS Vaccines - genetics | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Genetic Vectors | Viral Vaccines - immunology | Monkeys | Vaccines | T cells | Health aspects | Immunotherapy | Immunoglobulin G | Antigens | Medical research | AIDS vaccines | Immune response | Communicable diseases | Adenoviruses | Medicine, Experimental | Development and progression | Studies | Ebola virus | Patents | Immunoglobulins | Inventors | Clinical trials | Viruses | Monkeys & apes | Vectors (Biology) | Deoxyribonucleic acid--DNA
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2015, Volume 349, Issue 6245, pp. 320 - 324
Journal Article
Journal Article