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ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, ISSN 1743-7555, 07/2016, Volume 12, pp. 36 - 36
Conference Proceeding
Molecular Cancer Therapeutics, ISSN 1535-7163, 01/2017, Volume 16, Issue 1, pp. 35 - 44
Abiraterone suppresses intracrine androgen synthesis via inhibition of CYP17A1. However, clinical evidence suggests that androgen synthesis is not fully... 
STEROIDOGENIC ENZYME AKR1C3 | CYP17A1 INHIBITION | ONCOLOGY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE AKR1C3 | INCREASED SURVIVAL | ENZALUTAMIDE RESISTANCE | ANTITUMOR-ACTIVITY | ANDROGEN RECEPTOR GENE | EXPRESSION | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | Prostatic Neoplasms - metabolism | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Male | Androstenes - pharmacology | Hydroxyprostaglandin Dehydrogenases - metabolism | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Prostatic Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | 3-Hydroxysteroid Dehydrogenases - metabolism | Transcription, Genetic | Prostatic Neoplasms - drug therapy | Disease Models, Animal | Prostatic Neoplasms - pathology | Gene Expression | Antineoplastic Agents, Hormonal - pharmacology | Cell Transformation, Neoplastic - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Animals | Aldo-Keto Reductase Family 1 Member C3 | Cell Line, Tumor | Mice | Cell Transformation, Neoplastic - drug effects | 3-Hydroxysteroid Dehydrogenases - genetics | Neoplasm Staging | Medical research | Transcription | Medical services | Clinical trials | Activation | Signaling | Androgens | Synthesis | Steroidogenesis | Indomethacin | Inhibition | Prostate cancer | Prostate | Cancer | Index Medicus | AKR1C3 | prostate cancer | intracrine androgens | abiraterone | indomethacin
Journal Article
Journal Article
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 07/2019, Volume 25, Issue 14, pp. 4493 - 4503
Purpose: OBI-3424 is a highly selective prodrug that is converted by aldo-keto reductase family 1 member C3 (AKR1C3) to a potent DNA-alkylating agent. OBI-3424... 
ACTIVATION | PHARMACOKINETICS | MECHANISM | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | ALDO-KETO REDUCTASES | AKR1C3 | RESISTANCE | SENSITIVITY | CHILDHOOD | CELL
Journal Article
Chemometrics and Intelligent Laboratory Systems, ISSN 0169-7439, 12/2014, Volume 139, pp. 132 - 138
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 06/2015, Volume 234, pp. 309 - 319
Estrogens have important roles in the pathogenesis of endometrial cancer. They can have carcinogenic effects through stimulation of cell proliferation or... 
Aromatase pathway | Sulfatase pathway | Phase I and phase II estrogen metabolism | Aldo–keto reductase 1C3 (AKR1C3) | 17β-Hydroxysteroid dehydrogenases (17β-HSDs, HSD17B) | Catechol-O-methyl transferase (COMT) | 17b-Hydroxysteroid dehydrogenases | (17b-HSDs HSD17B)Aldoketo reductase 1C3 (AKR1C3) | 17 beta-Hydroxysteroid dehydrogenases (17 beta-HSDs, HSD17B) | DEHYDROGENASES | QUINONES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROGESTERONE ACTION | 17-BETA-ESTRADIOL | CARCINOGENESIS | OVARIAN ENDOMETRIOSIS | Aldo-keto reductase 1C3 (AKR1C3) | ENZYMES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PHASE-I | CARCINOMA | PRE-RECEPTOR REGULATION | Sulfatases - genetics | Progesterone Reductase - metabolism | Humans | Endometrial Neoplasms - metabolism | Aromatase - metabolism | Catechol O-Methyltransferase - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Androstenedione - metabolism | Catechol O-Methyltransferase - metabolism | Aromatase - genetics | Endometrial Neoplasms - genetics | Sulfatases - metabolism | Estrogens - genetics | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Sulfotransferases - metabolism | Estrogens - metabolism | Quinones - pharmacology | Glutathione S-Transferase pi - genetics | Sulfotransferases - genetics | Estrone - genetics | Quinone Reductases - metabolism | Androstenedione - genetics | Glutathione S-Transferase pi - metabolism | Estrogens - biosynthesis | RNA, Messenger - genetics | Transcriptome - genetics | Progesterone Reductase - genetics | Arylsulfotransferase - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Estrone - analogs & derivatives | Aldo-Keto Reductase Family 1 Member C3 | Estrone - metabolism | Cell Line, Tumor | Quinone Reductases - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | Arylsulfotransferase - metabolism | Physiological aspects | Endometrial cancer | Sulfates | Genes | Estrogen | Steroids | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2019, Volume 25, Issue 4, pp. 1291 - 1301
Purpose: Steroidogenic enzymes are essential for prostate cancer development. Enzymes inactivating potent androgens were not investigated thoroughly, which... 
ANDROGEN-DEPRIVATION THERAPY | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-2 | TARGET | ONCOLOGY | STATISTICS | HSD3B1 | GENE-EXPRESSION | AKR1C3 | MECHANISMS | DRUG-RESISTANCE | ABIRATERONE
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 04/2019, Volume 62, Issue 7, pp. 3590 - 3616
Aldo-keto reductase 1C3 (AKR1C3) catalyzes the synthesis of 9 alpha,11 beta-prostaglandin (PG) F-2 alpha and PGF(2 alpha) prostanoids that sustain the growth... 
TARGET | CHEMISTRY, MEDICINAL | RETINOIC ACID | OLDER PATIENTS | ANALOGS | PROSTATE-CANCER | RESISTANCE | RECEPTOR | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE AKR1C3 | F SYNTHASE | CARBOHYDRATE BINDERS
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2017, Volume 139, pp. 936 - 946
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 08/2016, Volume 7, Issue 8, pp. 774 - 779
We report the design, synthesis, and evaluation of potent and selective inhibitors of aldo-keto reductase 1C3 (AKR1C3), an important enzyme in the regulatory... 
synergism | etoposide | acute myeloid leukemia | adjuvant | AKR1C3 Inhibitor | daunorubicin | CHEMISTRY, MEDICINAL | ACUTE MYELOGENOUS LEUKEMIA | MEDROXYPROGESTERONE ACETATE | IDENTIFICATION | RETINOIC ACID | METABOLISM | PROSTAGLANDINS | KETO REDUCTASE 1C3 | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE AKR1C3 | DRUG-COMBINATION
Journal Article
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 09/2014, Volume 143, pp. 250 - 258
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2018, Volume 17, Issue 9, pp. 1833 - 1845
Aldo-keto reductase 1C3 (AKR1C3), also known as type 5 17 beta-hydroxysteroid dehydrogenase, is responsible for intratumoral androgen biosynthesis,... 
ANDROGEN RECEPTOR | ACTIVATION | METABOLISM | ONCOLOGY | 5 17-BETA-HYDROXYSTEROID-DEHYDROGENASE AKR1C3 | TESTOSTERONE | RESISTANCE | PHASE-II | F SYNTHASE | CANCER | ADRENAL ANDROGENS | Index Medicus
Journal Article
MEDCHEMCOMM, ISSN 2040-2503, 08/2019, Volume 10, Issue 8, pp. 1476 - 1480
Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals.... 
AKR1C3 | CHEMISTRY, MEDICINAL | ACID | INHIBITORS | DERIVATIVES | BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal Article
BIOCHEMICAL PHARMACOLOGY, ISSN 0006-2952, 08/2018, Volume 154, pp. 64 - 74
PR-104A is a clinical-stage nitrogen mustard prodrug that is activated for DNA alkylation by reduction of a nitro group to the corresponding hydroxylamine... 
CELLS | PR-104A | Predictive biomarkers | INTERSTRAND | OXIDOREDUCTASE | AKR1C3 | SENSITIVITY | HYPOXIA | HEPATOCELLULAR-CARCINOMA | P450 oxidoreductase | CROSS-LINK REPAIR | ACUTE LYMPHOBLASTIC-LEUKEMIA | KETO REDUCTASE 1C3 | PHARMACOLOGY & PHARMACY | DNA adducts | CYTOTOXICITY
Journal Article